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| 1 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 2 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 3 | The use of ultrasound for enzymatic preparation of ACE-inhibitory peptides from wheat germ protein显示文摘 | JIA Junqiang MA Haile ZHAO Weirui | 2010 | Food Chemistry2010，119，： | 1 |
| 4 | ACE-inhibitory peptides produetion from defatted wheat germ protein by continuous coupling of enzymatic hydrolysis and membrane separation:Modeling and ex- perimental studies显示文摘 | Wenjuan Qu Haile Ma Weirui Zhao | 2013 | Chemieal Engineering Journal2013，226，： | 1 |
| 5 | The use of ultrasound for enzymatic preparation of ACE-inhibitory peptides from wheat germprotein显示文摘 | Jia Junqiang Ma Haile Zhao Weirui | 2010 | Food Chemistry2010，119，： | 1 |
| 6 | The use of ultrasound for enzymatic preparation of ACE-inhibitory peptides from wheat germ protein显示文摘 | Junqiang Jia Haile Ma Weirui Zhao Zhenbin Wang Wanmin Tian Lin Luo Ronghai He | 2009 | Food Chemistry2009，，1： | 1 |
| 7 | ACE - inhibitory pep- tides production from defatted wheat germ protein by continu- ous coupling of enzymatic hydrolysis and membrane separa- tion : Modeling and experimental studies 显示文摘 | Qu Wenjuan Ma Haile Weirui Zhao | 2013 | Chemical Engi- neering Journal2013，，116： | 1 |
| 8 | The use of ultrasound for enzymatic preparation of ACE - inhibitory peptides from wheat germ protein 显示文摘 | Junqiang Jia Haile Ma Weirui Zhao | 2010 | Food Chemistry2010，119，1： | 1 |
| 9 | The use of ultrasound for enzymatic preparation of ACE-inhibitory peptides from wheat germ protein 显示文摘 | JIA Junqiang MA Haile ZHAO Weirui | 2010 | Food Chem2010，119，1： | 1 |
| 10 | The use of ultrasound for enzymatic preparation of ACE inhibitory peptides from wheat germ protein显示文摘 | JIA Junqiang MA Haile ZHAO Weirui | 2010 | Food Chemistry2010，119，1： | 1 |
| 11 | The use of ultrasound for enzymatic preparation of ACE-inhibitory peptides from wheat germ protein显示文摘 | Junqiang Jia Haile Ma Weirui Zhao | 2010 | Food Chemistry2010，119，1： | 1 |
| 12 | The use of ultrasound for enzymatic preparation of ACE inhibitory peptides from wheat germ protein显示文摘 | JIA Junqiang MA Haile ZHAO Weirui | | 0，，01： | 1 |
| 13 | The use of ultrasound for enzymatic preparation of ACE-inhibitory peptides from wheat germ protein显示文摘 | Junqiang Jia Haile Ma Weirui Zhao | 2010 | Food Chemistry2010，，119： | 1 |
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