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| 1 | Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation显示文摘AIM To investigate clinicopathological features of early stage gastric cancer with enteroblastic differentiation(GCED).METHODS We retrospectively investigated data on 6 cases of early stage GCED and 186 cases of early stage conventional gastric cancer(CGC: well or moderately differentiated adenocarcinoma) who underwent endoscopic submucosal dissection or endoscopic mucosal resection from September 2011 to February 2015 in our hospital.GCED was defined as a tumor having a primitive intestine-like structure composed of cuboidal or columnar cells with clear cytoplasm and immunohistochemical positivity for either alpha-fetoprotein, Glypican 3 or SALL4. The following were compared between GCED and CGC: age, gender, location and size of tumor, macroscopic type, ulceration, depth of invasion, lymphatic and venous invasion, positive horizontal and vertical margin, curative resection rate.RESULTS Six cases(5 males, 1 female; mean age 75.7 years; 6 lesions) of early gastric cancer with a GCED component and 186 cases(139 males, 47 females; mean age 72.7 years; 209 lesions) of early stage CGC were investigated. Mean tumor diameters were similar but rates of submucosal invasion, lymphatic invasion, venous invasion, and non-curative resection were higher in GCED than CGC(66.6% vs 11.4%, 33.3% vs 2.3%, 66.6% vs 0.4%, 83.3% vs 11% respectively, P < 0.01). Deep submucosal invasion was not revealed endoscopically or by preoperative biopsy. Histologically, in GCED the superficial mucosal layer was covered with a CGC component. The GCED component tended to exist in the deeper part of the mucosa to the submucosa by lymphatic and/or venous invasion, without severe stromal reaction. In addition, Glypican 3 was the most sensitive marker for GCED(positivity, 83.3%), immunohistochemically.CONCLUSION Even in the early stage GCED has high malignant potential, and preoperative diagnosis is considered difficult. Endoscopists and pathologists should know the clinicopathological features of this highly malignant type of cancer. | Kohei Matsumoto Hiroya Ueyama Kenshi Matsumoto Yoichi Akazawa Hiroyuki Komori Tsutomu Takeda Takashi Murakami Daisuke Asaoka Mariko Hojo Natsumi Tomita Akihito Nagahara Yoshiaki Kajiyama Takashi Yao Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，36： | 20 |
| 2 | Low preoperative platelet counts predict a high mortality after partial hepatectomy in patients with hepatocellular carcinoma显示文摘AIM: To assess the validity of our selection criteria for hepatectomy procedures based on indocyanine green disappearance rate (KICG), and to unveil the factors affecting posthepatectomy mortality in patients with hepatocellular carcinoma (HCC).METHODS: A retrospective analysis of 198 consecutive patients with HCC who underwent partial hepatectomies in the past 14 years was conducted. The selection criteria for hepatectomy procedures during the study period were KICG≥0.12 for hemihepatectomy, KICG≥0.10 for bisegmentectomy, KICG≥0.08 for monosegmentectomy, and KICG ≥0.06 for nonanatomic hepatectomy. The hepatectomies were categorized into three types: major hepatectomy (hemihepatectomy or a more extensive procedure),bisegmentectomy, and limited hepatectomy. Univariate (Fishers exact test) and multivariate (the logistic regression model) analyses were used.RESULTS: Postoperative mortality was 5% after major hepatectomy, 3% after bisegmentectomy, and 3% after limited hepatectomy. The three percentages were comparable (P = 0.876). The platelet count of ≤ 10x 104/μL was the strongest independent factor for postoperative mortality on univariate (P = 0.001) and multivariate (risk ratio,12.5; P= 0.029) analyses. No patient with a platelet count of >7.3x 104/μL died of postoperative morbidity, whereas 25% (6/24 patients) of patients with a platelet count of ≤7.3x 104/μL died (P<0.001).CONCLUSION: The selection criteria for hepatectomy procedures based on KICG are generally considered valid,because of the acceptable morbidity and mortality with these criteria. The preoperative platelet count independently affects morbidity and mortality after hepatectomy, suggesting that a combination of KICG and platelet count would further reduce postoperative mortality. | Kazuhiro Kaneko Yoshio Shirai Toshifumi Wakai Naoyuki Yokoyama Kohei Akazawa Katsuyoshi Hatakeyama | 2005 | World Journal of Gastroenterology2005，11，37： | 7 |
| 3 | Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry显示文摘 | Atsushi Nashimoto Kohei Akazawa Yoh Isobe Isao Miyashiro Hitoshi Katai Yasuhiro Kodera Shunichi Tsujitani Yasuyuki Seto Hiroshi Furukawa Ichiro Oda Hiroyuki Ono Satoshi Tanabe Michio Kaminishi | 2013 | Gastric Cancer2013，，1： | 6 |
| 4 | Macrophage colony-stimulating factor expressed in non-cancer tissues provides predictive powers for recurrence in hepatocellular carcinoma显示文摘AIM To investigate the role of macrophage colony-stimulating factor(M-CSF) in patients with hepatocellular carcinoma(HCC) after surgery. METHODS Expression of M-CSF, distribution of M2 macrophages(Mφs), and angiogenesis were assessed in the liver, including tumors and peritumoral liver tissues. The prognostic power of these factors was assessed. Mouse isolated hepatic Mφs or monocytes were cultured with media containing M-CSF. The concentration of vascular endothelial growth factor(VEGF) in media was assessed. Furthermore, the role of the M-CSF-matured hepatic Mφs on proliferation of the vascular endothelial cell(VEC) was investigated. RESULTS A strong correlation between the expressions of M-CSF and CD163 was observed in the peritumoral area. Also, groups with high density of M-CSF, CD163 or CD31 showed a significantly shorter time to recurrence(TTR) than low density groups. Multivariate analysis revealedthe expression of M-CSF or hepatic M2Mφs in the peritumoral area as the most crucial factor responsible for shorter TTR. Moreover, the expression of M-CSF and hepatic M2Mφs in the peritumoral area had better predictable power of overall survival. Values of VEGF in culture media were significantly greater in the hepatic Mφs compared with the monocytes. Proliferation of the VEC was greatest in the cells co-cultured with hepatic Mφs when M-CSF was present in media.CONCLUSION M-CSF increases hepatocarcinogenesis, most likely by enhancing an angiogenic factor derived from hepatic Mφ and could be a useful target for therapy against HCC. | Hiroshi Kono Hideki Fujii Shinji Furuya Michio Hara Kazuyoshi Hirayama Yoshihiro Akazawa Yuuki Nakata Masato Tsuchiya Naohiro Hosomura Chao Sun | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 5 | Increased Rectal Wall Thickness May Predict Relapse in Ulcerative Colitis: A Pilot Follow-Up Study by Ultrasonographic Colonoscopy显示文摘 | S. Higaki H. Nohara Y. Saitoh A. Akazawa H. Yanai T. Yoshida K. Okita | 2002 | Endoscopy2002，，03： | 2 |
| 6 | 显示文摘 | FUJIOKA N AKAZAWA R OHASHI K | 1999 | J Viral1999，73，2： | 1 |
| 7 | Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis显示文摘 | NAITO A T SHIOJIMA I AKAZAWA H | 2006 | Processings of the National Academy of Sciences of the United States of American2006，103，19： | 1 |
| 8 | Long-Term Results of Subtotal Esophagectomy with Three-Field Lymphadenectomy for Carcinoma of the Thoracic Esophagus显示文摘 | Masamichi Baba Takashi Aikou Heiji Yoshinaka Shoji Natsugoe Toshitaka Fukumoto Hisaaki Shimazu Kouhei Akazawa | 1994 | Annals of Surgery1994，，3： | 1 |
| 9 | Burden of concomitant asthma and COPD in a medicaid population显示文摘 | Shaya FT Dongyi D Akazawa MO | 2008 | Chest2008，134，1： | 1 |
| 10 | Vascular endothelial growth factor-C and vascular endothelial growth factor-d messenger RNA expression in breast cancer:association with lymph node metastasis显示文摘 | Koyama Y Kaneko K Akazawa K | 2003 | Clin Breast Cancer2003，4，5： | 1 |
| 11 | Effects of sevoflurane on cardiovascular dynamics coronary circulation and myocardial metabolism in dogs显示文摘 | Akazawa S Shimizu R Kasnda H | 1988 | J Anesth1988，2，： | 1 |
| 12 | A novel mechanism of mechanical stressinduced angiotensin Ⅱ type 1 -receptor activation without the involvement of angiotensin Ⅱ 显示文摘 | Yasuda N Akazawa H Qin Y | 2008 | Naunyn Sch miedebergs Arch Pharmacol2008，377，： | 1 |
| 13 | 显示文摘 | Sano N Akazawa H | 2003 | Carbon2003，41，： | 1 |
| 14 | Enzymic mechanism of starch breakdown in germination rice seeds Ⅲα-amylase显示文摘 | Takao M Akazawa T Fukuchi S | 1970 | Plant Physiology1970，46，： | 1 |
| 15 | Pleiotropic effects of cytokines on acute myocardial infarction:G-CSF as a novel therapy for acute myocardial infarction显示文摘 | Takano H Obtsuka M Akazawa H | 2003 | Curt Pharm Des2003，9，14： | 1 |
| 16 | CD81 expression is important for the permissiveness of huh7 cell clones for heterogeneous hepatitis C virus infection显示文摘 | Akazawa D Date T Morikawa K | 2007 | Journal of Virology2007，81，10： | 1 |
| 17 | Angiotensin Ⅱ type 1 and type 2 receptor-induced cell signaling 显示文摘 | Akazawa H Yano M Yabumoto C | 2013 | Curt Pharm Des2013，19，17： | 1 |
| 18 | Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepato- cyte lipoapoptosis 显示文摘 | Akazawa Y Cazanave S Mott JL | 2010 | JHepatol2010，52，4： | 1 |
| 19 | Burden of concomitant asthma and COPD in a Medicaid population显示文摘 | Syaya FT Dongyi D Akazawa MO | 2008 | Chest2008，，134： | 1 |
| 20 | CD81 expression is important for the permissiveness of huh7 cell clones for heterogeneous hepatitis C virus infection显示文摘 | Akazawa D Date T Morikawa K | 2007 | J Virol2007，81，10： | 1 |
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