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| 1 | 过瘤胃蛋氨酸、赖氨酸和组氨酸对泌乳奶牛生产性能的影响显示文摘试验旨在研究饲料中单独添加或综合添加过瘤胃(RP)蛋氨酸、赖氨酸和组氨酸及可代谢蛋白(MP)对泌乳后期奶牛生产性能的影响。试验选取72头荷斯坦奶牛,随机分为6组,试验期9周。奶牛随机分配到6个试验组中,2周作为1个变量周期:MPA组,根据美国国家科学研究委员会(2001)标准,在饲料中添加调节MP到243 g·d-1;MPD组,不添加MP,MP含量低于标准量54 g·d-1;MPDM组,在MPD组的基础上加入RP蛋氨酸;MPDL组,在MPD组的基础上加入RP赖氨酸;MPDH组,在MPD组的基础上加入组氨酸;MPDMLH组,在MPD组的基础上加入RP蛋氨酸、RP赖氨酸和RP组氨酸。试验结果表明,与MPA组对比,MPD组的干物质采食量(DMI)、产奶量、乳成分(乳脂肪、乳蛋白和乳糖)及能量校正的牛乳(ECM)、ECM饲料利用效率、牛奶和血浆中的N均降低。在MPD基础上补充RP赖氨酸可使乳蛋白率、血浆中葡萄糖浓度增加,且牛奶中N元素含量有增加的趋势;补充RP组氨酸可使DMI、牛奶浓缩蛋白增加,且乳脂肪、乳蛋白和ECM显著增加;补充3种RP氨基酸时,增加了乳蛋白率,使DMI和乳脂率有增加趋势,也提高了乳脂肪、乳蛋白含量和ECM及ECM饲料利用效率。与MPA相比,MPD组牛奶中N的含量有降低趋势,且血浆中必需氨基酸(除赖氨酸和蛋氨酸)浓度均降低。补充RP赖氨酸、RP蛋氨酸和RP组氨酸提高了血浆中蛋氨酸(除MPDM组)、赖氨酸和组氨酸浓度。饲喂MPD的奶牛血红蛋白浓度降低,血浆生长素含量高于MPA组。MPD组牛奶中总饱和脂肪酸浓度有高于MPA和MPDMLH组的趋势。MPD组的多元不饱和脂肪、牛奶中奇链与支链脂肪酸含量与MPA组相比,有降低趋势。试验结果表明,对于饲料中缺乏MP的奶牛,在饲料中添加组氨酸和添加3种RP氨基酸(赖氨酸、蛋氨酸和组氨酸)均有提高牛奶产量和牛奶组分含量的可能性。 | Giallongo F Harper M T Oh J Lopes J C Lapierre H Patton R A Parys C Shinzato I Hristov A N | 2016 | 饲料博览2016，0，7： | 4 |
| 2 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 3 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 4 | Adding protein context to the human protein -protein interaction network to reveal meaningful inter- actions显示文摘 | SCHAEFER M H LOPES T J S MAH N et at | 2013 | PLoS Comput Biol2013，9，10： | 1 |
| 5 | A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6 -dependent B cell lymphomas显示文摘 | Cerchietti L C Lopes E C Yang S N | | Nat Med0，15，1： | 1 |
| 6 | Effect of bleaching agents on the hardness and morphology of enamel 显示文摘 | Lopes G C Bonissoni L Baratieri L N | 2002 | J Esther Restor Dent2002，14，1： | 1 |
| 7 | Islands of Runaway Electrons in the TEXTOR T-okamak and Relation to Transport in a Stochastic Field显示文摘 | Jaspers R Lopes Cardozo N J Finken K H | 1994 | Phys Rev Lett1994，，26： | 1 |
| 8 | TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia显示文摘 | Doriane A. Gouas Stéphanie Villar Sandra Ortiz-Cuaran Pénélope Legros Gilles Ferro Gregory D. Kirk Olufunmilayo A. Lesi Maimuna Mendy Ebrima Bah Marlin D. Friesen John Groopman Isabelle Chemin Pierre Hainaut | 2012 | Carcinogenesis2012，，6： | 1 |
| 9 | Characteristic interactions with phosphatidylinositol4,5-bisphosphate determine regulation of Kir channels by diverse modulators 显示文摘 | Du X N Zhang H L Lopes C | 2004 | J Biol Chem2004，279，37： | 1 |
| 10 | Identification of oligomers in polyethyleneterephthalate bottles for mineral water and fruit juice development and validation of a high-performance liquid chromatographic method for the determination of first series cyclic trimer显示文摘 | NASSER A L M LOPES L M X EBERLIN M N | 2005 | Journal of Chromatography A2005，1097，12： | 1 |
| 11 | Intergating distributed generation into electric power systems:a review of olrivers,challenges and opportunities显示文摘 | PECAS LOPES J A HATZIARGYRIOU N MUTALE J | 2007 | Electric Power Systems Research2007，77，9： | 1 |
| 12 | An Ab initio Study of the C2H2-HF,C2 H (CH3)-HF and C2 (CH3) 2-HF Hydrogen-Bonded Complexes显示文摘 | Ramos M N Lopes K C Venture E et at | | 0，，： | 1 |
| 13 | The short form of the SUR1 and its functional implications in the damaged brain显示文摘Sulfonylurea receptor(SUR) belongs to the adenosine 5′-triphosphate(ATP)-binding cassette(ABC) transporter family;however,SUR is associated with ion channels and acts as a regulatory subunit determining the opening or closing of the pore.Abcc8 and Abcc9 genes code for the proteins SUR1 and SUR2,respectively.The SUR1 transcript encodes a protein of 1582 amino acids with a mass around 140–177 k Da expressed in the pancreas,brain,heart,and other tissues.It is well known that SUR1 assembles with Kir6.2 and TRPM4 to establish K_(ATP) channels and non-selective cation channels,respectively.Abbc8 and 9 are alternatively spliced,and the resulting transcripts encode different isoforms of SUR1 and SUR2,which have been detected by different experimental strategies.Interestingly,the use of binding assays to sulfonylureas and Western blotting has allowed the detection of shorter forms of SUR(-65 k Da).Identity of the SUR1 variants has not been clarified,and some authors have suggested that the shorter forms are unspecific.However,immunoprecipitation assays have shown that SUR2 short forms are part of a functional channel even coexisting with the typical forms of the receptor in the heart.This evidence confirms that the structure of the short forms of the SURs is fully functional and does not lose the ability to interact with the channels.Since structural changes in short forms of SUR modify its affinity to ATP,regulation of its expression might represent an advantage in pathologies where ATP concentrations decrease and a therapeutic target to induce neuroprotection.Remarkably,the expression of SUR1 variants might be induced by conditions associated to the decrease of energetic substrates in the brain(e.g.during stroke and epilepsy).In this review,we want to contribute to the knowledge of SUR1 complexity by analyzing evidence that shows the existence of short SUR1 variants and its possible implications in brain function. | Iván Alquisiras-Burgos Javier Franco-Pérez Moisés Rubio-Osornio Penélope Aguilera | 2022 | Neural Regeneration Research2022，17，3： | 1 |
| 14 | Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex显示文摘 | Rebola N Porciuncula LO Lopes LV | 2005 | Epilepsia2005，46，： | 1 |
| 15 | Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort 显示文摘 | Pop-Busui R Lu J Lopes N | 2009 | J Peripher Nerv Syst2009，14，1： | 1 |
| 16 | Integrating distributed generation into electric power systems: a review of drivers,challenges and opportunities显示文摘 | Lopes J A P Hatziargyriou N Mutale J | 2007 | Electric Power Systems Research2007，77，9： | 1 |
| 17 | Induction of central tolerance by the factor Aire: molecular and epigenetic regulation显示文摘 | Lopes N Ferrier P Irla M | 2015 | Med Sci (Paris)2015，31，89： | 1 |
| 18 | Paradox - breaking RAF inhibitors that also target SRC are effective in drug - resistant BRAF mutant melanoma显示文摘 | Girotti MR Lopes F Preece N | 2015 | Cancer Ce112015，27，1： | 1 |
| 19 | Integrating distributed generation into electric power systems : a review of drivers , challenges and opportunities显示文摘 | Peas Lopes J A Hatziargyriou N Mutale J | 2007 | Electric Power Systems Research2007，77，9： | 1 |
| 20 | Acid catalyzed alco- holysis of soybean oil 显示文摘 | Goff M J Bauer N S Lopes S | 2004 | J Am Oil Chem Soc2004，81，4： | 1 |
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