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| 1 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 2 | Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms显示文摘 | Ida Rasmusson Olle Ringdén Berit Sundberg Katarina Le Blanc | 2005 | Experimental Cell Research2005，，1： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | SPARC Inhibits LPA-Mediated Mesothelial-Ovarian Cancer Cell Crosstalk 显示文摘 | Neveen AS Ida N Matthew JS | 2007 | Neoplasia2007，9，1： | 1 |
| 5 | Incremental value ofT2-we i gh t ed and d i f f us i on-weighted MRI for predictionof biochemical recurrenceafter radical prostatectomy inclinically localized prostatecancer 显示文摘 | N i sh ida K Yuen S Kamo i K et a 1 | 2011 | Acta Radiol2011，52，2： | 1 |
| 6 | Real-time PCR for quantification of streptococcus mutans显示文摘 | YanoA Kaneko N Ida H | 2002 | Fems Microbiol Letl2002，217，1： | 1 |
| 7 | On the statistical correlation of over-horizon VHF signals with meteorological radio ducting and seismicity显示文摘 | Yonaiguchi N Ida Y Hayakawa M | 2007 | Journal of Atmospheric and Solar-Terrestrial Physics2007，69，6： | 1 |
| 8 | Real-time PGR for quantification of Streptococcus mutans显示文摘 | Yano A Kaneko N Ida H Yamaguchi T | 2002 | FEMS Microbiol Lett2002，217，1： | 1 |
| 9 | Finite Element Modeling of Pulsed Ed,ty-Current NDT Phenomena 显示文摘 | ALLEN B IDA N LORD W | 1985 | IEEE Trans- actions on Magnetics1985，21，6： | 1 |
| 10 | Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress显示文摘 | María C. Salgado Isidoro Metón Ida G. Anemaet Isabel V. Baanante | 2014 | BBA - Gene Regulatory Mechanisms2014，，4： | 1 |
| 11 | Are Therapeutic Human Mesenchymal Stromal Cells Compatible with Human Blood?显示文摘 | Guido Moll Ida Rasmusson‐Duprez Lena von Bahr Anne‐Marie Connolly‐Andersen Graciela Elgue Lillemor Funke Osama A. Hamad Helena L?nnies Peetra U. Magnusson Javier Sanchez Yuji Teramura Kristina Nilsson‐Ekdahl Olle Ringdén Olle Korsgren Bo Nilsson Katarina | 2012 | STEM CELLS2012，，7： | 1 |
| 12 | Reverse relationship between beta-amyloid precursor protein and beta-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease显示文摘 | Egensperger R Weggen S Ida N | 1999 | Acta Neuropathol (Berl)1999，97，2： | 1 |
| 13 | Angiotensin Blockade and Progressive Loss of Kidney Function in Hemodialysis Patients: A Randomized Controlled Trial显示文摘 | Krista Dybtved Kjaergaard Christian Daugaard Peters Bente Jespersen Ida N?rager Tietze Jens Kristian Madsen Birgitte Bang Pedersen Marija Kristina Novosel Kathrine Skaaning Laursen Bo Martin Bibby Charlotte Strandhave Jens Dam Jensen | 2014 | American Journal of Kidney Diseases2014，，： | 1 |
| 14 | Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling显示文摘 | Ida T Sawa T Ihara H Tsuchiya Y Watanabe Y Kumagai Y Suematsu M Motohashi H Fujii S Matsunaga T Yamamoto M Ono K Devarie O N Xian M Fukuto M F Akaike T | 2014 | Proceedings of the National Academy of Sciences2014，111，21： | 1 |
| 15 | Identification of potential biomarkers of lymphnede metastasis in oral squamous cell carcinoma by cDNA microarray analysis显示文摘 | Hajime F Hiroko IDA | 2003 | Int J Cancer2003，106，： | 1 |
| 16 | HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefronal cortex and limbic/paralimbic regions 显示文摘 | Aihara M Ida I Yuuki N | 2007 | Psychiatry Res2007，155，3： | 1 |
| 17 | Real-time PCR for quantification of Streptococcusmutans mutans 显示文摘 | Yano A Kaneko N Ida H | 2002 | FEMS Microbiology Letters2002，217，1： | 1 |
| 18 | 1 The proportion of consolidation to ground-grass opacity on high resolution CT is a good predictor for distinguishing the population of non-invasive peripheral adenocarc-inoma显示文摘 | Ohde Y N aga iK Yosh ida J et a | 2003 | Lung Cancer2003，42，： | 1 |
| 19 | Immunohist ochemi calstudy of Muc1,Muc2 and human gastricmucin in breast carcinoma:relationship w ith prognostic factors显示文摘 | XU Y KIMURA N YOSH IDA R | | 0，，05： | 1 |
| 20 | Electrostatic Generation of Alginate Microbeads Loaded with Brewing Yeast 显示文摘 | Viktor A N Bojana O Ida L | 2001 | Process Biochem2001，37，1： | 1 |
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