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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005.RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings. | Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，7： | 17 |
| 3 | 肠道微生态与益生菌显示文摘一、肠道微生态系统
除口腔外,人体消化道自上而下的细菌数量逐渐增多.成人肠道菌群主要集中在结肠和末端小肠,有多达1013个不同类型、不同含量的细菌,其细菌数是人体体细胞的10倍.在正常生理状态下,肠道含有近500个细菌品种,近200万个编码基因.宿主和细菌之间相互作用、相互影响,共同维系着肠道微生态的动态平衡.宿主的许多因素会影响肠道微生态的构成,如宿主的年龄、饮食结构、是否使用益生菌和/或抗生素、婴儿所处的外部环境、母亲的肠道菌群、分娩方式等. | Josef Neu 董璞 | 2005 | 新生儿科杂志2005，20，6： | 9 |
| 4 | 免疫营养素与新生儿感染显示文摘胃肠道拥有人体最大的表面积,它是微生物、异种抗原以及毒素进入宿主内环境的主要场所。胃肠道是全身炎症反应综合征的起源地,随着对肠道在炎症发生和多器官衰竭中作用认识的提高,具有免疫增强功能的肠内营养正日益引起人们的关注。本文将讨论谷氨酰胺、精氨酸、核苷酸以及乳铁蛋白等营养素参与机体免疫调节的机制和它们作为免疫营养素在新生儿感染中的临床应用前景。 | 黄瑛 邵肖梅 Josef Neu | 2003 | 国外医学(儿科学分册)2003，30，3： | 9 |
| 5 | Study on Steel-Mushy Al-20Sn Alloy Bonding显示文摘Steel-mushy Al-20Sn alloy bonding was studied for the first time. The relationship model about preheat temperature of steel plate, solid fraction of Al-20Sn alloy mushy, rolling speed and interfacial shear strength of bonding plate could be established by artificial neural networks perfectly. This model could be optimized with a genetic algorithm. The optimum bonding parameters were: 505’C for preheat temperature of steel plate, 34.3% for solid fraction of Al20Sn alloy musry and 10 mm/s for rolling speed, and the largest interfacial shear strength of bonding plate was 71.2 MPa. | Peng ZHANG, Yunhui DU and Daben ZENG Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China Jianzhong CUI Metal Forming Department, NEU, Shenyang 110006, China Limin BA Anshan Automobile Fittings Factory, Anshan 114014, China | 2001 | Journal of Materials Science & Technology2001，17，2： | 7 |
| 6 | Short lessons in basic life support improve self-assurance in performing cardiopulmonary resuscitation显示文摘BACKGROUND:There are several reasons why resuscitation measures may lead to inferior results:difficulties in team building,delayed realization of the emergency and interruption of chest compression.This study investigated the outcome of a new form of in-hospital cardiopulmonary resuscitation(CPR) training with special focus on changes in self-assurance of potential helpers when faced with emergency situations.METHODS:Following a 12-month period of CPR training,questionnaires were distributed to participants and non-participants.Those non-participants who intended to undergo the training at a later date served as control group.RESULTS:The study showed that participants experienced a significant improvement in selfassurance,compared with their remembered self-assurance before the training.Their self-assurance also was significantly greater than that of the control group of non-participants.CONCLUSION:Short lessons in CPR have an impact on the self-assurance of medical and non-medical personnel. | Mario Kobras Sascha Langewand Christina Murr Christiane Neu Jeannette Schmid | 2016 | World Journal of Emergency Medicine2016，7，4： | 7 |
| 7 | 鹅细小病毒VP3基因重组禽痘病毒转移载体的构建显示文摘从含有鹅细小病毒 (GPV)H1株主要结构蛋白VP3基因的重组质粒pPROEXHTb VP3中切取GPVH 1株VP3基因片段 ,将其亚克隆于 pSY5 3 8的EcoRⅠ位点 ,并将带有痘苗病毒启动子P11的LacZ报告基因平端克隆于上述重组子的SmaⅠ位点 ,再用NotⅠ切下同时含有VP3基因和LacZ报告基因的片段 ,亚克隆于pSY681的NotⅠ位点 ,构建了含有VP3基因的重组禽痘病毒转移载体。 | 田丽红 贾永清 王君伟 李一经 赵丽荣 Ulrich Neu mann | 2002 | 中国兽医科技2002，32，9： | 5 |
| 8 | Bactericera cockerelli(Sulc), a potential threat to China’s potato industry显示文摘The potato psyllid Bactericera cockerelli(Hemiptera:Triozidae)has recently emerged as a serious pest of potatoes and other solanaceous crops.It causes direct feeding damage and also vectors Candidatus Liberibacter solanaceaerum(Lso),a pathogen that causes zebra chip disease in potatoes and which potentially costs growers millions of dollars each year.Such producers rely on frequent sprays of pesticides for psyllid control but the results are unsatisfactory and there are negative side effects.The psyllid has spread beyond its native range in southwest US and northern Mexico to Canada,El Salvador,Honduras,Guatemala and Nicaragua via medium to long range dispersal flights perhaps aided by wind currents,and through anthropogenic means.It was accidentally introduced into New Zealand in 2006 and most recently Australia,most likely through the importation of infested plant material.This review summarizes information from studies on the biology,impact and management of B.cockerelli,and highlights the imminent risk of this insect and its associated pathogen invading China,the world’s largest producer of fresh potatoes.Development of risk maps leading to increased surveillance,could prevent or delay an incursion and facilitate early detection or eradication should this occur.Long-term management with Lso-tolerant potato cultivars and psyllid control using the parasitic wasp Tamarixia triozae and other natural enemies should be pursued,rather than depending on synthetic pesticides. | Oluwashola OLANIYAN Neus RODRÍGUEZ-GASOL Nathalie CAYLA Eleonor MICHAUD Steve D.WRATTEN | 2020 | Journal of Integrative Agriculture2020，19，2： | 3 |
| 9 | Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties显示文摘 | Sarah Schwitalla Alexander A. Fingerle Patrizia Cammareri Tim Nebelsiek Serkan I. G?ktuna Paul K. Ziegler Ozge Canli Jarom Heijmans David J. Huels Guenievre Moreaux Rudolf A. Rupec Markus Gerhard Roland Schmid Nick Barker Hans Clevers Roland Lang Jens Neu | 2013 | Cell2013，，： | 3 |
| 10 | Complications of percutaneous transhepatic biliary drainage in patients with dilated and nondilated intrahepatic bile ducts显示文摘 | Andreas Weber Jochen Gaa Bogdan Rosca Peter Born Bruno Neu Roland M. Schmid Christian Prinz | 2008 | European Journal of Radiology2008，，3： | 3 |
| 11 | Self-powered smart patch for sweatconductivity monitoring显示文摘A self-powered skin patch for the measurement of sweat conductivity is presented.The key component of the patch consists of a paper battery that is activated upon absorption of sweat.This body fluid acts as the battery electrolyte,the conductivity of which has a direct impact on the battery-generated output power and voltage.This particular behaviour enables the operation of a very simple and robust conductivity sensor in direct current mode without needing an external power source.The device presented in this paper takes advantage of this new measurement method to develop a sweat patch for screening cystic fibrosis that operates with an extremely simple electronic circuit that minimizes its cost and environmental impact.The patch provides an unambiguous digital result that can be read in an electrochromic display and yields 95%sensitivity and 100%specificity when tested with artificial eccrine perspiration samples. | Laura Ortega Anna Llorella Juan Pablo Esquivel Neus Sabate | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 12 | 二肽精氨酰-谷氨酰胺对脂多糖致肠道上皮细胞损伤的保护作用显示文摘目的探讨二肽精氨酰-谷氨酰胺(Arg-Gln)对脂多糖(LPS)致肠道上皮细胞Caco-2炎性反应、细胞活力及屏障功能损伤的影响及其可能的机制。方法用不含Gln的培养液加入不同水平的Arg-Gln培养Caco-2细胞24 h,同时加或不加Gln合成抑制剂———甲硫氨酸亚矾胺(MS)4.0 mmol.L-1。然后分别进行如下实验:(1)加入LPS 0.05 g.L-1,再培养24 h,分别测定促炎细胞因子IL-8水平(ELISA法)、细胞活力(MTS法)变化;比较相同水平(2.5 mmol.L-1)Arg-Gln和Gln、Arg的抗炎效果。(2)加入LPS0.4 g.L-1,再培养24 h,测定Caco-2细胞跨上皮电阻(TER)变化。(3)加入LPS 0.05 g.L-1再培养5 h,测定细胞核因子-κB(NF-κB)及其抑制因子I-κB表达的变化(免疫印迹法)。结果与不加LPS的细胞相比,加入LPS 0.05 g.L-1培养24 h可显著刺激Caco-2细胞产生IL-8,抑制细胞活力(Pa<0.05);加MS时,大剂量LPS(0.4 g.L-1)导致TER明显下降(P<0.05)。1.25~5.00 mmol.L-1 Arg-Gln可抑制LPS诱导的IL-8水平(P<0.05);同样剂量时(2.5 mmol.L-1),Gln对IL-8的抑制效果优于Arg-Gln和Arg。2.0~4.0 mmol.L-1Arg-Gln明显促进LPS抑制的Caco-2细胞活力的恢复(Pa<0.05);Arg-Gln可抑制LPS诱导的TER下降(P<0.05)。LPS(0.05 g.L-1)或Arg-Gln(2.0 mmol.L-1)对NF-κB和I-κB表达均无明显影响。结论 Arg-Gln可减轻LPS诱导的肠道上皮细胞屏障障碍及炎性反应,恢复细胞活力;Arg-Gln的保护机制可能与NF-κB途径无明显关系。 | 马丽亚 李楠 陈睿 周平 Josef NEU | 2012 | 实用儿科临床杂志2012，27，7： | 2 |
| 13 | P-Selectin Expression and Kupffer Cell Activation in Rat Acute Pancreatitis显示文摘 | Emma Folch Neus Prats Georgina Hotter Santiago López Emilio Gelpi Joan Roselló-Catafau Daniel Closa | 2000 | Digestive Diseases and Sciences2000，，8： | 2 |
| 14 | Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib显示文摘 | Maria Reig Ferran Torres Carlos Rodriguez-Lope Alejandro Forner Neus LLarch Jordi Rimola Anna Darnell José Ríos Carmen Ayuso Jordi Bruix | 2014 | Journal of Hepatology2014，，： | 2 |
| 15 | 氟喹诺酮类药物的新进展显示文摘氟喹诺酮类抗菌剂已在美国和欧洲的一般临床中应用5年多了。诺氟沙星是在美国注册应用的第一个氟喹诺酮类抗菌剂,曾批准可用于治疗尿路感染,但最近已用于治疗感染性腹泻。已批准环丙沙星可口服用于治疗因敏感细菌如流感杆菌和肺炎链球菌引起的尿路感染和呼吸道感染,如支气管炎的细菌性发作和肺炎。 | Neu HC 王金生 | 1993 | 国外医药(合成药.生化药.制剂分册)1993，14，6： | 2 |
| 16 | Postprogression survival of patients with advanced hepatocellular carcinoma: Rationale for second‐line trial design显示文摘 | Maria Reig Jordi Rimola Ferran Torres Anna Darnell Carlos Rodriguez‐Lope Alejandro Forner Neus LLarch José Ríos Carmen Ayuso Jordi Bruix | 2013 | Hepatology2013，，6： | 2 |
| 17 | 喹诺酮类药物的前景显示文摘新氟喹诺酮类药物已在不同国家的医院中和社会上应用2~5年了。这些药物已被医生所广泛接受,并确证对许多感染均非常有用.我们对这些药物已经认识到了什么呢?是将更有效的应用它们呢?还是改变我们的用药方法呢?本文的目的是对较新氟喹诺酮类药物作一展望。 | Neu HC 王金生 | 1992 | 国外医药(抗生素分册)1992，13，1： | 2 |
| 18 | Enteral Glutamine supplementation for very low birth Weight infants decrease morbidny显示文摘 | Neu J Roig JC Meetze WH | 1997 | J Pediatr1997，131，5： | 1 |
| 19 | Cognitive function over the treatment course of depression in middle-aged patients:correlation with brain MRI signal hyperintensities显示文摘 | Peter Neu Malek Bajbouj Andreas Schilling | 2005 | Journal of Psychiatric Research2005，3，9： | 1 |
| 20 | Plasticity in plolycrystalline fretting fatigue contacts 显示文摘 | Goh C H McDowell D L Neu R W | 2006 | J Mech Phys Solids2006，54，： | 1 |
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