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| 1 | Arterial steroid injection therapy can inhibit the progression of severe acute hepatic failure toward fulminant liver failure显示文摘AIM: To utilize transcatheter arterial steroid injection therapy (TASIT) via the hepatic artery to reduce hepatic macrophage activity in patients with severe acute hepatic failure.METHODS: Thirty-four patients with severe acute hepatic failure were admitted to our hospital between June 2002 to June 2006 providing for the possibility of liver transplantation (LT). Seventeen patients were treated using traditional liver supportive procedures, and the other 17 patients additionally underwent TASIT with 1000 mg methylprednisolone per day for 3 continuous days. RESULTS: Of the 17 patients who received TASIT, 13 were cured without any complications, 2 died, and 2 underwent LT. Of the 17 patients who did not receive TASIT, 4 were self-limiting, 7 died, and 6 underwent LT. Univariate logistic analysis revealed that ascites, serum albumin, prothrombin time, platelet count, and TASIT were significant variables for predicating the prognosis. Multivariate logistic regression analysis using stepwise variable selection showed that prothrombin time, platelet count, and TASIT were independent predictive factors. CONCLUSION: TASIT might effectively prevent the progression of severe acute hepatic failure to a fatal stage of fulminant liver failure. | Kazuhiro Kotoh Munechika Enjoji Makoto Nakamuta Tsuyoshi Yoshimoto Motoyuki Kohjima Shusuke Morizono Shinsaku Yamashita Yuki Horikawa Kengo Yoshimitsu Tsuyoshi Tajima Yoshiki Asayama Kousei Ishigami Masakazu Hirakawa | 2006 | World Journal of Gastroenterology2006，12，41： | 13 |
| 2 | Local recurrence is an important prognostic factor of hepatocellular carcinoma显示文摘AIM: To clarify the importance of complete treatment by PEIT.METHODS: A total of 140 previously untreated cases of HCC were enrolled in this study from 1988 to 2002. The inclusion criteria were: a solitary tumor less than 4 cm in diameter or multiple tumors, fewer than four in number and less than 3 cm in diameter, without extrahepatic metastasis or vessel invasion. As general principles for the treatment of HCC, the patients underwent transcatheter arterial chemoembolization (TACE) prior to PEIT. After the initial treatment of the patients,ultrasonography and computed tomography were performed, and measurement of serum levels of α-fetoprotein (AFP) was determined. When tumor recurrences were detected, PEIT and/or TACE were repeated whenever the hepatic functional reserve of the patient permitted. We then analyzed the variables that could influence prognosis, including tumor size and number, the serum levels of AFP, the parameters of hepatic function (albumin, bilirubin, ALT, hepaplastin test,platelet number, and indocyanine green retention at 15min [ICG-R15]), combined therapy with TACE, distant recurrence, and local recurrence.RESULTS: Univariate analysis identified the ICG test,serum levels of AFP and albumin, tumor size and number,and local recurrence, but not distant recurrence, as significant prognostic variables. In multivariate analysis using those five parameters, the ICG test, tumor size, tumor number,and local recurrence were identified as significant prognostic factors. In both univariate and multivariate analyses, the relative risk for the ICG test was the highest, followed by local recurrence.CONCLUSION: We found that local recurrence is an independent prognostic factor of HCC, indicating that achieving complete treatment for HCC on first treatment is important for improving the prognosis of patients with HCC. | Eiichirou Arimura Kazuhiro Kotoh Makoto Nakamuta Shusuke Morizono Munechika Enjoji Hajime Nawata | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 3 | Scattered and rapid intrahepatic recurrences after radio frequency ablation for hepatocellular carcinoma显示文摘AIM: To evaluate a series of patients with hepatocellular carcinoma (HCC) treated with several different protocols and devices.METHODS: We treated 138 patients [chronic hepatitis/liver cirrhosis (Child-Pugh A/B/C), 3/135 (107/25/3)]with two different devices and protocols: cool-tip needle [initial ablation at 60 W (standard method) (n=37)or at 40 W (modified method) (n = 28)] or; ablation with a LeVeen needle using a standard single-step, full expansion (single-step) method (n = 39) or a multi-step,incremental expansion (multi-step) method.RESULTS: Eleven patients experienced rapid and scattered recurrences 1 to 7 mo after the ablation. Nine patients were treated by the cool-tip original protocol (60 W) (9/37=24%) and the other two by the LeVeen single-step method (2/39=5%). The location of the recurrence was surrounding and limited to the site of ablation segment in three cases, and spread over one lobule or both lobules in the other eight cases. There was no recurrence in the patients treated with the modified cool-tip modified method (40 W) or the LeVeen multi-step method.CONCLUSION: There is a risk of rapid and scattered recurrence after RFA, especially when the standard cooltip procedure is used. Because such recurrence would worsen the prognosis, we recommend that modified protocols for the cool-tip and LeVeen needle methods should be used in clinical practice. | Kazuhiro Kotoh Munechika Enjoji Eiichirou Arimura Shusuke Morizono Motoyuki Kohjima Hironori Sakai Makoto Nakamuta | 2005 | World Journal of Gastroenterology2005，11，43： | 7 |
| 4 | Baseline characterization of patients aged 70 years and above with hepatocellular carcinoma显示文摘AIM: To characterize the baseline profiles of patients aged 70 years and above with hepatocellular carcinoma (HCC).METHODS: A series of 127 consecutive patients with HCC were enrolled between 2000 and 2004, and none of them had been diagnosed as having HCC previously. Baseline profiles, including parameters of hepatic function such as serum transaminase and prothrombin time [PT (% activity)] were compared between patients aged ≥70 and <70 years.RESULTS: Patients ≥70 years old showed significantly lower levels of aspartate aminotransferase (P = 0.04)and alanine aminotransferase (P = 0.01), and significantly higher PTs (P= 0.04) and platelet counts (P = 0.02).Concomitantly, among ≥70-year-old patients, HCC was more common in non-cirrhotics, whereas among patients <70 years old, HCC was more common in cirrhotics. There was no significant difference between the groups in the number or size of tumors.CONCLUSION: Older HCC patients showed less inflammation and better preservation of hepatic function, indicating that not only cirrhotic patients but also noncirrhotic patients should be considered as a high-risk group among the elderly. | Makoto Nakamuta Shusuke Morizono Motoyuki Kohjima Kazuhiro Kotoh Munechika Enjoji | 2005 | World Journal of Gastroenterology2005，11，47： | 6 |
| 5 | Feasibility and safety of laparoscopic and endoscopic cooperative surgery for gastric submucosal tumors, including esophagogastric junction tumors显示文摘 | Shu Hoteya Shusuke Haruta Hisashi Shinohara Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Daisuke Kikuchi Toshifumi Mitani Osamu Ogawa Akira Matsui Toshiro Iizuka Harushi Udagawa Mitsuru Kaise | 2014 | Digestive Endoscopy2014，，4： | 4 |
| 6 | Bronchial bleeding caused by recurrent pneumonia after radical esophagectomy for esophageal cancer显示文摘We herein report a case of bronchial bleeding afterradical esophagectomy that was treated with lobectomy.A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden hemoptysis.After the esophagectomy,bilateral vocal cord paralysis was observed,and the patient suffered from repeated episodes of aspiration pneumonia.Bronchoscopy revealed hemosputum in the right middle lobe bronchus,and contrast-enhanced computed tomography showed tortuous arteries arising from the right inferior phrenic artery and left subclavian artery toward the right middle lobe bronchus.Although bronchial arterial embolization was performed twice to control the recurrent hemoptysis,the procedures were unsuccessful.Right middle lobectomy was therefore performed via video-assisted thoracic surgery.Engorged bronchial arterys with medial hypertrophy and overgrowth of the small branches were noted near the bronchus in the resected specimen.The patient recovered uneventfully and was discharged on postoperative day 14. | Toshihiro Kitajima Kota Momose Seigi Lee Shusuke Haruta Masaki Ueno Hisashi Shinohara Sakashi Fujimori Takeshi Fujii Ryoji Takei Tadasu Kohno Harushi Udagawa | 2015 | World Journal of Gastroenterology2015，21，11： | 3 |
| 7 | Dendritic cell-based vaccination in metastatic melanoma patients: PhaseII clinical trial显示文摘 | Chie Oshita Masako Takikawa Akiko Kume Haruo Miyata Tadashi Ashizawa Akira Iizuka Yoshio Kiyohara Shusuke Yoshikawa Ryuji Tanosaki Naoya Yamazaki Akifumi Yamamoto Kazutoh Takesako Ken Yamaguchi Yasuto Akiyama | 2012 | Oncology Reports2012，，4： | 2 |
| 8 | Nondestructivethree-dimensional measurement of gas temperature distribu-tion by phase tomography显示文摘 | TOMIOKA Satoshi NISHIYAMA Shusuke | 2012 | Proc of SPIE2012，8296，： | 1 |
| 9 | Production of Niobium Powder by Magnesiothermic Reduction of Feed Preform 显示文摘 | Shusuke W | 2003 | I S I J International2003，43，12： | 1 |
| 10 | KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation显示文摘 | Takuya Abe Masamichi Ishiai Yoshifumi Hosono Akari Yoshimura Shusuke Tada Noritaka Adachi Hideki Koyama Minoru Takata Shunichi Takeda Takemi Enomoto Masayuki Seki | 2008 | Cellular Signalling2008，，11： | 1 |
| 11 | Selective Enhancement Filters for Nodules, Vessels, and Airway Walls in Two- and Three- dimensional CT Scans 显示文摘 | Qiang Li Shusuke Sone Kunio Doi | 2003 | Med Phys (S0094-2405)2003，30，1： | 1 |
| 12 | Small solitary pulmonary nodules ( < or = lcm) detected at population-based CT screening for lung can- cer: reliable high-resolution CT features of benign lesions显示文摘 | Shodayu T Shusuke S Feng L Yuichiro M Minom H Tsuyoshi M | 2003 | American Journal of Roentgenol2003，180，4： | 1 |
| 13 | Lung cancers missed at lowdose helical CT screening in a general population:comparison of clinical,histopathologic and imaging findings显示文摘 | LI P SHUSUKE S HIROYUKI A | 2002 | Radiology2002，225，10： | 1 |
| 14 | Primary signet-ringcell carcinoma of the urinary bladder显示文摘 | Shusuke A Akira T Masaaki I | 2010 | Urology2010，75，3： | 1 |
| 15 | Risk factors of hepatocellular carcinoma development in non‐cirrhotic patients with sustained virologic response for chronic hepatitis C virus infection显示文摘 | Hidenori Toyoda Takashi Kumada Toshifumi Tada Seiki Kiriyama Makoto Tanikawa Yasuhiro Hisanaga Akira Kanamori Shusuke Kitabatake Takanori Ito | 2015 | J Gastroenterol Hepatol2015，，7： | 1 |
| 16 | Selective enhancement filters for nodules ,vessels,and airway wails in two- and three-dimensional CT seans显示文摘 | LI Qiang SHUSUKE S KONIO D | 2003 | Med Phys2003，30，8： | 1 |
| 17 | Computer-aided diagnostic scheme for distinction between benign and malignant nodules in thoracic low-dose CT by use of massive training artificial neural network显示文摘 | KENJI S LI Feng SHUSUKE S | 2005 | IEEE Transactions on Medical Imaging2005，24，9： | 1 |
| 18 | Malignant versus Benign Nodules at CT Screening for Lung Cancer:Comparison of Thin-Section CT Findings显示文摘 | Feng Li Shusuke Sone Hiroyuki Abe | 2004 | Radiology2004，233，： | 1 |
| 19 | MR imaging of primary leiomyosarcoma of the thyroid gland显示文摘 | Fumiyoshi Takayama Shodayu Takashima Hideki Matsuba Shinya Kobayashi Nobuo Ito Shusuke Sone | 2001 | European Journal of Radiology2001，，1： | 1 |
| 20 | Cloning of a gene encoding flavin reeducates coupling with dibenzothiophene monooxygenase through coexpression screening using indigo production as selective indication显示文摘 | Shusuke Takahashi Yoshitaka Ishii | 2004 | Biochemical and Biophysical Research Communications2004，313，： | 1 |
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