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| 1 | Effect of alcohol consumption on liver stiffness measured by transient elastography显示文摘AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or continuation.METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver disease.TE was performed at least one week apart by senior operator.TE examinations with less than ten successful measures or with an interquartile range above 30% were excluded.We retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was available.Concomitant biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were recorded.Putative fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis C.Initial and final putative fibrosis score were compared according to alcohol consumption during follow-up.RESULTS:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two examinations.Thirty-seven patients met our criteria with a median follow-up of 32.5 wk.At the end of the study,13(35%) were abstinent,and 24(65%) relapsers.Eight patients had liver biopsy during follow-up.TE decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off value.In relapsers TE increased in 45% and decreased in 54% of patient.There was no statistical difference between initial and final TE in relapsers.In the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final TE.Using 19.5 kPa as cut-off for cirrhosis,7 patients had cirrhosis at initial TE and 5 patients had cirrhosis at final TE.Using 12.5 kPa as cut-off for cirrhosis,16 patients had cirrhosis at initial TE and 15 patients had cirrhosis at final TE.Evolution of biological data was in accordance with the relapse or abstinent status:abstinence ratio(duration of abstinence/duration follow-up) was correlated with AST ratio(r =-0.465,P = 0.007) and GGT ratio(r =-0.662,P<0.0001).GGT was correlated with initial(r = 0.488,P = 0.002) and final TE(r = 0.49,P<0.005).Final TE was correlated with AST(r = 0.362,P<0.05).Correlation between TE ratio and AST ratio(r = 0.44,P = 0.01) revealed that TE varied proportionally to AST for all patients irrespective of their alcohol status.The same relationship was observed between TE ratio and GGT ratio(r = 0.65,P<0.0001).Evolution of TE was significantly correlated with the ratio of time of abstinence to observation time(r =-0.387,P = 0.016) and the evolution of liver enzymes.CONCLUSION:TE significantly decreased with abstinence.Results of TE in alcoholic liver disease cannot be interpreted without taking into account alcohol consumption and liver enzymes. | Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain Moirand | 2013 | World Journal of Gastroenterology2013，19，4： | 20 |
| 2 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 3 | Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease显示文摘AIM: To evaluate the performance of elastography by ultrasound with acoustic radiation force impulse(ARFI) in determining fibrosis stage in patients with alcoholic liver disease(ALD) undergoing alcoholic detoxification in relation to biopsy.METHODS: Eighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy onthe same day. Fibrosis was staged according to the METAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each patient.RESULTS: Sixty-nine males and thirteen females(one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 ± 128.8 standard drinks per week and mean cumulative year duration of 17.6 ± 9.5 years. Sensitivity and specificity were respectively 82.4%(0.70-0.95) and 83.3%(0.73-0.94)(AUROC = 0.87) for F ≥ 2 with a cut-off value of 1.63m/s; 82.4%(0.64-1.00) and 78.5%(0.69-0.89)(AUROC = 0.86) for F ≥ 3 with a cut-off value of 1.84m/s; and 92.3%(0.78-1.00] and 81.6%(0.72-0.90)(AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/s.CONCLUSION: ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification. | Anita Kiani Vanessa Brun Fabrice Lainé Bruno Turlin Jeff Morcet Sophie Michalak Antonia Le Gruyer Ludivine Legros Edouard Bardou-Jacquet Yves Gandon Romain Moirand | 2016 | World Journal of Gastroenterology2016，22，20： | 6 |
| 4 | 比较应用对比增强MR与多层CT检测急性和慢性心肌梗死的特点 | Gerber B.L. Belge B. Legros G.J. 吴晓燕 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，0，7： | 4 |
| 5 | 新一代光缆结构形式:复合光纤松套管——在OPGW光缆中的应用显示文摘 | LEGROS F KERTSCHER E BULUSCHEK B | 2000 | 光纤与电缆及其应用技术2000，，5： | 3 |
| 6 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 7 | Iron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation显示文摘BACKGROUND Liver transplantation(LT)is the best treatment for patients with liver cancer or end stage cirrhosis,but it is still associated with a significant mortality.Therefore identifying factors associated with mortality could help improve patient management.The impact of iron metabolism,which could be a relevant therapeutic target,yield discrepant results in this setting.Previous studies suggest that increased serum ferritin is associated with higher mortality.Surprisingly iron deficiency which is a well described risk factor in critically ill patients has not been considered.AIM To assess the impact of pre-transplant iron metabolism parameters on posttransplant survival.METHODS From 2001 to 2011,553 patients who underwent LT with iron metabolism parameters available at LT evaluation were included.Data were prospectively recorded at the time of evaluation and at the time of LT regarding donor and recipient.Serum ferritin(SF)and transferrin saturation(TS)were studied as continuous and categorical variable.Cox regression analysis was used to determine mortality risks factors.Follow-up data were obtained from the local and national database regarding causes of death.RESULTS At the end of a 95-mo median follow-up,196 patients were dead,38 of them because of infections.In multivariate analysis,overall mortality was significantly associated with TS>75%[HR:1.73(1.14;2.63)],SF<100μg/L[HR:1.62(1.12;2.35)],hepatocellular carcinoma[HR:1.58(1.15;2.26)],estimated glomerular filtration rate(CKD EPI Cystatin C)[HR:0.99(0.98;0.99)],and packed red blood cell transfusion[HR:1.05(1.03;1.08)].Kaplan Meier curves show that patients with low SF(<100μg/L)or high SF(>400μg/L)have lower survival rates at 36 mo than patients with normal SF(P=0.008 and P=0.016 respectively).Patients with TS higher than 75%had higher mortality at 12 mo(91.4%±1.4%vs 84.6%±3.1%,P=0.039).TS>75%was significantly associated with infection related death[HR:3.06(1.13;8.23)].CONCLUSION Our results show that iron metabolism imbalance(either deficiency or overload)is associated with post-transplant overall and infectious mortality.Impact of iron supplementation or depletion should be assessed in prospective study. | Elodie Fallet Michel Rayar Amandine Landrieux Christophe Camus Pauline Houssel-Debry Caroline Jezequel Ludivine Legros Thomas Uguen Martine Ropert-Bouchet Karim Boudjema Dominique Guyader Edouard Bardou-Jacquet | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 8 | Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome 显示文摘 | Legro RS Driscoll D Strauss JF | 1998 | Proc Natl Acad Sci USA1998，95，14： | 2 |
| 9 | 基于中医国际学会构建专科协同创新网络显示文摘中医药实现国际化、现代化是国家发展中医药事业的战略目标。但国内中医药科研领域缺乏既具备中医药特点又符合国际化要求的现代的、科学的科研模式与方法。'中医生殖发育协作网'是为了推动中医药国际化而创建的协同创新网络。它是以国际标准规范为依据,组建国际化的临床试验团队,开展中医药临床特色疗效研究的全新科研模式及方法。文章主要对'中医生殖发育协作网'的发展背景(世界中联生殖医学专业委员会)、组成部分(SC、DCC、DSMB、国内分中心科研协作网)、运行机制(定性质控、定量质控)等方面进行介绍。从而突出其实现学会功能,促进中医药事业发展,推动中医药走向世界的重要意义。 | 文雁 高敬书 常惠 吴鸿裕 Legro Richard 吴效科 | 2017 | 世界中西医结合杂志2017，12，2： | 2 |
| 10 | The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot显示文摘 | Schlichtholz B Legros Y Gillet D | 1992 | Cancer Res1992，52，22： | 1 |
| 11 | Characterization of acute and chronic myocardial infarcts by multidetector computed tomography: comparison with contrast-enhanced magnetic resonance 显示文摘 | Gerber BL Beige B Legros GJ | 2006 | Circulation2006，113，6： | 1 |
| 12 | Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness:role of insulin resistance显示文摘 | Vgontzas AN Legro vs Bixler EO | 2001 | Clin Endo Metab2001，86，2： | 1 |
| 13 | Mass vaccination campaign with a two - dose oral cholera vaccine in a refugee camp显示文摘 | Legros D Paquet C Perea W | 1999 | Bull of WHO1999，77，10： | 1 |
| 14 | Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype 显示文摘 | Legro RS Chiu P Kunselman AR | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 15 | Role of tissue - plasminogen activator in a mouse model of neonatal white matter lesions : Interaction with plasmin inhibitors and anti - inflammatory drugs 显示文摘 | Leroux P Hennebert O Legros H | 2007 | Neuroscience2007，146，2： | 1 |
| 16 | Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome显示文摘 | Legro RS Dfiseoll D Strauss JF | 1998 | PNAS1998，95，14： | 1 |
| 17 | A patient's guide: polycystic ovary syndrome(PCOS)显示文摘 | Hoeger K M Legro R S Welt C K | 2014 | J Clin Endocrinol Metab2014，99，1： | 1 |
| 18 | Changes in glucose tolerance over time in women with polyeystie ovary syndrome:a controlled study显示文摘 | Legro RS Gnatuk CL Kunselman AR | 2005 | J Clin Endoerinol Metab2005，90，6： | 1 |
| 19 | Changes in glucose tolerance over time in women with polycystic ovary syndrome:a controlled study显示文摘 | Legro RS Gnatuk CL Kunselman AR | 2005 | J Clin Endocrinol Metab2005，90，6： | 1 |
| 20 | Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance 显示文摘 | VGONTZAS A N LEGRO R S BIXLER E O | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
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