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| 1 | Metabolomic Screening Applied to Rice FOX Arabidopsis Lines Leads to the Identification of a Gene-Changing Nitrogen Metabolism显示文摘植物 metabolomics 作为一个强大的工具发展了检验基因功能并且获得更深的卓见进植物房间的生理学。在这研究,我们屏蔽了 Arabidopsis 线 overexpressing 米饭全身(FL ) 用煤气的 chromatographytime-of-flight 团 spectrometry (GCTOF/MS ) 的 cDNAs (米饭狐狸 Arabidopsis 线) 基于技术识别引起了新陈代谢的变化的米饭基因。这个屏蔽系统允许显示出改变的代谢物侧面的候选人线的快、可靠的鉴定。我们执行了怀有 Arabidopsis 的侧面的机关边界(高球) 领域(LBD )/Asymmetric 象 Leaves2 一样(ASL ) 基因的米饭 ortholog 的 FL cDNA 的一根米饭狐狸 Arabidopsis 线的 metabolomic 和 transcriptomic 分析, At-LBD37/ASL39。调查米饭狐狸 Arabidopsis 线在与氮新陈代谢有关的代谢物的层次显示出突出的变化。象从 Arabidopsis At-LBD37/ASL39-overexpressor 植物的代谢物分析的结果一样的 transcriptomic 数据与这些调查结果一致。而且, Os-LBD37/ASL39-overexpressing 米饭植物的 metabolomic 和 transcriptomic 分析显示 Os-LBD37/ASL39 在米饭与与氮新陈代谢有关的过程被联系。因此,一个基于 metabolomics 的屏蔽方法的联合和一条 gain-of-function 途径为在 Arabidopsis 和米饭的新奇基因的快速的描述是有用的。 | Doris Albinsky Miyako Kusano Mieko Higuchi Naomi Hayashi Makoto Kobayashi Atsushi Fukushima Masaki Mori Takanari Ichikawa Keiko Matsui Hirofumi Kuroda Yoko Horii Yuko Tsumoto Hitoshi Sakakibara Hirohiko Hirochika Minami Matsui Kazuki Saito | 2010 | Molecular Plant2010，3，1： | 15 |
| 2 | Screening for hilar biliary invasion in ampullary cancer patients显示文摘BACKGROUND The treatment for ampullary cancer is pancreatoduodenectomy or local ampullectomy.However,effective methods for the preoperative investigation of hilar biliary invasion in ampullary cancer patients have not yet been identified.AIM To determine the necessity of and an appropriate method for investigating hilar biliary invasion of ampullary cancer.METHODS Among 43 ampullary cancer patients,34 underwent endoscopic treatment(n=9)or surgery(n=25).The use of imaging findings(thickening and enhancement of the bile duct wall on contrast-enhanced computed tomography,irregularity on endoscopic retrograde cholangiography,thickening of the entire bile duct wall on intraductal ultrasonography(IDUS),and partial thickening of the bile duct wall on IDUS)and biliary biopsy results for diagnosing hilar biliary invasion of ampullary cancer was compared.RESULTS Hilar invasion was not observed in every patient.Among the patients who did not undergo biliary stent insertion,the combination of partial thickening of the bile duct wall on IDUS and biliary biopsy results showed the highest accuracy(100%)for diagnosing hilar biliary invasion.However,each imaging method and biliary biopsy yielded some false-positive results.CONCLUSION Although some false-positive results were obtained with each method,the combination of partial thickening of the bile duct wall on IDUS and biliary biopsy results was useful for diagnosing hilar biliary invasion of ampullary cancer.However,hilar invasion of ampullary cancer is rare;therefore,the investigation of hilar biliary invasion of ampullary cancer might be unnecessary. | Tadayuki Takagi Mitsuru Sugimoto Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Jun Nakamura Mika Takasumi Minami Hashimoto Tsunetaka Kato Ryoichiro Kobashi Takumi Yanagita Yuko Hashimoto Shigeru Marubashi Takuto Hikichi Hiromasa Ohira | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，9： | 2 |
| 3 | Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart显示文摘 | Hideyuki Kinoshita Koichiro Kuwahara Motohiro Nishida Zhong Jian Xianglu Rong Shigeki Kiyonaka Yoshihiro Kuwabara Hitoshi Kurose Ryuji Inoue Yasuo Mori Yuhao Li Yasuaki Nakagawa Satoru Usami Masataka Fujiwara Yuko Yamada Takeya Minami Kenji Ueshima Kazuwa | 2010 | Circulation Research2010，，12： | 2 |
| 4 | ECT 2 amplification and overexpression as a new prognostic biomarker for early‐stage lung adenocarcinoma显示文摘 | Yoshihiko Murata Yuko Minami Reika Iwakawa Jun Yokota Shingo Usui Koji Tsuta Kouya Shiraishi Shingo Sakashita Kaishi Satomi Tatsuo Iijima Masayuki Noguchi | 2014 | Cancer Sci2014，，： | 1 |
| 5 | Benefits of surgery for patients with pulmonary metastases from colorectal carcinoma显示文摘 | Masayoshi Inoue Mitsunori Ohta Keiji Iuchi Akihide Matsumura Kan Ideguchi Tsutomu Yasumitsu Katsuhiro Nakagawa Kenjiro Fukuhara Hajime Maeda Shin-ichi Takeda Masato Minami Yuko Ohno Hikaru Matsuda | 2004 | The Annals of Thoracic Surgery2004，，1： | 1 |
| 6 | The in-crease of female breast Cancer incidence in Japan:emergence ofbirth cohort effect显示文摘 | Minami Yuko Tsubono Yoshitaka Nishino Yoshikazu | 2004 | Int J Cancer2004，108，6： | 1 |
| 7 | Gene deletions in Japanese patients with Duchenne and Becker muscular dystrophy显示文摘 | Jun-ichi Asano Shunji Tomatsu Kazuko Sukegawa Seiji Yamaguchi Yuko Ikedo Ryoji Minami Mitsuo Iida Masaaki Nishimura Masanori Nakagawa Morio Ohshiro Tadao Orii | 1990 | The Japanese Journal of Human Genetics1990，，2： | 1 |
| 8 | Peroral endoscopic myotomy for esophageal achalasia: C linical impact of 28 cases显示文摘 | Hitomi Minami Hajime Isomoto Naoyuki Yamaguchi Kayoko Matsushima Yuko Akazawa Ken Ohnita Fuminao Takeshima Haruhiro Inoue Kazuhiko Nakao | 2014 | Digestive Endoscopy2014，，1： | 1 |
| 9 | Preparation of microcapsules containing a curing agent for epoxy resin by polyaddition reaction with the self - assembly of phase - separated polymer method in aqueous dispeed system显示文摘 | HIDETO MINAMI HIROYUKI KANAMORI YUKO HATA | 2008 | Langmuir2008，24，： | 1 |
| 10 | Hepatocyte Growth Factor Expression in EGFR Mutant Lung Cancer with Intrinsic and Acquired Resistance to Tyrosine Kinase Inhibitors in a Japanese Cohort显示文摘 | Seiji Yano Tadaaki Yamada Shinji Takeuchi Keisei Tachibana Yuko Minami Yasushi Yatabe Tetsuya Mitsudomi Hidenori Tanaka Tatsuo Kimura Shinzoh Kudoh Hiroshi Nokihara Yuichiro Ohe Jun Yokota Hidetaka Uramoto Kosei Yasumoto Katsuyuki Kiura Masahiko Higashiya | 2011 | Journal of Thoracic Oncology2011，，12： | 1 |
| 11 | Benefits of surgery for patients with pulmonary metastases from colorectal carcinoma显示文摘 | Masayoshi Inoue Mitsunori Ohta Keiji Iuchi Akihide Matsumura Kan Ideguchi Tsutomu Yasumitsu Katsuhiro Nakagawa Kenjiro Fukuhara Hajime Maeda Shin-ichi Takeda Masato Minami Yuko Ohno Hikaru Matsuda | 2004 | The Annals of Thoracic Surgery2004，，1： | 1 |
| 12 | SD3, an Arabidopsis thaliana Homolog of TIM21, Affects Intracellular ATP Levels and Seedling Development显示文摘植物怎么由房间分割,延伸,和区别控制他们的生长,糟糕被理解。我们描绘了幼苗致命的变异的分离失真 3 (sd3 ) 那出现了一当在光成长并且在黑暗中,与减少的 ploidy 层次有短胚轴时,很使显型相形见绌。SD3 的相应基因在内部 mitochondrial 膜上与高类似编码蛋白质到酵母 translocase 21 (TIM21 ) ,它是 TIM23 建筑群的一个部件。确实, SD3 蛋白质熔化了到在线粒体局部性的 GFP。SD3 overexpression 在黑暗中在光和胚轴厚度增加了子叶尺寸。为呼吸链的建筑群 III 和 IV 的几个子单元的基因的表示在 SD3-overexpressing 植物是起来调整的。而且,而 sd3 的那些是低的,这些植物显示出 ATP 的高水平。这些结果建议 SD3 由提起呼吸链的子单元基因的表示在房间尺寸导致了增加并且因此增加了细胞内部的 ATP 层次。我们建议线粒体控制调整的细胞内部的 ATP 层次种机关尺寸。 | Hidefumi Hamasaki Takeshi Yoshizumi Naoki Takahashi Mieko Higuchi Takashi Kuromori Yuko Imura Hiroaki Shimada Minami Matsui | 2012 | Molecular Plant2012，5，2： | 0 |
| 13 | Characteristics and outcomes of avoidant/restrictive food intake disorder in Japanese elementary-school students on total parenteral nutrition显示文摘The clinical outcomes of adolescents with avoidant/restrictive food intake disorder(ARFID)remain unclear.Furthermore,no report has compared the characteristics of ARFID and restricting-type anorexia nervosa(R-AN)in elementary-school students on total parenteral nutrition(TPN).This study retrospectively reviewed inpatients diagnosed with ARFID or R-AN between 2005 and 2019.Patients with ARFID(two boys and seven girls)and R-AN(13 girls)were hospitalized because of rapid physical deterioration,and nutrition therapy was continued without withdrawal.The ARFID group exhibited significantly lower body weights at admission than the R-AN group and gained an average of 6.5 kg during hospitalization;furthermore,the monthly weight gain during hospitalization was significantly higher,and no relapse was observed.Early physical improvement in ARFID resulted in good recovery.In conclusion,TPN can be easily introduced to patients with ARFID,in whom aversive eating is a concern,and is a suitable treatment for ARFID. | Akira Tamura Koichi Minami Yuko Tsuda Hiroshi Tsujimoto Takayuki Ichikawa Kazuhiro Mizumoto Hiroyuki Suzuki | 2021 | Pediatric Investigation2021，5，4： | 0 |
| 14 | Push vs pull method for endoscopic ultrasound-guided fine needle aspiration of pancreatic head lesions: Propensity score matching analysis显示文摘AIM To evaluate the efficacy of endoscopic ultrasoundguided fine needle aspiration(EUS-FNA) of pancreatic head cancer when pushing(push method) or pulling the echoendoscope(pull method).METHODS Overall, 566 pancreatic cancer patients had their first EUS-FNA between February 2001 and December 2017. Among them, 201 who underwent EUS-FNA for pancreatic head lesions were included in this study. EUS-FNA was performed by the push method in 85 patients, the pull method in 101 patients and both the push and pull methods in 15 patients. After propensity score matching(age, sex, tumor diameter, and FNA needle), 85 patients each were stratified into the push and pull groups. Patient characteristics and EUSFNA-related factors were compared between the two groups.RESULTS Patient characteristics were not significantly different between the two groups. The distance to lesion was significantly longer in the push group than in the pull group(13.9 ± 4.9 mm vs 7.0 ± 4.9 mm, P < 0.01). The push method was a significant factor influencing the distance to lesion(≥ median 10 mm)(P < 0.01). Additionally, tumor diameter ≥ 25 mm(OR = 1.91, 95%CI: 1.02-3.58, P = 0.043) and the push method(OR = 1.91, 95%CI: 1.03-3.55, P = 0.04) were significant factors contributing to the histological diagnosis of malignancy.CONCLUSION The pull method shortened the distance between the endoscope and the lesion and facilitated EUS-FNA of pancreatic head cancer. The push method contributed to the histological diagnosis of pancreatic head cancer using EUS-FNA specimens. | Mitsuru Sugimoto Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Minami Hashimoto Yuko Hashimoto Takuto Hikichi Hiromasa Ohira | 2018 | World Journal of Gastroenterology2018，24，27： | 0 |
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