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| 1 | Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial显示文摘 | Tetsuya Mitsudomi Satoshi Morita Yasushi Yatabe Shunichi Negoro Isamu Okamoto Junji Tsurutani Takashi Seto Miyako Satouchi Hirohito Tada Tomonori Hirashima Kazuhiro Asami Nobuyuki Katakami Minoru Takada Hiroshige Yoshioka Kazuhiko Shibata Shinzoh Kudoh Ei | 2010 | Lancet Oncology2010，，2： | 8 |
| 2 | Improvement of prognosis for unresectable biliary tract cancer显示文摘AIM:To evaluate the chemotherapeutic outcomes and confirm the recent improvement of prognosis for unresectable biliary tract cancer.METHODS:A total of 186 consecutive patients with unresectable biliary tract cancer,who had been treated with chemotherapy between 2000 and 2009 at five institutions in Japan,were retrospectively analyzed.These patients were divided into three groups based on the year beginning chemotherapy:Group A(2000-2003),Group B(2004-2006),and Group C(2007-2009).The data were fixed at the end of December 2011.Overall survival and time-to-progression were analyzed and compared chronologically.RESULTS:No patient characteristics were significantly different among the three groups.The gallbladder was involved in about half of the patients in each group,and metastatic biliary tract cancer was present in three quarters of the enrollees.In Group A,5-fluorouracilbased chemotherapies were primarily selected as firstline chemotherapy,and only 24% were treated with second-line chemotherapy.In Group B,gemcitabine or S-1 monotherapy was mainly introduced as firstline chemotherapy,and 51% of the patients who were refractory to first-line chemotherapy were treated with second-line chemotherapy mainly with monotherapy.In Group C,the combination therapy with gemcitabine and S-1 was mainly chosen as first-line chemotherapy,and 53% of the patients refractory to first-line chemotherapy were treated with second-line chemotherapy mainly with combination therapy.The median timeto-progressions were 4.4 mo,3.5 mo and 5.9 mo in Groups A,B and C,respectively(4.4 mo vs 3.5 mo vs 5.9 mo,P < 0.01).The median overall survivals were 7.1,7.3,and 11.7 mo in Groups A,B and C(7.1 mo vs 7.3 mo vs 11.7 mo,P = 0.03).Induction rates of all three drugs(gemcitabine,platinum analogs,and fluoropyrimidine) in Groups A,B and C were 4%,2% and 27%(4% vs 2% vs 27%,P < 0.01).CONCLUSION:The prognosis of unresectable biliary tract cancer has improved recently.Using three effective drugs(gemcitabine,platinum analogs,and fluoropyrimidine) may improve the prognosis of this cancer. | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Naminatsu Takahara Naoki Sasahira Hirofumi Kogure Suguru Mizuno Hiroshi Yagioka Yukiko Ito Natsuyo Yamamoto Kenji Hirano Nobuo Toda Minoru Tada Masao Omata Kazuhiko Koike | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 3 | 中国和日本的加工食品贸易格局和经济效率分析显示文摘本文运用贸易经济效率指数比较了两个典型的东亚国家中国和日本在加工食品方面的贸易表现。由于大国效应和数量庞大的中小贸易公司的恶性竞争,以及缺少有效的贸易管理措施,中国大部分加工食品出口和部分产品进口的经济效率恶化了。而日本仅在食品进口方面经济效率下降,可能原因是严格的技术壁垒导致进口来源集中于发达国家。本文建议中国通过整顿贸易秩序以及合理选择贸易时机来提高加工食品贸易的经济效率,日本的可行对策则是在保证产品质量的同时改变进口来源。 | 刘合光 秦富 孙东升 Minoru Tada 张洁 | 2008 | 农业技术经济2008，，5： | 7 |
| 4 | 中国对拉美农产品出口的影响因素分析及前景展望显示文摘利用引力模型,应用1995~2004年的贸易数据,考察了中国对拉美主要国家农产品出口的影响因素。计算结果显示,中国农产品供给能力、进口国GDP以及距离因素是中国对拉美农产品出口的重要影响因素。进一步的分析表明,中国对拉美主要贸易伙伴的农产品出口属于'贸易活跃'状况,其中乌拉圭的农产品市场已经得到较深入的开拓,而委内瑞拉、阿根廷和厄瓜多尔等3个国家的出口潜力还需要进一步挖掘。 | 张洁 刘合光 Chien Hsiaoping Minoru Tada | 2008 | 农业展望2008，4，8： | 6 |
| 5 | Clinical analysis of high serum IgE in autoimmune pancreatitis显示文摘AIM: To clarify the clinical significance of high serum IgE in autoimmune pancreatitis (AIP). METHODS: Forty-two AIP patients, whose IgE was measured before steroid treatment, were analyzed. To evaluate the relationship between IgE levels and the disease activity of AIP, we examined (1) Frequency of high IgE (> 170 IU/mL) and concomitant allergic dis-eases requiring treatment; (2) Correlations between IgG, IgG4, and IgE; (3) Relationship between the presence of extrapancreatic lesions and IgE; (4) Re-lationship between clinical relapse and IgE in patients treated with steroids, and (5) Transition of IgE before and after steroid treatment. RESULTS: IgE was elevated in 36/42 (86%) patients.Concomitant allergic disease was observed in seven patients (allergic rhinitis in three, bronchial asthma in three, and urticaria in one). There were no signifi-cant correlations between IgG, IgG4, and IgE (r = -0.168 for IgG, and r = -0.188 for IgG4). There was no significant difference in IgE in the patients with and without extrapancreatic lesions (526 ± 531 IU/mL vs 819 ± 768 IU/mL, P = 0.163), with and without clini-cal relapse (457 ± 346 IU/mL vs 784 ± 786 IU/mL, P = 0.374). There was no significant difference in IgE between before and after steroid treatment (723 ± 744 IU/mL vs 673 ± 660 IU/mL, P = 0.633). CONCLUSION: Although IgE does not necessarily reflect the disease activity, IgE might be useful for the diagnosis of AIP in an inactive stage. | Kenji Hirano Minoru Tada Hiroyuki Isayama Kazumichi Kawakubo Hiroshi Yagioka Takashi Sasaki Hirofumi Kogure Yousuke Nakai Naoki Sasahira Takeshi Tsujino Nobuo Toda Kazuhiko Koike | 2010 | World Journal of Gastroenterology2010，16，41： | 4 |
| 6 | A mutation of the start codon in the X region of hepatitis B virus DNA in a patient with non-B,non-C chronic hepatitis显示文摘There are cases of hepatitis involving occult hepatitis B virus(HBV)infection in which,even though the HB surface antigen(HBsAg)is negative,HBV-DNA is detected by a polymerase chain reaction(PCR).We con-ducted a sequence analysis of the entire HBV region in a case of non-B non-C chronic hepatitis in a 46-yearold female.A diagnosis of non-B non-C chronic hepatitis was made.Although HBV markers,such as HBs antibody(anti-HBs),anti-HBc,HBeAg and anti-HBe,were negative,HBV-DNA was positive.Nested PCR was performed to amplify the precore region of HBV-DNA and all remaining regions by long nested PCR.Sequence analysis of the two obtained bands was conducted by direct sequencing.Compared with the control strains,the ATG(Methionine)start codon in the X region had mut ated to GTG(Valine).It is assumed that a mutation at the start codon in the X region may be the reason why HBV markers are negative in some cases of hepatitis that involve occult HBV infection. | Kiyotaka Fujise Keiko Tatsuzawa Midori Kono Sadayori Hoshina Akihito Tsubota Minoru Niiya Yoshihisa Namiki Norio Tada Hisao Tajiri | 2011 | World Journal of Hepatology2011，3，2： | 3 |
| 7 | Risk factors for pancreatitis following transpapillary self-expandable metal stent placement显示文摘 | Kazumichi Kawakubo Hiroyuki Isayama Yousuke Nakai Osamu Togawa Naoki Sasahira Hirofumi Kogure Takashi Sasaki Saburo Matsubara Natsuyo Yamamoto Kenji Hirano Takeshi Tsujino Nobuo Toda Minoru Tada Masao Omata Kazuhiko Koike | 2012 | Surgical Endoscopy2012，，3： | 2 |
| 8 | Covered metallic stents in the management of malignant and benign pancreatobiliary strictures显示文摘 | Hiroyuki Isayama Yousuke Nakai Osamu Togawa Hirofumi Kogure Yukiko Ito Takashi Sasaki Naoki Sasahira Kenji Hirano Takeshi Tsujino Minoru Tada Takao Kawabe Masao Omata | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，5： | 2 |
| 9 | Outcomes after clearance of pancreatic stones with or without pancreatic stenting显示文摘 | Naoki Sasahira Minoru Tada Hiroyuki Isayama Kenji Hirano Yousuke Nakai Natsuyo Yamamoto Takeshi Tsujino Nobuo Toda Yutaka Komatsu Haruhiko Yoshida Takao Kawabe Masao Omata | 2007 | Journal of Gastroenterology2007，，1： | 2 |
| 10 | Diagnostic utility of biopsy specimens for autoimmune pancreatitis显示文摘 | Kenji Hirano Noriyoshi Fukushima Minoru Tada Hiroyuki Isayama Suguru Mizuno Keisuke Yamamoto Yoko Yashima Hiroshi Yagioka Takashi Sasaki Hirofumi Kogure Yousuke Nakai Naoki Sasahira Takeshi Tsujino Takao Kawabe Masashi Fukayama Masao Omata | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 11 | Cholecystitis After Metallic Stent Placement in Patients With Malignant Distal Biliary Obstruction显示文摘 | Hiroyuki Isayama Takao Kawabe Yousuke Nakai Takeshi Tsujino Naoki Sasahira Natsuyo Yamamoto Toshihiko Arizumi Osamu Togawa Saburou Matsubara Yukiko Ito Takashi Sasaki Kenji Hirano Nobuo Toda Yutaka Komatsu Minoru Tada Haruhiko Yoshida Masao Omata | 2006 | Clinical Gastroenterology and Hepatology2006，，9： | 1 |
| 12 | KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation显示文摘 | Takuya Abe Masamichi Ishiai Yoshifumi Hosono Akari Yoshimura Shusuke Tada Noritaka Adachi Hideki Koyama Minoru Takata Shunichi Takeda Takemi Enomoto Masayuki Seki | 2008 | Cellular Signalling2008，，11： | 1 |
| 13 | Short- and long-term outcomes of endoscopic papillary large balloon dilation with or without sphincterotomy for removal of large bile duct stones显示文摘 | Hirofumi Kogure Takeshi Tsujino Hiroyuki Isayama Naminatsu Takahara Rie Uchino Tsuyoshi Hamada Koji Miyabayashi Suguru Mizuno Dai Mohri Yoko Yashima Kazumichi Kawakubo Takashi Sasaki Natsuyo Yamamoto Yousuke Nakai Kenji Hirano Naoki Sasahira Minoru Tada K | 2013 | Scandinavian Journal of Gastroenterology2013，，1： | 1 |
| 14 | Oculocutaneous Albinism Type 4 Is One of the Most Common Types of Albinism in Japan显示文摘 | Katsuhiko Inagaki Tamio Suzuki Hiroshi Shimizu Norihisa Ishii Yoshinori Umezawa Joji Tada Noriaki Kikuchi Minoru Takata Kenji Takamori Mari Kishibe Michi Tanaka Yoshinori Miyamura Shiro Ito Yasushi Tomita | 2004 | The American Journal of Human Genetics2004，，3： | 1 |
| 15 | Detection of common bile duct stones: comparison between endoscopic ultrasonography, magnetic resonance cholangiography, and helical-computed-tomographic cholangiography显示文摘 | Shintaro Kondo Hiroyuki Isayama Masaaki Akahane Nobuo Toda Naoki Sasahira Yosuke Nakai Natsuyo Yamamoto Kenji Hirano Yutaka Komatsu Minoru Tada Haruhiko Yoshida Takao Kawabe Kuni Ohtomo Masao Omata | 2004 | European Journal of Radiology2004，，2： | 1 |
| 16 | Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial显示文摘 | Tetsuya Mitsudomi Satoshi Morita Yasushi Yatabe Shunichi Negoro Isamu Okamoto Junji Tsurutani Takashi Seto Miyako Satouchi Hirohito Tada Tomonori Hirashima Kazuhiro Asami Nobuyuki Katakami Minoru Takada Hiroshige Yoshioka Kazuhiko Shibata Shinzoh Kudoh Ei | 2010 | Lancet Oncology2010，，2： | 1 |
| 17 | Comorbidity, not age, is prognostic in patients with advanced pancreatic cancer receiving gemcitabine-based chemotherapy显示文摘 | Yousuke Nakai Hiroyuki Isayama Takashi Sasaki Naoki Sasahira Takeshi Tsujino Hirofumi Kogure Hiroshi Yagioka Yoko Yashima Osama Togawa Toshihiko Arizumi Saburo Matsubara Kenji Hirano Minoru Tada Masao Omata Kazuhiko Koike | 2010 | Critical Reviews in Oncology and Hematology2010，，： | 1 |
| 18 | Single machine scheduling problems with fuzzy precedence relation显示文摘 | Hiroaki Ishii Minoru Tada | 1995 | European Journal of Operational Research1995，87，： | 1 |
| 19 | Two scheduling problems with fuzzy due-dates显示文摘 | Hiroaki Ishii Minoru Tada Teruo Masuda | 1992 | Fuzzy Sets and Systems1992，46，： | 1 |
| 20 | Bezafibrate for the treatment of primary sclerosing cholangitis显示文摘 | Suguru Mizuno Kenji Hirano Minoru Tada Keisuke Yamamoto Yoko Yashima Hiroshi Yagioka Kazumichi Kawakubo Yukiko Ito Hirofumi Kogure Takashi Sasaki Toshihiko Arizumi Osamu Togawa Saburo Matsubara Yousuke Nakai Naoki Sasahira Takeshi Tsujino Hiroyuki Isayama | 2010 | Journal of Gastroenterology2010，，7： | 1 |
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