| 3 | Dimethyltyrosine, the Viagra of Opioids显示文摘The introduction of 2′,6′-dimethyl-L-tyrosine(Dmt) [1] at the N-terminus of Tyr-Tic(1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid)-containing δ-opioid antagonists [2—8] enhances receptor affinity and in vitro bioactivity to several orders of magnitude [1] and its application in the formation of ligands with new properties [9], such as potent inverse agonism [10]. For example, the δ_ 2 agonist, [Dmt 1] deltorphin B [11], has become bifunctional and a high affinity δ/μ agonist [12]. [Dmt 1] DALDA has acquired higher μ affinity and activity [13], while enkephalin analogs have gained extraordinary high δ affinity and enhanced stability [14] , similar to those observed for Dmt-pyrazinone derivatives(Okada.Y., personal communications). Thus, Dmt facilitates opioid ligand recognition toward both δ and μ receptors [15] , underscoring similarities in their molecular binding sites within the receptor [16]. The Tic residue appears to be responsible for δ antagonism [17] as the substitution of the Dmt-Tic pharmacophores at the N-terminus of unrelated opioid agonists can transform them into δ antagonists, such as enkephalin(δ) [18], dermorphin(μ) [18] and dynorphin A(1—11) NH_ 2(κ) [19]; however, some Dmt-Tic analogs have mixed δ/μ antagonist/agonist activities [20]. | Lawrence H. Lazarus Sharon D. Bryant Severo Salvadori Remo Geurrini Gianfranco Balboni Yuko Tsuda Yoshio Okada | 2006 | Chemical Research in Chinese Universities2006，22，2： | 0 |
| 4 | Characteristics and outcomes of avoidant/restrictive food intake disorder in Japanese elementary-school students on total parenteral nutrition显示文摘The clinical outcomes of adolescents with avoidant/restrictive food intake disorder(ARFID)remain unclear.Furthermore,no report has compared the characteristics of ARFID and restricting-type anorexia nervosa(R-AN)in elementary-school students on total parenteral nutrition(TPN).This study retrospectively reviewed inpatients diagnosed with ARFID or R-AN between 2005 and 2019.Patients with ARFID(two boys and seven girls)and R-AN(13 girls)were hospitalized because of rapid physical deterioration,and nutrition therapy was continued without withdrawal.The ARFID group exhibited significantly lower body weights at admission than the R-AN group and gained an average of 6.5 kg during hospitalization;furthermore,the monthly weight gain during hospitalization was significantly higher,and no relapse was observed.Early physical improvement in ARFID resulted in good recovery.In conclusion,TPN can be easily introduced to patients with ARFID,in whom aversive eating is a concern,and is a suitable treatment for ARFID. | Akira Tamura Koichi Minami Yuko Tsuda Hiroshi Tsujimoto Takayuki Ichikawa Kazuhiro Mizumoto Hiroyuki Suzuki | 2021 | Pediatric Investigation2021，5，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员