| 8 | Renal cell carcinoma escapes NK cell-mediated immune surveillance through the downregulation of DNAM-1显示文摘Dear Editor,The activating receptor DNAX accessory molecule-1(DNAM-1)plays an important role in T and natural killer(NK)cell-mediated cytotoxicity via the interaction with its ligands poliovirus receptor(PVR,CD155)and Nectin-2(CD112).Compared with peripheral blood NK cells,tumor-infiltrating NK cells show reduced expression of DNAM-1 across several solid tumors,including ovarian and breast cancer resulting in impaired NK cell function.Early studies reported an inverse correlation between DNAM-1 expression and its ligands in leukemic blasts and ovarian cancer[1]. | Veronika Kremer Shi Yong Neo Yaxuan Liu Yi Chen Arnika Kathleen Wagner Ying Yang Ziqing Chen Christina Seitz Nicholas Patrick Tobin Maarten Alexander Ligtenberg Evren Alici Xinsong Chen Felix Haglund Barbara Seliger Ulrika Harmenberg Eugenia Colón Ann-Helén Scherman Plogell Lisa Lei Liu Andreas Lundqvist | 2023 | Cancer Communications2023，43，7： | 0 |
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