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| 1 | Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis显示文摘BACKGROUND The gut-liver axis has attracted much interest in the context of chronic liver disease pathogenesis.Prebiotics such as dietary fibers were shown to attenuate non-alcoholic fatty liver disease(NAFLD)by modulating gut microbiota.Partially hydrolyzed guar gum(PHGG),a water-soluble dietary fiber,has been reported to alleviate the symptoms of various intestinal diseases and metabolic syndromes.However,its effects on NAFLD remain to be fully elucidated.To determine whether treatment with PHGG attenuates NAFLD development in mice through the gut-liver axis.METHODS Seven-week-old male C57BL/6J mice with increased intestinal permeability were fed a control or atherogenic(Ath)diet(a mouse model of NAFLD)for 8 wk,with or without 5%PHGG.Increased intestinal permeability was induced through chronic intermittent administration of low-dose dextran sulfate sodium.Body weight,liver weight,macroscopic findings in the liver,blood biochemistry[aspartate aminotransferase(AST)and alanine aminotransferase(ALT),total cholesterol,triglyceride,free fatty acids,and glucose levels],liver histology,myeloperoxidase activity in liver tissue,mRNA expression in the liver and intestine,serum endotoxin levels in the portal vein,intestinal permeability,and microbiota and short-chain fatty acid(SCFA)profiles in the cecal samples were investigated.RESULTS Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels,liver fat accumulation,liver inflammatory(tumor necrosis factor-αand monocyte chemotactic protein-1)and fibrogenic(collagen 1a1 andαsmooth muscle actin)marker levels,and liver myeloperoxidase activity,which were significantly attenuated by PHGG treatment.Furthermore,the Ath diet combined with increased intestinal permeability resulted in elevated portal endotoxin levels and activated toll-like receptor(TLR)4 and TLR9 expression,confirming that intestinal permeability was significantly elevated,as observed by evaluating the lumen-to-blood clearance of fluorescein isothiocyanate-conjugated dextran.PHGG treatment did not affect fatty acid metabolism in the liver.However,it decreased lipopolysaccharide signaling through the gut-liver axis.In addition,it significantly increased the abundance of cecal Bacteroides and Clostridium subcluster XIVa.Treatment with PHGG markedly increased the levels of SCFAs,particularly,butyric acid,acetic acid,propionic acid,and formic acid,in the cecal samples.CONCLUSION PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles. | Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya Iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa Takeshi Ishikawa Zenta Yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 2 | ATOMIC SCALE MECHANISM OF RESTRAINED EMBRITTLEMENT IN AMORPHOUS Fe_(78)B_(13)Si_9 ALLOY BY ELECTRIC PULSE RAPID ANNEALING显示文摘The direct observations of the atomic arrangements in both conventional furnace annealed and electric pulse rapid annealed Fe78B13Si9 amorphous alloy have been conducted by the lattice imaging technique in a higt resolution electron microscope. The results showed that the embrittlement of the alloy was related to the extent of atomic rearrangements during the annealing processes. The embrittlement of the alloy after 1hour conventional furnace annealing at about 270℃ is caused by the sufficient atomic rearrangements which are characterized by the growth of some bct Fe3B-like atomic short range ordering regions already existed in the as-quenched structure. Electric pulse rapid annealing can effectively retard the above-mentioned atomic rearrangements and thus restrain the embrittlement. The embrittlement only occurs when certain amount of bcc α-Fe nanocrystals are precipitated in the amorphous matrix during electric pulse rapid annealing. | J.L. Huang X.G. Cao E. Sukedai S. Yamasaki and H.C.Gu(Department of Materials Engineering, Luoyang Institute of Technology, Luoyang 471039, China)(Department of Mechanical Engineering, Okayama University of Science, 1-1 Ridai-Cho,Okayama City,Okayma | 1998 | Acta Metallurgica Sinica(English Letters)1998，11，4： | 3 |
| 3 | 使用新型铸机生产优质超厚钢板显示文摘1996年,日本新日铁公司名古屋厂建成兼具模铸和连铸优点的新型铸机.该铸机有三大特点:板坯厚度变化范围为245~400mm(最厚600mm);通过垂直浇铸与控制凝固,减少非金属夹杂物和偏析,生产优质板坯;该设备能够像连铸工艺那样生产锅炉、压力容器、可移动海洋建筑结构和其它重载结构用优质超厚钢板.生产的优质超厚钢板最厚达200mm,低碳超厚钢板最厚达330mm.本文介绍这种新型铸机及其生产效果. | Yutaka OKAYAMA 梁慧智 | 2005 | 鞍钢技术2005，，5： | 2 |
| 4 | Hypertension and medical expenditure in the Japanese population:Review of prospective studies显示文摘Hypertension is a major determinant of health and is likely to have an effect on medical economics.The economic burden due to hypertension may be attributable not only to antihypertensive medication but also to the very expensive procedures required for cases of cardiovascular disease that occur more frequently in hypertensive compared with normotensive individuals.The objective of this article was to review articles published on prospective cohort studies that measured medical expenditure attributable to hypertension in community-dwelling populations in Japan.Many medical services in these populations are provided under the medical insurance system that requires the enrolment of all Japanese residents.Personal medical expenditure attributable to hypertension increases with worsening severity of the condition.Medical expenditure was increased further in cases of hypertensive patients who have another concomitant cardiovascular risk factor.In particular,hypertension,especially moderate-to-severe untreated hypertension,increases the risk of long-term hospitalization resulting in considerably higher medical expenditure,compared with non-hospitalized cases.Therefore,assuming that the use of antihypertensive medication is essential for hypertensive patients to prevent serious vascular diseases,a cost-effective highrisk strategy needs to be considered to reduce both ill-health and the economic burden due to hypertension.However,from a population perspective,medical expenditure attributable to hypertension comes mainly from pre-to-mild hypertension.Therefore,there is also a need to consider a population strategy that aims to shift the entire population to lower levels of blood pressure. | Koshi Nakamura Tomonori Okamura Katsuyuki Miura Akira Okayama | 2014 | World Journal of Cardiology2014，6，7： | 2 |
| 5 | High-efficiency cloning of full-length cDNA显示文摘 | Okayama H Berg P | 1982 | Mol Cell Biol1982，，2： | 2 |
| 6 | Calcium phosphate -mediated gene transfer: A highly efficient transfection system for stably transforming cells with plasmid DNA显示文摘 | Chen C A Okayama H | 1988 | Biotechniques1988，6，7： | 1 |
| 7 | A primitive study of a fire detection method control by artificial neural net显示文摘 | OKAYAMA Y | 1991 | Fire Safety Journal1991，17，6： | 1 |
| 8 | Relation between interleukin-18 and PGE2 in synovial fluid of osteoarthritis: a potential therapeutic target of cartilage degradation 显示文摘 | Futani H Okayama A Matsui K | 2002 | Immunotherapy2002，25，1： | 1 |
| 9 | Loop-mediated isothermal amplification of DNA显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Res2000，28，12： | 1 |
| 10 | Studies on coumarins of Chinese drug 'Qian-Hu'显示文摘 | Okayama T Shibata S | 1981 | Planta Media1981，42，1： | 1 |
| 11 | Hepatocyte growth factor reduces cardiac fibrosis by inhibiting endothelial mesenchymal transition显示文摘 | Okayama K Azuma J Dosaka N | 2012 | Hypertension2012，59，5： | 1 |
| 12 | interactions between Anmotensin-converting deletion polymorphism and response to eibenzoline in patients with hypertrophic obstructive cardiomyopathy显示文摘 | Ogimoto A Okayama H Nagai T | 2010 | Cardiovasc Pharmaeol2010，55，5： | 1 |
| 13 | Development, migration and survival of mast cells 显示文摘 | OKAYAMA Y KAWAKAMI T | 2006 | Immunol Res2006，34，2： | 1 |
| 14 | Mechanisms of inhibitory activity of the aldose reductase inhibitor, epalrestat, on high glucose-mediated endothelial injury: neutrophil-endothelial cell adhesin and surface expression of endothelial adhesion molecules显示文摘 | Okayama N Omi H Okouchi M | 2002 | J Diabes Complications2002，16，5： | 1 |
| 15 | Stroke incidence and case fatality in Shiga,Japan 1989-1993显示文摘 | Okayama A Ueshima H | 1999 | Int J Epidemiol1999，28，6： | 1 |
| 16 | Loop-mediated isothermal amplification of DNA显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Research2000，28，12： | 1 |
| 17 | Computer evaluation of sprinkler irrigation uniformity显示文摘 | Fukui Y Nakanishi K Okayama S | 1980 | Irrigation Science1980，2，1： | 1 |
| 18 | High efficiency transformation of Escherichia coli with plasmids显示文摘 | Inoue H Nojima H Okayama H | 1990 | Gene1990，96，1： | 1 |
| 19 | Simple genotype analysis of the Asp299Gly polymorphism of the Toll-like receptor- 4 gene that is associated with lipopolysaccharide hyporesponsive- ness 显示文摘 | Okayama N Fujimura K Suehiro Y | 2002 | J Clin Lab Anal2002，16，1： | 1 |
| 20 | Loop-mediated isothermal amplification of DNA 显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Res2000，28，12： | 1 |
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