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| 1 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 2 | Direct cholangioscopy combined with doubleballoon enteroscope-assisted endoscopic retrograde cholangiopancreatography显示文摘Double-balloon enteroscope (DBE)-assisted endoscopic retrograde cholangiopancreatography (ERCP) is an effective endoscopic approach for pancreatobiliary disorders in patients with altered gastrointestinal anatomy. Endoscopic interventions via DBE in these postoperative settings remain difficult because of the lack of an elevator and the use of extra-long ERCP accessories. Here, we report the usefulness of direct cholangioscopy with an ultra-slim gastroscope during DBE-assisted ERCP. Three patients with choledocholithiasis in postoperative settings (two patients after Billroth Ⅱ gastrojejunostomy and one patient after Roux-en-Y gastrojejunostomy) were treated. DBE was used to gain access to the papilla under carbon dioxide insufflation, and endoscopic sphincterotomy was performed with a conventional sphincterotome. For direct cholangioscopy, the enteroscope was exchanged for an ultra-slim gastroscope through an incision in the overtube, which was inserted directly into the bile duct. Direct cholangioscopy was used to extract retained bile duct stones in two cases and to confirm the complete clearance of stones in one case. Bile duct stones were eliminated with a 5-Fr basket catheter under direct visual control. No adverse events were noted in any of the three cases. Direct cholangioscopy with an ultra-slim gastroscope facilitates subsequent treatment within the bile duct. This procedure represents another potential option during DBE-assisted ERCP. | Tatsuya Koshitani Shogo Matsuda Koji Takai Takayuki Motoyoshi Makoto Nishikata Yasuhide Yamashita Toshihiko Kirishima Naomi Yoshinami Hiroyuki Shintani Toshikazu Yoshikawa | 2012 | World Journal of Gastroenterology2012，18，28： | 6 |
| 3 | Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance显示文摘 | Yoshizumi Shintani Hajime Fujie Hideyuki Miyoshi Takeya Tsutsumi Kazuhisa Tsukamoto Satoshi Kimura Kyoji Moriya Kazuhiko Koike | 2004 | Gastroenterology2004，，3： | 3 |
| 4 | DOING META-ANALYSIS IN SLA:PRACTICES,CHOICES,AND STANDARDS显示文摘Meta-analysis is a statistical method used to synthesize the cumulative effect of an interventional treatment or a certain relationship that has been subjected to empirical investigation.Notwithstanding the increasing popularity of meta-analysis in second language acquisition(SLA)research,there is considerable methodological inconsistency in the 22SLA meta-analyses published to date.Also,given the highly technical nature of some aspects of this statistical procedure and the specialized knowledge associated with it,it is a daunting task to conduct a meta-analysis and understand or interpret meta-analytic results.This paper seeks to solve the conundrum surrounding metaanalysis by explicating its basic procedure and technical aspects in an accessible manner.Utilizing SLA meta-analyses as examples,it discusses the methodological options of each stage of a meta-analysis,makes recommendations about how to handle some key issues,and points out the pitfalls that might undermine the robustness and credibility of meta-analytic findings. | SHAOFENG LI NATSUKO SHINTANI ROD ELLIS | 2012 | 当代外语研究2012，，12： | 3 |
| 5 | Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance显示文摘 | Yoshizumi Shintani Hajime Fujie Hideyuki Miyoshi Takeya Tsutsumi Kazuhisa Tsukamoto Satoshi Kimura Kyoji Moriya Kazuhiko Koike | 2004 | Gastroenterology2004，，3： | 3 |
| 6 | Frequent β-catenin aberration in human hepatocellular carcinoma显示文摘 | Hajime Fujie Kyoji Moriya Yoshizumi Shintani Takeya Tsutsumi Tadatoshi Takayama Masatoshi Makuuchi Satoshi Kimura Kazuhiko Koike | 2001 | Hepatology Research2001，，1： | 2 |
| 7 | Phase II study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer显示文摘 | Yasushi Sato Tetsuji Takayama Tamotsu Sagawa Yasuo Takahashi Hiroyuki Ohnuma Syunichi Okubo Naoaki Shintani Shingo Tanaka Masaya Kida Yasuhiro Sato Hidetoshi Ohta Koji Miyanishi Tsutomu Sato Rishu Takimoto Masayoshi Kobune Koji Yamaguchi Koichi Hirata Yos | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 2 |
| 8 | Tissue distribution and immtmocytochemical localization of neurotrophin - 3 in the brain and peripheral tissure of rats 显示文摘 | Katoh - Semba R Kaisho Y Shintani A | 1996 | J Neruochtma1996，66，1： | 1 |
| 9 | Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway显示文摘 | PENG H SHINTANI S KIM Y al | 2006 | Neoplasia2006，8，： | 1 |
| 10 | Mobilization of endothelial progenitor cells in patients with acute myocardial infarction显示文摘 | Shintani S Murohara T Ikeda H | 2001 | Circulation2001，103，23： | 1 |
| 11 | Troglitazone induces GIUT4 translocation in L6 myotubes 显示文摘 | Yonemitsu S Nishimura H Shintani M | 2001 | Diabetes2001，50，： | 1 |
| 12 | Glycyrrhizin ( licorice)- induced hypokalemic myopathy: report of 2 cases end review of the literature显示文摘 | Shintani SH Murase HT Shiigai T | 1992 | Eur Neurol1992，32，： | 1 |
| 13 | lesioning of the rat basal forebrain leads to memory impairments in passive and active avoidance tasks显示文摘 | Miyamoto M shintani M Gaoka A | 1985 | Brain Res1985，328，： | 1 |
| 14 | Autophagy in health and disease:a double-edged sword 显示文摘 | Shintani T Klionsky DJ | 2004 | Science2004，306，： | 1 |
| 15 | Mobilization of endothelial progenifor cells in patients with acute myocardiai infarcti on 显示文摘 | Shintani S Murohara T Ikeda H | 2001 | Circulation2001，103，23： | 1 |
| 16 | Expression of decorin, a small leucine-rich proteoglycan, as a prognostic factor in soft tissue tumors显示文摘 | Matsumine A Shintani K Kusuzaki K | 2007 | J Surg Oncol2007，96，5： | 1 |
| 17 | Elevating the Vitamin E content of plants through metabolic engineering显示文摘 | Shintani D DellaPenna D | 1998 | Science1998，282，11： | 1 |
| 18 | Can News be a Major Source of Aggregate Fluctuations?A Bayesian DSGE Approach显示文摘 | Fujiwara I Hirose Y Shintani M | 2011 | Journal of Money Credit and Banking2011，43，1： | 1 |
| 19 | High frequency of homo- zygous deletion and methylation of p16 (INK4A)gene in oral squa- mous cell carcinomas 显示文摘 | Nakahara Y Shintani S Mihara M | 2001 | Cancer Lett2001，163，2： | 1 |
| 20 | Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients 显示文摘 | Pandharipande P Shintani A Peterson J | 2006 | Anesthesiology2006，104，1： | 1 |
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