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| 1 | Xanthogranulomatous cholecystitis:a premalignant condition?显示文摘BACKGROUND:Xanthogranulomatous cholecystitis(XGC)is an uncommon variant of chronic cholecystitis,characterized by marked thickening of the gallbladder wall and dense local adhesions.It often mimics a gallbladder carcinoma(GBC), and may coexist with GBC,leading to a diagnostic dilemma. Furthermore,the premalignant nature of this entity is not known.This study was undertaken to assess the p53,PCNA and beta-catenin expression in XGC in comparison to GBC and chronic inflammation. METHODS:Sections from paraffin-embedded blocks of surgically resected specimens of GBC(69 cases),XGC(65), chronic cholecystitis(18)and control gallbladder(10)were stained with the monoclonal antibodies to p53 and PCNA, and a polyclonal antibody to beta-catenin.p53 expression was scored as the percentage of nuclei stained.PCNA expression was scored as the product of the percentage of nuclei stained and the intensity of the staining(1-3).A cut-off value of 80 for this score was taken as a positive result. Beta-catenin expression was scored as type of expression-membranous,cytoplasmic or nuclear staining. RESULTS:p53 mutation was positive in 52%of GBC cases and 3%of XGC,but was not expressed in chronic cholecystitis and control gallbladders.p53 expression was lower in XGC than in GBC(P<0.0001).PCNA expression was seen in 65%of GBC cases and 11%of XGC,but not in chronic cholecystitis and control gallbladders.PCNA expression was higher in GBC than XGC(P=0.0001),but there was no significant difference between the XGC,chronic cholecystitis and control gallbladder groups.Beta-catenin expression was positive in the GBC,XGC, chronic cholecystitis and control gallbladder groups.But the expression pattern in XGC,chronic cholecystitis and control gallbladders was homogenously membranous,whereas in GBC the membranous expression pattern was altered to cytoplasmic and nuclear.CONCLUSION:The expression of p53,PCNA and beta-catenin in XGC was significantly different from GBC and similar to chronic cholecystitis,thus indicating the inflammatory nature of XGC and may not support a premalignant nature of the lesion. | Mila Ghosh Puja Sakhuja Anil K Agarwal | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 11 |
| 2 | “打扰”的艺术--导演李玉专访显示文摘时问:2012年11月29日地点:北京李玉工作室受访者:李玉(电影导演)采访者:李莉(中国传媒大学电影学博士研究生)MilaZuo(美国加州大学洛杉矶分校电影系博士研究生)整理者:李莉、MilaZuo关于观众与市场问:你感受到的当下国内做电影的环境是怎样的?答:我选择在中国大陆做一个导演,我不想出去,我想拍中国的电影。当下中国是个很出故事的时代,但是真实的表达很难,我就只能在这里面找一些平衡。我跟李睿瑁也聊过,我很喜欢他。我跟他说:“你可以这么自由地去做电影。”但是他自己也很难,做完这一部之后未来是什么他也不知道。这种真实的表达在中国现有的体制下还是非常难的。 | 李玉 李莉 Mila Zuo | 2014 | 当代电影2014，，5： | 7 |
| 3 | The Fusarium oxysporum Avr2-Six5 Effector Pair Alters Plasmodesmatal Exclusion Selectivity to Facilitate Cell-to-Cell Movement of Avr2显示文摘病原体使用受动器蛋白质操作他们的主人。在西红柿的感染期间,真菌镰刀霉 oxysporum 分泌受动器 Avr2 和 Six5。而 Avr2 足够在 heterologous 系统触发 I-2-mediated 房间死亡,两个受动器在西红柿为 I-2-mediated 疾病抵抗被要求。Six5 怎么参予被触发的抵抗,是未知的。用双分子的荧光互补,我们发现了那 Avr2 和 Six5 的试金在 plasmodesmata 交往。单个房间的转变表明 2xRFP 标记蛋白质和 Avr2-GFP 仅仅面对 Six5 搬到附近的房间。因为 2xRFP 仅仅面对两个受动器是 translocated, Six5 独自不改变 plasmodesmatal transduction。在表示 SIX5 转基因的植物,病毒地表示的 Avr2-GFP 的分发,和 I-2-mediated 房间死亡的随后的发作,在野类型的西红柿不同于那。一起拿,我们的数据表演 ? 面对 Six5, Avr2 从房间搬到房间,它在易受影响的植物,但是在包含植物的 I-2 贡献毒力导致抵抗。 | Lingxue Cao Mila C. Blekemolen Nico Tintor Ben J.C. Cornelissen Frank L.W. Takken | 2018 | Molecular Plant2018，11，5： | 3 |
| 4 | EGFR靶向抑制剂在肿瘤放射治疗中的应用显示文摘大部分实体肿瘤有表皮生长因子受体(EGFR)的高表达,并且其高表达能显著降低肿瘤细胞的放射敏感性。近年来,开发了针对EGFR的靶向抑制剂,并且在临床前期研究和临床应用中发现其能提高一部分肿瘤对放射治疗的敏感性。现对EGFR的结构和信号传导途径、EGFR 的表达对肿瘤放射治疗预后的影响及其机制和其靶向抑制剂在放射治疗中的应用研究作一综述。 | 陆雪官 Luka Milas | 2006 | 国际肿瘤学杂志2006，33，4： | 3 |
| 5 | Satraplatin提高头颈部鳞癌放射治疗疗效的动物实验研究显示文摘目的:观察satraplatin是否能提高移植性FaDu头颈部鳞癌的放射治疗疗效。方法:建立裸鼠肿瘤模型70只,当位于每只裸鼠右大腿的肿瘤直径达到8.0 mm(7.6~8.3 mm)时开始实验。实验共分成7组(每组10只),分别是对照组、satra- platin组、放疗(radiotherapy,RT)组、satraplatin+RT(6 h后)组、satraplatin+RT(24 h后)组、RT+satraplatin(6 h后)组和RT+satraplatin(24 h后)组。观察指标为肿瘤生长延迟时间(肿瘤直径从8.0 mm生长至12.0 mm所需时间)和肿瘤治愈的情况。结果:3只荷瘤鼠在治疗过程中死亡,其余67只无治愈。观察肿瘤生长情况发现satraplatin组和放疗组的绝对延迟时间分别为(0.7±0.4)d和(5.5±1.1)d,而satraplatin+RT(6 h后)组、satraplatln+RT(24 h后)组、RT+satraplatin(6 h后)组和RT+satraplatin(24 h后)组的绝对延迟时间则分别为(8.1±1.3)、(7.8±1.1)、(6.6±1.1)和(4.3±0.6)d,其标准化的延迟时间分别为(7.4±1.3)、(7.1±1.1)、(5.9±0.6)和(3.6±0.6)d,增益因子分别为1.30、1.25、1.04和0.63。结论:实验结果显示在放疗前6或24 h应用satraplatin能提高移植性FaDu头颈部鳞癌的放射治疗疗效。 | 陆雪官 LUKA Milas | 2007 | 肿瘤2007，27，3： | 3 |
| 6 | Shear rate, concentration,molecule weight and temperature viscosity dependencies of hyaluronate, a wormlike polyelectrolyte 显示文摘 | Fouissac E Milas M Rinaudo M | 1993 | Macromolecules1993，26，2： | 2 |
| 7 | Persistent ectopic pregnancy after linear salpingotomy:a non-predictable complication to conservative surgery for tubal gestation 显示文摘 | Lund CO Milas L Bangsgaard N | 2002 | Act Obstet Gynecol Stand2002，81，11： | 1 |
| 8 | In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody显示文摘 | Mason K Hunter N | 2000 | Clin Cancer Res2000，6，： | 1 |
| 9 | Persist eetopie pregnancy af- ter linear salpingotomy : a Don - predictable complication to conser- vative surgery for tubal gestation 显示文摘 | Lund C O Milas L Bangsgard N | 2005 | Acta Obstet Gynecol Scand2005，81，11： | 1 |
| 10 | Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer:report of a randomized comparative trial显示文摘 | Komaki R Lee JS Milas L | 2004 | Int J Radiat Oncol Biol Phys2004，58，5： | 1 |
| 11 | Long- run structural estimation of labour market equations with an application to Greece 显示文摘 | Milas C | 1999 | Economic modelling1999，16，： | 1 |
| 12 | Genome-wide iden- tification, functional analysis and expression profiling of the Aux/ IAA gene family in tomato 显示文摘 | Audran-Delalande C Bassa C Mila I | 2012 | Plant Cell Physiol2012，53，4： | 1 |
| 13 | Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol显示文摘 | Luka Milas Nancy R. Hunter Belma Kurdoglu Kathryn A. Mason Raymond E. Meyn L. C. Stephens Lester J. Peters | 1995 | Cancer Chemotherapy and Pharmacology1995，，4： | 1 |
| 14 | Enhancement of tum- or response to e-radiation by an inhibitor of cyclooxi- dase-2 enzyme显示文摘 | Gallo O Milas L Mason K | 2000 | Natl Cancer lnst2000，92，4： | 1 |
| 15 | Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways显示文摘 | Cardona K Korbutt GS Milas Z | | 0，，03： | 1 |
| 16 | Persistent ectopic pregnancy after linear salpingotomy : a non-predictable complication to conservative surgery for tubal gestation 显示文摘 | Lund CO Milas L Bangsgsgard N | 2002 | Act Obstet Gynecol Scand2002，81，： | 1 |
| 17 | Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer: report of a randomized comparative trial显示文摘 | KOMAKI R LEE J S MILAS L | 2004 | International Journal of Radiation Oncology Biology Physics2004，58，5： | 1 |
| 18 | Maximizing therapeutic gain with gemcitabine and fractionated radiation显示文摘 | Mason KA Milas L Hunter NR | 1999 | Int J Radiat Oncol Biol Phys1999，44，5： | 1 |
| 19 | CpG oligodeoxynuclvotide enhances tumor response to radiation 显示文摘 | Milas L Mason KA Ariga H | 2004 | Cancer Res2004，64，15： | 1 |
| 20 | CpG oligodeoxyn- ucleotide enhances tumor response to radiation 显示文摘 | Milas L Mason KA Ariga H | 2004 | Cancer Res2004，164，15： | 1 |
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