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| 1 | NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis显示文摘AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, 'NAT2*4', was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity. | Norihide Higuchi Naoko Tahara Katsunori Yanagihara Kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu Kobayashi Koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa Katsuhisa Omagari Yohei Mizuta Shigeru Kohno Kazuhiro Tsukamoto | 2007 | World Journal of Gastroenterology2007，13，45： | 21 |
| 2 | A case of very large intrahepatic bile duct adenoma followed for 7 years显示文摘A 70-year-old man was referred to our hospital due to abnormal liver function. A tumor of 92 mm × 61 mm was detected on ultrasound screening of the left liver lobe. Although the tumor was suspected to be intrahepatic bile duct carcinoma, he had chronic heart disease and was unable to undergo surgery. Therefore, he was followed without further testing. No increase in tumor serum markers or tumor size was observed for the subsequent 7 years. We continued to suspect intrahepatic bile duct carcinoma, and we decided to perform a tumor biopsy. Tumor biopsy findings indicated intrahepatic bile duct adenoma(BDA), which is a rare benign epithelial liver tumor typically ranging from 1 mm to20 mm. We herein report a case of very large BDA followed for 7 years. | Futa Koga Hiroto Tanaka Seigo Takamatsu Shinnichi Baba Hiroshi Takihara Akioko Hasegawa Eri Yanagihara Taro Inoue Toshihiro Nakano Chie Ueda Wataru Ono | 2012 | World Journal of Clinical Oncology2012，3，4： | 3 |
| 3 | Micro RNA ‐148a is downregulated in gastric cancer, targets MMP 7, and indicates tumor invasiveness and poor prognosis显示文摘 | Naoya Sakamoto Yutaka Naito Naohide Oue Kazuhiro Sentani Naohiro Uraoka Htoo Zarni Oo Kazuyoshi Yanagihara Kazuhiko Aoyagi Hiroki Sasaki Wataru Yasui | 2014 | Cancer Sci2014，，2： | 2 |
| 4 | Effects of short interfering RNA against methicillin-resistant Staphylococcus aureus coagulase vitro and vivo显示文摘 | Yanagihara K Tashiro M Fukuda Y | 2006 | J Antimicrob Chemother2006，57，： | 1 |
| 5 | Cerebral ischemia in the gerbil transmission electron microscopic and immunoelectron microscopic investigation显示文摘 | Morimoto K Yanagihara T | 1986 | Brain Res1986，384，1： | 1 |
| 6 | A comparison of anal endosonography with electromyography and manometry in high and intermediate anorectal anomalies显示文摘 | Iwai N Yanagihara J | 1997 | J Pediatr Surg1997，32，6： | 1 |
| 7 | Sox2 is freqnentlydownreglated in gastric cancers and inhibits cell growth through cell -eyele arrest and apoptosis 显示文摘 | Otsubo T Akiyama Y Yanagihara K | 2008 | Br J Cancer2008，98，4： | 1 |
| 8 | Evalutation of angiogenesis in non - small cell lung cancer: comparsion bettween anti - CD34 antibody and anti- CD105 antibody 显示文摘 | Tanaka F Otake Y Yanagihara K | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 9 | Modulation of adhesion molecules and monocyte chemoattractant protein by tumor necrosis factor-sand salicylic acid in primary human coronary attery endothelial cells显示文摘 | Chua PK Yanagihara R Melish ME | 2003 | Cell Mol Biol2003，49，7： | 1 |
| 10 | Maltol(3-hydroxy-2-methyl-4-pyrone)toxicity in neuroblastoma cell lines and primary murine fetal hippocampal neuronalcultures显示文摘 | Hironishi M Kordek R Yanagihara R | 1996 | Neurodegeneration1996，5，4： | 1 |
| 11 | Maltol(3-hydroxy2-methyl-4-pyrone)toxicity in Neuroblastoma cell Lines and primary murine fetal hippocampal neuronal cultures显示文摘 | Kordek R Yanagihara R | 1996 | Neurodegeneration1996，5，4： | 1 |
| 12 | Expression of angiopoietins and its clinical significance in non-small cell lung cancer显示文摘 | Tanaka F Ishikawa S Yanagihara K | 2002 | Cancer Res2002，62，71： | 1 |
| 13 | Antimicrobial susceptibility by Etest of Bartonella henselae isolated from cats and human in Japan显示文摘 | Tsuneoka H Yanagihara M Nojima J | 2010 | J Infect Chemother2010，16，6： | 1 |
| 14 | Antiproliferation effect of isoflavones on human cancer cell lins established from the gastrointestinal tract显示文摘 | Yanagihara K Ito A Toge T | 1993 | Cancer Res1993，53，： | 1 |
| 15 | Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer 显示文摘 | Ishikawa S Takenaka K Yanagihara K | 2004 | Clin Cancer Res2004，10，19： | 1 |
| 16 | Comparison ot usefulness of plasma procaleition and C-reactive protein measure- ments for estimation of severity in adults with community acquired pneumonia 显示文摘 | Hirakata Y Yanagihara K Kurihara S | 2008 | Diagn Microbiol Infect Dis2008，61，2： | 1 |
| 17 | Differential susceptibility and resistance of immunocompetent and immunodeficient mice to fetal Hantaan virus infection 显示文摘 | Yanagihara R Gibbs CJ | 1985 | Arch Virol1985，86，12： | 1 |
| 18 | Induction of c-fos and c-jun gene products and heat shock protein after brief and prolonged cerebral ischemia in gerbils 显示文摘 | Takemoto O Tomimoto H Yanagihara T | 1995 | Stroke1995，26，： | 1 |
| 19 | Examination of the conversion products of pyrethrins and pyrethrin formulations exposed to sunlight by gas chromatography and mass spectrometry显示文摘 | KAWANO Y Yanagihara K | 1980 | Chromatography1980，198，： | 1 |
| 20 | Expression of Angiopoietins and Its Clinical Significance in Non-Small Cell Lung Cancer 显示文摘 | Tanaka F Ishikawa S Yanagihara K | 2002 | Cancer Res2002，62，23： | 1 |
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