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| 1 | Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues显示文摘Reactive oxygen species (ROS) are produced under oxidative stress, such as high oxygen concentration and during the metabolic consumption of oxygen molecules. Male reproductive tissues appear to be continuously exposed to ROS produced by active metabolism. In addition, spermatozoa must pass through a high oxygen environ-ment during the mating process. Thus, to maintain viable reproductive ability, a protective mechanism against oxida-tive stress is of importance. Here, we overview our current understanding of the cooperative function of antioxidative and redox systems that are involved in male fertility. Superoxide dismutase and glutathione peroxidase are major enzymes that scavenge harmful ROS in male reproductive organs. In turn, glutathione and thioredoxin systems constitute the main redox systems that repair oxidized and damaged molecules and also play a role in regulating a variety of cellular functions. While glutathione functions as an antioxidant by donating electrons to glutathione peroxidase and thioredoxin donates electrons to peroxiredoxin as a counterpart of glutathione peroxidase. In addition,aldo-keto reductases, which detoxify carbonyl compounds produced by oxidative stress, are present at high levels in the epithelia of the genital tract and Sertoli cells of the testis. Since these systems are involved in cross-talk, a comprehensive understanding will be required to maintain the physiological functions of male reproductive system.( Asian J Andro12003 Sep; 5: 231-242) | Junichi Fujii Yoshihito Iuchi Shingo Matsuki Tatsuya Ishii | 2003 | Asian Journal of Andrology2003，5，3： | 19 |
| 2 | Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus显示文摘The kidneys and the blood system mutually exert influence in maintaining homeostasis in the body. Because the kidneys control erythropoiesis by producing erythropoietin and by supporting hematopoiesis, anemia is associated with kidney diseases. Anemia is the most prevalent genetic disorder, and it is caused by a deficiency of glucose 6-phosphate dehydrogenase(G6PD), for which sulfhydryl oxidation due to an insufficient supply of NADPH is a likely direct cause. Elevated reactive oxygen species(ROS) result in the sulfhydryl oxidation and hence are another potential cause for anemia. ROS are elevated in red blood cells(RBCs) under superoxide dismutase(SOD1) deficiency in C57BL/6 mice. SOD1 deficient mice exhibit characteristics similar to autoimmune hemolytic anemia(AIHA) and systemic lupus erythematosus(SLE) at the gerontic stage. An examination of AIHA-prone New Zealand Black(NZB) mice, which have normal SOD1 and G6 PD genes, indicated that ROS levels in RBCs are originally high and further elevated during aging. Transgenic overexpression of human SOD1 in erythroid cells effectively suppresses ROS elevation and ameliorates AIHA symptoms such as elevated anti-RBC antibodies and premature death in NZB mice. These results support the hypothesis that names oxidative stress as a risk factor for AIHA and other autoimmune diseases such as SLE. Herein we discuss the association between oxidative stress and SLE pathogenesis based mainly on the genetic and phenotypic characteristics of NZB and New Zealand white mice and provide insight into the mechanism of SLE pathogenesis. | Junichi Fujii Toshihiro Kurahashi Tasuku Konno Takujiro Homma Yoshihito Iuchi | 2015 | World Journal of Nephrology2015，4，2： | 7 |
| 3 | 左心房结构和功能改变可早期预测无症状高血压患者左心室功能不全显示文摘该研究旨在探索无症状高血压患者左心房结构和功能改变与左心室功能不全之间的关系。入选左心室射血分数(1eft ventricular ejection fraction,LVEF)≥60%的无症状高血压患者126例。应用常规脉冲组织多普勒及二维斑点追踪超声心动图(two-dimensional speckle—tracking echocardiography,2DSTE)检测和分析左心房结构与功能改变的独立影响因素。 | Miyoshi H Oishi Y Mizuguchi Y Iuchi A Nagase N Ara N Oki T 刘莉 叶鹏 | 2013 | 中华高血压杂志2013，21，5： | 2 |
| 4 | Solitary squamous papilloma of the bronchus associated with human papilloma virus type ll显示文摘 | Kawaguchi T Matumura A Iuchi K | 1999 | Int Med1999，38，： | 1 |
| 5 | 17 beta-estrodial degradation by TiO2 photocatalysis as means of reducing estrogenic activity显示文摘 | OHKO Y IUCHI K I NIWA C | 2002 | Environmental Science and Technology2002，36，19： | 1 |
| 6 | Purification and partial characterization of high choriolytic enzyme ( HCE), a component of the hatching enzyme of the teleost, Oryzias latipes 显示文摘 | Yasumasu S Iuchi I Yamagami K | 1989 | J Biochem1989，105，2： | 1 |
| 7 | MRI prediction of fibrous pituitary adenomas 显示文摘 | Iuchi T Saeki N Tanaka M | 1998 | Acta Neurochir (wien)1998，140，8： | 1 |
| 8 | Proliferation vascular endothelial growth factor expression and cavernous sinus invasionin growth hormone secreting pituitary adenomas显示文摘 | Saeki N Osato K Yamaura A | 2000 | Acta Neurochir(Wien)2000，142，12： | 1 |
| 9 | Virtual sonographic radiofrequency ablation of hepatocellular carcinoma visualized on CT but not on conventional sonography显示文摘 | Hirooka M Iuchi H Kumagi T | 2006 | AJR2006，186，5： | 1 |
| 10 | Three classes of C2H2 zinc finger proteins显示文摘 | Iuchi S | 2001 | Cell Mol Life Sci2001，58，4： | 1 |
| 11 | Regulation of drought tolerance by gene manipulation of 9-cis epoxycarotenoid dioxygen- ase, a key enzyme in abscisic acid biosynthesis in Arabidopsis 显示文摘 | IUCHI S KOBAYASHI M TAJI T | 2001 | Plant J2001，27，4： | 1 |
| 12 | MRI prediction of fibrous pituitary adenomas显示文摘 | Iuchi T Saeki N Tanaka M | 1998 | Acta Neurochir1998，140，8： | 1 |
| 13 | Identification of Arabidopsisaccession with resistance U> Botrytis cinerea by natural variation a-nalysis, and characterization of the resistance response 显示文摘 | Namsaka M Yao N Iuchi A | 2013 | PlantBiotechnology2013，30，1： | 1 |
| 14 | Intrinsicoxidative stress causes either 2-cell arrest or cell deathdepending on developmental stage of the embryos fromSOD1-deficient mice显示文摘 | KIMURA N TSUNODA S IUCHI Y | 2010 | Molecular Human Repro-duction2010，16，7： | 1 |
| 15 | Crystallization and preliminary X-ray analysis of HCE-1, a hatching enzyme of medaka fish, Oryzias latipes 显示文摘 | Kudo N Yasumasu S Iuchi I | 2004 | Acta Crystallogr D Biol Crystallogr2004，60，4： | 1 |
| 16 | A stress-inducible gene for 9-cis-expoy-carotenoid dioxygenase involved in abscisic acid biosynthesis under water stress in drought-tolerant cowpea显示文摘 | Iuchi S Kobayashi M Yamaguchi-Shinozaki K | 2000 | Plant Physiology2000，123，： | 1 |
| 17 | Glucose and methionine uptake and proliferative activity in meningiomas显示文摘 | Iuchi T Iwadate Y Namba H | 1999 | Neurol Res1999，21，7： | 1 |
| 18 | 17β-Estradiol degradation by TiO2 photocatalysis as a means of reducing estrogenic activity 显示文摘 | Ohko Y Iuchi K-I Niwa C | 2002 | Environ Sci Technol2002，36，19： | 1 |
| 19 | Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase,a key enzyme in abscisic acid biosynthesis in Arabidopsis显示文摘 | Iuchi S Kobayashi M Taji T | 2001 | Plant J2001，27，： | 1 |
| 20 | Phase 1] trial of gefitini~ alone without radiation therapy for Japanese patient with brain metastases from EGFR-mutant lung adenocarcino显示文摘 | Iuchi T Shingyogi M Sakaida T | 2013 | Lung Cancer2013，82，2： | 1 |
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