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| 1 | 俄亥俄州立大学信息素养教育实践及启示显示文摘首先对美国信息素养教育的发展进行了概述,然后具体地考察了美国信息素养教育的一个成功案例——俄亥俄州立大学信息素养教育实践,分析了它的主要特点,最后结合我国信息素养教育的现状得出了俄亥俄州立大学信息素养教育实践的借鉴意义。 | 赵浩镇 Nancy O'Hanlon | 2008 | 情报理论与实践2008，31，3： | 9 |
| 2 | Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer显示文摘AIM: To investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma(HNSCC). METHODS: In this retrospective study,19 HNSCC patients underwent pre- and intra-treatment DCEMRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images,generating maps of volume transfer rate(Ktrans) and volume fraction of the extravascular extracellular space(ve). Image texture analysis was then employed on maps of Ktrans and ve,generating two texture measures: Energy(E) and homogeneity.RESULTS: No significant changes were found for the mean and standard deviation for Ktrans and ve between pre- and intra-treatment(P > 0.09). Texture analysis revealed that the imaging biomarker E of ve was significantly higher in intra-treatment scans,relative to pretreatment scans(P < 0.04). CONCLUSION: Chemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors. | Jacobus FA Jansen Yonggang Lu Gaorav Gupta Nancy Y Lee Hilda E Stambuk Yousef Mazaheri Joseph O Deasy Amita Shukla-Dave | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 3 | 室外空气污染、早产和低出生体重:世界卫生组织孕产妇和围产期保健全球调查分析显示文摘[背景]吸入细颗粒物(颗粒物直径≤2.5μm,PM2.5)能诱发氧化应激和炎症反应,并有可能导致早产和其他不良的围产期结局。[目的]检测2004—2008年,世界卫生组织在全球22个国家中进行的孕产妇和围产期保健调查中,室外PM2.5是否与不良妊娠结局相关。[方法]以有新生儿出生的各医疗诊所周围50 km为半径的圆弧缓冲区计算室外PM2.5的长期均值(2001—2006年)。应用广义估计方程确定诊所的PM2.5水平与个体的早产和低出生体重之间的相关性,调整个人、诊所和国家水平的季节性因素及潜在的混杂因素。另外还对各国中的相关性进行了研究。[结果]在所有国家中,调整季节性因素后,PM2.5与早产无关联,但是与低出生体重相关[PM2.5的第四个四分位数段(〉20.2μg/m3)与第一个四分位数(〈6.3μg/m3)相比,比值比(OR)=1.22;95%CI:1.07-1.39]。中国是PM2.5测量值范围最大的国家,早产和低出生体重均仅与PM2.5的最高四分位数段相关,提示可能存在阈值效应(PM2.5≥36.5μg/m3与PM2.5〈12.5μg/m3相比,早产和低出生体重比值比分别为:OR=2.54;CI:1.42-4.55和OR=1.99;CI:1.06-3.72)。[结论]室外PM2.5浓度与低出生体重相关,但与早产不相关。在快速发展的国家中,例如中国,最高的空气污染水平可能与两个结局都相关。 | Nancy L.Fleischer Mario Merialdi Aaron van Donkelaar Felipe Vadillo-Ortega Randall V.Martin Ana Pilar Betran Jo?o Paulo Souza Marie S.O'Neill 王晓宇 汪源 金泰廙 | 2014 | 环境与职业医学2014，31，12： | 4 |
| 4 | Heart Disease and Stroke Statistics—2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Thomas Thom Nancy Haase Wayne Rosamond Virginia J. Howard John Rumsfeld Teri Manolio Zhi-Jie Zheng Katherine Flegal Christopher O’Donnell Steven Kittner Donald Lloyd-Jones David C. Goff Yuling Hong Robert Adams Gary Friday Karen Furie Philip Gorelick Bret | 2006 | Circulation2006，，6： | 3 |
| 5 | The Accountable Care Organization results:Population health management and quality improvement programs associated with increased quality of care and decreased utilization and cost of care显示文摘Objective:The Accountable Care Organization(ACO)model of health care delivery is based on new payment models for general practice to reward improved quality and decreased cost of care.Methods:Banner Health Network(BHN)is one of the original CMS Pioneer ACO programs and implemented a comprehensive disease management program based on the collaborative care model.Key performance indicators for CMS reflected quality and cost of care.Results:BHN has demonstrated both improved quality and cost savings in the first two years of the pilot program.The disease management program based on the collaborative care model appears to have improved patient health outcomes based on quality improvement measures.In addition the program has reduced emergency department and hospital utilization,resulting in cost savings.Conclusions:The BHN quality improvement program is the platform for analyzing and improving on the BHN ACO model.This model appears to have excellent application to the China health care system that is also focused on prevention and improvement of chronic disease and cost-effectiveness. | Ronald O’Donnell Nishant Shaun Anand Caroline Ganser Nancy Wexler | 2015 | Family Medicine and Community Health2015，3，1： | 2 |
| 6 | Characteristics, Treatments, and Outcomes of Patients With Preserved Systolic Function Hospitalized for Heart Failure显示文摘 | Gregg C. Fonarow Wendy Gattis Stough William T. Abraham Nancy M. Albert Mihai Gheorghiade Barry H. Greenberg Christopher M. O'Connor Jie Lena Sun Clyde W. Yancy James B. Young | 2007 | Journal of the American College of Cardiology2007，，8： | 2 |
| 7 | Characteristics, Treatments, and Outcomes of Patients With Preserved Systolic Function Hospitalized for Heart Failure显示文摘 | Gregg C. Fonarow Wendy Gattis Stough William T. Abraham Nancy M. Albert Mihai Gheorghiade Barry H. Greenberg Christopher M. O’Connor Jie Lena Sun Clyde W. Yancy James B. Young | 2007 | Journal of the American College of Cardiology2007，，8： | 2 |
| 8 | Heart Disease and Stroke Statistics—2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Wayne Rosamond Katherine Flegal Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan M. Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Donald Lloyd-Jones Mary McDermott James Meigs Claudia Moy Graham Nichol Christopher O’Donnell Veroniqu | 2008 | Circulation2008，，4： | 1 |
| 9 | Intrahepatic Cholangiocarcinoma: Rising Frequency, Improved Survival, and Determinants of Outcome After Resection显示文摘 | Itaru Endo Mithat Gonen Adam C. Yopp Kimberly M. Dalal Qin Zhou David Klimstra Michael D?Angelica Ronald P. DeMatteo Yuman Fong Lawrence Schwartz Nancy Kemeny Eileen O?Reilly Ghassan K. Abou-Alfa Hiroshi Shimada Leslie H. Blumgart William R. Jarnagin | 2008 | Annals of Surgery2008，，1： | 1 |
| 10 | SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model显示文摘 | Lesley J. Murray Tinya J. Abrams Kelly R. Long Theresa J. Ngai Lisa M. Olson Weiru Hong Paul K. Keast Jacqueline A. Brassard Anne Marie O’Farrell Julie M. Cherrington Nancy K. Pryer | 2003 | Clinical and Experimental Metastasis2003，，8： | 1 |
| 11 | Endostatin improves radioresponse and blocks tumor revascularization after radiation therapy for A431 xenografts in mice显示文摘 | Satoshi Itasaka Ritsuko Komaki Roy S. Herbst Keiko Shibuya Tomoaki Shintani Nancy R. Hunter Amir Onn Corazon D. Bucana Luka Milas K. Kian Ang Michael S. O’Reilly | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，： | 1 |
| 12 | Cancer and Comorbidity显示文摘 | Karen S O G Marie Swanson Nancy Woods | 2000 | Cancer2000，，88： | 1 |
| 13 | The Vanderbilt Professional nursing prac-tice program,part 2显示文摘 | Nancy O Hara Mary D | 2003 | Journal of Nursing Advance2003，33，10： | 1 |
| 14 | Call to action on use and reimbursement for home blood pressure monitoring: executive summary: a joint scientific statement from the American heart asso- ciation, American society of hypertension , and preventive cardio- vascular nurses association显示文摘 | Thomas G P Nancy H M Gbenga O | 2008 | J Am Soc Hypertension2008，2，3： | 1 |
| 15 | Prospects for Targeting Protein Kinase C Isozymes in the Therapy of Drug-resistant Cancer – An Evolving Story显示文摘 | Catherine A. O’Brian Nancy E. Ward Jubilee R. Stewart Feng Chu | 2001 | Cancer and Metastasis Reviews2001，，1： | 1 |
| 16 | Selection and characterization of mixed starter cultures for lactic acid fermentation of carrot, cabbage, beet and onion vegetable mixtures 显示文摘 | NANCY J G TONY S PAULE O | 2001 | Int J Food Microbiol2001，64，： | 1 |
| 17 | Surgical outcomes following pancreatic resection at a low-volume community hospital: do all patients need to be sent to a regional cancer center?显示文摘 | John David Cunningham Nancy O'Donnell Paul Starker | 2009 | The American Journal of Surgery2009，，2： | 1 |
| 18 | HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium显示文摘BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence factor.AIM To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) cells.METHODS Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional modeling.RESULTS HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium cells.Immunogold technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS cells.Bioinformatics analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein to the external environment. The programs also showed a similarity with the Tip-alpha protein of H. pylori. Tip-alpha is an exotoxin that penetrates cells and induces tumor necrosis factor alpha production, and HP0953 could have a similar function as posttranslational modification sites were found;modifications in turn require enzymes located in eukaryotic cells. Thus, to be functional, HP0953 may necessarily need to be translocated inside the cell where it can trigger different mechanisms producing cellular damage.CONCLUSION The location of HP0953 around infected cells, the probable posttranslational modifications, and its similarity to an exotoxin suggest that this protein is a virulence factor. | Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García Norma Velázquez-Guadarrama | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 19 | Evaluation of downstream effects of specialty chemicals in the Bayer process显示文摘 | David O O Lawrence J C Peter A D Anthony E G Nancy L P | 1991 | Light Metals1991，，： | 1 |
| 20 | Supercritical CO2 extraction of essential oil and oleoresin from chamonile显示文摘 | Nanci P Povh Iarcia O I Iarques I Angela A Ieireles | 2001 | Journal of Supercritical Fluids2001，21，3： | 1 |
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