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| 1 | Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation显示文摘Gut inflammation is a challenging concern in humans and animals,which disturbs normal growth and leads to severe bowel diseases.Short chain fatty acids(SCFA)are the gut microbiota metabolites produced from fermentation of non-digestible carbohydrates,and have been reported to modulate gut inflammation.SCFA have been implicated as the potential therapeutic bioactive molecules for gut inflammatory diseases,and could be an alternative to antibiotic growth promoters(AGP).In this review,the existing knowledge about the types of SCFA,the related gut microbes producing SCFA,the roles of SCFA in maintaining gut homeostasis,and how SCFA modulate gut inflammation is summarized.The therapeutic application of SCFA in the treatment of inflammatory bowel disease(IBD)is also highlighted | Muhammad Akhtar Yan Chen Ziyu Ma Xiaolong Zhang Deshi Shi Jawaria AKhan Huazhen Liu | 2022 | Animal Nutrition2022，，1： | 8 |
| 2 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 3 | Tubeimoside-1 induces oxidative stress-mediated apoptosis and GJG1 phase arrest in human prostate carcinoma cells in vitro显示文摘瞄准:Tubeimoside-1 (TBMS1 ) , triterpenoid saponin 从中草药 Bolbostemma paniculatum (格言) 提取了 Franquet (Cucurbitaceae ) ,在各种各样的癌症房间线显示出 anticancer 活动。这研究的目的是在 vitro.Methods 在人的前列腺癌症房间调查 anticancer 活动和 TBMS1 的分子的目标:DU145 和 P3 人的前列腺癌症房间与 TBMS1 被对待。房间生存能力和 apoptosis 被检测。ROS 产生, mitochondrial 膜潜力和房间周期侧面被检验。西方的弄污被用来在 cells.Results 测量相关蛋白质的表示:TBMS1 (5-100 μ mol/L ) 显著地与约 10 和 20 μ 的 IC 50 价值压制了 DU145 和 P3 房间的生存能力; mol/L 分别地。而且, TBMS1 dose-dependently 在 DU145 和 P3 房间在 G 0/G1 阶段导致了 apoptosis 和房间周期拘捕。在 DU145 房间, TBMS1 导致了 mitochondrial apoptosis,由 ROS 产生, mitochondrial 机能障碍, endoplasmic 蜂窝胃压力,调制 Bcl-2 家庭蛋白质和劈开的 caspase-3 证实了,并且激活 ASK-1 和它的下游的目标 p38 和 JNK。G 0/G1 阶段拘捕被连接到 p53 和 p21 的增加的表示并且减少 cyclin E 和 cdk2 的表示。有 Z-VAD-FMK (pan-caspase 禁止者) 的合作处理能稀释导致 TBMS1 的 apoptosis,但是没阻止 G 0/G1 拘捕。而且,有 NAC (ROS scavenger ) 的合作处理, SB203580 (p38 禁止者) , SP600125 (JNK 禁止者) 或 salubrinal (嗯压力禁止者) 显著地稀释的导致 TBMS1 的 apoptosis.Conclusion:TBMS1 经由 mitochondrial 小径在 vitro 在 DU145 人的前列腺癌症房间导致氧化调停压力的 apoptosis。 | Jing-bo YANG Muhammad KHAN Yang-yang HE Min YAO Yong-ming LI Hong-wen GAO Tong-hui MA | 2016 | Acta Pharmacologica Sinica2016，37，7： | 5 |
| 4 | Qualitatively and quantitatively assessing the aggregation ability of sludge during aerobic granulation process combined XDLVO theory with physicochemical properties显示文摘Inexact mechanism of aerobic granulation still impedes optimization and application of aerobic granules. In this study, the extended Derjaguin, Landau, Verwey, and Overbeek(XDLVO) theory and physicochemical properties were combined to assess the aggregation ability of sludge during aerobic granulation process qualitatively and quantitatively. Results show that relative hydrophobicity of sludge and polysaccharide content of extracellular polymeric substances(EPS) increased, while electronegativity of sludge decreased during acclimation phase. After 20 days' acclimation, small granules began to form due to high aggregation ability of sludge. Since then, coexisted flocs and granules possessed distinct physicochemical properties during granulation and maturation phase. The relative hydrophobicity decreased while electronegativity increased for flocs, whereas that for granules presented reverse trend. Through analyzing the interaction energy using the XDLVO theory, small granules tended to self-grow rather than self-aggregate or attach of flocs due to poor aggregation ability between flocs and granules during the granulation phase. Besides, remaining flocs were unlikely to self-aggregate owing to poor aggregation ability, low hydrophobicity and high electronegativity. | Shasha Yuan Mingming Gao Hui Ma Muhammad Zaheer Afzal Yun-Kun Wang Mingyu Wang Hai Xu Shu-Guang Wang Xin-Hua Wang | 2018 | Journal of Environmental Sciences2018，30，5： | 4 |
| 5 | Mechanisms and molecular approaches for heat tolerance in rice (Oryza sativa L.) under climate change scenario显示文摘Rice, a staple cereal crop in many parts of the world, has been confronted with multiple environmental stresses including high temperature, negatively impacts the booting as well as anthesis growth stages. The situation is further complicated by the changing climatic conditions, resulting in gradual escalation of temperature as well as changing the rainfall pattern and frequency, thus raising a concern of food security worldwide. The situation can be combat by developing rice varieties with excellent genetics with improved morpho-physiological, biochemical, and molecular mechanisms, together can minimize the adverse effects of heat stress. Here, several strategies(encompassing genetic and genomic, and mechanisms involved) for mitigating the impact of high temperature on rice have been discussed. Finally, the utilization of genomic knowledge in augmenting the conventional breeding approaches have been comprehensively elaborated to develop heat tolerant germplasm. | Syed Adeel Zafar Amjad Hameed Muhammad Amjad Nawaz MA Wei Mehmood All Noor Muzammil Hussain Mehboob-ur-Rahman | 2018 | Journal of Integrative Agriculture2018，17，4： | 4 |
| 6 | Mechanical strength of wheat grain varieties influenced by moisture content and loading rate显示文摘Mechanical shear resistance of wheat grain is a significant concern for the designers and researchers related to the design of threshing,handling and processing machinery of the field crops.The grain mechanical properties directly affect the machine geometry and its operational parameters.The present study was carried out to determine the shear resistance of five wheat varieties(Locally names;TD-02,Sindhu-1105,Benazir,China and SKD-118)influenced by moisture content(16.7%,18.7%and 19.5%)and loading rate(3 mm/s,6 mm/s and 9 mm/s).However,some physio-dimensional properties(length,width,thickness,slenderness ratio,surface area and sphericity)were obtained at different moisture contents.The results showed that the shear resistance reduced by increasing the moisture content and loading rate.The average shear resistance decreased from 10.45 N to 3.74 N for 3-9 mm/s loading rate at moisture content of 16.7%to 19.5%.Thus,the maximum correlation(r=0.905)of shear resistance obtained at 16.7%,whereas minimum correlation(r=0.692)obtained at 19.5%.The shear resistance of wheat grain was highly significant(p<0.05)at 9 mm/s for 19.5%.Shear resistance decreased with an increase in the moisture content in the grain whereas deformation is increasing with the increase of moisture content.However,the maximum bulk density of wheat grain obtained at 19.5%for SKD-118,while the minimum obtained at 16.7%for TD-02.It is recommended that the design and modification of wheat grain processing equipment should be executed on the physio-mechanical properties of grain varieties. | Yaoming Li Farman Ali Chandio Zheng Ma Imran Ali Lakhiar Abdul Razaque Sahito Fiaz Ahmad Irshad Ali Mari Umer Farooq Muhammad Suleman | 2018 | International Journal of Agricultural and Biological Engineering2018，11，4： | 4 |
| 7 | Breakthrough Technologies for the Biorefining of Organic Solid and Liquid Wastes显示文摘有机固液废弃物包含大量能量、养分和水分,不应仅视其为废物。数十年来,人们一直对城市固体废物进行回收、堆制和燃烧,并从中提取能量和有价值的物质。污水的首要管理策略是治理和排放。随着技术的进步,通过新方法使利用固体废物和废水成为可能。考虑到废物特殊的化学、物理和生物性质,需要整合多种技术以使废物的能量和价值回收最大化。为此,生物炼制是完全利用废物中的能量和价值的一个合适的方法。研究证明,不可回收废弃物和生物固体可通过不同方法转化为可利用的热能、电能、燃料和化学品,并且液体废物或能帮助农作物和藻类的成长,为能量回收和食物生产提供不同的选择。本文针对有机固液废物提出新型生物炼制方案,这些废物来源于城市废料、食品和生物加工厂以及动物生产设施。四大新型突破性科技——真空辅助高温厌氧消化、扩展鱼菜共生系统、含油废物经甘油裂解制取生物柴油和微波辅助热化学转化,均可运用于生物炼制方案中,从而成功将废物转化,用以生产化学品、化肥、能量(沼气、合成气、生物柴油和生物油)、食物、饲料,得到干净的水并显著减少污染物的排放。 | Paul Chen Erik Anderson Min Addy Renchuan Zhang Yanling Cheng Peng Peng Yiwei Ma Liangliang Fan Yaning Zhang Qian Lu Shiyu Liu Nan Zhou Xiangyuan Deng Wenguang Zhou Muhammad Omar Richard Griffith Faryal Kabir Hanwu Lei Yunpu Wang Yuhuan Liu Roger Ruan | 2018 | Engineering2018，4，4： | 3 |
| 8 | Luminous composite ultrathin films of CdTe quantum dots/silk fibroin co-assembled with layered doubled hydroxide:Enhanced photoluminescence and biosensor application显示文摘Quantum dots(QDs)luminescent films are extensively applied to optoelectronics and optical devices.However,QDs aggregation results in the quenching of their fluorescence property which limits their practical applications to a greater extent.In order to resolve this issue,3-mercaptopropionic acid(3-MPA)functionalized Cadmium Tellurium(CdTe)QDs were stabilized by silk fibroin(SB)and coassembled with layered doubled hydroxide(LDH)to form(QDs@SF/LDH)_(n)ultrathin films(UTFs)via the layer-by-layer(LBL)technique.UV-Vis absorption and fluorescence spectroscopy showed a stepwise and normal growth of the films upon increasing the number of deposition cycles.XRD and AFM studies confirmed the formation of a periodic layered structure and regular surface morphology of the thin films.As compared to(CdTe QDs/LDH)_(n)UTFs,the(CdTe QDs@SF/LDH)_(n)UTFs displayed fluorescence enhancement and longer fluorescent lifetime,both in solid states and aqueous solutions.Furthermore compared with the solution state,the fluorescence enhancement of SF-RC and SF-β are,respectively,7 times and 17 times in the(CdTe QDs@SF/LDH)_(n)UTFs,indicating that the LDH nanosheets favor the fluorescence enhancement effect on the CdTe QDs@SF.The fabricated materials displayed fluorescence response to a biological molecule such as immune globulin,lgG.Thus,the(CdTe QDs@SF/LDH)_(n)UTFs has a potential to be used as biosensor. | Muhammad Sohail Haroone Ling Li Aftab Ahmad Yaping Huang Ruili Ma Ping Zhang Yuehua Hu Qari Muhammad Kaleem Jun Lu | 2018 | Journal of Materiomics2018，4，2： | 3 |
| 9 | Advancement in Layered Transition Metal Dichalcogenide Composites for Lithium and Sodium Ion Batteries显示文摘 | Muhammad Yousaf Asif Mahmood Yunsong Wang Yijun Chen Zhimin Ma Ray P. S. Han | 2016 | Journal of Electrical Engineering2016，4，2： | 3 |
| 10 | Investigating the trip configured causal effect of distracted driving on aggressive driving behavior for e-hailing taxi drivers显示文摘Risky driving behavior of taxi drivers typically evaluated for full operation or sometimes sorted into occupied and empty running trips.In this paper,we simultaneously analyze aggressive driving and distracted driving of taxi drivers under three different trip categories.Trip origin is considered a transition from without ride-order to with ride-order travelling or from with ride-order to occupied travelling,and a destination as a transition from occupied to without ride-order travelling and vice versa.Distracted driving is characterized by driver interference,driver mobile use and some entertainment aspects,while specific harmful and risky actions are considered for aggressive driving.High-resolution and real-time kinematic parameters of taxis were recorded by the in-vehicle recorder VBOX for overall 562 trips.The distracted driving parameters and aggressive driving actions were monitored through python data collector web application that was specially programmed for this particular research.Besides dual dash cam(i.e.,front and inside car camera),drivers’ whole day driving history from their Chinese ride-hailing Di Di smart application was used to differentiate occupied trips,unoccupied trips with ride-order and unoccupied trips without ride-order.Structural equation modeling(SEM) is practiced in this paper to understand the influence of distracted driving indicators on aggressive driving behaviors.The multi-group model analysis of SEM indicated that handling distracted risky driving could control aggressive driving behavior up to 96% and 98% inunoccupied without ride-order trips and unoccupied trips with ride-order respectively.The model has also identified the sensitive risky driving indicators for each group separately. | Muhammad Sajjad Ansar Yongfeng Ma Shuyan Chen Kun Tang Ziyu Zhang | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，5： | 3 |
| 11 | Gastric mucosal precancerous lesions in Helicobacter pyloriinfected pediatric patients in central China:A single-center,retrospective investigation显示文摘BACKGROUND Helicobacter pylori(H.pylori)infects about 50%of the world population and is the major cause of chronic gastritis,peptic ulcers,and gastric cancer.Chronic H.pylori infection induces gastric mucosal precancerous lesions mostly in adulthood,and it is debatable whether these pathological conditions can occur in childhood and adolescents as well.Since this is a critical issue to determine if intervention should be offered for this population group,we investigated the gastric mucosal precancerous lesions in pediatric patients in an area in central China with a high prevalence of H.pylori and gastric cancer.AIM To investigate the relationship of H.pylori infection and gastric mucosal precancerous lesions in children and adolescents in central China.METHODS We screened 4258 ward-admitted children and adolescent patients with upper gastrointestinal symptoms,and finally enrolled 1015 pediatric patients with H.pylori infection and endoscopic and histological data.H.pylori infection status was determined by rapid urease test and histopathological examination.Both clinical and pathological data were collected and analyzed retrospectively.Occurrence of gastric mucosal precancerous lesions,inflammatory activity and degree of inflammatory cell infiltration between H.pylori-positive and-negative groups were compared.RESULTS Among the 1015 eligible children and adolescents,the overall H.pylori infection rate was 84.14%(854/1015).The infection rate increased with age.The incidence of gastric mucosal precancerous lesions in H.pylori-infected children was 4.33%(37/854),which included atrophic gastritis(17 cases),intestinal metaplasia(11 cases)and dysplasia(9 cases).In H.pylori-negative patients,only 1 atrophic gastritis case[0.62%,(1/161)]was found(P<0.05).Active inflammation in H.pyloriinfected patients was significantly higher than that in non-infected patients,and the H.pyloriinfected group showed more severe lymphocyte and neutrophil granulocyte infiltration(P<0.001).In addition,endoscopy revealed that the most common findings in H.pylori-positive patients were antral nodularity,but in H.pylori-negative patients only superficial gastritis was observed.CONCLUSION In children and adolescents,gastric mucosal precancerous lesions occurred in 4.33%of H.pyloriinfected patients in central China.These cases included atrophic gastritis,intestinal metaplasia,and dysplasia.The data revealed an obvious critical issue requiring future investigation and intervention for this population group. | Miao Yu Jing Ma Xiao-Xia Song Qiao-Qiao Shao Xue-Chun Yu Muhammad Noman Khan Ya-Bin Qi Ruo-Bing Hu Pei-Ru Wei Wei Xiao Bai-Ling Jia Yan-Bo Cheng Ling-Fei Kong Chuan-Liang Chen Song-Ze Ding | 2022 | World Journal of Gastroenterology2022，28，28： | 2 |
| 12 | Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes显示文摘 | Xiaokang Wu Chaofeng Ma Lei Han Muhammad Nawaz Fei Gao Xuyan Zhang Pengbo Yu Chang’an Zhao Lianchuan Li Aiping Zhou Juan Wang John E. Moore B. Cherie Millar Jiru Xu | 2010 | Current Microbiology2010，，1： | 2 |
| 13 | Detrital apatite fission track constraints on Cenozoic tectonic evolution of the northeastern Qinghai-Tibet Plateau, China: Evidence from Cenozoic strata in Lulehe section, Northern Qaidam Basin显示文摘The Northern Qaidam Basin is located at the northeastern part of the Qinghai-Tibetan Plateau. It contains very thick Cenozoic terrestrial clastic sediments, which records the formation of the northern Qaidam Basin due to compressional deformation during the Indo-Asian collision. In this paper, we used detrital apatite fission-track thermochronology, including 4 sandstones and 2 conglomerates samples from the Lulehe section, to reveal the Cenozoic evolution of the northern Qaidam Basin. Fission-track dating indicated the source region of the Lulehe section has experiencedimportant cooling and uplifting in the Late Cretaceous(at ~85.1 Ma and ~65 Ma) and the Eocene(~52 Ma), respectively. The AFT age distribution on the section suggested that the provenance of Lulehe section sediments were mainly derived from the south Qilian Shan(Qilian Mountains) and Altun Shan(Altun Mountains), and two significantly provenance changes may occur at 43.4-46.1 Ma and ~37.8 Ma, respectively. The results may have strong constrains on the Cenozoic deformation and tectonic evolution of the northern Qaidam Basin and Qinghai-Tibet Plateau. | DU Ding-ding ZHANG Cheng-jun MUGHAL Muhammad Saleem WANG Xiao-yu BLAISE Dembele GAO Jun-ping MA Yuan LUO Xin-rong | 2018 | Journal of Mountain Science2018，15，3： | 2 |
| 14 | Cobalt protoporphyrin-induced nano-self-assembly for CT imaging,magnetic-guidance,and antioxidative protection of stem cells in pulmonary fibrosis treatment显示文摘Mesenchymal stem cells(MSCs)transplantation is a promising approach for pulmonary fibrosis(PF),however it is impeded by several persistent challenges,including the lack of long-term tracking,low retention,and poor survival of MSCs,as well as the low labeling efficiency of nanoprobes.Herein,a cobalt protoporphyrin IX(CoPP)aggregation-induced strategy is applied to develop a multifunctional nano-self-assembly(ASCP)by combining gold nanoparticle(AuNPs),superparamagnetic iron oxide nanoparticles(SPIONs),and CoPP through a facile solvent evaporation-driven approach.Since no additional carrier materials are employed during the synthesis,high loading efficiency of active ingredients and excellent biocompatibility are achieved.Additionally,facile modification of the ASCPs with bicyclo[6.1.0]nonyne(BCN)groups(named as ASCP-BCN)enables them to effectively label MSCs through bioorthogonal chemistry.The obtained ASCP-BCN could not only help to track MSCs with AuNP-based computed tomography(CT)imaging,but also achieve an SPIONs-assisted magnetic field based improvement in the MSCs retention in lungs as well as promoted the survival of MSCs via the sustained release of CoPP.The in vivo results demonstrated that the labeled MSCs improved the lung functions and alle-viated the fibrosis symptoms in a bleomycin–induced PF mouse model.Collectively,a novel ASCP-BCN multi-functional nanoagent was developed to bioorthogonally-label MSCs with a high efficiency,presenting a promising potential in the high-efficient MSC therapy for PF. | Yimeng Shu Ming Ma Xiaoxia Pan Muhammad Shafiq Huizhu Yu Hangrong Chen | 2023 | Bioactive Materials2023，，3： | 2 |
| 15 | Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinomacells via simultaneous induction of apoptosis and autophagy显示文摘 | Azhar Rasul Bo Yu Lili Zhong Muhammad Khan Hong Yang Tonghui Ma | 2012 | Oncology Reports2012，，5： | 1 |
| 16 | Field incurred chlorpyrifos and 3, 5, 6-trichloro-2-pyridinol residues in fresh and processed vegetables显示文摘 | Randhawa MA Muhammad AF Anwaar A | 2007 | Food Chemistry2007，103，3： | 1 |
| 17 | Adaptation of Drosophila species to climate change——A literature review since 2003显示文摘Global climate warming has been exerting impacts on agricultural pests. Pests also take some strategies to adapt to climate change. Understanding such adaptation could benefit more accurate predictions and integrated management of pest. However, adaptation to climate change has not been widely investigated in agricultural pests but has been well documented in model species, Drosophila, and reviewed by Hoffmann before 2003. To provide recent progress and references for agricultural entomologists who interested in thermal biology, here we have reviewed literatures since 2003 about adaptation to temperature changes under climate change. We mainly summarized thermal adaptation of Drosophila(especially to high temperatures) from three aspects, behaviors, plastic responses and micro-evolution and discussed how Drosophila increases their heat tolerance through these three mechanisms. Finally, we summarized the measures of thermotolerance and concluded the main progress in recent decade about the behavioral thermoregulation, mortality risks driven by limited evolutionary and plastic response under climate change, geographic distribution based on basal rather than plastic thermotolerance. We propose future work focus on better understanding adaptation of organisms including agricultural pests to climate change. | XUE Qi Muhammad Zeeshan Majeed ZHANG Wei MA Chun-sen | 2019 | Journal of Integrative Agriculture2019，18，4： | 1 |
| 18 | Coordinated Controller Tuning of a Boiler Turbine Unit with New Binary Particle Swarm Optimization Algorithm显示文摘Coordinated controller tuning of the boiler turbine unit is a challenging task due to the nonlinear and coupling characteristics of the system.In this paper,a new variant of binary particle swarm optimization (PSO) algorithm,called probability based binary PSO (PBPSO),is presented to tune the parameters of a coordinated controller.The simulation results show that PBPSO can effectively optimize the control parameters and achieves better control performance than those based on standard discrete binary PSO,modified binary PSO,and standard continuous PSO. | Muhammad Ilyas Menhas Ling Wang Min-Rui Fei Cheng-Xi Ma | 2011 | International Journal of Automation and computing2011，8，2： | 1 |
| 19 | Renal dysfunction in liver cirrhosis: renal duplex Doppler US vs Scintigraphy for early identification显示文摘 | AL- Kareemy EA Sobh MA Muhammad AM | 1998 | Clinical Radiology1998，53，1： | 1 |
| 20 | High-temperature stress suppresses allene oxide cyclase 2 and causes male sterility in cotton by disrupting jasmonic acid signaling显示文摘Cotton(Gossypium spp.) yield is reduced by stress. In this study, high temperature(HT) suppressed the expression of the jasmonic acid(JA) biosynthesis gene allene oxide cyclase 2(GhAOC2), reducing JA content and causing male sterility in the cotton HT-sensitive line H05. Anther sterility was reversed by exogenous application of methyl jasmonate(MeJA) to early buds. To elucidate the role of GhAOC2 in JA biosynthesis and identify its putative contribution to the anther response to HT, we created gene knockout cotton plants using the CRISPR/Cas9 system. Ghaoc2 mutant lines showed male-sterile flowers with reduced JA content in the anthers at the tetrad stage(TS), tapetum degradation stage(TDS), and anther dehiscence stage(ADS). Exogenous application of MeJA to early mutant buds(containing TS or TDS anthers) rescued the sterile pollen and indehiscent anther phenotypes, while ROS signals were reduced in ADS anthers. We propose that HT downregulates the expression of GhAOC2 in anthers, reducing JA biosynthesis and causing excessive ROS accumulation in anthers, leading to male sterility. These findings suggest exogenous JA application as a strategy for increasing male fertility in cotton under HT. | Aamir Hamid Khan Yizan Ma Yuanlong Wu Adnan Akbar Muhammad Shaban Abid Ullah Jinwu Deng Abdul Saboor Khan Huabin Chi Longfu Zhu Xianlong Zhang Ling Min | 2023 | The Crop Journal2023，11，1： | 1 |
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