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| 1 | Pre-hepatectomy type Ⅳ collagen 7S predicts post-hepatectomy liver failure and recovery显示文摘BACKGROUND Liver resection is an effective treatment for benign and malignant liver tumors.However,a method for preoperative evaluation of hepatic reserve has not yet been established.Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term recovery of hepatic reserve.When determining eligibility for hepatectomy,the underlying pathophysiology needs to be considered to determine if the functional hepatic reserve can withstand both surgery and any postoperative therapy.AIM To identify pre-hepatectomy factors associated with both early postoperative liver failure and long-term postoperative liver function recovery.METHODS This study was a retrospective cohort study.We retrospectively investigated 215 patients who underwent hepatectomy at our hospital between May 2013 and December 2016.Early post-hepatectomy liver failure(PHLF)was defined using the International Study Group of Liver Surgery’s definition of PHLF.Long-term postoperative recovery of liver function was defined as the time taken for serum total bilirubin and albumin levels to return to levels of<2 mg/dL and>2.8 g/dL,respectively,and the time taken for Child-Pugh score to return to Child-Pugh class A.RESULTS Preoperative type IV collagen 7S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver function.Further analysis revealed that the time taken for the recovery of Child-Pugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7S≤6 ng/mL than in those with type IV collagen 7S>6 ng/mL.In additional analyses,similar results were observed in patients without chronic viral hepatitis associated with fibrosis.CONCLUSION Preoperative type IV collagen 7S is a preoperative predictor of PHLF and longterm postoperative liver function recovery.It can also be used in patients without chronic hepatitis virus. | Masatsugu Ishii Osamu Itano Masahiro Shinoda Minoru Kitago Yuta Abe Taizo Hibi Hiroshi Yagi Ayano Takeuchi Hanako Tsujikawa Tokiya Abe Yuko Kitagawa | 2020 | World Journal of Gastroenterology2020，26，7： | 3 |
| 2 | Laparoscopic-extracorporeal surgery performed with a fixation device for adnexal masses complicating pregnancy: Report of two cases显示文摘The potential complications associated with an adnexal mass discovered during early pregnancy call for surgical treatment. Ideally, surgery is performed after gestational week 12, but uterine expansion after the first trimester makes surgery difficult. We report two pregnancies complicated by adnexal masses for which we used an organ fixation device for safe performance of single-site umbilical laparoscopic surgery. Pelvic magnetic resonance imaging depicted a dichorionic, diamniotic twin pregnancy and 60-mm right adnexal mass in the first patient and bilateral adnexae in the second. All three masses were suspected mature cystic teratomas. Both patients underwent laparoscopic surgery during gestational week 14. With use of an organ fixation device, traction was applied until the mass reached the umbilicus; tumor resection was performed extracorporeally. In the second patient, the second mass was simply aspirated because adhesions were encountered. Our single-site laparoscopicextracorporeal technique proved to be a safe approach to an otherwise high-risk situation. | Hanako Kasahara Iwaho Kikuchi Aya Otsuka Yoko Tsuzuki Michio Nojima Koyo Yoshida | 2017 | World Journal of Methodology2017，7，4： | 3 |
| 3 | Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation显示文摘 | Masato Suzuki Hitomi Mimuro Kotaro Kiga Makoto Fukumatsu Nozomi Ishijima Hanako Morikawa Shigenori Nagai Shigeo Koyasu Robert H. Gilman Dangeruta Kersulyte Douglas E. Berg Chihiro Sasakawa | 2009 | Cell Host & Microbe2009，，1： | 2 |
| 4 | Axillary lymph node dissection can be avoided in women with breast cancer with intraoperative, false-negative sentinel lymph node biopsies显示文摘 | Hiroyuki Takei Masafumi Kurosumi Takashi Yoshida Yuko Ishikawa Yuji Hayashi Jun Ninomiya Katsunori Tozuka Hanako Oba Kenichi Inoue Shigenori Nagai Yoshihiro Saito Tomoko Kazumoto Jun-ichi Saitoh Toshio Tabei | 2010 | Breast Cancer2010，，1： | 2 |
| 5 | Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells显示文摘 | Hanako I Fumitaka O Kiichi W | 2005 | Proc Natl Acad Sci USA2005，102，11： | 1 |
| 6 | Biosynthesis of poly-γ-glutamic acid in plants: Transient expression of poly-γ-glutamate synthetase complex in tobacco leaves显示文摘 | Yutaka Tarui Hanako Iida Eiichiro Ono Wataru Miki Eiji Hirasawa Ken-ichi Fujita Toshio Tanaka Makoto Taniguchi | 2005 | Journal of Bioscience and Bioengineering2005，，4： | 1 |
| 7 | Plectasin has antibacterial activity and no affect on cell viability or IL-8 production显示文摘 | Shintaro Hara Hiroshi Mukae Noriho Sakamoto Hiroshi Ishimoto Misato Amenomori Hanako Fujita Yuji Ishimatsu Katsunori Yanagihara Shigeru Kohno | 2008 | Biochemical and Biophysical Research Communications2008，，4： | 1 |
| 8 | Ionic conductance of gel electrolyte using a polyurethane matrix for rechargeable lithium batteries显示文摘 | Nobuko Y Hanako N | 2004 | Electrochimica Acta2004，50，23： | 1 |
| 9 | An antifungal compound involved in symbiotic germination of Cypripedium macranthos var. rebunense (Orchidaceae)显示文摘 | Hanako Shimura Mayumi Matsuura Noboru Takada Yasunori Koda | 2007 | Phytochemistry2007，，10： | 1 |
| 10 | Characterization of mycorrhizal fungi isolated from the threatened Cypripedium macranthos in a northern island of Japan: two phylogenetically distinct fungi associated with the orchid显示文摘 | Hanako Shimura Mai Sadamoto Mayumi Matsuura Takayuki Kawahara Shigeo Naito Yasunori Koda | 2009 | Mycorrhiza2009，，8： | 1 |
| 11 | Enhancement of pleural dissemination and lymph node metastasis of intrathoracic lung cancer cells by vascular endothelial growth factors (VEGFs)显示文摘 | HARUHIKO I TAKUYA Y HANAKO S | 2004 | Lung Cancer2004，45，： | 1 |
| 12 | Evans syndrome with cytomegalovirus infection followed by emerging peripheral T-cell lymphoma显示文摘 | Go Yamamoto Masataka Hosoi Takuya Miyagawa Hanako Ohmatsu Motoshi Ichikawa Makoto Sugaya Mineo Kurokawa | 2012 | Annals of Hematology2012，，1： | 1 |
| 13 | Modulation of valosin-containing protein by Kyoto University Substances(KUS) as a novel therapeutic strategy for ischemic neuronal diseases显示文摘Retinal ischemia causes several vision-threatening diseases, including diabetic retinopathy, retinal artery occlusion, and retinal vein occlusion. Intracellular adenosine triphosphate(ATP) depletion and subsequent induced endoplasmic reticulum(ER) stress are proposed to be the underlying mechanisms of ischemic retinal cell death. Recently, we found that a naphthalene derivative can inhibit ATPase activity of valosin-containing protein, universally expressed within various types of cells, including retinal neural cells, with strong cytoprotective activity. Based on the chemical structure, we developed novel valosin-containing protein modulators, Kyoto University Substances(KUSs), that not only inhibit intracellular ATP depletion, but also ameliorate ER stress. Suppressing ER stress by KUSs is associated with neural cell survival in animal models of several neurodegenerative diseases, such as glaucoma and retinal degeneration. Given that a major pathology of ischemic retinal diseases, other than intracellular ATP depletion, is ER stress-induced cell death, KUSs may provide a novel strategy for cell protection in ischemic conditions. Hence, we investigated the efficacy of KUS121 in a rat model of retinal ischemic injury. Intravitreal injections of KUS121, which is clinically preferable route of drug administration in retinal diseases, significantly suppressed inner retinal thinning and retinal cell death, and maintained visual functions. Valosin-containing protein modulation by KUS is a promising novel therapeutic strategy for ischemic retinal diseases. | Masayuki Hata Hanako Ohashi Ikeda | 2017 | Neural Regeneration Research2017，12，8： | 1 |
| 14 | Cancer stem cell: Implications in cancer biology and therapy with special reference to lung cancer显示文摘 | Hitoshi Kitamura Koji Okudela Takuya Yazawa Hanako Sato Hiroaki Shimoyamada | 2009 | Lung Cancer2009，，3： | 1 |
| 15 | Archaeal Diversity and Distribution along Thermal and Geochemical Gradients in Hydrothermal Sediments at the Yonaguni Knoll IV Hydrothermal Field in the Southern Okinawa Trough显示文摘 | Takuro N Hanako O Miwako N | | 0，，04： | 1 |
| 16 | Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation显示文摘 | Masato Suzuki Hitomi Mimuro Kotaro Kiga Makoto Fukumatsu Nozomi Ishijima Hanako Morikawa Shigenori Nagai Shigeo Koyasu Robert H. Gilman Dangeruta Kersulyte Douglas E. Berg Chihiro Sasakawa | 2009 | Cell Host & Microbe2009，，1： | 1 |
| 17 | Treatment effects of bisphosphonates on ovariectomy-induced osteopenia in rats:Comparison between clodronate and etidronate显示文摘 | Fumiaki l Masataka S Hanako K | 1999 | J Bone Min Metab1999，17，： | 1 |
| 18 | S100A9 in BALF is a candidate biomarker of idiopathic pulmonary fibrosis显示文摘 | Atsuko Hara Noriho Sakamoto Yuji Ishimatsu Tomoyuki Kakugawa Shota Nakashima Shintaro Hara Misato Adachi Hanako Fujita Hiroshi Mukae Shigeru Kohno | 2011 | Respiratory Medicine2011，，4： | 1 |
| 19 | Effect of cation radius ratio and unit cell free volume on oxide-ion conductivity in oxide systerms with pyrochore-type composition显示文摘 | HANAKO N YAMAMURA H AARAI T | 2004 | J Ceram Soc Jpn2004，112，54： | 1 |
| 20 | Doppler Radar Study on the Successive Development of Snowbands at a Convergence Line near the Coastal Region of Hokuriku District 显示文摘 | Hanako Y KAWASHIMA M ARAI K | 2004 | Jour of the Meteo Soc of Japan2004，82，4： | 1 |
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