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| 1 | Endoscopic submucosal dissection of gastric tumors: A systematic review and meta-analysis显示文摘AIM: To systematically review the medical literature in order to evaluate the safety and efficacy of gastric endoscopic submucosal dissection(ESD).METHODS: We performed a comprehensive literature search of MEDLINE, Ovid, CINAHL, and Cochrane for studies reporting on the clinical efficacy and safety profile of gastric ESD.RESULTS: Twenty-nine thousand five hundred and six tumors in 27155 patients(31% female) who underwent gastric ESD between 1999 and 2014 were included in this study. R0 resection rate was 90%(95%CI: 87%-92%) with significant between-study heterogeneity(P < 0.001) which was partly explained by difference in region(P = 0.02) and sample size(P = 0.04). Endoscopic en bloc and curative resection rates were 94%(95%CI: 93%-96%) and 86%(95%CI: 83%-89%) respectively. The rate of immediate and delayed perforation rates were 2.7%(95%CI: 2.1%-3.3%) and 0.39%(95%CI: 0.06%-2.4%) respectively while rates of immediate and delayed major bleeding were 2.9%(95%CI: 1.3-6.6) and 3.6%(95%CI: 3.1%-4.3%). After an average follow-up of about 30 mo post-operative, the rate of tumor recurrence was 0.02%(95%CI: 0.001-1.4) among those with R0 resection and 7.7%(95%CI: 3.6%-16%) among those without R0 resection. Overall, irrespective of the resection status, recurrence rate was 0.75%(95%CI: 0.42%-1.3%).CONCLUSION: Our meta-analysis, the largest and most comprehensive assessment of gastric ESD till date, showed that gastric ESD is safe and effective for gastrictumors and warrants consideration as first line therapy when an expert operator is available. | Emmanuel Akintoye Itegbemie Obaitan Arunkumar Muthusamy Olalekan Akanbi Mayowa Olusunmade Diane Levine | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，15： | 10 |
| 2 | LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis显示文摘Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate decision.Different structural determinants account for HP1α Localization and function during cell division cycle.Our earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors.Here,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis.LRIF1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its C-terminus.Importantly,the LRIF1-HPla interaction is critical for Aurora B activity in the inner centromere.Mutation of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome segregation.These findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division. | Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu | 2018 | Journal of Molecular Cell Biology2018，10，6： | 5 |
| 3 | Notch signaling in hepatocellular carcinoma:molecular targetingin an advanced disease显示文摘The use of alternative therapeutic approaches in advanced carcinogenesis is a growing investigative base.One such cancer,primary liver cancer,is one of the most commonly occurring cancers worldwide and often presents in late stage disease consequently preventing traditional curative modalities.As a result,hepatocellular carcinoma(HCC),representing the majority of primary liver cancer,is the third most common cause of cancer-related deaths globally.Survival rates are linked to stage of presentation as well as concomitant cirrhosis limiting the 5-year survival in these patients to<20%.Alternative strategies are in dire need as patients in this cohort have limited palliative options.Currently,sorafenib is the only approved systemic therapy;however,it has a limited survival advantage and low effi cacy prompting the empirical need for further evaluation.Understanding of cancer therapy has led to an enhanced focus on the Notch pathway as a potential target for advanced HCC.Notch signaling is a critical component of development and cell fate and has been linked to various modalities including liver regeneration and as a key driver in carcinogenesis.In this review,we will provide a review of the current status of the Notch signaling in liver cancer and of Notch as an alternative potential strategy for advanced HCC. | Kevin M.Sokolowski Mariappan Balamurugan Selvi Kunnimalaiyaan T.Clark Gamblin Muthusamy Kunnimalaiyaan | 2015 | Hepatoma Research2015，1，1： | 3 |
| 4 | 慢性酒精中毒对男性生殖激素和精液质量的影响显示文摘 | Muthusami KR 郭小燕(摘) 曹缵孙(校) | 2006 | 国外医学(计划生育.生殖健康分册)2006，25，5： | 3 |
| 5 | Anticoagulation in simultaneous pancreas kidney transplantation - On what basis?显示文摘BACKGROUND Despite technical refinements,early pancreas graft loss due to thrombosis continues to occur.Conventional coagulation tests(CCT)do not detect hypercoagulability and hence the hypercoagulable state due to diabetes is left untreated.Thromboelastogram(TEG)is an in-vitro diagnostic test which is used in liver transplantation,and in various intensive care settings to guide anticoagulation.TEG is better than CCT because it is dynamic and provides a global hemostatic profile including fibrinolysis.AIM To compare the outcomes between TEG and CCT(prothrombin time,activated partial thromboplastin time and international normalized ratio)directed anticoagulation in simultaneous pancreas and kidney(SPK)transplant recipients.METHODS A single center retrospective analysis comparing the outcomes between TEG and CCT-directed anticoagulation in SPK recipients,who were matched for donor age and graft type(donors after brainstem death and donors after circulatory death).Anticoagulation consisted of intravenous(IV)heparin titrated up to a maximum of 500 IU/h based on CCT in conjunction with various clinical parameters or directed by TEG results.Graft loss due to thrombosis,anticoagulation related bleeding,radiological incidence of partial thrombi in the pancreas graft,thrombus resolution rate after anticoagulation dose escalation,length of the hospital stays and,1-year pancreas and kidney graft survival between the two groups were compared.RESULTS Seventeen patients who received TEG-directed anticoagulation were compared against 51 contemporaneous SPK recipients(ratio of 1:3)who were anticoagulated based on CCT.No graft losses occurred in the TEG group,whereas 11 grafts(7 pancreases and 4 kidneys)were lost due to thrombosis in the CCT group(P=0.06,Fisher’s exact test).The overall incidence of anticoagulation related bleeding(hematoma/gastrointestinal bleeding/hematuria/nose bleeding/re-exploration for bleeding/post-operative blood transfusion)was 17.65%in the TEG group and 45.10%in the CCT group(P=0.05,Fisher’s exact test).The incidence of radiologically confirmed partial thrombus in pancreas allograft was 41.18%in the TEG and 25.50%in the CCT group(P=0.23,Fisher’s exact test).All recipients with partial thrombi detected in computed tomography(CT)scan had an anticoagulation dose escalation.The thrombus resolution rates in subsequent scan were 85.71%and 63.64%in the TEG group vs the CCT group(P=0.59,Fisher’s exact test).The TEG group had reduced blood product usage{10 packed red blood cell(PRBC)and 2 fresh frozen plasma(FFP)}compared to the CCT group(71 PRBC/10 FFP/2 cryoprecipitate and 2 platelets).The proportion of patients requiring transfusion in the TEG group was 17.65%vs 39.25%in the CCT group(P=0.14,Fisher’s exact test).The median length of hospital stay was 18 days in the TEG group vs 31 days in the CCT group(P=0.03,Mann Whitney test).The 1-year pancreas graft survival was 100%in the TEG group vs 82.35%in the CCT group(P=0.07,log rank test)and,the 1-year kidney graft survival was 100%in the TEG group vs 92.15%in the CCT group(P=0.23,log tank test).CONCLUSION TEG is a promising tool in guiding judicious use of anticoagulation with concomitant prevention of graft loss due to thrombosis,and reduces the length of hospital stay. | Jeevan Prakash Gopal Frank JMF Dor Jeremy S Crane Paul E Herbert Vassilios E Papalois Anand SR Muthusamy | 2020 | World Journal of Transplantation2020，10，7： | 2 |
| 6 | Identification of SNP and InDel variations in the promoter and 5′ untranslated regions of γ-tocopherol methyl transferase(ZmVTE4) affecting higher accumulation of α-tocopherol in maize kernel显示文摘Deficiency of vitamin-E or tocopherol causes neurological and cardiovascular disorders in humans. Though maize kernel is rich in total tocopherol, the level of α-tocopherol possessing the highest vitamin-E activity is low. Mutant allele of ZmVTE4 with deletion of 7 bp and 118 bp (0/0: most favorable haplotype) in 5′UTR and promoter region, respectively significantly enhances α-tocopherol in maize kernel than wild type haplotype (7/118).α- tocopherol estimation in 15 diverse inbreds revealed that mean α-/γ-tocopherol and α-/ total-tocopherol was much higher in genotypes with favorable haplotype (1.51 and 0.41) than unfavorable class (0.19 and 0.13), respectively. However even within favorable class,α- tocopherol ranged from 4.76 to 30.07 μg g 1. Sequence analysis of part of 5′UTR and promoter of ZmVTE4 among the genotypes with favorable haplotype revealed 14 SNPs (SNP1 to SNP14) and eight InDels (InDel1 to InDel8). SNP7 at 606 bp (G to A), and InDels viz., InDel1 (27 bp), InDel4 (27 bp) and InDel8 (14 bp) differentiated low and high α-tocopherol accumulating inbreds with favorable haplotype. Hence the newly identified SNP and InDels in addition to the already reported InDels can be useful in selection of favorable genotypes with higher α-tocopherol in maize. | Abhijit Kumar Das Rashmi Chhabra Vignesh Muthusamy Hema Singh Chauhan Rajkumar Uttamrao Zunjare Firoz Hossain | 2019 | The Crop Journal2019，7，4： | 2 |
| 7 | Plastic biliary stent patency in patients with locally advanced pancreatic adenocarcinoma receiving downstaging chemotherapy显示文摘 | Phillip S. Ge Christopher M. Hamerski Rabindra R. Watson Srinadh Komanduri Birtukan B. Cinnor Kiran Bidari Jason B. Klapman Cui L. Lin Janak N. Shah Sachin Wani Timothy R. Donahue V. Raman Muthusamy | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 8 | Antibiotic Prophylaxis for Gi Endoscopy显示文摘 | Mouen A. Kashab Ruben D. Acosta David H. Bruining Vinay Chandrasekhara Krishnavel V. Chithadi Mohamad A. Eloubeidi Robert D. Fanelli S.A.G.E.S. Representative Ashley L. Faulx Lisa Fonkalsrud Jenifer R. Lightdale V. Raman Muthusamy Shabana F. Pasha John R. | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 9 | Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis显示文摘 | Nagendra Singh Ashish Gurav Sathish Sivaprakasam Evan Brady Ravi Padia Huidong Shi Muthusamy Thangaraju Puttur D. Prasad Santhakumar Manicassamy David H. Munn Jeffrey R. Lee Stefan Offermanns Vadivel Ganapathy | 2014 | Immunity2014，，1： | 2 |
| 10 | Aloe emodin glycosidesstimulates glucose transport and glycogen storage through PI3Kdependent mechanism in L6 myotubes and inhibits adipocyte diffe-rentiation in 3T3L1 adipocytes显示文摘 | Anand S Muthusamy VS Sujatha S | 2010 | FEBS Lett2010，584，14： | 1 |
| 11 | Polyehlorinated biphenyl ( Aroclor 1254 ) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells 显示文摘 | P Murugesan T Muthusamy K Balasubramanian | 2008 | Reproductive toxicology2008，25，1： | 1 |
| 12 | RAF1 mutations in childhood-onset dilated cardiomyopathy 显示文摘 | Dhandapany P S Razzaque M A Muthusami U | 2014 | Nat gen2014，46，6： | 1 |
| 13 | Signaling pathway cooperation in TGF-15-induced epithelial-mesenchymal transition 显示文摘 | Derynck R Muthusamy B P Saeteurn K Y | 2014 | Curt Opin Cell Biol2014，31，： | 1 |
| 14 | Effect of chronic alcoholism on male fertility hormones and semen quality显示文摘 | Muthusami KR Chinnaswamy P | | 0，，04： | 1 |
| 15 | Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity显示文摘Dear Editor,The promptness and continuous expansion of the coronavirus disease 2019(COVID-19)pandemic,elicited by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,has presented an unprecedented impact on human health(WHO Coronavirus(COVID-19)Dashboard,2021).Although vaccination has attenuated the severe symptoms,there is no specific antiviral medication available for preventing the viral spread(Drayman et al.,2021). | Wenwen Wang Fengrui Yang Jie Lin Saravanakumar Muthusamy Shihao Du McKay Mullen Fatima Garba Wanjuan Wang Xu Liu Tao Li Zhihong Yang Xia Ding Felix Aikhionbare Xinjiao Gao Zhikai Wang Xing Liu Xuebiao Yao | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 16 | Impact of excess al- dosterone on glucose homeostasis in adult male rat显示文摘 | Selvaraj J Muthusamy T Srinivasan C | 2009 | Clin Chim Acta2009，407，12： | 1 |
| 17 | Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition 显示文摘 | Muthusamy V S Anand S Sangeetha K N | 2008 | Chem-Biol Interact2008，174，1： | 1 |
| 18 | Staged sacrecto- my--an adaptive approach 显示文摘 | Ramamurthy R Bose J C Muthusamy V | 2009 | J Neurosurg Spine2009，11，3： | 1 |
| 19 | Initiation of insulin for type 2 diabetes mellitus patients: what are the issues? A quali- tative study显示文摘 | Tan AM Muthusamy L Ng CC | 2011 | Singapore Med J2011，52，11： | 1 |
| 20 | Thoracoscopic resection of esophageal duplication cysts 显示文摘 | Herbella FA Tedesco P Muthusamy R | 2006 | Dis Esophagus2006，19，2： | 1 |
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