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| 1 | Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation显示文摘在房间期间,分割要求忠诚有丝分裂的锭子汇编和染色体分离的基因信息的稳定的传播。运用了 GTPase 戏在有丝分裂的锭子汇编的一个关键角色。然而,在锭子的 Ran-GTP 的一个化学坡度的产生怎么被联合到有丝分裂的 translational 以后修正,从来没被描绘过。这里,我们解决了复杂结构与核苷酸版本因素 Mog1 跑了并且描出一个新奇有丝分裂特定的调整 acetylation 的 Ran-Mog1 相互作用在染色体分离期间。我们的指导结构的功能的分析表明那 Mog1 与 RCC1 竞争为以一种 GTP/GDP-dependent 方式变有约束力。生物化学的描述表明了那 Mog1 固定跑阻止 RCC1 有约束力、随后的 GTP 装载。令人惊讶地,跑了是 TIP60 的真正的底层,并且由 TIP60 的 Lys134 的 acetylation 解放 Mog1 从在有丝分裂期间变有约束力。重要地,这个得到 acetylation 的开关对 RCC1 变有约束力支持 Ran-GTP 的高水平,它为染色体排列是必要的。这些结果建立一以前 TIP60 由调节在提供 Ran-GTP 水平的 homeostatic 控制的规章的机制运用了的 uncharacterized 为在有丝分裂的染色体分离的受动器绑定。 | Xiaoling Bao Heng Liu Xing Liu Ke Ruan Yonshui Zhang Zhiyong Zhang Qi Hu Ying Liu Saima Akram Jiahai Zhang Qingguo Gong Wenwen wang Xiao Yuan Jian-Li Lingli Zhao Zhen Dou Ruijun Tian Xuebiao Yao Jihui Wu Yunyu Shi | 2018 | Journal of Molecular Cell Biology2018，10，1： | 8 |
| 2 | LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis显示文摘Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate decision.Different structural determinants account for HP1α Localization and function during cell division cycle.Our earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors.Here,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis.LRIF1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its C-terminus.Importantly,the LRIF1-HPla interaction is critical for Aurora B activity in the inner centromere.Mutation of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome segregation.These findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division. | Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu | 2018 | Journal of Molecular Cell Biology2018，10，6： | 5 |
| 3 | PML–LRIF1 interactions form a novel link between promyelocytic leukemia bodies and centromeres显示文摘Dear Editor,Promyelocytic leukemia(PML)is the scaffold protein that organizes PML bod-ies,which are nuclear membraneless organelles involved in various biologi-cal processes,including tumor suppres-sion and antiviral responses(Ugge et al.,2022).Early electron microscopic analy-ses revealed contacts between the sur-face of PML bodies and chromatin struc-ture(Corpet et al.,2020).In fact,sev-eral chromatin and cell cycle regulators,such as TIP60,P300,and heterochro-matin protein 1(HP1),are localized in PML bodies in interphase cells(Corpet et al.,2020). | Junying Li Xiao Yuan Fengrui Yang Jun Cao Chunyue Wang Saima Akram Peng Zou Felix Aikhionbare Xuejun Li Yong Chen Liangyu Zhang Chuanhai Fu Zhikai Wang Xing Liu Xuebiao Yao | 2023 | Journal of Molecular Cell Biology2023，15，6： | 0 |
| 4 | Computer Methodologies for the Comparison of Some Efficient Derivative FreeSimultaneous Iterative Methods for Finding Roots of Non-Linear Equations显示文摘In this article,we construct the most powerful family of simultaneous iterative method with global convergence behavior among all the existing methods in literature for finding all roots of non-linear equations.Convergence analysis proved that the order of convergence of the family of derivative free simultaneous iterative method is nine.Our main aim is to check out the most regularly used simultaneous iterative methods for finding all roots of non-linear equations by studying their dynamical planes,numerical experiments and CPU time-methodology.Dynamical planes of iterative methods are drawn by using MATLAB for the comparison of global convergence properties of simultaneous iterative methods.Convergence behavior of the higher order simultaneous iterative methods are also illustrated by residual graph obtained from some numerical test examples.Numerical test examples,dynamical behavior and computational efficiency are provided to present the performance and dominant efficiency of the newly constructed derivative free family of simultaneous iterative method over existing higher order simultaneous methods in literature. | Yuming Chu Naila Rafiq Mudassir Shams Saima Akram Nazir Ahmad Mir Humaira Kalsoom | 2021 | Computers, Materials & Continua2021，，1： | 0 |
| 5 | Computer Geometries for Finding All Real Zeros of Polynomial Equations Simultaneously显示文摘In this research article,we construct a family of derivative free simultaneous numerical schemes to approximate all real zero of non-linear polynomial equation.We make a comparative analysis of the newly constructed numerical schemes with a well-known existing simultaneous method for determining all the distinct real zeros of polynomial equations using computer algebra system Mat Lab.Lower bound of convergence of simultaneous schemes is calculated using Mathematica.Global convergence property of the numerical schemes is presented by taking random starting initial approximation and their convergence history are graphically presented.Some real life engineering applications along with some higher degree polynomials are considered as numerical test problems to show performance and efficiency of the derivative free family of numerical methods with comparison of an existing method of same order in literature.Local computational order of convergence,CPU time,graph of computational order of convergence and residual error graphs elaborate efficiency,robustness and authentication of the suggested family of numerical methods in its domain. | Naila Rafiq Saima Akram Mudassir Shams Nazir Ahmad Mir | 2021 | Computers, Materials & Continua2021，，11： | 0 |
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