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| 1 | Evaluation and outcomes of patients with obscure gastrointestinal bleeding显示文摘Obscure gastrointestinal bleeding(OGIB) is defined as recurrent or persistent bleeding or presence of iron deficiency anaemia after evaluation with a negative bidirectional endoscopy. OGIB accounts for 5% of gastrointestinal bleeding and presents a diagnostic challenge. Current modalities available for the investigation of OGIB include capsule endoscopy, balloon assisted enteroscopy, spiral enteroscopy and computed tomography enterography. These modalities overcome the limitations of previous techniques. Following a negative bidirectional endoscopy, capsule endoscopy and double balloon enteroscopy remain the cornerstone of investigation in OGIB given their high diagnostic yield. Longterm outcome data in patients with OGIB is limited, but is most promising for capsule endoscopy. This article reviews the current literature and provides an overview of the clinical evaluation of patients with OGIB, available diagnostic and therapeutic modalities and longterm clinical outcomes. | Cositha Santhakumar Ken Liu | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 5 |
| 2 | Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis显示文摘 | Nagendra Singh Ashish Gurav Sathish Sivaprakasam Evan Brady Ravi Padia Huidong Shi Muthusamy Thangaraju Puttur D. Prasad Santhakumar Manicassamy David H. Munn Jeffrey R. Lee Stefan Offermanns Vadivel Ganapathy | 2014 | Immunity2014，，1： | 2 |
| 3 | Modulation of adaptive immunity with Toll-like receptors显示文摘 | Santhakumar Manicassamy Bali Pulendran | 2009 | Seminars in Immunology2009，，4： | 2 |
| 4 | The Role of the Charged Residues of the GP2 Helical Regions in Ebola Entry显示文摘The glycoprotein(GP) of Ebola is the sole structural protein that forms the spikes on the viral envelope. The GP contains two subunits,GP1 and GP2,linked by a disulfide bond,which are responsible for receptor binding and membrane fusion,respectively. In this study,the full length of GP gene of Ebola Zaire species,2028 base pairs in length,was synthesized using 38 overlapping oligonucleotides by multiple rounds of polymerase chain reaction(PCR) . The synthesized GP gene was shown to be efficiently expressed in mammalian cells. Furthermore,an efficient HIV-based pseudotyping system was developed using the synthetic GP gene,providing a safe approach to dissecting the entry mechanism of Ebola viruses. Using this pseudotyping system and mutational analysis,the role of the charged residues in the GP2 helical regions was examined. It was found that substitutions of the most charged residues in the regions did not adversely affect GP expression,processing,or viral incorporation,however,most of the mutations greatly impaired the ability of GP to mediate efficient viral infection. These results demonstrate that these charged residues of GP2 play an important role in GP-mediated Ebola entry into its host cells. We propose that these charged residues are involved in forming the intermediate conformation(s) of GP in membrane fusion and Ebola entry. | Haiqing Jiang Jizhen Wang Balaji Manicassamy Santhakumar Manicassamy Michael Caffrey Lijun Rong | 2009 | Virologica Sinica2009，24，2： | 2 |
| 5 | Reliability analysis and full - scale testing of transmission tower显示文摘 | Alam M J Santhakumar A R | 1994 | Journal of Structural Engineering ASCE1994，122，3： | 1 |
| 6 | Topological determinants of epileptogenesis in large -scale structural and functional models of the dentate gyrus derived from experimental data显示文摘 | Dyhrfjeld -Johnsen J Santhakumar V Morgan RJ | 2007 | J Neurophysiol2007，97，： | 1 |
| 7 | Reliability analysis and fullscale testing of transmission tower显示文摘 | Alam M J Santhakumar A R | 1996 | Journal of Structural Engineering ASCE1996，122，3： | 1 |
| 8 | AnMysis of Retrofitted Reinforced Concrete Shear Beams using Carbon Fiber Composites显示文摘 | Santhakumar R Chandrasekaran E Dhanaraj R | 2004 | Electronic Journal of Structural Engineering2004，，4： | 1 |
| 9 | Behavior of Internaly Ring -Stiffened Joints of Offshore Platforms显示文摘 | Thandavamoorthy T S Rao A G M Santhakumar A R | 1999 | Journal of Structural Engineering1999，11，： | 1 |
| 10 | Reliability analysis and full-scale testing of transmission tower 显示文摘 | ALAM M J SANTHAKUMAR A R | 1996 | Journal of Structure Engineering1996，122，33： | 1 |
| 11 | Synthesis, characterization and micellization behaviour of some surface active mixed - ligand complexes of cobalt (Ⅲ) 显示文摘 | KUMARAGURU N SANTHAKUMAR K ARUNACHALAM S | 2006 | Polyhedron2006，25，17： | 1 |
| 12 | Behavior of Internally Ring-Stiffened Joints of Offshore Platforms显示文摘 | Thandavamoortgy T S Madhava Rao A G Santhakumar A R | 1998 | Journal of Structural Engineering1998，125，11： | 1 |
| 13 | Expression of avian influenza virus (H5N1) hemagglutinin and matrix protein 1 in pichia pastoris and evaluation of their immunogenicity in mice 显示文摘 | Subathra M Santhakumar P Satyam Naidu S | 2014 | Appl Biochem Bioteehnol2014，172，7： | 1 |
| 14 | Two-stage high-gain high-power distributed amplifier using dual-gate GaN HEMTs 显示文摘 | SANTHAKUMAR R THIBEAULT B HIGASHIWAKI M | 2011 | IEEE Trans Microwave Theo & Tech2011，59，8： | 1 |
| 15 | Suppression of alkene isomerisation in products from intramolecular heck reactions by addition of Tl (1) salts显示文摘 | Crigg R Loganathan V Santhakumar V | 1991 | Tetrahedron Lett1991，32，5： | 1 |
| 16 | Behavior of internally ring-stiffened joints of offshore platforms 显示文摘 | THANDAVAMOORTHY T S MADHAVA A G SANTHAKUMAR A R | 1999 | Journal of Structural Engineering ASCE1999，125，11： | 1 |
| 17 | The influence of geometry on the blast response of circular arches 显示文摘 | Dharaneepathy M V Kewava Rao M N Santhakumar A R | 1992 | Computers & Structures1992，45，： | 1 |
| 18 | Behavior of internally ring-stiffened joints of offshore platforms显示文摘 | THANDAVAMOORTGY T S MADHAVA RAO A G SANTHAKUMAR A R | 1998 | Journal of Structural Engineering1998，125，11： | 1 |
| 19 | Strengthening of reinforced concrete beams using glass fibre reinforced plastic laminates显示文摘 | Santhakumar R Kannabiran S Dhanaraj R | 1999 | Indian Concrete Journal1999，73，12： | 1 |
| 20 | The influence of geometry on the blast response ofcircular arches 显示文摘 | Dharaneepathy M V Kewava Rao M N Santhakumar AR | 1992 | Computers & Structures1992，45，： | 1 |
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