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| 1 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 2 | Long Memory in Stock Market Volatility and the Volatility-in-Mean Effect: The FIEGARCH-M Model显示文摘 | Bent Jesper Christensen Morten rregaard Nielsen Jie Zhu | 2010 | Journal of Empirical Finance2010，17，3： | 1 |
| 3 | Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study显示文摘OBJECTIVES To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 years.In addition,one-year all-cause mortality and AF relapse were compared.METHODS&RESULTS All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide registries.Patients aged 65−74 years served as the reference group for patients≥75 years.Relapse of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within follow-up.The composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUSION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age. | Jesper Nielsen Kristian Hay Kragholm Sofie Brix Christensen Arne Johannessen Christian Torp-Pedersen Steen Buus Kristiansen Peter Karl Jacobsen Peter Steen Hansen Mogens Stig Djurhus Christoffer Polcwiartek Peter Søgaard Anna Margrethe Thøgersen Uffe Jakob Ortved Gang Ole Dan Jørgensen Filip Lyng Lindgren Sam Riahi | 2021 | Journal of Geriatric Cardiology2021，18，11： | 1 |
| 4 | Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells显示文摘 | Axel C. P. Diederichsen J. Hjelmborg Per B. Christensen Jesper Zeuthen Claus Fenger | 2003 | Cancer Immunology Immunotherapy2003，，7： | 1 |
| 5 | E uropean S troke O rganisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage显示文摘 | Thorsten Steiner Rustam Al‐Shahi Salman Ronnie Beer Hanne Christensen Charlotte Cordonnier Laszlo Csiba Michael Forsting Sagi Harnof Catharina J. M. Klijn Derk Krieger A. David Mendelow Carlos Molina Joan Montaner Karsten Overgaard Jesper Petersson Risto | 2014 | Int J Stroke2014，，： | 1 |
| 6 | Food spoilage—interactions between food spoilage bacteria显示文摘 | Lone Gram Lars Ravn Maria Rasch Jesper Bartholin Bruhn Allan B Christensen Michael Givskov | 2002 | International Journal of Food Microbiology2002，，1： | 1 |
| 7 | The role of implied volatility in forecasting future realized volatility and jumps in foreign exchange, stock, and bond markets显示文摘 | Thomas Busch Bent Jesper Christensen Morten ?rregaard Nielsen | 2010 | Journal of Econometrics2010，，1： | 1 |
| 8 | Inactivation of OslRX10 Leads to Decreased Xylan Content in Rice Culm Cell Walls and Improved Biomass Saccharification显示文摘Dear Editor, Xylan polysaccharides constitute the major non-cellulosic components in secondary cell walls of dicots and in both primary and secondary cell walls of grasses (Scheller and Ulvskov,2010).Xylan is composed of a linear backbone of 13(1-4)-linked xylose (Xyl).In grasses,the xylan backbone is substituted with O3-1inked and O2-1inked arabinose residues and,to a lesser extent,α(1-3)-Iinked glucuronic acid residues.A unique feature of grass xylans is the presence of hydroxycinnamate esters (ferulic and p-coumaric acid residues)attached to C5 of some of the arabinosyl residues (Carpita,1996;Vogel,2008;Scheller and Ulvskov,2010).Xylan contributes to the recalcitrance of plant cell walls to enzymatic degradation probably through direct interaction with cellulose microfibrils and also through formation of ferulate cross-links (liyama et al.,1994;Yin et al.,2011). | Xuewei Chen Miguel E. Vega-Sanchez Yves Verhertbruggenb Dawn Chiniquy Patrick E. Canlas Alexandra Fagerstrom Lina Prak Ulla Christensen Ai Oikawa Mawsheng Chern Shimin Zuo Fan Lin Manfred Auer William G.T. Willats Laura Bartley Jesper Harholt Henrik V. Scheller Pamela C. Ronald | 2013 | Molecular Plant2013，6，2： | 1 |
| 9 | The Development of Geographical Specialization of Venture Capital显示文摘 | Jesper Lindgaard Christensen | 2007 | European Planning Studies2007，，6： | 1 |
| 10 | Plasma TIMP-1 and CEA in detection of primary colorectal cancer: a prospective, population based study of 4509 high-risk individuals显示文摘 | Hans J. Nielsen Nils Brünner Lars N. Jorgensen Jesper Olsen Hans B. Rahr Knud Thygesen Ute Hoyer S?ren Laurberg Petra Stieber Marinus A. Blankenstein Gerard Davis Barry L. Dowell Ib J. Christensen | 2011 | Scandinavian Journal of Gastroenterology2011，，1： | 1 |
| 11 | Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells显示文摘 | Axel C. P. Diederichsen J. Hjelmborg Per B. Christensen Jesper Zeuthen Claus Fenger | 2003 | Cancer Immunology Immunotherapy2003，，7： | 1 |
| 12 | Screening ofpolybrominated diphenyl ethers in bluemussels,marine and freshwater sediments inDenmark显示文摘 | Jan H Christensen Jesper Platz | 2011 | J Environ Monit2011，3，5： | 1 |
| 13 | Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells显示文摘 | Axel C. P. Diederichsen J. Hjelmborg Per B. Christensen Jesper Zeuthen Claus Fenger | 2003 | Cancer Immunology Immunotherapy2003，，7： | 1 |
| 14 | Deregulation of tumor suppressive ASXL1−PTEN/AKT axis in myeloid malignancies显示文摘Mutations of epigenetic regulators are pervasive in human tumors.ASXL1 is frequently mutated in myeloid malignancies.We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A(H2AK119ub1),a Polycomb repressive mark.However,a complete mechanistic understanding of ASXL1 in transcriptional regulation and tumor suppression remains to be defined.Here,we find that depletion of Asxl1 confers murine 32D cells to IL3-independent growth at least partly due to sustained activation of PI3K/AKT signaling.Consistently,Asxl1 is critical for the transcriptional activation of Pten,a key negative regulator of AKT activity.Then we confirm that Asxl1 is specifically enriched and required for H2AK119 deubiquitylation at the Pten promoter.Interestingly,ASXL1 and PTEN expression levels are positively correlated in human blood cells and ASXL1 mutations are associated with lower expression levels of PTEN in human myeloid malignancies.Furthermore,malignant cells with ASXL1 downregulation or mutations exhibit higher sensitivity to the AKT inhibitor MK2206.Collectively,this study has linked the PTEN/AKT signaling axis to deregulated epigenetic changes in myeloid malignancies.It also provides a rationale for mechanism-based therapy for patients with ASXL1 mutations. | Lei Cao Xianyou Xia Yu Kong Fengqin Jia Bo Yuan Rui Li Qian Li YuxinWang Mingrui Cui Zhongye Dai Huimin Zheng Jesper Christensen Yuan Zhou Xudong Wu | 2020 | Journal of Molecular Cell Biology2020，12，9： | 0 |
| 15 | 乐高之家显示文摘'乐高之屋展现了乐高积木的无限可能性。通过系统的创造力,让所有年龄段的孩子都能够使用这些工具来创造他们自己的世界,并通过游戏的方式生活其中。最棒的是,建筑和乐高游戏都是这样的:使人们能够想象比现状更令人兴奋和更具表现力的新世界,并为他们提供使之成为现实的技能。这就是孩子们每天用乐高积木来做的事情,这也是我们今天用真实的砖石在乐高之屋里完成的事情. | Snorre Nash Andreas Klok Pedersen Agne Tamasauskaite Annette Birthe Jensen Ariel Joy Norback Wallner Ask Hvas Birgitte Villadsen Chris Falla Christoffer Gotfredsen Daruisz Duong Vu Hong David Zahle Esben Christoffersen Franck Fdida Ioana Fartadi Scurtu Jakob Andreassen Jakob Ohm Laursen Jakob Sand Jakub Matheus Wlodarczyk Jesper Bo Jensen Jesper Boye Andersen Julia Boromissza Kasper Reimer Hansen Katarzyna Krystyna Siedlecka Katarzyna Stachura Kekoa Charlot Leszek Czaja Lone Fenger Albrechtsen Louise B■geskov Hou Mads Enggaard Stidsen Magnus Algreen Suhr Manon Otto Marta Christensen Mathias Bank Stigsen Michael Kepke Ole Dau Mortensen Ryohei Koike Sergiu Calacean S■ren Askehave Stefan Plugaru Stefan Wolf Thomas Jakobsen Randb■ll Tobias Hjortdal Tommy Bj■rnstrup Iwan Baan Kim Christensen 陈思瑾(译) | 2019 | 城市环境设计2019，0，2： | 0 |
| 16 | 法罗群岛教育中心显示文摘格拉西尔坐落于法罗群岛起伏的峡湾上,坐拥大海和青翠的海湾景观,首都托尔斯港的景色一览无余。格拉西尔旨在把法罗群岛体育学校、托尔斯港技术学院和法罗群岛商学院合并在一起,提高整体效率,惠及1 750名师生和员工。通过创新孵化器的形式,不同于传统学校,格拉西尔既保留了三所学校的自主权,又为学校之间合作学习的蓬勃发展创造了理想条件。根据学生和教师的内部需求. | H■gni Laksáfoss Alberte Danvig Alejandro Mata Gonzales Alessio Valmori Alexandre Carpentier Annette Birthe Jensen Armen Menendian Athena Morella Baptiste Blot Boris Peianov Camille Crepin Claudio Moretti Dag Pr■stegaard Daniel Pihl David Zahle Edouard Boisse Elisha Nathoo Enea Michelesio Eskild Nordbud Ewelina Moszczynska Frederik Lyng Goda Luksaite Henrik Kania H■gni Laksáfoss Jakob Lange Jakob Teglg■rd Hansen Jan Besikov Jan Kudlicka Jan Magasanik Jeppe Ecklon Jesper Boye Andersen Ji-Young Yoon Johan Cool Kari-Ann Petersen Kim Christensen Kristoffer Negendahl Long Zuo Martin Cajade Michael Sch■nemann Jensen Mikkel Marcker Stubgaard Niklas Rausch Norbert Nadudvari Oana Simionescu Richard Howis Sabine Kokina Simonas Petrakas Sofia Sofianou Takumi Iwasawam Tobias Hjortdal Tommy Bj■rnstrup Victor Bejenaru Xiao Xuan Lu Rasmus Hjortshoj 曲鸿 | 2019 | 城市环境设计2019，0，2： | 0 |
| 17 | 瑞士巴塞尔老工业混凝土仓房改建显示文摘巴塞尔的Transitlager坐落于Dreispitz的未来城区中心位置,是众多用于美术馆、餐厅和创意产业的新老建筑中的其中一座。它位于设想的Soho区和皇后区的边缘。与城市一样,周围的工业区域也充斥着基础设施的几何形体。通过对原仓库进行新的功能规划和扩建,使其成为一座多功能的建筑. | Agnete Jukneviciute Alexandra Gustaffson Andreas Johansen Annette Jensen Barbara Srpkova Buster Christensen Camila Stadler Dennis Rasmussen Dominic Black Enea Michelesio Erik de Haan Gül Ertekin Franck Fdida Helen Chen Ioannis Gio Jan Magasanik Jesper Andersen Lorenzo Boddi Marcelina Kolasinska Teresa Fernandez Martin Voelkle Miao Zhang Michael Sch■nemann Mikkel Marcker Stubgaard Ole Elkj■r-Larsen Ricardo Palma Ryohei Koike Sergiu Calacean Tobias Hjortdal Laurian Ghinitoiu 朱翰林(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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