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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | Complications of percutaneous transhepatic biliary drainage in patients with dilated and nondilated intrahepatic bile ducts显示文摘 | Andreas Weber Jochen Gaa Bogdan Rosca Peter Born Bruno Neu Roland M. Schmid Christian Prinz | 2008 | European Journal of Radiology2008，，3： | 3 |
| 3 | Cognitive function over the treatment course of depression in middle-aged patients:correlation with brain MRI signal hyperintensities显示文摘 | Peter Neu Malek Bajbouj Andreas Schilling | 2005 | Journal of Psychiatric Research2005，3，9： | 1 |
| 4 | Complications of percutaneous transhepatic biliary drainage in patients with dilated and nondilated intrahepatic bile ducts显示文摘 | Andreas Weber Jochen Gaa Bogdan Rosca Peter Born Bruno Neu Roland M. Schmid Christian Prinz | 2008 | European Journal of Radiology2008，，3： | 1 |
| 5 | Functional correlation approach to operational risk in banking orgnizations显示文摘 | Reimer Kuhn Peter Neu | 2003 | Physica A2003，322，5： | 1 |
| 6 | Endoscopic stent therapy in patients with chronic pancreatitis:A 5-year follow-up study显示文摘AIM:This study analyzed clinical long-term outcomes after endoscopic therapy,including the incidence and treatment of relapse. METHODS:This study included 19 consecutive patients(12 male,7 female,median age 54 years)with obstructive chronic pancreatitis who were admitted to the 2nd Medical Department of the Technical University of Munich.All patients presented severe chronic pancreatitis(stageⅢ°)according to the Cambridge classification.The majority of the patients suffered intermittent pain attacks.6 of 19 patients had strictures of the pancreatic duct;13 of 19 patients had strictures and stones.The first endoscopic retrograde pancreatography(ERP)included an endoscopic sphincterotomy, dilatation of the pancreatic duct,and stent placement.The first control ERP was performed 4 wk after the initial intervention,and the subsequent control ERP was performed after 3 mo to re-evaluate the clinical and morphological conditions.Clinical follow-up was performed annually to document the course of pain and the management of relapse.The course of pain was assessed by a pain scale from 0 to 10.The date and choice of the therapeutic procedure were documented in case of relapse. RESULTS:Initial endoscopic intervention was successfully completed in 17 of 19 patients.All 17 patients reported partial or complete pain relief after endoscopic intervention.Endoscopic therapy failed in 2 patients. Both patients were excluded from further analysis.One failed patient underwent surgery,and the other patient was treated conservatively with pain medication.Seventeen of 19 patients were followed after the successful completion of endoscopic stent therapy.Three of 17 patients were lost to follow-up.One patient was not avail-able for interviews after the 1st year of follow-up.Two patients died during the 3rd year of follow-up.In both patients chronic pancreatitis was excluded as the cause of death.One patient died of myocardial infarction, and one patient succumbed to pneumonia.All three patients were excluded from follow-up analysis.Followup was successfully completed in 14 of 17 patients.4 patients at time point 3,2 patients at time point 4,3 patients at time point 5 and 2 patients at time point 6 and time point 7 used continuous pain medication after endoscopic therapy.No relapse occurred in 57%(8/14) of patients.All 8 patients exhibited significantly reduced or no pain complaints during the 5-year follow-up.Seven of 8 patients were completely pain free 5 years after endoscopic therapy.Only 1 patient reported continuous moderate pain.In contrast,7 relapses occurred in 6 of the 14 patients.Two relapses were observed during the 1st year,2 relapses occurred during the 2nd year,one relapse was observed during the 3rd year,one relapse occurred during the 4th year,and one relapse occurred during the 5th follow-up year.Four of these six patients received conservative treatment with endoscopic therapy or analgesics.Relapse was conservatively treated using repeated stent therapy in 2 patients.Analgesic treatment was successful in the other 2 patients. CONCLUSION:57%of patients exhibited long-term benefits after endoscopic therapy.Therefore,endoscopic therapy should be the treatment of choice in patients being inoperable or refusing surgical treatment. | Andreas Weber Jochen Schneider Bruno Neu Alexander Meining Peter Born Stefan von Delius Monther Bajbouj Roland M Schmid Hana Algül Christian Prinz | 2013 | World Journal of Gastroenterology2013，19，5： | 1 |
| 7 | Functional Correlation Approach to Operational Risk in Banking Organizations显示文摘 | Reimer Kühn Peter Neu | 2003 | Physical A2003，322，： | 1 |
| 8 | 繁荣兴盛的全球银行业显示文摘2006年,全球银行业的竞争局势发生了翻天覆地的变化,波士顿咨询公司(BCG)最新发布的银行业研究报告令人惊异地显示,有3家中国国内银行从市值上看已跻身世界最大的前十位银行之列(前七)。报告认为,除了市值增长,为投资人带来了特别丰厚的回报之外,中国国内银行的竞争性也日益提高,过去五年的业绩均超出了西方银行。目前,中国的银行及其未来策略得到广泛关注。投资者期望这些银行采取广泛的行动。有些人士预期这些银行可能采取防御性模式,侧重迅猛增长的国内市场开发;另一些人士预测它们将采取更积极的战略,即可能通过收购打入外国市场。报告作者之一、BCG合伙人兼执行董事邓俊豪先生认为,数家中国银行在今后五到十年内就会向领先的西方银行发起挑战,并且在此时期内,中国及其它BRIC国家银行的增长速度将高于西方银行。但他同时指出,发展中市场也存在更高的波动性,如果市场信心下降,对些银行的估值可能会很快发生变化。 | 邓俊豪 Ranu Dayal Gerold Grasshoff Lars-Uwe Luther Peter Neu Eric Olsen Walter Sinn | 2007 | 中国企业家2007，，10： | 0 |
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