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| 1 | Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw显示文摘AIM: To investigate the effects of emodin on the treatment of non-alcoholic fatty liver in rats induced by high caloric laboratory chaw.METHODS: Non-alcoholic fatty liver model was successfully established by feeding with high caloric laboratory chaw for 12 wk. Then the model rats were randomly divided into 3 groups, namely model control group, emodin group and dietary treatment group. The rats in emodin group in othergroups were given distilled water of the same volume. The rats in model control group were fed with high caloric laboratory chaw while animals in other groups were fed with normal diet. Four weeks later, liver index (liver/body weight ratio), serum activities of liver-associated enzymes, blood lipid, fasting blood glucose, fasting plasma insulin, HOMA insulin resistance index (HOMA-IR), hepatic triglyceride content and histology features of all groups were assayed. The expression of hepatic peroxisomal proliferator activated receptor (PPAR) gamma was determined by RT-PCR.RESULTS: The body weight, liver index, serum activities of alanine aminotransferase (ALT), blood lipid, hepatic triglyceride content of model control group were significantly elevated, with moderate to severe hepatocyte steatosis.The expression of hepatic PPAR gamma mRNA was obviously reduced in model control group. Compared with model control group, the body weight, liver index, serum activities of ALT, blood lipids and hepatic triglyceride of emodin group significantly decreased and hepatic histology display was also greatly improved. Meanwhile, the expression of hepatic PPAR gamma mRNA was elevated.However, high serum activities of ALT and hyperlipidemia were persisted in dietary treatment group although liver index was decreased and liver histology was somewhat improved.CONCLUSION: It is suggested that emodin might be effective in the treatment of non-alcoholic fatty liver in rats. Its therapeutic mechanism could be associated with increasing the expression of hepatic PPAR gamma mRNA. | HuiDong Fu-ErLu Zhi-QiangGao Li-JunXu Kai-FuWang XinZou | 2005 | World Journal of Gastroenterology2005，11，9： | 28 |
| 2 | Hemiballism-hemichorea induced by ketotic hyperglycemia: case report with PET study and review of the literature显示文摘Hemiballism-hemichorea(HB-HC)is commonly used to describe the basal ganglion dysfunction in non-ketotic hyperglycemic elderly patients.Here we report two elderly female patients with acute onset of involuntary movements induced by hyperglycemia with positive urine ketones.We described the computed tomography and magnetic resonance imaging findings in these two patients,which is similar to that of non-ketotic hyperglycemic HB-HC patients.FDG-PET was performed and the glucose metabolism in the corresponding lesion in these two patients was contradictory with each other.We tried to clarify the underlying mechanisms of HB-HC and explain the contradictory neuroradiological findings in FDG-PET as being performed at different clinical stages. | Yuyan Tan Xiaoyu Xin Qin Xiao Shengdi Chen Li Cao Huidong Tang | 2014 | Translational Neurodegeneration2014，3，1： | 21 |
| 3 | Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation显示文摘Haploidentical stem cell transplantation(haplo-SCT)achieves superior or at least comparable clinical outcomes to HLA-matched sibling donor transplantation(MSDT)in treating hematological malignancies.To define the underlying regulatory dynamics,we analyzed time courses of leukemia burden and immune abundance of haplo-SCT or MSDT from multiple dimension.First,we employed two nonirradiated leukemia mouse models which carried human AML-ETO or MLL-AF9 fusion gene to establish haplo-identical and major histocompatibility(MHC)-matched transplantation models and investigated the immune cell dynamic response during leukemia development in vivo.We found that haplo-matching the MHCs of leukemia cells with recipient mouse T cells prolonged leukemic mice survival and reduced leukemia burden.The stronger graft-versus-leukemia activity in haplo-SCT group mainly induced by decreased apoptosis and increased cytotoxic cytokine secretion including tumor necrosis factor–α,interferon-γ,pore-forming proteins and CD107a secreted by T cells or natural killer cells.Furthermore,we conducted a prospective clinical trial which enrolled 135 patients with t(8;21)acute myeloid leukemia that displayed minimal residual disease before transplantation and underwent either haplo-SCT or MSDT.The results showed that the haplo-SCT slowed the kinetics of the leukemia burden in vivo and reduced the cumulative incidence of relapse compared with MSDT.Ex vivo experiments showed that,1 year after transplantation,cytotoxic T lymphocytes from the haplo-SCT group had higher cytotoxicity than those from the MSDT group during the same period.Our results unraveled the role of immune cells in superior antileukemia effects of haplo-SCT compared with MSDT. | Huidong Guo Ying-Jun Chang Yan Hong Lan-Ping Xu Yu Wang Xiao-Hui Zhang Ming Wang Huan Chen Yu-Hong Chen Feng-Rong Wang Wei-Han Yu-Qian Sun Chen-Hua Yan Fei-Fei Tang Xiao-Dong Mo Kai-Yan Liu Xiao-Jun Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 11 |
| 4 | Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population显示文摘AIM: Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk. Our objective was to investigate the possible association between p53Arg72Pro polymorphism and susceptibility to hepatocellular carcinoma (HCC) among Chinese population.METHODS: The p53 Arg72Pro genotypes were determined by PCR-based restriction fragment length polymorphism (RFLP) analysis in 507 HCC cases and 541 controls. Odds ratios (ORs) for HCC and 95% confidence intervals (CIs)from unconditional logistic regression models were used to evaluate relative risks. Potential risk factors were included in the logistic regression models as covariates in the multivariate analyses on genotype and HCC.RESULTS: The frequencies for Pro and Arg alleles were 44.5%, 55.5% in HCC cases, and 40.3% and 59.7% in controls, respectively. The Pro allele was significantly associated with the presence of HCC (P = 0.05) and had a higher risk for HCC (OR = 1.19, 95% CI 1.00-1.41) as compared with the Arg allele. After adjusted for potential risk factors, Arg/Pro heterozygotes had an 1.21-fold increased risk (95% CI 0.82-1.78, P = 0.34) of HCC compared with Arg homozygotes, whereas the risk for Pro homozygotes was 1.79 (95% CI 1.06-3.01, P = 0.03) times higher than that for Arg homozygotes. Pro-allele carriers had a higher relative risk of HCC than the Arg-only carriers (adjusted OR = 1.33, 95% CI 0.92-1.92, P = 0.13), although the difference was not statistically significant.CONCLUSION: Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for HCC in Chinese population. The p53 Arg72Pro polymorphism may be used as a stratification marker in screening individuals at a high risk of HCC. | Zhong-ZhengZhu Wen-MingCong Shu-FangLiu HuiDong Guan-ShanZhu Meng-ChaoWu | 2005 | World Journal of Gastroenterology2005，11，2： | 10 |
| 5 | An experiment-library least-squares method on on-line coal element contents analysis显示文摘A new experiment-library least-squares(experiment-LLs) method used in the neutron inelastic-scattering and thermal-capture analysis(NITA) technique for on-line coal analysis was developed,which has significantly decreased the non-linear radiation effects.In this method,sixty samples with preset elemental contents were made,from whose experimental spectra twenty single-element spectrum libraries corresponding to twenty kinds of coal were built using the least-squares method.The spectrum of the unknown sample was analyzed based on these twenty libraries to estimate its element contents.With the initial estimated result,the procedure of developing library and analysis was iterated to build a new library with the closest element contents to the unknown sample.Hence the experiment-LLs method can reduce non-linear radiation effects.The experiment-LLs method was performed on an improved coal analysis system which was equipped with a long-life 14 MeV pulsed-neutron generator,a bulk BGO detector with a temperature controller,a moisture meter and coal-smoothing device.The precisions of this system for ash content,water content,volatile content and calorific value have reached 1.0wt%,0.5wt%,1.0wt%,350 kJ/kg,respectively. | WANG HuiDong LU JingBin LU YuPing YANG Dong MA KeYan YANG Kang LIU YuMin CHENG DaoWen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 6 |
| 6 | A high-throughput model for screening anti-tumor agents capable of promoting polymerization of tubulin in vitro显示文摘AIM: To establish a high-throughput model for screening anti-tumor agents capable of promoting the polymeriza- tion of tubulin in vitro. METHODS: Tubulin was prepared in different purity for two screening steps. The first step was a high-throughput screening (HTS) for a set of 1500 samples using the GTP-containing tubulin and the end-reading method. The second step was performed on 119 hits from the first screening by a kinetic assay with GTP-lacking tubulin. RESULTS: The HTS for 1500 samples was accomplished in less than 3 h. From the screening, 108 samples were identified with >20 % promotion activity at 10 mg/L. Five of 108 were further confirmed by the kinetic assay using the purified tubulin subsequently. Three of the hit compounds were Epothilone A or its analogs, the other two compounds had new structures with a common pharmacophore for cytotoxic natural products that stabilize microtubules. In an MTT test, the five selected samples from the screening showed a minimal IC50 at0.28±0.06 nmol/Lto Helacells. CONCLUTION: The two-stepscreening methodis a high-throughtput, cost-effective, and efficient approach to identify microtubule-stabilizing agents. | WeiHU HuiDONG Yue-zhongLI Xi-taoHU Guan-junHAN Yin-boQU | 2004 | Acta Pharmacologica Sinica2004，25，6： | 4 |
| 7 | Multi-task Joint Feature Selection for Multi-label Classification显示文摘Multi-label learning deals with each instance which may be associated with a set of class labels simultaneously. We propose a novel multi-label classification approach named MFSM(Multi-task joint feature selection for multi-label classification). In MFSM, we compute the asymmetric label correlation matrix in the label space. The multi-label learning problem can be formulated as a joint optimization problem including two regularization terms,one aims to consider the label correlations and the other is used to select the similar sparse features shared among multiple different classification tasks(each for one label).Our model can be reformulated into an equivalent smooth convex optimization problem which can be solved by the Nesterov's method. The experiments on sixteen benchmark multi-label data sets demonstrate that our method outperforms the state-of-the-art multi-label learning algorithms. | HE Zhifen YANG Ming LIU Huidong | 2015 | Chinese Journal of Electronics2015，24，2： | 4 |
| 8 | Selection of Chelated Fe(Ⅲ)/Fe(Ⅱ) Catalytic Oxidation Agents for Desulfurization Based on Iron Complexation Method显示文摘Optimization of factors influencing the experiments on reactions involving 8 different chelating agents and soluble Fe(III)/Fe(II) salts was carried out to yield chelated iron complexes. A combination of optimized influencing factors has resulted in a Fe chelating capacity of the iron-based desulfurization solution to be equal to 6.83—13.56 g/L at a redox potential of 0.185—0.3. The desulfurization performance of Fe(III)/Fe(II) chelating agents was investigated on a simulated sulfur-containing industrial gas composed of H2 S and N2 in a cross-flow rotating packed bed. Test results have revealed that the proposed iron-based desulfurization solution showed a sulfur removal efficiency of over 99% along with a Fe chelating capacity exceeding 1.35 g/L. This desulfurization technology which has practical application prospect is currently in the phase of commercial scale-up study. | Luo Ying Liu Youzhi Qi Guisheng Guo Huidong Zhu Zhengfeng | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，2： | 4 |
| 9 | Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice显示文摘Group A streptococcus(GAS),an important human pathogen,can cause various kinds of infections including superficial infections and potentially lethal infections,and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA(an Fn-binding protein expressed on the surface of GAS) with that of M protein,the best immunogen of GAS. Assay for immune response showed that FbaA,similar to M protein,could induce protein-specific high IgG titer in BALB/c mice. Furthermore,following GAS challenge,the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. | Cuiqing Ma Caihong Li Xiurong Wang Ruihong Zeng Xiaolin Yin Huidong Feng Lin Wei | 2009 | Cellular & Molecular Immunology2009，6，1： | 4 |
| 10 | Photocatalytic nitrogen reduction to ammonia:Insights into the role of defect engineering in photocatalysts显示文摘Engineering of defects in semiconductors provides an effective protocol for improving photocatalytic N_(2) conversion efficiency.This review focuses on the state-of-the-art progress in defect engineering of photocatalysts for the N_(2) reduction toward ammonia.The basic principles and mechanisms of thermal catalyzed and photon-induced N_(2) reduction are first concisely recapped,including relevant properties of the N_(2) molecule,reaction pathways,and NH3 quantification methods.Subsequently,defect classification,synthesis strategies,and identification techniques are compendiously summarized.Advances of in situ characterization techniques for monitoring defect state during the N_(2) reduction process are also described.Especially,various surface defect strategies and their critical roles in improving the N_(2) photoreduction performance are highlighted,including surface vacancies(i.e.,anionic vacancies and cationic vacancies),heteroatom doping(i.e.,metal element doping and nonmetal element doping),and atomically defined surface sites.Finally,future opportunities and challenges as well as perspectives on further development of defect-engineered photocatalysts for the nitrogen reduction to ammonia are presented.It is expected that this review can provide a profound guidance for more specialized design of defect-engineered catalysts with high activity and stability for nitrogen photochemical fixation. | Huidong Shen Mengmeng Yang Leiduan Hao Jinrui Wang Jennifer Strunk Zhenyu Sun | 2022 | Nano Research2022，15，4： | 3 |
| 11 | Preparation of Cu/ZrO2 catalysts for methanol synthesis from CO2/H2显示文摘为从 CO2/H2 的甲醇合成的 Cu/ZrO2 催化剂被免职一起沉淀(DP ) 和稳固的州的反应(SR ) 分别地准备方法。在铜和氧化锆之间有一个亲密相互作用,它强烈影响减小性质和催化剂的催化性能。越强壮相互作用,越多降低减小温度并且更好催化剂的表演。表面区域,毛孔结构和催化剂的水晶结构被准备方法和合成系统的碱度主要控制。CO2 的变换和甲醇的选择比为 SP 催化剂为 DP 催化剂是更高的。 | Xinmei LIU Shaofen BAI Huidong ZHUAN Zifeng YAN | 2012 | Frontiers of Chemical Science and Engineering2012，6，1： | 3 |
| 12 | Synthesis and assembly with mesoporous silica of platinum (Ⅱ) porphyrin complexes bearing carbazyl groups: Luminescent and oxygen sensing properties显示文摘A series of platinum meso-tetrakis [3-methoxy-4-(N-carbazyl)n-alkyloxyphenyl]porphyrin (Pt-4Cn-TPP, n = 4, 6 and 8) are synthesized. Pt-4C4-TPP, Pt-4C6-TPP and Pt-4C8-TPP exhibit similar luminescent properties in solution and solid state. Three protonated platinum (II) porphyrins are assembled with mesoporous silica MCM-48, respec- tively, resulting in assembly materials Pt-4Cn-TPP4+/ MCM-48 (n = 4, 6 and 8). The luminescent intensity of Pt-4Cn-TPP4+/MCM-48 can be extremely quenched by molecular oxygen with high sensitivity (I0/I100 > 9). The Stern-Volmer plots of these assembly materials display considerable linearity within a wide range of oxygen concentration (0 to 100%). The re- sponse time is all ≤ 1 s and recovery time ≤ 22 s for these assembly materials. | HUO Cheng ZHANG Huidong GUO Jianhua ZHANG Hongyu ZHANG Ping WANG Yue | 2006 | Chinese Science Bulletin2006，51，19： | 3 |
| 13 | Relationship between increase rate of human plague in China and global climate index as revealed by cross-spectral and cross-wavelet analyses显示文摘Plague has caused the death of hundreds of millions of people throughout the human history.Today this disease is again re-emerging and hence is again becoming an increasing threat to human health in several parts of the world.However,impacts of global climate variation(e.g.El Nino and Southern Oscillation[ENSO])and global warming on plagues are largely unknown.Using cross-spectral analysis and cross-wavelet analysis,we have analyzed the relationship between increase rate of human plague in China during 1871–2003 and the following climate factors(as measured by the Southern Oscillation Index[SOI],Sea Surface Temperature of east Pacific equator[SST]and air Temperature of the Northern Hemisphere[NHT]).We found in the frequency domain that increase rate of human plague was closely associated with SOI and SST.Cross-spectral analysis reveals that significant coherencies between increase rate of human plague and ENSO were found over short periods(2–3 years),medium periods(6–7 years)and long periods(11–12 years,30–40 years).Cross-wavelet analysis reveals that increase rate of human plague oscillates in phase with SOI,but in anti-phase with SST over periods of 2–4 years and approximately 8 years(6–10 years).These results indicate that ENSO-driven climate variation may be important for occurrences of human plague in China.However,there is a need for a further analysis of the underlying mechanism between human plague in China and ENSO. | Zhibin ZHANG Zhenqing LI Yi TAO Min CHEN Xinyu WEN Lei XU Huidong TIAN Nils Chr.STENSETH | 2007 | Integrative Zoology2007，2，3： | 3 |
| 14 | OmpA-like protein Loa22 from Leptospira interrogans serovar Lai is cytotoxic to cultured rat renal cells and promotes inflammatory responses显示文摘细螺旋体病肾的疾病是细螺旋体病的普通临床的表明之一,包括尖锐肾的失败和 tubulointerstitial 肾炎。外部膜蛋白质相似蛋白质 Loa22 是从螺旋体 interrogans 的脂蛋白并且被建议了是一个相应毒力因素。然而,在 leptospiral nephropathy 的 Loa22 的角色还没被理解。在现在的学习,我们构造了向量并且人工地在 Escherichia coli BL21 (DE ) pLysS 房间表示了 Loa22。在广泛的纯化以后,与 GST 标签蛋白质控制一起, Loa22 蛋白质被用来在有教养的老鼠测试 cytotoxicity 近似小管房间(NRK52E ) 并且在煽动性的回答的正式就职上检验它的效果。用词法检查,2,3二度( 2-methoxy-4-nitro-5-sulfophenyl ) -5-[(phenylamino)carbonyl]-2H-tetrazoium hydrixide 吸收度,喂奶脱氢酶试金和经由流动 cytometry 的 apoptosis 的分析, Loa22 蛋白质调停,这被发现以一种剂量依赖者方式的 NRK52E 房间上的直接细胞毒素的效果。用即时 PCR,西方的弄污和 immunofluorescence,它被发现那 Loa22 蛋白质 upregulates 像使用费的受体的表示 2 (TLR2 ) ,导致氮的氧化物 synthase 并且支持氮的氧化物的生产(没有) 并且由 NRK52E 房间的单核白血球 chemoattractant protein-1 (MCP-1 ) 。用堵住抗体的 TLR2,在 Loa22 刺激要求 TLR2 的激活以后,另外,它被 NRK52E 房间发现那和 MCP-1 生产。一起,我们的数据建议 Loa22 是 L 的一个批评毒力因素。interrogans 并且通过直接调停涉及 leptospiral nephropathy cytotoxicity 和提高的煽动性的回答。 | Ying Zhang Lang Bao Hailong Zhu Bi Huang Huidong Zhang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 3 |
| 15 | In-situ observation of electrical tree evolution in epoxy dielectrics with internal cracks显示文摘Gas-filled internal crack might appear in thermoset materials like epoxy resin during the equipment manufacturing,which would become a vulnerable local region to initiate the electrical tree,thus prone to cause insulation failure.The withstand voltage test was carried on epoxy samples with artificial cracks based on a rod-plane electrode arrange-ment.Simultaneously,surface state variation and tree evolution with crack were observed by an optical microscope in conjunction with a charge-coupled device camera.The changes in morphology and chemical status of the crack surface were characterized by scanning electron microscopy,laser Raman spectrometer and energy dispersive spec-trometer,respectively.It was found that the erosion and tree started from the borderline of crack under a relatively low electric field strength;however,the area near the electrode had relatively little damage.The breaking of epoxy molecular chains coarsens the crack surface and further forms deep channels on a micro-level,which is the forerunner of the electrical tree inception.Based on these,the initiation mechanisms of the crack-induced electrical tree and the reasons for the erosion near the borderline have been revealed.This study provides a train thought for the polymer degradation opening up into the initial tree channel during tree evolution processes. | Zehua Wu Huidong Tian Sijia Zhu He Li Qingyu Wang Zongliang Xie Peng Liu Zongren Peng | 2021 | High Voltage2021，6，2： | 3 |
| 16 | Novel nanoporous binary Ag-Ni electrocatalysts for hydrazine oxidation显示文摘From an aqueous mixture of Ag(I)-EDTA complex and Ni(II) nitrate, silver and nickel particles were co-deposited on the surface of titanium substrates by the hydrothermal method using hydrazine hydrate as a reduction agent. The prepared titanium-supported nano-scale Ag and Ag-Ni particles (nano Ag/Ti, nano Ag86Ni14/Ti, nano Ag77Ni23/Ti, and nano Ag74Ni26/Ti) exhibit nanoporous 3D network textures. Their electrocatalytic activity towards hydrazine oxidation in alkaline solutions was evaluated by cyclic voltammetry and chronoamperometry. The results show that the four samples present a low onset potential of ca. -0.60 V vs. SCE and considerably high and stable anodic current densities for hydrazine oxidation. Among them, the nano Ag86Ni14/Ti electrode exhibits the highest anodic current density towards hydrazine oxidation, showing an increment of electro-active sites on the nano Ag86Ni14/Ti due to the addition of Ni to Ag particles. | YI Qingfeng, LI Lei, YU Wenqiang, LIU Xiaoping, ZHOU Zhihua, and NIE Huidong School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China | 2010 | Rare Metals2010，29，1： | 3 |
| 17 | Influence of Si Content on Properties of Ti1-xSixN Coatings显示文摘To investigate the evolution of microstructure and wear behavior of TiSiN coatings with the variation of Si in targets and lays the foundation for its controllable mass production, Ti1-xSixN composite coatings were deposited onto Si(100) and cemented carbide substrates using TiSi targets with different Si content by cathodic arc ion plating. The influences of Si on the microstructure and mechanical properties were studied. Nano-amorphous composite structure appeared in the Ti1-xSixN coatings when Si content in TiSi target was higher than 5 at%. However, further increase of Si content in TiSi target exhibited a negligible effect on the microstructure of Ti1-xSixN coatings. Hardness and deformation resistance were correlated to the content of Si in TiSi targets. Maximum hardness was obtained as the Si content in target increased up to 20 at%. Friction coefficient and wear rate significantly decreased with addition of Si in TiN coating, and then dually increased with the increase of Si content in targets. | 万强 LIU Nian YANG Bing LIU Huidong CHEN Yanming | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，4： | 3 |
| 18 | A sensitivity study of the WRF model in offshore wind modeling over the Baltic Sea显示文摘Accurate wind modeling is important for wind resources assessment and wind power forecasting. To improve the WRF model configuration for the offshore wind modeling over the Baltic Sea, this study performed a sensitivity study of the WRF model to multiple model configurations, including domain setup,grid resolution, sea surface temperature, land surface data, and atmosphere-wave coupling. The simulated offshore wind was evaluated against LiDAR observations under different wind directions, atmospheric stabilities, and sea status. Generally, the simulated wind profiles matched observations, despite systematic underestimations. Strengthening the forcing from the reanalysis data through reducing the number of nested domains played the largest role in improving wind modeling. Atmosphere-wave coupling further improved the simulated wind, especially under the growing and mature sea conditions.Increasing the vertical resolution, and updating the sea surface temperature and the land surface information only had a slight impact, mainly visible during very stable conditions. Increasing the horizontal resolution also only had a slight impact, most visible during unstable conditions. Our study can help to improve the wind resources assessment and wind power forecasting over the Baltic Sea. | Huidong Li Björn Claremar Lichuan Wu Christoffer Hallgren Heiner Körnich Stefan Ivanell Erik Sahlée | 2021 | Geoscience Frontiers2021，12，6： | 2 |
| 19 | Microstructure control of organic semiconductors via UV-ozone for high-sensitivity NO2 detection显示文摘Developing high sensitive organic semiconductors(OSCs)in organic thin-film transistors(OTFTs)is the key for OTFT based gas sensors.Herein,we report a simple processing route of highly sensitive OSCs for high performance OTFT based nitrogen dioxide(NO2)sensors,where the active OSC layer is based on ultraviolet-ozone(UVO)treated poly(3-hexylthiophene-2,5-diyl)(P3HT).Compared to conventional P3HT based OTFT sensors,the reported device exhibits a remarkable improvement of the gas response from 350%to 30000%.The studies in morphologies,chemical compositions and microstructures of the UVOtreated films reveal that a large number of carrier traps generated in the P3HT films is the decisive reason for the enhancement of sensing performance.Moreover,the optimized device shows great potential of practical applications on the stand points of sensitivity,selectivity,reusability and the ability of recovery,as well as limit of detection of~7.3 ppb.This simple method provides an innovative understanding for the role of the carrier traps in sensing performance and demonstrates a bright future for developing high performance OTFT gas sensors. | HOU SiHui FAN HuiDong WU MengGe YU XinGe YU JunSheng | 2021 | Science China(Technological Sciences)2021，64，5： | 2 |
| 20 | Experimental study and simulation of a three-phase flow stirred bioreactor显示文摘In order to obtain the reasonable operating conditions and minimize the power consumption in the stirred bioreactor, the hydrodynamic experiments in the stirred bioreactor have been taken to obtain the basic data. Subsequently, an Eulerian model for the gas–liquid–solid three phase flow in the stirred bioreactor has been proposed and the CFD simulation has been conducted. By comparing the results of experiment and simulation, it can be concluded that the simulation results were consistent with the experimental data. The inner relationship between operating variables and indicators could be obtained by comparing the results of just suspension speed, gas holdup, power consumption and operational maps, further the reasonable operating conditions could be also determined under the minimum power consumption. The operational maps could provide the theoretical foundation for industrial application of the gas–liquid–solid stirred bioreactors under the low solid concentration(no more than 20 wt%). | Chenghui Zheng Jiashun Guo Chengkai Wang Yuanfeng Chen Huidong Zheng Zuoyi Yan Qinggen Chen | 2019 | Chinese Journal of Chemical Engineering2019，27，3： | 2 |
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