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| 1 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 5 |
| 2 | Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C显示文摘 | Michael T. Dill Francois H.T. Duong Julia E. Vogt Stéphanie Bibert Pierre–Yves Bochud Luigi Terracciano Andreas Papassotiropoulos Volker Roth Markus H. Heim | 2011 | Gastroenterology2011，，3： | 2 |
| 3 | Percutaneous liver biopsy complicated by hemobilia-associated acute cholecystitis显示文摘肝活体检视通常被认为一只保险箱和高度有用的过程。它经常在众多的肝混乱为诊断和后续在一个门诊病人背景被执行。自从它在第 19 世纪,宽广经验,新成像技术和专辑的结束的介绍,针显著地减少了与肝活体检视联系的复杂并发症的率。肝的经皮的活体检视的已知的复杂并发症包括血腹膜,代替胶囊的血肿,低血压,气胸和败血。另外的 intra 腹的复杂并发症是不太普通的。胆道出血由于 arterio 胆汁的管管被描述了,它临床上仅仅很少被表示了为胆汁或胰腺炎。我们报导开发了在经皮的肝活体检视以后的 12 天在一个门诊病人背景执行了的严重尖锐胆汁的十五个 57 岁的男孩的一个案例。病原学清楚地被表明联系 hemobilia,并且临床的功课要求了 laparoscopic 胆囊炎的表演。起作用的柱子路线是平静的,病人回家被解除。经皮的肝活体检视是一个安全、通常执行的过程。然而,严重复杂并发症能偶尔发生。当处理这些稀罕事件时,医药、外科的选择应该被评估。 | Yair Edden Hugo St Hilaire Keith Benkov Michael T Harris | 2006 | World Journal of Gastroenterology2006，12，27： | 2 |
| 4 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 5 | Spectroscopic determination of protein concentrations from proteinase K digests 显示文摘 | Michael K Michael E Germain ST | 2002 | Anal Biochem2002，307，： | 1 |
| 6 | Composites of micro- and mesoporous materials: simultaneous syntheses of MFI/MCM-41 like phases by a mixed template approach显示文摘 | Arne Karlsson Michael St?cker Ralf Schmidt | 1998 | Microporous and Mesoporous Materials1998，，2： | 1 |
| 7 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B?hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Stéphane | 2013 | European Heart Journal2013，，28： | 1 |
| 8 | Treating diabetes to accepted standards of care: A 10-year projection of the estimated economic and health impact in patients with type 1 and type 2 diabetes mellitus in the United States显示文摘 | Michael E. Minshall Stéphane Roze Andrew J. Palmer William J. Valentine Volker Foos Joshua Ray Claudia Graham | 2005 | Clinical Therapeutics2005，，6： | 1 |
| 9 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe Mancia Robert Fagard Krzysztof Narkiewicz Josep Redon Alberto Zanchetti Michael B? hm Thierry Christiaens Renata Cifkova Guy De Backer Anna Dominiczak Maurizio Galderisi Diederick E. Grobbee Tiny Jaarsma Paulus Kirchhof Sverre E. Kjeldsen Sté pha | 2013 | Blood Pressure2013，，4： | 1 |
| 10 | A heptosyltransferase mutant of Pasteurella multocida produces a tuuncated lipopolysaccharide structure and is attenuated in virulence显示文摘 | Cox A D St Michael F | 2004 | Infection and Immunity2004，72，： | 1 |
| 11 | Upergastrointestinal tract endoscopy in the pediatric patient显示文摘 | Manureen C Robert W Michael ST | 1989 | Pediatry1989，115，： | 1 |
| 12 | Heavy metal accumulation by recombinant mammalian metallothionein within Escherichia coli protects against elevated metal exposure显示文摘 | Sandrine Sauge-Merle Catherine Lecomte-Pradines Patrick Carrier Stéphan Cuiné Michael DuBow | 2012 | Chemosphere2012，，8： | 1 |
| 13 | Banks’ regulatory capital buffer and the business cycle: Evidence for Germany显示文摘 | Stéphanie Stolz Michael Wedow | 2009 | Journal of Financial Stability2009，，2： | 1 |
| 14 | Clinical pharmacokinetics profile of ivermectin 1% cream after dermal applications on the face显示文摘AIM: To investigate the pharmacokinetics profile of Ivermectin 1% cream after topical treatment in patients with papulopustular rosacea(PPR).METHODS: Ivermectin 1% cream is a new, effective, and safe treatment for PPR. The human pharmacokinetic(PK) profile of ivermectin and its circulating metabolites were assessed following topical application of ivermectin 1% cream to the face. Clinical PK assessments were conducted after 4 wk of treatment using healthy volunteers and PPR subjects. Additionally, PK sampling was conducted up to 1 year of treatment in clinical phase 3 studies. Plasma concentrations of ivermectin and ivermectin metabolites were determined using high-performance liquid chromatography with fluorescence detection after a specific derivation to increase sensitivity.RESULTS: Systemic exposure to ivermectin was quantifiable at low levels in healthy and moderate to severe PPR subjects following the first topical application of ivermectin 1% cream(mean Cmax of 0.5 ± 0.2 ng/mL and 0.7 ± 0.5 ng/mL in healthy volunteers and PPR subjects, respectively). Ivermectin plasma levels reached a plateau after 2 wk of repeated topical application, indicating that steady-state concentrations had been reached. No further ivermectin plasma accumulation was observed during the long-term clinical studies that investigated ivermectin treatment up to 1 year. Investigation of ivermectin metabolites indicated that 2 circulating metabolites represented more than 10% of parent drug systemic exposure at steady state. Repeated topical application of ivermectin 1% cream resulted in lower systemic exposure levels when compared with orally administered ivermectin, suggesting limited transdermal absorption of ivermectin. Topically applied ivermectin is cleared from the plasma slowly(with a prolonged plasma half-life when compared to the oral route).CONCLUSION: Applications of ivermectin 1% cream result in low systemic exposure levels. Steady–state conditions are achieved by 2 wk without further accumulation under chronic treatment. | Khaled Benkali Fran?ois Rony Michael Graeber Jean Jacovella Jean-Paul Chappuis Marie-Helene Peirone Michel Poncet Stéphane Delage Ronan Bouer Nathalie Wagner | 2016 | World Journal of Dermatology2016，5，1： | 1 |
| 15 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet2013，，9867： | 1 |
| 16 | Clinical Phase I study with an Insulin-like Growth Factor-1 Receptor Inhibitor: Experiences in patients with squamous non-small cell lung carcinoma显示文摘 | Simon Ekman Jan-Erik Fr? din Johan Harmenberg Antonina Bergman ? sa Hedlund Pia Dahg Carina Alvfors Birgitta St? hl Stefan Bergstr? m Michael Bergqvist | 2011 | Acta Oncologica2011，，3： | 1 |
| 17 | Sarcoidosis 显示文摘 | Michael CI Benjamin AR Alvin ST | 2007 | N Engl J Med2007，357，： | 1 |
| 18 | Effect of Cardiac Resynchronization Therapy on Left Ventricular Size and Function in Chronic Heart Failure显示文摘 | Martin G. St John Sutton Ted Plappert William T. Abraham Andrew L. Smith David B. DeLurgio Angel R. Leon Evan Loh Dusan Z. Kocovic Westby G. Fisher Myrvin Ellestad John Messenger Kristin Kruger Kathryn E. Hilpisch Michael R.S. Hill | 2003 | Circulation: Journal of the American Heart Association2003，，： | 1 |
| 19 | Incidence of and case fa-tality following acute myocardial infarction in aboriginal and non-aboriginal western Australians(2000-2004):A linked data study显示文摘 | Judith MK Frank MS Michael ST | 2010 | Heart Lung and Circulation2010，19，： | 1 |
| 20 | Hypothalamic clamp on insulin release by leptin-transgene expression显示文摘 | Stéphane Boghossian Michael G. Dube Rita Torto Pushpa S. Kalra Satya P. Kalra | 2006 | Peptides2006，，12： | 1 |
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