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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 3 | Recent advances in gel polymer electrolyte for high-performance lithium batteries显示文摘Lithium batteries (LBs) have become increasingly important energy storage systems in our daily life. However, their practical applications are still severely plagued by the safety issues from liquid electrolyte, especially when the batteries are exposed to mechanical, thermal, or electrical abuse conditions. Gel polymer electrolytes (GPEs) are being considered as an effective solution to replace currently available organic liquid electrolyte for building safer LBs. This review provides recent advancements in GPEs applied for high-performance LBs. On the one hand, from the environmental and economic point of view, the skeletons of GPEs changed from traditional polymer to renewable and degradable polymer. On the other hand, in addition to being as a component with good electrochemical and physical characterizations, the GPEs also need to provide some functions for addressing the concerns of lithium (Li) dendrites, unstable cathode electrolyte interface, dissolution and migration of transition metal ions,'shuttle effect' of polysulfides, and so on. Finally, to synchronously meet the challenges from the advanced cathode and Li metal anode, the bio-based GPEs with multi-functionality are proposed to develop high-energy/powerdensity batteries in the future. | Ming Zhu Jiaxin Wu Yue Wang Mingming Song Lei Long Sajid Hussain Siyal Xiaoping Yang Gang Sui | 2019 | Journal of Energy Chemistry2019，28，10： | 17 |
| 4 | Changes in soil properties and erodibility of gully heads induced by vegetation restoration on the Loess Plateau, China显示文摘Soil erosion on the Loess Plateau of China is effectively controlled due to the implementation of several ecological restoration projects that improve soil properties and reduce soil erodibility. However, few studies have examined the effects of vegetation restoration on soil properties and erodibility of gully head in the gully regions of the Loess Plateau. The objectives of this study were to quantify the effects of vegetation restoration on soil properties and erodibility in this region. Specifically, a control site in a slope cropland and 9 sites in 3 restored land-use types(5 sites in grassland, 3 in woodland and 1 in shrubland) in the Nanxiaohegou watershed of a typical gully region on the Loess Plateau were selected, and soil and root samples were collected to assess soil properties and root characteristics. Soil erodibility factor was calculated by the Erosion Productivity Impact Calculator method. Our results revealed that vegetation restoration increased soil sand content, soil saturated hydraulic conductivity, organic matter content and mean weight diameter of water-stable aggregate but decreased soil silt and clay contents and soil disintegration rate. A significant difference in soil erodibility was observed among different vegetation restoration patterns or land-use types. Compared with cropland, soil erodibility decreased in the restored lands by 3.99% to 21.43%. The restoration patterns of Cleistogenes caespitosa K. and Artemisia sacrorum L. in the grassland showed the lowest soil erodibility and can be considered as the optimal vegetation restoration pattern for improving soil anti-erodibility of the gully heads. Additionally, the negative linear change in soil erodibility for grassland with restoration time was faster than those of woodland and shrubland. Soil erodibility was significantly correlated with soil particle size distribution, soil disintegration rate, soil saturated hydraulic conductivity, water-stable aggregate stability, organic matter content and root characteristics(including root average diameter, root length density, root surface density and root biomass density), but it showed no association with soil bulk density and soil total porosity. These findings indicate that although vegetation destruction is a short-term process, returning the soil erodibility of cropland to the level of grassland, woodland and shrubland is a long-term process(8–50 years). | GUO Mingming WANG Wenlong KANG Hongliang YANG Bo | 2018 | Journal of Arid Land2018，10，5： | 14 |
| 5 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 6 | Comprehensive analysis of NAC transcription factors and their expression during fruit spine development in cucumber (Cucumis sativus L.)显示文摘The cucumber(Cucumis sativus L.)is an important vegetable crop worldwide,and fruit trichomes or spines are an important trait for external fruit quality.The mechanisms underlying spine formation are not well understood,but the plant-specific NAC family of transcription factors may play important roles in fruit spine initiation and development.In this study,we conducted a genome-wide survey and identified 91 NAC gene homologs in the cucumber genome.Clustering analysis classified these genes into six subfamilies;each contained a varying number of NAC family members with a similar intron–exon structure and conserved motifs.Quantitative real-time PCR analysis revealed tissue-specific expression patterns of these genes,including 10 and 12 that exhibited preferential expression in the stem and fruit,respectively.Thirteen of the 91 NAC genes showed higher expression in the wild-type plant than in its near-isogenic trichome mutant,suggesting their important roles in fruit spine development.Exogenous application of four plant hormones promoted spine formation and increased spine density on the cucumber fruits;several NAC genes showed differential expression over time in response to phytohormone treatments on cucumber fruit,implying their essential roles in fruit-trichome development.Among the NAC genes identified,12 were found to be targets of 13 known cucumber micro-RNAs.Collectively,these findings provide a useful resource for further analysis of the interactions between NAC genes and genes underlying trichome organogenesis and development during fruit spine development in cucumber. | Xingwang Liu Ting wang Ezra Bartholomew Kezia Black Mingming Dong Yaqi Zhang Sen Yang Yanling Cai Shudan Xue Yiqun Weng Huazhong Ren | 2018 | Horticulture Research2018，5，1： | 10 |
| 7 | A blind quantum signature protocol using the GHZ states显示文摘Recently,some blind quantum signature(BQS) protocols have been proposed.But the previous schemes have security and efficiency problems.Based on the entangled Greenberger-Horne-Zeilinger(GHZ) states,a new weak BQS protocol is proposed.Compared with some existing schemes,our protocol has 100% efficiency.Besides,the protocol is simple and easy to implement.The security of the protocol is guaranteed by the correlation of the GHZ particles held by each participant.In our protocol,the signatory is kept blind from the content of the message.According to the security analysis,the signatory cannot disavowal his/her signature while the signature cannot be forged by others. | WANG MingMing CHEN XiuBo YANG YiXian | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 10 |
| 8 | Evaluation of soil washing process with carboxymethyl-β-cyclodextrin and carboxymethyl chitosan for recovery of PAHs/heavy metals/fluorine from metallurgic plant site显示文摘Polycyclic aromatic hydrocarbons(PAHs)/heavy metals/fluorine(F) mixed-contaminated sites caused by abandoned metallurgic plants are receiving wide attention. To address the associated environmental problems,this study was initiated to investigate the feasibility of using carboxymethyl-β-cyclodextrin(CMCD) and carboxymethyl chitosan(CMC) solution to enhance ex situ soil washing for extracting mixed contaminants. Further,Tenax extraction method was combined with a first-three-compartment model to evaluate the environmental risk of residual PAHs in washed soil. In addition,the redistribution of heavy metals/F after decontamination was also estimated using a sequential extraction procedure. Three successive washing cycles using50 g/L CMCD and 5 g/L CMC solution were effective to remove 94.3% of total PAHs,93.2% of Pb,85.8% of Cd,93.4% of Cr,83.2% of Ni and 97.3% of F simultaneously. After the 3rd washing,the residual PAHs mainly existed as very slowly desorbing fractions,which were in the form of well-aged,well-sequestered compounds; while the remaining Pb,Cd,Cr,Ni and F mainly existed as Fe–Mn oxide and residual fractions,which were always present in stable mineral forms or bound to non-labile soil fractions. Therefore,this combined cleanup strategy proved to be effective and environmentally friendly. | Mao Ye Mingming Sun Fredrick Orori Kengara Jingting Wang Ni Ni Li Wang Yang Song Xinglun Yang Huixin Li Feng Hu Xin Jiang | 2014 | Journal of Environmental Sciences2014，26，8： | 8 |
| 9 | Architecture of PtFe/C catalyst with high activity and durability for oxygen reduction reaction显示文摘PtFe/C 催化剂被列在后面由的受精和高温度的减小综合了酸沥滤。X 光检查衍射, X 光检查光电子光谱学和在边光谱学描述附近原子的 X 光检查揭示那磅 < 潜水艇 class= “ a-plus-plus ” > 3 Fe 合金形成发生在高温度的减小和那不稳定的 Fe 种期间被溶解进酸溶液。在到表面并且强壮的 O-Fe 结合的从核心区域的 Fe 集中的差别可以驾驶 Fe 的外面的散开到高度弄皱的磅骨骼,并且高度结果驱散表面 FeO <潜水艇class=“ a-plus-plus ”> x 在酸的媒介是稳定的,导致磅的构造<潜水艇class=“ a-plus-plus ”> 3 Fe@Pt-FeO <潜水艇class=“ a-plus-plus ”> x 建筑学。是准备了 PtFe/C 催化剂与 Pt/C 催化剂相比为氧减小反应表明一项更高的活动和可比较的耐久性,它可能在 PtFe/C 催化剂由于表面和表面下的 Fe 种类的合作效果。 | Jiayuan Li Guoxiong Wang Jing Wang Shu Miao Mingming Wei Fan Yang Liang Yu Xinhe Bao | 2014 | Nano Research2014，7，10： | 8 |
| 10 | High-performance Zn battery with transition metal ions co-regulated electrolytic MnO_(2)显示文摘Electrolytic MnO_(2)/Zn batteries have attracted extensive attention for use in large-scale energy storage applications due to their low cost,high output voltage,safety,and environmental friendliness.However,the poor electrical conductivity of MnO_(2)limits its deposition and dissolution at large capacities,which leads to sluggish reaction kinetics and drastic capacity decay.Here,we report a theory-guided design principle for an electrolytic MnO_(2)/Zn battery co-regulated with transition metal ions that has improved electrochemical performance in terms of deposition and stripping chemistries.We start with first-principles calculations to predict the electrolytic effects of regulating transition metal ions in the deposition/stripping chemistry of the MnO_(2)cathode.The results indicate that with the simultaneous incorporation of strongly electronegative Co and Ni,the MnO_(2)cathode tends to possess more active electron states,faster charge-transfer kinetics,and better electrical conductivity than either MnO_(2)regulated with Co or Ni on their own,or pristine MnO_(2);hence,this co-regulation is beneficial for the cathode solid/liquid MnO_(2)/Mn2t reactions.We then fabricate and demonstrate a novel Co2t and Ni2t coregulated MnO_(2)/Zn(Co-Ni-MnO_(2)/Zn)battery that yields significantly better electrochemical performance,finding that the synergistic regulation of Co and Ni on MnO_(2)can significantly increase its intrinsic conductivity and achieve high rates and Coulombic efficiencies at large capacities.The aqueous Co-Ni-MnO_(2)/Zn battery exhibits a high rate(10C,100 mA cm^(-2)),high Coulombic efficiency(91.89%),and excellent cycling stability(600 cycles without decay)at a large areal capacity of 10 mAh cm^(-2).Our proposed strategy of co-regulation with transition metal ions offers a versatile approach for improving the electrochemical performance of aqueous electrolytic MnO_(2)/Zn batteries in large-scale energy storage applications. | Mingyan Chuai Jinlong Yang Mingming Wang Yuan Yuan Zaichun Liu Yan Xu Yichen Yin Jifei Sun Xinhua Zheng Na Chen Wei Chen | 2021 | eScience2021，1，2： | 8 |
| 11 | Modeling of delta-wing type vortex generators显示文摘A numerical model of delta-wing type vortex generator was developed in two steps.The first step was to obtain a parameterized model of the shedding vortex based on delta-wing theory,which relates the geometry parameters and flow field parameters to the strength of shedding vortex which directly decides the source term.In the second step,a method was proposed to add source terms into the flow control equations so that the shedding vortex could be simulated numerically.As soon as the numerical model was completed,two cases:One for a plate and another for an airfoil segment were investigated for test.Comparison showed that the flow field structure and aerodynamic performance agreed well with those obtained from cases with real vortex generators. | ZHANG Lei YANG Ke XU JianZhong ZHANG MingMing | 2011 | Science China(Technological Sciences)2011，54，2： | 8 |
| 12 | Friction and wear behaviors of MoS2-multi-walled-carbonnanotube hybrid reinforced polyurethane composite coating显示文摘MoS2-multi-walled-carbon-nanotube(MWCNT)hybrids containing two-dimensional MoS2 and one-dimensional MWCNTs were synthesized through a one-step hydrothermal reaction.X-ray-diffraction and transmission-electron-microscopy results demonstrated that MoS2 nanosheets were successfully synthesized,and uniformly anchored on the MWCNTs’surfaces.Furthermore,the effects of the Mo S2-MWCNT hybrids on the tribological performances of polyurethane composite coatings were investigated using a UMT-2MT tribo-tester.Friction and wear test results revealed that the friction coefficient and wear rate of a 3 wt%Mo S2-MWCNT-1 filled polyurethane composite coating were reduced by 25.6% and 65.5%,respectively.The outstanding tribological performance of the MoS2-MWCNT-1 reinforced polyurethane composite coating was attributed to the excellent load-carrying capacity of the MWCNTs and good lubricant ability of MoS2.The surface morphologies of the worn surfaces and counterpart ball surfaces were investigated to reveal the wear mechanisms. | Zhaozhu ZHANG Mingming YANG Junya YUAN Fang GUO Xuehu MEN | 2019 | Friction2019，7，4： | 7 |
| 13 | Sheep manure application increases soil exchangeable base cations in a semi-arid steppe of Inner Mongolia显示文摘The long-term productivity of a soil is greatly influenced by cation exchange capacity(CEC).Moreover,interactions between dominant base cations and other nutrients are important for the health and stability of grassland ecosystems.Soil exchangeable base cations and cation ratios were examined in a 11-year experiment with sheep manure application rates 0–1,500 g/(m2?a) in a semi-arid steppe in Inner Mongolia of China,aiming to clarify the relationships of base cations with soil p H,buffer capacity and fertility.Results showed that CEC and contents of exchangeable calcium(Ca2+),magnesium(Mg2+),potassium(K+) and sodium(Na+) were significantly increased,and Ca2+ saturation tended to decrease,while K+ saturation tended to increase with the increases of sheep manure application rates.The Ca2+/Mg2+ and Ca2+/K+ ratios decreased,while Mg2+,K+ and Na+ saturations increased with increasing manure application rates.Both base cations and CEC were significantly and positively correlated with soil organic carbon(SOC) and soil p H.The increases of SOC and soil p H would be the dominant factors that contribute to the increase of cations in soil.On a comparison with the initial soil p H before the experiment,we deduced that sheep manure application could partly buffer soil p H decrease potentially induced by atmospheric deposition of nitrogen and sulfur.Our results indicate that sheep manure application is beneficial to the maintenance of base cations and the buffering of soil acidification,and therefore can improve soil fertility in the semi-arid steppes of northeastern China. | YuGe ZHANG Shan YANG MingMing FU JiangPing CAI YongYong ZHANG RuZhen WANG ZhuWen XU YongFei BAI Yong JIANG | 2015 | Journal of Arid Land2015，7，3： | 7 |
| 14 | Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells(MSCs)显示文摘Cartilage injuries caused by arthritis or trauma pose formidable challenges for effective clinical management due to the limited intrinsic proliferative capability of chondrocytes.Autologous stem cell-based therapies and transgene-enhanced cartilage tissue engineering may open new avenues for the treatment of cartilage injuries.Bone morphogenetic protein 2(BMP2)induces effective chondrogenesis of mesenchymal stem cells(MSCs)and can thus be explored as a potential therapeutic agent for cartilage defect repair.However,BMP2 also induces robust endochondral ossification.Although the precise mechanisms through which BMP2 governs the divergence of chondrogenesis and osteogenesis remain to be fully understood,blocking endochondral ossification during BMP2-induced cartilage formation may have practical significance for cartilage tissue engineering.Here,we investigate the role of Sox9-donwregulated Smad7 in BMP2-induced chondrogenic differentiation of MSCs.We find that overexpression of Sox9 leads to a decrease in BMP2-induced Smad7 expression in MSCs.Sox9 inhibits BMP2-induced expression of osteopontin while enhancing the expression of chondrogenic marker Col2a1 in MSCs.Forced expression of Sox9 in MSCs promotes BMP2-induced chondrogenesis and suppresses BMP2-induced endochondral ossification.Constitutive Smad7 expression inhibits BMP2-induced chondrogenesis in stem cell implantation assay.Mouse limb explant assay reveals that Sox9 expands BMP2-stimulated chondrocyte proliferating zone while Smad7 promotes BMP2-intitated hypertrophic zone of the growth plate.Cell cycle analysis indicates that Smad7 induces significant early apoptosis in BMP2-stimulated MSCs.Taken together,our results strongly suggest that Sox9 may facilitate BMP2-induced chondrogenesis by downregulating Smad7,which can be exploited for effective cartilage tissue engineering. | Chen Zhao Wei Jiang Nian Zhou Junyi Liao Mingming Yang Ning Hu Xi Liang Wei Xu Hong Chen Wei Liu Lewis L.Shi Leonardo Oliveira Jennifer Moriatis Wolf Sherwin Ho Aravind Athiviraham H.M.Tsai Tong-Chuan He Wei Huang | 2017 | Genes & Diseases2017，4，4： | 7 |
| 15 | In situ reduction and functionalization of graphene oxide to improve the tribological behavior of a phenol formaldehyde composite coating显示文摘The development of a phenol formaldehyde/graphene(PF-graphene)composite coating with high performance is desirable but remains a challenge,because of the ultrahigh surface area and surface inertia of the graphene.Herein,we synthesized PF-graphene composites by the in situ polymerization of phenol and formaldehyde with the addition of graphene oxide,resulting in improved compatibility between the graphene and phenolic resin(PF)matrix and endowing the phenolic resin with good thermal stability and excellent tribological properties.Fourier-transform infrared(FTIR)spectra and X-ray diffraction(XRD)patterns demonstrated that the graphene oxide was reduced during the in-situ polymerization.The PF-graphene composites were sprayed onto steel blocks to form composite coatings.The effects of an applied load and of the sliding speed on the tribological properties of the PF-graphene composite coating were evaluated using a block-on-ring wear tester;in addition,the worn surface and the transfer film formed on the surface of the counterpart ring were studied by scanning electron microscopy(SEM).The results show that the PF-graphene composite coating exhibited enhanced tribological properties under all tested conditions. | Mingming YANG Zhaozhu ZHANG Xiaotao ZHU Xuehu MEN Guina REN | 2015 | Friction2015，3，1： | 6 |
| 16 | Characteristics of Late-Quaternary Activity and Seismic Risk of the Northeastern Section of the Longmenshan Fault Zone显示文摘Following the 2008 Wenchuan M8 earthquake,the seismic risk of the northeastern section of the Longmenshan fault zone and the adjacent Hanzhong basin has become an issue that receives much concern.It is facing,however,the problem of a lack of sufficient data because of little previous work in these regions.The northeastern section of the Longmenshan fault zone includes three major faults:the Qingchuan fault,Chaba-Lin’ansi fault,and Liangshan south margin fault,with the Hanzhong basin at the northern end.This paper presents investigations of the geometry,motion nature,and activity ages of these three faults,and reveals that they are strike slip with normal faulting,with latest activity in the Late Pleistocene.It implies that this section of the Longmenshan fault zone has been in an extensional setting,probably associated with the influence of the Hanzhong basin.Through analysis of the tectonic relationship between the Longmenshan fault zone and the Hanzhong basin,this work verifies that the Qingchuan fault played an important role in the evolution of the Hanzhong basin,and further studies the evolution model of this basin.Finally,with consideration of the tectonic setting of the Longmenshan fault zone and the Hanzhong basin as well as seismicity of surrounding areas,this work suggests that this region has no tectonic conditions for great earthquakes and only potential strong events in the future. | WANG Mingming ZHOU Bengang YANG Xiaoping XIE Chao GAO Xianglin | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 6 |
| 17 | Recombinant rabies virus expressing IL-15 enhances immunogenicity through promoting the activation of dendritic cells in mice显示文摘Rabies remains a public health threat that kills approximately 59,000 people worldwide each year,most of which are from the developing countries of Africa and Asia where dog rabies are endemic.Therefore, developing an affordable and efficacious vaccine is crucial for rabies control in these countries. Interleukin(IL)-15, an immunoregulatory cytokine, is a pluripotent molecule with therapeutic potential, which targets many cell types and links the innate and adaptive immune system. In this study, IL-15 gene was cloned and inserted into the genome of a recombinant rabies virus(RABV) strain LBNSE(designated as LBNSE-IL15), and the effect of over-expression of IL-15 on the immunogenicity of RABV was investigated. It was found that mice vaccinated with LBNSEIL15 could induce significantly higher level of virus-neutralizing antibody(VNA) than those immunized with LBNSE, resulting in the higher protection after challenge. Further investigation was performed to find out the possible role of IL-15 plays in the process of antibody induction, and it was found that LBNSE-IL15 could enhance the maturation of dendritic cells(DCs) in immunized mice. Furthermore, the mice immunized with LBNSE-IL15 could promote the T_(FH) cells differentiation and the generation of germinal center B cells and plasma cells. Together, these data indicated that IL-15 could be a potential adjuvant in enhancing the immunogenicity of RABV, contributing to the development of more-efficacious rabies vaccines. | Tiange Chen Yajing Zhang Zhao Wang Jie Yang Mingming Li Kunlun Wang Min Cui Zhen F.Fu Ling Zhao Ming Zhou | 2017 | Virologica Sinica2017，32，4： | 5 |
| 18 | Lactobacillus reuteri-derived extracellular vesicles maintain intestinal immune homeostasis against lipopolysaccharideinduced inflammatory responses in broilers显示文摘Background:Lactobacillus reuteri strains are widely used as probiotics to prevent and treat inflammatory bowel disease by modulating the host’s immune system.However,the underlying mechanisms by which they communicate with the host have not been clearly understood.Bacterial extracellular vesicles(EVs)have been considered as important mediators of host-pathogen interactions,but their potential role in commensals-host crosstalk has not been widely studied.Here,we investigated the regulatory actions of EVs produced by L.reuteri BBC3,a gut-associated commensal bacterium of Black-Bone chicken,in the development of lipopolysaccharide(LPS)-induced intestinal inflammation in a chicken model using both in vivo and in vitro experiments.Results:L.reuteri BBC3 produced nano-scale membrane vesicles with the size range of 60-250 nm.Biochemical and proteomic analyses showed that L.reuteri BBC3-derived EVs(LrEVs)carried DNA,RNA and several bioactive proteins previously described as mediators of other probiotics’beneficial effects such as glucosyltransferase,serine protease and elongation factor Tu.In vivo broiler experiments showed that administration of LrEVs exerted similar effects as L.reuteri BBC3 in attenuating LPS-induced inflammation by improving growth performance,reducing mortality and decreasing intestinal injury.LrEVs suppressed the LPS-induced expression of pro-inflammatory genes(TNF-α,IL-1β,IL-6,IL-17 and IL-8),and improved the expression of anti-inflammatory genes(IL-10 and TGF-β)in the jejunum.LrEVs could be internalized by chicken macrophages.In vitro pretreatment with LrEVs reduced the gene expression of TNF-α,IL-1βand IL-6 by suppressing the NF-κB activity,and enhanced the gene expression of IL-10 and TGF-βin LPS-activated chicken macrophages.Additionally,LrEVs could inhibit Th1-and Th17-mediated inflammatory responses and enhance the immunoregulatory cells-mediated immunosuppression in splenic lymphocytes of LPS-challenged chickens through the activation of macrophages.Finally,we revealed that the reduced content of both vesicular proteins and nucleic acids attenuated the suppression of LrEVs on LPS-induced inflammatory responses in ex vivo experiments,suggesting that they are essential for the LrEVs-mediated immunoregulation.Conclusions:We revealed that LrEVs participated in maintaining intestinal immune homeostasis against LPSinduced inflammatory responses in a chicken model.Our findings provide mechanistic insight into how commensal and probiotic Lactobacillus species modulate the host’s immune system in pathogens-induced inflammation. | Rujiu Hu Hua Lin Mimi Wang Yuezhen Zhao Haojing Liu Yuna Min Xiaojun Yang Yupeng Gao Mingming Yang | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 5 |
| 19 | Pravastatin alleviates lipopolysaccharide-induced placental TLR4 over-activation and promotes uterine arteriole remodeling without impairing rat fetal development显示文摘Preeclampsia is associated with over-activation of the innate immune system in the placenta,in which toll-like receptor 4(TLR4) plays an essential part.With their potent anti-inflammatory effects,statins have been suggested as potential prevention or treatment of preeclampsia,although evidence remains inadequate.Herewith,we investigated whether pravastatin could ameliorate preeclampsia-like phenotypes in a previously established lipopolysaccharide(LPS)-induced rat preeclampsia model,through targeting the TLR4/NF-κB pathway.The results showed that pravastatin reduced the blood pressure [maximum decline on gestational day(GD) 12,(101.33±2.49) mmHg vs.(118.3±1.37) mmHg,P<0.05] and urine protein level [maximum decline on GD9,(3,726.23± 1,572.86) μg vs.(1,991.03 ±609.37)μg,P< 0.05],which were elevated following LPS administration.Pravastatin also significantly reduced the rate of fetal growth restriction in LPS-treated rats(34.10% vs.8.99%,P<0.05).Further pathological analyses suggested a restoration of normal spiral artery remodeling in preeclampsia rats by pravastatin treatment.These effects of pravastatin were associated with decreased TLR4/NF-κB protein levels in the placenta and IL-6/MCP-1 levels in serum.Additionally,no obvious abnormalities in fetal liver,brain,and kidney were found after administration of pravastatin.These results provide supportive evidence for use of pravastatin in preventing preeclampsia. | Muyi Yang Zhenyu Diao Zhiyin Wang Guijun Yan Guangfeng Zhao Mingming Zheng Anyi Dai Yimin Dai Yali Hu | 2018 | The Journal of Biomedical Research2018，32，4： | 5 |
| 20 | Controlled Cyclic Remote State Preparation of Arbitrary Qubit States显示文摘Quantum secure communications could securely transmit quantum information by using quantum resource.Recently,novel applications such as bidirectional and asymmetric quantum protocols have been developed.In this paper,we propose a new method for generating entanglement which is highly useful for multiparty quantum communications such as teleportation and Remote State Preparation(RSP).As one of its applications,we propose a new type of quantum secure communications,i.e.cyclic RSP protocols.Starting from a four-party controlled cyclic RSP protocol of one-qubit states,we show that this cyclic protocol can be generalized to a multiparty controlled cyclic RSP protocol for preparation of arbitrary qubit states.We point out that previous bidirectional and asymmetric protocols can be regarded as a simpler form of our cyclic RSP protocols. | Mingming Wang Chen Yang Reza Mousoli | 2018 | Computers, Materials & Continua2018，，5： | 4 |
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