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| 1 | Homotopic mapping solving method for gain fluency of a laser pulse amplifier显示文摘The model for gain fluency of a laser pulse amplifier is studied. Using the homotopic mapping method, firstly, the system of the original model is packed up standardization; secondly, introducing a homotopic mapping, taking the property of the mapping, inducing a contrived parameter, the solving of a nonlinear problem translates into the solving of a linear problem. Then the approximate expressions of the solution for the corresponding model are obtained. And the precision for the approximate solution is compared. It illuminates that the obtained approximate solution using the homotopic mapping method possesses higher approximate degree. At one time, the expansion of solution through the homotopic mapping method can be kept in the analytic operation. Thus it also enables us through differential and integral operations to obtain other physics behavior for the gain fluency of laser pulse amplifier. | MO JiaQi1,2 1 Anhui Normal University, Wuhu 241000, China 2 Division of Computational Science, E-Institutes of Shanghai Universities, at SJTU, Shanghai 200240, China | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，7： | 124 |
| 2 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 3 | Predictive value of C-reactive protein/albumin ratio in acute pancreatitis显示文摘BACKGROUND:Serum C-reactive protein(CRP) increases and albumin decreases in patients with inflammation and infection.However,their role in patients with acute pancreatitis is not clear.The present study was to investigate the predictive significance of the CRP/albumin ratio for the prognosis and mortality in acute pancreatitis patients.METHODS:This study was performed retrospectively with 192 acute pancreatitis patients between January 2002 and June 2015.Ranson scores,Atlanta classification and CRP/albumin ratios of the patients were calculated.RESULTS:The CRP/albumin ratio was higher in deceased patients compared to survivors.The CRP/albumin ratio was positively correlated with Ranson score and Atlanta classification in particular and with important prognostic markers such as hospitalization time,CRP and erythrocyte sedimentation rate.In addition to the CRP/albumin ratio,necrotizing pancreatitis type,moderately severe and severe Atlanta classification,and total Ranson score were independent risk factors of mortality.It was found that an increase of 1 unit in the CRP/albumin ratio resulted in an increase of 1.52 times in mortality risk.A prediction value about CRP/albumin ratio >16.28 was found to be a significant marker in predicting mortality with 92.1% sensitivity and 58.0% specificity.It was seen that Ranson and Atlanta classification were higher in patients with CRP/albumin ratio >16.28 compared with those with CRP/albumin ratio ≤16.28.Patients with CRP/albumin ratio >16.28 had a 19.3 times higher chance of death.CONCLUSION:The CRP/albumin ratio is a novel but promising,easy-to-measure,repeatable,non-invasive inflammationbased prognostic score in acute pancreatitis. | Mustafa Kaplan Ihsan Ates Muhammed Yener Akpinar Mahmut Yuksel Ufuk Baris Kuzu Sabite Kacar Orhan Coskun Ertugrul Kayacetin | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，4： | 53 |
| 4 | Liquid Crystal Motion Picture Projector显示文摘LiquidCrystalMotionPictureProjector①SHIYongji(LuoyangTechnologyColege,Luoyang471003,CHN)Abstract:Aliquidcrystalmovingpicturep... | SHI Yongji(Luoyang Technology College,Luoyang 471003,CHN)Abstract: A liquid crystal moving picture projector and method are described.Light incident on a liquid crystal display-type device is selectively scattered or transmitted by respective portions of liquid crystal display,and a projection mechanism projects an image formed by either such scattered light or such transmitted light.A liquid crystal moving picture projector includes a liquid crystal display for creating characteristics of an image,and projecttion optics for projecting images sequentially created by the display.The display includes a liquid crystal material capable of temporary storing information at respective areas.The temporary storage may be a function of charge storing directly on liquid crystal material.A method of projecting plural images in sequence includes:creating an image or characteristics of an image in a liquid crystal material,storing such image in such liquid crystal material,directing light at such liquid crystal material,projecting such image as a function of light transmitted through or scattered by such liquid crystal material,and creating a further image in such liquid crystal material for subsequent projection. | 1997 | Semiconductor Photonics and Technology1997，3，3： | 35 |
| 5 | Carbon isotope composition of the Lower Triassic marine carbonates, Lower Yangtze Region, South China显示文摘Studies on three Lower Triassic sections located on the shallow water platform, the deep water slope and in the deep water basin in the Lower Yangtze Region, South China, show the similar trend of carbon isotope evolution. Biostratigraphic correlations among the Lower Triassic sections on the basis of standard conodont zones indicate that three negative shifts occurred in the Griesbachian, the Smithian and the late Spathian stages respectively, and one distinctly positive shift occurred in the early Spathian stage. Trend of carbon isotope evolution of the Lower Triassic reflects some significant changes in the global carbon cycle. Moreover, δ 13C background values are intensively controlled by palaeogeographic environment. In general, δ 13C values from deep-water slope carbonates are lighter than those from carbonate platform and heavier than those from deep-water basin carbonates. The positive carbon isotope excursion may be induced by a significant amount of organic carbon burial in marine sediments and increase in primary productivity. The large negative carbon isotope excursions during the Early Triassic in Lower Yangtze Region are interpreted to relate to volcano eruptions based on tuffaceous claystone interlayers observed near the Permian-Triassic boundary, the Induan- Olenekian boundary and the Lower Triassic-Middle Triassic boundary. | ZUO Jingxun1,2, TONG Jinnan3, QIU Haiou4 & ZHAO Laishi3 1. Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences, Nanjing 210008, China 2. Henan Institute of Geological Survey, Zhengzhou 450007, China 3. State Key Laboratory of Geological Processes and Mineral Resources at China University of Geosciences, Wuhan 430074, China 4. Faculty of Material Sciences and Chemical Engineering, China University of Geosciences, Wuhan 430074, China | 2006 | Science China Earth Sciences2006，49，3： | 32 |
| 6 | Seasonal water storage change of the Yangtze River basin detected by GRACE显示文摘US-Germany co-sponsered satellite gravimetry mission GRACE (Gravity Recovery And Climate Experiment), launched in March 2002, has been producing monthly time series of Earth gravity models up to degree and order of 120. The GRACE mission consists of two identical satellites flying on an almost polar orbit with an altitude of about 300-500 km and satelite-to-satellite ranging of about 220 km. Thanks to the payloads of space-borne GPS receivers, accelerometers and high-precision K-band satelite-to-satellite ranging mesurements, GRACE gravity models are expected to achieve more than one order of magnitude of improvement over previous models at spatial scales of a few hundred kilometers or larger. Recovery of surface mass re-distribution based on GRACE’s time-varying gravity models is applied to studies in solid Earth geophysics, oceanography, climatology and geodesy. At secular time scales, GRACE is expected to provide valuable information on global ice changes, whose variations have profound influences on global climate, and in particular, on sea level changes. At seasonal time scales, GRACE is expected to reveal surface water changes with an ac- curacy of less than 1 cm, or ocean bottom pressure changes with an accuracy of less than 1 mbar (1 mbar =102 Pa). These surface mass redistribution measurements would impove our understanding of the global and regional mass and energy cycles that are critical to human life. Using 15 GRACE monthly gravity models covering the period from April 2002 to December 2003, this study compares seasonal water storage changes recovered from GRACE data and hydrology models at global and regional scales, with particular focus on the Yangtze River basin of China. Annual amplitude of 3.4 cm of equivalent water height change is found for the Yangtze River basin with maximum in Spring and Autumn, agreeing with two state-of-the-art hydrology models. The differences between GRACE re- sults and model predictions are less than 1-2 cm. We conclude that satellite gravimetry has huge potentials in monitering water storage changes in large river basins such as Yangtze. | HU Xiaogong1, CHEN Jianli1,2, ZHOU Yonghong1, HUANG Cheng1 & LIAO Xinhao1 1. Center for Astro-geodynamics Research, Shanghai Astronomical Observatory, National Astronomical Observatories, Shanghai 200030, China 2. Center for Space Research, University of Texas at Austin, 3925 W. Braker Lane, Suite 200, Austin, TX78750, USA | 2006 | Science China Earth Sciences2006，49，5： | 29 |
| 7 | Early J_2 basalts in SE China:Incipience of large-scale late Mesozoic magmatism显示文摘Magmatism in SE China was dormant during 204―180 Ma, but was reactivated in 180― 170 Ma (early J2), and then became more and more intensive towards the end of early Cretaceous. The small-scale early J2 magmatism is the incipience to long-term and large-scale magmatism in this region. A near east-west (EW) trend volcanic belt was distributed across south Hunan, south Jiangxi and southwest Fujian was formed during early J2 time. Along this belt from the inland toward the coast, the lithology of basalts changes from alkali into tholeiite, and the amount of erupted volcanic rocks and the proportions of rhyolites coexisting with the basalts increase. On the basis of geochemical char- acteristics of these basalts, we infer that the melting degree of source rocks and the extent of frac- tional crystallization and crustal contamination all increased whereas the depth of mantle source de- creased from the inland to the coast, which led to the variations of geological characteristics of the volcanic belt. In early J2, the western spreading Pacific plate began to subduct underneath SE China continental block, reactivating near EW trend deep fault that was originally formed during the Indos- inian event. The stress of the western spreading Pacific plate and the extent of asthenosphere up- welling increased from the inland to the coast, which is consistent with the generation and evolution of early J2 basalts. | XIE Xin1, XU Xisheng1, ZOU Haibo2, JIANG Shaoyong1, ZHANG Ming3 & QIU Jiansheng1 1. State Key Laboratory of Mineral Deposit Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Department of Earth and Space Sciences, University of California at Los Angeles, Los Angeles, CA90095-1567, USA. 3. GEMOC ARC National Key Centre, Department of Earth and Planetary Sciences, Macquarie University, Sydney, N.S.W. 2109, Australia | 2006 | Science China Earth Sciences2006，49，8： | 30 |
| 8 | Design Principles of the Non-smooth Surface of Bionic Plow Moldboard显示文摘The diverse non-smooth body surfaces to reduce soil adhesion are the evolutional results for the soil animals to fit the adhesive and wet environment and can be used as a biological basis for the design of bionic plow moldboard. The model surfaces for bionic simulation should be taken from soil animal digging organs, on which the soil motion is similar to what is on the surface of moldboard. By analyzing the distribution of non-smooth units on the body surface of the ground beetle jaw and the soil moving stresses, the design principles of the bionic moldboard for the local and the whole moldboard were presented respectively. As well, the effect of soil moving speed on reducing adhesion, the dimensions relationship between soil particles and non-smooth convexes, the relationship between the enveloping surface of non-smooth convexes and the initial smooth surface of the plow body, and the convex types of the sphere coronal and the pangolin scales,etc.were discussed. | Luquan Ren, Shiqiao Deng, Jingchun Wang, Zhiwu Han Key Laboratory of Terrain-Machine Bionics Engineering (Ministry of Education,China), Jilin University at Nanling Campus, Changchun 130022,P.R. China | 2004 | Journal of Bionic Engineering2004，1，1： | 28 |
| 9 | Continuity of Higher Order Commutators on Certain Hardy Spaces | DING Yong LU Shan Zhen Department of Mathematics,Beijing Normal University,Beijing 100875.P.R.China E-mail:dingy@bnu.edu.cn lusz@bnu.edu.cnZHANG Pu Department of Mathematics.Zhejiang University(at Xixi Campus).Hangzhou 310028,P.R.China,E-mail:zhpjj@263,net | 2002 | Acta Mathematica Sinica,English Series2002，18，2： | 21 |
| 10 | Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice显示文摘AIM To evaluate antihepatoma effect ofantisense phosphorothioate oligodeo-xyribonucleotides (S-ODNs) targeted to alpha-fetoprotein (AFP) genes in vitro and in nudemice.METHODS AFP gene expression was examinedby immunocytochemical method or enzyme-linked immunosorbent assay. Effect of S-ODNson SMMC-7721 human hepatoma cell growth invitro was determined using microculturetetrazolium assay. In vivo antitumor activitiesof S-ODNs were monitored by measuring tumorweight differences in treated and control micebearing SMMC-7721 xenografts. Induction of cellapoptosis was evaluated by fluorescence-activated cell sorter (FACS) analysis.RESULTS Antisense S-ODN treatment led toreduced AFP gene expression. Specificantisense S-ODNs, but not control S-ODNs,inhibited the growth of heaptoma cells in vitro.In vivo. only antisense S-ODNs exhibitedobvious antitumor activities. FACS analysisrevealed that the growth inhibition by antisenseS. ODNs was associated with their cell apoptosisinduction.CONCLUSION Antisense S-ODNs targeted toAFP genes inhibit the growth of human hepatomacells and solid hepatoma, which is related totheir cell apoptosis induction. | Xing Wang Wang~1 Jin Hui Yuan~1 Ru Gang Zhang~1 Li Xia Guo~1 Yong Xie~2 Hong Xie~1 ~1Department of Biotherapy,Shanghai Institute of Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China ~2Department of Biology,Hong Kong University of Science and Technology,ChinaDr.Xing Wang Wang earned Ph.D.from Shanghai Institute of Materia Medical,Chinese Academy of Sciences in 1997.Now a professor at Shanghai Institute of Cell Biology,Chinese Academy of Sciences. | 2001 | World Journal of Gastroenterology2001，7，3： | 21 |
| 11 | SATB2表达模式有助于卵巢转移性结直肠或阑尾肿瘤与卵巢原发性黏液性或子宫内膜样肿瘤的鉴别显示文摘由于部分卵巢外的转移性肿瘤可显示出相似的显微镜下特点及免疫表型特征,给卵巢黏液性肿瘤的确诊带来困难,如原发于结直肠、阑尾、胃、胰腺、子宫内膜样腺癌的转移可与卵巢原发性黏液性囊腺瘤、交界性黏液性肿瘤及黏液腺癌相似。 | Moh M Krings G Ates D 许文静(摘译) 余英豪(审校) | 2016 | 临床与实验病理学杂志2016，32，5： | 21 |
| 12 | Effects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes显示文摘AIM To study the effects of aminoguanidine(AG) and two L-arginine analogues Nω-nitro-L-arginine methyl ester (L-NAME) and Nω-nitro-L-arginine (L-NNA) on nitric oxide (NO) productioninduced by cytokines (TNF-α, IL-11β, and IFN-γ)and bacterial lipopolysaccharide (LPS) mixture(CM) in the cultured rat hepatocytes, andexamine their mechanisms action.METHODS Rat hepatocytes were incubatedwith AG, L-NAME, L-NNA, Actinomycin D (ActD)and dexamethasene in a medium containing CM(LPS plus TNF-α, IL-1β, and IFN-γ) for 24 h. NOproduction in the cultured supernatant wasmeasured with the Griese reaction. IntracellularcGMP level was detected with radioimmunoasey.RESULTS NO production was markedlyblocked by AG and L-NAME in a dose-dependentmanner under inflammatory stimuli conditiontriggered by CM in vitro. The rate of themaximum inhibitory effects of L-NAME (38.9%)was less potent than that obtained with AG(53.7%, P<0.05). There was no significantdifference between the inhibitory effects of AGand two L-arginine analogues on intracellularcGMP accumulation in rat cultured hepatocytes.Non-specific NOS expression inhibitordexamethasone ( DEX ) and iNOS mRNAtranscriptional inhibitor ActD also significantlyinhibited CM-induced NO production. AG(0.1mmol.L-1) and ActD (0.2ng@Lt) wereequipotent in decreasing NO production inducedby inflammatory stimuli in vitro, and botheffects were more potent than that induced bynon-selectivity NOS activity inhibitor L-NAME(0. 1 mmol@ L- 1) under similar stimuli conditions(P | Guo Liang Zhang Ye Hong Wang Hui Ling Teng Zhi Bin Lin Department of Pharmacology,School of Basic Medical Sciences,Beijing University,Beijiog 100083,ChinaDr.Guo Liang Zhang graduated from Xinxiang Medical College in 1982,got Ph.D.at Nagoya City University Medical School,Japan in 1994,finished postdoctoral research at Beijing Medical Univcrsity in 1996,now an associate professor of pharmacology,specialized in hepatic pharmacology,having 15 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 20 |
| 13 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 14 | Effects of Microstructure on the Tensile, Fracture Toughness and Fatigue Behaviour of Gamma Titanium Aluminides显示文摘The effects of microstructure on the deformation and fracture behaviour of two-phase TiAl alloys were investjgated under monotonic and cyclical loading conditions, over a range of temperatu res.The tensile behaviour is analyzed for deformation temperatures between RT and 950℃, Fracture resistance behaviour and toughening mechanisms at RT and 800℃ are analyzed. and the inverse relationship botween ductility and toughness is explained using the crack initiation toughness. The preliminary results of load-controlled fatigue behaviour at 800℃ are interpreted using the tensile behaviour because deformation structure and fracture modes are similar under these two loading | Young- Won (Y-W.) Kim(UES, Inc., Materials Research Division, 4401 Dayton-Xenia Rd., Dayton, OH 45432, USA)(Paper presented at the International Workshop on OrderedIntermetallics 1992, Hangzhou, China) | 1994 | Journal of Materials Science & Technology1994，10，2： | 18 |
| 15 | USING DISPLACED CONE REPRESENTATION IN DEA MODELS FOR NONDOMINATED SOLUTIONSIN MULTIOBJECTIVE PROGRAMMING显示文摘Concepts revolving around 'displaced cones' are used to extend the ideas of nondominated solutions in multiobjective programming. Necessary and sufficient conditions are formed around the additive models of DEA to idelltify nondominated solutions. This provdes a basis for effecting contacts with other disciplines and other parts of DEA. | W. W. Cooper (Graduate School Of Business, University of Texas at Austin, Austin, Texas, USA 78712-1174)WEI Quanling (Department of Information Management, People’s University of China, Beliing 100872, China) G. Yu (Department of MSIS, University of Texas | 1997 | Systems Science and Mathematical Sciences1997，10，1： | 17 |
| 16 | Quantum secret sharing between multiparty and multiparty with Bell states and Bell measurements显示文摘We present a quantum secret sharing scheme between multiparty (m members in Group 1) and multiparty (n members in Group 2), and analyze its security. This scheme takes EPR pairs in Bell states as quantum resources. In order to obtain the shared key, all members only need to perform Bell measurements, rather than perform any local unitary operation. The total efficiency in this scheme approaches 100% as the classical information exchanged is not necessary except for the eavesdropping checks. | SHI RunHua 1,2* , HUANG LiuSheng 1,3 , YANG Wei 1,3 & ZHONG Hong 2 1 National High Performance Computing Center at Hefei, Department of Computer Science and Technology, University of Science and Technology of China, Hefei, 230027, China 2 School of Computer Science and Technology, Anhui University, Hefei 230039, China 3 Suzhou Institute for Advanced Study, USTC, Suzhou 215123, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 17 |
| 17 | 生物技术专业本科教学质量国家标准(征求意见稿)显示文摘根据教育部《关于全面提高高等教育质量的若干意见》(教高〔2012〕4号)文件和教育部高教司'2014年工作计划'要求,教育部高等学校生物技术、生物工程类专业教学指导委员会负责研制了《生物技术专业本科教学质量国家标准》。本文件是教学指导委员会面向全国高等学校的征求意见稿,不属于教育部正式文件,欢迎相关专业师生及时反馈意见(E-mail:xuehzhang@sjtu.edu.cn)。 | The University Teaching Committee of Biotechnology and Bioengineering at Ministry of Education | 2014 | 高校生物学教学研究(电子版)2014，4，4： | 17 |
| 18 | Immunization with chlamydial plasmid protein pORF5 DNA vaccine induces protective immunity against genital chlamydial infection in mice显示文摘To validate the immune protective efficacy of pORF5 DNA vaccine and to analyze potential mechanisms related to this protection. In this study, pORF5 DNA vaccine was constructed and evaluated for its protective immunity in a mouse model of genital chlamydial infection. Groups of BALB/c mice were immunized intranasally with pORF5 DNA vaccine. Humoral and cell mediated immune responses were evaluated. The clearance ability of chlamydial challenge from the genital tract and the chlamy- dia-induced upper genital tract gross pathology and histopathological characterization were also de- tected. The results showed that the total and the IgG2a anti-pORF5 antibody levels in serum were sig- nificantly elevated after pcDNA3.1-pORF5 vaccination, as were the total antibody and IgA levels in vaginal fluids. pcDNA3.1-pORF5 induced a significantly high level of Th1 response as measured by robust gamma interferon (IFN-γ). Minimal IL-4 was produced by immune T cells in response to the re-stimulation with pORF5 protein or the inactive elementary body in vitro. pcDNA3.1-pORF5-vacci- nated mice displayed significantly reduced bacterial shedding upon a chlamydial challenge and an accelerated resolution of infection. 100% of pcDNA3.1-pORF5 vaccinated mice successfully resolved the infection by day 24. pcDNA3.1-pORF5-immunized mice also exhibited protection against patho- logical consequences of chlamydial infection. The stimulated index was significantly higher than that of mice immunized with pcDNA3.1 and PBS (P<0.05). Together, these results demonstrated that immu- nization with pORF5 DNA vaccine is a promising approach for eliciting a protective immunity against a genital chlamydial challenge. | LI ZhongYu1,2, WANG ShiPing1, Wu YiMou2, ZHONG GuangMing3 & CHEN Ding3 1 Xiangya School of Medicine, Central South University, Changsha 410078, China 2 Department of Microbiology and Immunology, University of South China, Hengyang 421001, China 3 University of Texas Health Science Center at San Antonio, TX 78229, USA | 2008 | Science China(Life Sciences)2008，51，11： | 16 |
| 19 | Hongda New Material Improved Silicone Rubber Industrial Chain显示文摘 | Jiangsu Hongda Chemical New Material Co.,Ltd.(Hongda New material,SZ:002211)is located in Yangzhong,Jiangsu province.It got listed in Shenzhen Stock Exchange onFebruary 1st,2008.(CCR2008, No.3)The company mainly produces silicone monomersand high-temperature silicone rubber series.The capacity of silicone monomers and prod-ucts of silicone rubber series reached 30 000 t/a and 28 000 t/a respectively at the end of2007.The sales volume of high-temperature silicone rubber compound has grown steadilyat 30% a year.The company’s high-temperature silicone rubber capacity is still beingexpanded today and will hopefully reach 50 000 t/a at the end of 2008. | 2008 | China Chemical Reporter2008，，25： | 16 |
| 20 | Clinical features of nonalcoholic fatty liver disease-associated hepatocellular carcinoma显示文摘BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), especially nonalcoholic steatohepatitis, is a recognized risk factor for hepatocellular carcinoma (HCC). However, detailed analysis of the clinical features in patients with NAFLD and their association with HCC is lacking. This study aimed to update the clinical features of patients with NAFLD-associated HCC. DATA SOURCES: The clinical data of patients with NAFLD- associated HCC from 25 studies published between 1990 and 2010 in the Pubmed database were comprehensively reviewed. RESULTS: In a total of 169 patients with NAFLD-associated HCC, 72.8% were male. The median age at abnormal liver function tests and diagnosis of NAFLD and HCC was 60, 64 and 67 years, respectively. Most patients were obese (75%) and diabetic (59.8%), 32.3% had dyslipidemia, and 53% had hypertension. Nearly all patients (98.6%, 71/72) were complicated with at least one metabolic disorder. The majority (76%) of the HCC patients had a solitary tumor nodule, with the tumor size ranging from 0.8 to 20 cm in diameter (mean 3.4 cm). Most (61.1%) of the patients had moderately-differentiated HCC. In 40.2% of the patients, HCC occurred in the absence of cirrhosis. Among 130 patients, 57.7% underwent hepatectomy and 14.6% received liver transplantation. The mean follow-up of the treated patients for 25 months showed that 32.4% (24/74) died and 18.8% (9/48) had recurrence. CONCLUSIONS: Patients with NAFLD-associated HCC are usually accompanied with metabolic disorders. Regular surveillance in patients with NAFLD for HCC is necessary, especially for elderly men with metabolic syndrome. | Xiao-Yan Duan, Liang Qiao and Jian-Gao Fan Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China Storr Liver Unit at the Westmead Millennium Institute, the University of Sydney at Westmead Hospital, Westmead, NSW 2145, Australia | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 16 |
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