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| 1 | Enhanced recovery program is safe and improves postoperative insulin resistance in gastrectomy显示文摘AIM: To assess the safety of enhanced recovery after surgery(ERAS) program in gastrectomy and influences on nutrition state and insulin-resistance. METHODS: Our ERAS program involved shortening the fasting periods and preoperative carbohydrate loading. Eighty gastrectomy patients were randomly assigned to either the conventional group(CG) or ERAS group(EG). We assessed the clinical characteristics and postoperative outcomes prospectively. The primary endpoint was noninferiority in timely discharge from the hospital within 12 d. Secondary endpoints were the incidence of aspiration at anesthesia induction, incidence of postoperative complications, health related quality of life(HRQOL) using the SF8 Health Survey questionnaire, nutrition state [e.g., albumin, transthyretin(TTR), retinal-binding protein(RBP), and transferrin(Tf)], the homeostasis model assessment-insulin resistance(HOMA-R) index, postoperative urine volume,postoperative weight change, and postoperative oral intake.RESULTS: The ERAS program was noninferior to the conventional program in achieving discharge from the hospital within 12 d(95.0% vs 92.5% respectively; 95%CI:-10.0%-16.0%). There was no significant difference in postoperative morbidity between the two groups. Adverse events such as vomiting and aspiration associated with the induction of general anesthesia were not observed. There were no significant differences with respect to postoperative urine volume, weight change, and oral intake between the two groups. EG patients with preoperative HOMA-R scores above 2.5 experienced significant attenuation of their HOMA-R scores on postoperative day 1 compared to CG patients(P = 0.014). There were no significant differences with respect to rapid turnover proteins(TTR, RBP and Tf) or HRQOL scores using the SF8 method.CONCLUSION: Applying the ERAS program to patients who undergo gastrectomy is safe, and improves insulin resistance with no deterioration in QOL. | Nobuaki Fujikuni Kazuaki Tanabe Noriaki Tokumoto Takahisa Suzuki Minoru Hattori Toshihiro Misumi Hideki Ohdan | 2016 | World Journal of Gastrointestinal Surgery2016，8，5： | 23 |
| 2 | Patients with early recurrence of hepatocellular carcinoma have poor prognosis显示文摘BACKGROUND: Early recurrence(ER) after hepatic resection(HR) is a poor prognostic factor for patients with hepatocellular carcinoma(HCC). This study aimed to identify the clinicopathological features, outcomes, and risk factors for ER after HR for small HCC in order to clarify the reasons why ER is a worse recurrence pattern.METHODS: We retrospectively examined 130 patients who underwent HR for small HCC(≤30 mm). Recurrence was classified into ER(<2 years) and late recurrence(LR)(≥2 years). The clinicopathological features, outcomes, and risk factors for ER were analyzed by multivariate analysis.RESULTS: ER was observed in 39 patients(30.0%). The survival rate of the ER group was significantly lower than that of the LR group(P<0.005), and ER was an independent prognostic factor for poor survival(P=0.0001). The ER group had a significantly higher frequency(P=0.0039) and shorter interval(P=0.027) of development to carcinoma beyond the Milan criteria(DBMC) compared with the LR group, and ER was an independent risk factor for DBMC(P<0.0001). Multi-nodularity, non-simple nodular type, and microvascular invasion were independent predictors for ER(P=0.012, 0.010, and 0.019, respectively).CONCLUSIONS: ER was a highly malignant recurrence pattern associated with DBMC and subsequent poor survival after HR for small HCC. Multi-nodularity, non-simple nodular type, and microvascular invasion predict ER, and taking these factors into consideration may be useful for the decision of the treatment strategy for small HCC after HR. | Tomoki Kobayashi Hiroshi Aikata Tsuyoshi Kobayashi Hideki Ohdan Koji Arihiro Kazuaki Chayama | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 15 |
| 3 | Successful treatment of conversion chemotherapy for initially unresectable synchronous colorectal liver metastasis显示文摘A 72-year-old woman with a sigmoid colon cancer and a synchronous colorectal liver metastasis(CRLM),which involved the right hepatic vein(RHV)and the inferior vena cava(IVC),was referred to our hospital.The metastatic lesion was diagnosed as initially unresectable because of its invasion into the confluence of the RHV and IVC.After she had undergone laparoscopic sigmoidectomy for the original tumor,she consequently had 3 courses of modified 5-fluorouracil,leucovorin,and oxaliplatin(m FOLFOX6)plus cetuximab.Computed tomography revealed a partial response,and the confluence of the RHV and IVC got free from cancer invasion.After 3 additional courses of m FOLFOX6 plus cetuximab,preoperative percutaneous transhepatic portal vein embolization(PTPE)was performed to secure the future remnant liver volume.Finally,a right hemihepatectomy was performed.The postoperative course was uneventful.The patient was discharged from the hospital on postoperative day 13.She had neither local recurrence nor distant metastasis 18 mo after the last surgical intervention.This multidisciplinary strategy,consisting of conversion chemotherapy using FOLFOX plus cetuximab and PTPE,could contribute in facilitating curative hepatic resection for initially unresectable CRLM. | Kenta Baba Akihiko Oshita Mohei Kohyama Satoshi Inoue Yuta Kuroo Takuro Yamaguchi Hiroyuki Nakamura Yoichi Sugiyama Tatsuya Tazaki Masaru Sasaki Yuji Imamura Yutaka Daimaru Hideki Ohdan Atsushi Nakamitsu | 2015 | World Journal of Gastroenterology2015，21，6： | 10 |
| 4 | Hepatocellular 癌和在一个肝糖存储疾病病人的肝的焦点的榴状的增生显示文摘 Glycogen storage disease type Ia (GSD-Ia; also called von Gierke disease) is an autosomal recessive disorder of carbohydrate metabolism caused by glucose-6-phosphatase deficiency. There have been many reports describing hepatic tumors in GSD patients; however, most of these reports were of hepatocellular adenomas, whereas there are only few reports describing focal nodular hyperplasia (FNH) or hepatocellular carcinoma (HCC). We report a case with GSD-Ia who had undergone a partial resection of the liver for FNH at 18 years of age and in whom moderately differentiated HCC had developed. Preoperative imaging studies, including ultrasonography, dynamic computer tomography (CT) and magnetic resonance imaging, revealed benign and malignant features. In particular, fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT revealed the atypical findings that FDG accumulated at high levels in the non-tumorous hepatic parenchyma and low levels in the tumor. Right hemihepatectomy was performed. During the perioperative period, high-dose glucose and sodium bicarbonate were administered to control metabolic acidosis. He had multiple recurrences of HCC at 10 mo after surgery and was followed-up with transcatheter arterial chemoembolization. The tumor was already highly advanced when it was found by chance; therefore, a careful follow-up should be mandatory for GSD-I patients as they are at a high risk for HCC, similar to hepatitis patients. | Yoshihiro Mikuriya Akihiko Oshita Hirotaka Tashiro Hironobu Amano Tsuyoshi Kobayashi Kouji Arihiro Hideki Ohdan | 2012 | World Journal of Hepatology2012，4，6： | 4 |
| 5 | Prophylactic managements of hepatitis B viral infection inliver transplantation显示文摘Liver transplantation(LT)is a considerably effective treatment for patients with end-stage hepatitis B virus(HBV)-related liver disease.However,HBV infection often recurs after LT without prophylaxis.Since the1990s,the treatment for preventing HBV reinfection after LT has greatly progressed with the introduction of hepatitis B immunoglobulin(HBIG)and nucleos(t)ide analogues(NAs),resulting in improved patient survival.The combination therapy consisting of high-dose HBIG and lamivudine is highly efficacious for preventing the recurrence of HBV infection after LT and became the standard prophylaxis for HBV recurrence.However,mainly due to the high cost of HBIG treatment,an alternative protocol for reducing the dose and duration of HBIG has been evaluated.Currently,combination therapy using low-dose HBIG and NAs is considered as the most efficacious and cost-effective prophylaxis for post-LT HBV reinfection.Recently,NA monotherapy and withdrawal of HBIG from combination therapy,along with the development of new,potent high genetic barrier NAs,have provided promising efficacy,especially for low-risk recipients.This review summarizes the prophylactic protocol and their efficacy including prophylaxis of de novo HBV infection from anti-HBc antibody-positive donors.In addition,challenging approaches such as discontinuation of all prophylaxis and active immunity through hepatitis B vaccination are discussed. | Takashi Onoe Hiroyuki Tahara Yuka Tanaka Hideki Ohdan | 2016 | World Journal of Gastroenterology2016，22，1： | 3 |
| 6 | possible role of soluble fibrin monomer complex after gastroenterological surgery显示文摘AIM To examine the role of soluble fibrin monomer complex(SFMC) in the prediction of hypercoagulable state after gastroenterological surgery.METHODS We collected data on the clinical risk factors and fibrin-related makers from patients who underwent gastroenterological surgery at Hiroshima University Hospital between April 1, 2014 and March 31, 2015. We investigated the clinical significance of SFMC, which is known to reflect the early plasmatic activation of coagulation, in the view of these fibrin related markers.RESULTS A total of 123 patients were included in the present study. There were no patients with symptomatic VTE. Thirty-five(28%) patients received postoperative anticoagulant therapy. In the multivariate analysis, a high SFMC level on POD 1 was independently associated with D-dimer elevation on POD 7(OR = 4.31, 95%CI: 1.10-18.30, P = 0.03). The cutoff SFMC level was 3.8 μg/ml(AUC = 0.78, sensitivity, 63%, specificity, 89%). The D-dimer level on POD 7 was significantly reduced in high-SFMC patients who received anticoagulant therapy in comparison to highSFMC patients who did not.CONCLUSION The SFMC on POD 1 strongly predicted the hypercoagulable state after gastroenterological surgery than the clinical risk factors and the other fibrin related markers. | Masatoshi Kochi Manabu Shimomura Takao Hinoi Hiroyuki Egi Kazuaki Tanabe Yasuyo Ishizaki Tomohiro Adachi Hirotaka Tashiro Hideki Ohdan | 2017 | World Journal of Gastroenterology2017，23，12： | 3 |
| 7 | Impact of Rituximab Desensitization on Blood‐Type‐Incompatible Adult Living Donor Liver Transplantation: A Japanese Multicenter Study显示文摘 | H. Egawa S. Teramukai H. Haga M. Tanabe A. Mori T. Ikegami N. Kawagishi H. Ohdan M. Kasahara K. Umeshita | 2014 | American Journal of Transplantation2014，，1： | 3 |
| 8 | Current status of liver transplantation across ABO blood-type barrier显示文摘 | Egawa H Ohdan H Haga H | 2008 | Journal of Hepato-Biliary-Pancreatic Surgery2008，，02： | 2 |
| 9 | Biliary Complications after Duct-to-duct Biliary Reconstruction in Living-donor Liver Transplantation: Causes and Treatment显示文摘 | Hirotaka Tashiro Toshiyuki Itamoto Tamito Sasaki Hideki Ohdan Yasuhiro Fudaba Hironobu Amano Saburo Fukuda Hideki Nakahara Kohei Ishiyama Akihiko Ohshita Toshihiko Kohashi Hiroshi Mitsuta Kazuaki Chayama Toshimasa Asahara | 2007 | World Journal of Surgery2007，，11： | 2 |
| 10 | Impact of Pegylated Interferon Therapy on Outcomes of Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma After Curative Hepatic Resection显示文摘 | Yoshisato Tanimoto MD Hirotaka Tashiro MD Hiroshi Aikata MD Hironobu Amano MD Akihiko Oshita MD Tsuyoshi Kobayashi MD Shintaro Kuroda MD Hirofumi Tazawa MD Shoichi Takahashi MD Toshiyuki Itamoto MD Kazuaki Chayama MD Hideki Ohdan MD | 2012 | Annals of Surgical Oncology2012，，2： | 2 |
| 11 | Effect of Left Colonic Artery Preservation on Anastomotic Leakage in Laparoscopic Anterior Resection for Middle and Low Rectal Cancer显示文摘 | Takao Hinoi Masazumi Okajima Manabu Shimomura Hiroyuki Egi Hideki Ohdan Fumio Konishi Kenichi Sugihara Masahiko Watanabe | 2013 | World Journal of Surgery2013，，12： | 2 |
| 12 | Bacteriological investigation of bile in patients with cholelithiasis显示文摘 | Oshiro H Yamamoto Y | 1993 | Surg Today1993，23，5： | 1 |
| 13 | Leiomyosarcoma of the infrior vena cava:A case report of steroid-receptor-positive leiomyosarcoma显示文摘 | Ohdan H Fukuda Y Tanaka L | 1994 | Vasc Surg1994，28，2： | 1 |
| 14 | Characteristics of two forms of a-amylase and structural implication 显示文摘 | Ohdan K Kuriki T Kaneko H | 1999 | Appl Environ Microbiol1999，65，10： | 1 |
| 15 | Expression profiling of genes involved in starch synthesis in sink and source organs of rice 显示文摘 | Ohdan T Francisco PB Jr Sawada T | 2005 | J Exp Bot2005，56，422： | 1 |
| 16 | Role of the bcl2/bax pathway in hepatocyte apoptosis during acute rejection after rat liver transplantation显示文摘 | Yamamoto H Ohdan H Shintaku S | 1998 | Transpl Irt1998，11，1： | 1 |
| 17 | NK cell tolerance in mixed allo- geneie chimeras显示文摘 | Zhao Y Ohdan H Manilay JO | 2003 | J lmmunol2003，170，11： | 1 |
| 18 | High miR‐21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer显示文摘 | Naohide Oue Katsuhiro Anami Aaron J. Schetter Markus Moehler Hirokazu Okayama Mohammed A. Khan Elise D. Bowman Annett Mueller Arno Schad Manabu Shimomura Takao Hinoi Kazuhiko Aoyagi Hiroki Sasaki Masazumi Okajima Hideki Ohdan Peter R. Galle Wataru Yasui C | 2014 | Int. J. Cancer2014，，： | 1 |
| 19 | Expression profiling of starch metabolism-related plastidic translocator genes in rice显示文摘 | Toyota K Tamura M Ohdan T | 2006 | Planta2006，223，： | 1 |
| 20 | Bacteriological investigation of bile in patients with cholelithiasis显示文摘 | Hideki Ohdan Hisashi Oshiro Yasuji Yamamoto Issei Tanaka Kazuo Inagaki Kazuo Sumimoto Takao Hinoi | 1993 | Surgery Today1993，，5： | 1 |
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