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| 1 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 4 |
| 2 | A case of eosinophilic cholangitis:Imaging findings ofcontrast-enhanced ultrasonography, cholangioscopy, andintraductal ultrasonography显示文摘A 38-year-old woman was referred to our institution due to epigastralgia. She presented with obstructive jaundice and eosinophilia. Endoscopic retrograde cholangiopancreatography showed diffuse narrowing from the distal common bile duct to the bifurcation of the hepatic ducts. An endoscopic plastic biliary stent was inserted; the specimen obtained from the common bile duct wall revealed dense infiltration by eosinophils. Treatment was started with prednisolone 60 mg daily. The patient's biliary stenosis and eosinophilia gradually improved. Eosinophilic infiltration in the lungs or stomach is relatively common, but it is rare in the common bile duct. Most of the reported cases of eosinophilic cholangitis presented with eosinophilia; our patient's eosinophil count was over 1000/mm3. Since our patient had allergies to pollen and house dust, a relationship between the allergies and the eosinophilic cholangitis was suspected, but no cause was identified. | Naoki Matsumoto Kiyoshi Yokoyama Kazuhiko Nakai Toshiki Yamamoto Takeshi Otani Masahiro Ogawa Naohide Tanaka Ariyoshi Iwasaki Yasuyuki Arakawa Masahiko Sugitani | 2007 | World Journal of Gastroenterology2007，13，13： | 3 |
| 3 | Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors显示文摘AIM:To evaluate the histopathological findings of type C liver disease to determine risk factors for development of hepatocellular carcinoma(HCC).METHODS:We studied 232 patients,who underwent liver biopsy for type C chronic liver disease between 1992 and 2009,with sustained virological response(SVR)after interferon therapy.The patients were divided into two groups according to the F stage 0+1+2 group(n = 182)and F3+4 group(n = 50).We prospectively observed and compared the incidence of HCC of the patients with SVR in the F0+1+2 and F3+4 groups.Then,the background factors and liver histopathological findings,including the degree of fibrosis,F stage,inflammation,necrosis,bile duct obstruction,fat deposition,and degree of irregular regeneration(IR)of hepatocytes,were correlated with the risk of developing HCC.RESULTS:HCC developed in three of 182(1.6%)patients in the F0+1+2 group,and four of 50(8.0%)in the F3+4 group.The cumulative incidence of HCC in the former group was found to be significantly lower than in the F3+4 group(log rank test P = 0.0224).The presence of atypical hepatocytes among IR of hepatocytes in the F3+4 group resulted in a higher cumulative incidence of HCC,and was significantly correlated with risk of HCC development(RR = 20.748,95%CI:1.335-322.5,P = 0.0303).CONCLUSION:Atypical hepatocytes among the histopathological findings of type C liver disease may be an important risk factor for HCC development along with progression of liver fibrosis. | Hiroshi Matsumura Kazushige Nirei Hitomi Nakamura Teruhisa Higuchi Yasuo Arakawa Masahiro Ogawa Naohide Tanaka Mitsuhiko Moriyama | 2013 | World Journal of Gastroenterology2013，19，30： | 3 |
| 4 | Micro RNA ‐148a is downregulated in gastric cancer, targets MMP 7, and indicates tumor invasiveness and poor prognosis显示文摘 | Naoya Sakamoto Yutaka Naito Naohide Oue Kazuhiro Sentani Naohiro Uraoka Htoo Zarni Oo Kazuyoshi Yanagihara Kazuhiko Aoyagi Hiroki Sasaki Wataru Yasui | 2014 | Cancer Sci2014，，2： | 2 |
| 5 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 2 |
| 6 | Defining the Functional Network of Epigenetic Regulators in Arabidopsis thaliana显示文摘薄片薄片和 ChIP-seq 技术的开发允许为 epigenetic 管理者的联系染色质的标记和有约束力的地点的染色体宽的高分辨率的介绍。然而,发信号因为指导 epigenetic 修饰词到他们的目标地点没被理解。在这份报纸,我们测试了那个染色体地点能影响的假设用染色质制图的 epigenetic 管理者(CC ) 的参与排队,它把相同 transgene 构造在 Arabidopsis 染色体在不同地点插入了。为酶记者基因的 epigenetic silencing 显示出证据的四根 CC 线与个别地指向 epigenetic 管理者 LHP1, MOM1, CMT3, DRD1, DRM2, SUVH2, CLF,和 HD1 的 RNAi 向量被转变。在 silencing 的一个特别 epigenetic 管理者的参与在一根 CC 线的 transgene 地点被重要改变在管理者的表示的抑制以后在酶表示决定。我们的结果建议指向 epigenetic 管理者能被染色体地点以及顺序上下文影响。另外,一个 epigenetic 管理者的相对重要性能被织物身份影响。我们也报导一条新奇途径通过在通常认为的下游的目标的基因表示用改变聚类管理者的分析预言在 epigenetic 管理者之间的相互作用,包括内长的 loci 和 transgenes,在 epigenetic 异种或 RNAi 线。我们的数据支持服务在更高的植物协调并且控制全球基因表示的 epigenetic 管理者的一个复杂、动态的网络的存在。 | Chongyuan Luo Brittany G. Durgin Naohide Watanabe Eric Lain | 2009 | Molecular Plant2009，2，4： | 2 |
| 7 | Molecular pathology of gastric cancer: Research and practice显示文摘 | Wataru Yasui Kazuhiro Sentani Naoya Sakamoto Katsuhiro Anami Yutaka Naito Naohide Oue | 2011 | Pathology - Research and Practice2011，，10： | 2 |
| 8 | Bactericidal activity of wasabi(Wasabia japonica)against Helicobacter pylori显示文摘 | Shin I S Masuda H Naohide K | 2004 | International Journal of Food Microbiology2004，94，3： | 1 |
| 9 | Search for new biomarkers of gastric cancer through serial analysis of gene expression and its clinical implications显示文摘 | Wataru Yasui Naohide Oue Reiko Ito | 2004 | Cancer Sci2004，95，5： | 1 |
| 10 | Characterization of STZ-induced type 2 diabetes in zueker fatty rats 显示文摘 | Takashi Okamoto Naohide Kanemoto Yutaka Ohbuchi | 2008 | Exp Anita2008，57，4： | 1 |
| 11 | High miR‐21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer显示文摘 | Naohide Oue Katsuhiro Anami Aaron J. Schetter Markus Moehler Hirokazu Okayama Mohammed A. Khan Elise D. Bowman Annett Mueller Arno Schad Manabu Shimomura Takao Hinoi Kazuhiko Aoyagi Hiroki Sasaki Masazumi Okajima Hideki Ohdan Peter R. Galle Wataru Yasui C | 2014 | Int. J. Cancer2014，，： | 1 |
| 12 | Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma显示文摘 | Naohide Oue Hideo Shigeishi Hiroki Kuniyasu | 2001 | Int J Cancer2001，93，： | 1 |
| 13 | Ex pression of Wnt-Sa Is Correlated with Aggressiveness of Gastric Cancer by Stimulating Cell Migration and Invasion 显示文摘 | Manabu Kurayoshi Naohide Oue Hideki Yamamoto | 2006 | Cancer Res2006，66，10： | 1 |
| 14 | Imaging steps of lymphaticmetastasis reveals that vascular endothelial growth factor-C in-creases metastasis by increasing delivery of cancer cells to lymphnodes:therapeutic implications显示文摘 | Tohru H Naohide I Jer oen H | 2006 | Cancer Researeh2006，66，16： | 1 |
| 15 | Expression of POT1 is Associated with Tumor Stage and Telomere Length in Gastric Carcinoma显示文摘 | Tomohiro K Naohide O Kazuhiro Y | 2004 | Cancer Res2004，64，： | 1 |
| 16 | Molecular-pathological prognostic factors of gastric cancer: a review显示文摘 | Wataru Yasui Naohide Oue Phyu Phyu Aung Shunji Matsumura Mariko Shutoh Hirofumi Nakayama | 2005 | Gastric Cancer2005，，2： | 1 |
| 17 | Molecular signature in three types of hepatocellular carcinoma withdifferent viral origin by oligonucleotide microarray显示文摘 | Norio Iizuka Masaaki Oka Hisafumi Yamada-Okabe Kenji Hamada Hironobu Nakayama Naohide Mori Takao Tamesa Toshimasa Okada Norikazu Takemoto Katsuhiro Matoba Motonari Takashima Katsuhiko Sakamoto Akira Tangoku Takanobu Miyamoto Shunji Uchimura Yoshihiko Hama | 2004 | International Journal of Oncology2004，，3： | 1 |
| 18 | Architectura l analysis of multiple fiber ring networks employing optical paths 显示文摘 | Watanable Atsushi Okamoto Satoru | 1997 | IEEE J Ligthwave Technology1997，15，17： | 1 |
| 19 | Undrained dynamic-loading ring-shear apparatus and its application to landslide dynamics显示文摘 | Kyoji Sassa Hiroshi Fukuoka Gonghui Wang Naohide Ishikawa | 2004 | Landslides2004，，1： | 1 |
| 20 | A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer显示文摘 | Shunji Matsumura Naohide Oue Hirofumi Nakayama Yasuhiko Kitadai Kazuhiro Yoshida Yoshiyuki Yamaguchi Kazue Imai Kei Nakachi Keisuke Matsusaki Kazuaki Chayama Wataru Yasui | 2005 | Journal of Cancer Research and Clinical Oncology2005，，1： | 1 |
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