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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Gastric food retention at endoscopy is associated with severity of liver cirrhosis显示文摘BACKGROUND Gastrointestinal symptoms are prevalent in patients with cirrhosis.Cirrhotic patients have a known predilection to delayed gastric emptying compared to those without cirrhosis.However,the contributing factors have not been fully elucidated.Retained gastric food on esophagogastroduodenoscopy(EGD)has been used as a surrogate marker for delayed gastric emptying with reasonably high specificity.Therefore,we hypothesize that the frequency of retained gastric food contents at EGD will be higher in a cirrhotic population compared to a control population without liver disease.Additionally,we hypothesize that increased frequency of gastric food contents will be associated with increased severity of cirrhosis.AIM To determine the relative frequency of delayed gastric emptying among cirrhotics as compared to non-cirrhotics and to identify associated factors.METHODSWe performed a retrospective case-control study of cirrhotic subjects whounderwent EGD at an academic medical center between 2000 and 2015. Threehundred sixty-four patients with confirmed cirrhosis, who underwent a total of1044 EGDs for the indication of esophageal variceal screening or surveillance,were identified. During the same period, 519 control patients without liverdisease, who underwent a total of 881 EGDs for the indication of anemia, wereidentified. The presence of retained food on EGD was used as a surrogate fordelayed gastric emptying. The relative frequency of delayed gastric emptyingamong cirrhotics was compared to non-cirrhotics. Characteristics of patients withand without retained food on EGD were compared using univariable andmultivariable logistic regression analysis to identify associated factors.RESULTSOverall, 40 (4.5%) patients had evidence of retained food on EGD. Cirrhotics weremore likely to have retained food on EGD than non-cirrhotics (9.1% vs 1.4%, P <0.001). Characteristics associated with retained food on univariable analysisincluded age less than 60 years (12.6% vs 5.2%, P = 0.015), opioid use (P = 0.004),Child-Pugh class C (24.1% Child-Pugh class C vs 6.4% Child-Pugh class A, P =0.007), and lower platelet count (P = 0.027). On multivariate logistic regressionanalysis, in addition to the presence of cirrhosis (adjusted OR = 5.83;95%CI: 2.32-14.7, P < 0.001), diabetes mellitus (types 1 and 2 combined) (OR = 2.34;95%CI:1.08-5.06, P = 0.031), opioid use (OR = 3.08;95%CI: 1.29-7.34, P = 0.011), andChild-Pugh class C (OR = 4.29;95%CI: 1.43-12.9, P = 0.01) were also associatedwith a higher likelihood of food retention on EGD.CONCLUSIONCirrhotics have a higher frequency of retained food at EGD than non-cirrhotics.Decompensated cirrhosis, defined by Child-Pugh class C, is associated with ahigher likelihood of delayed gastric emptying. | David B Snell Shirley Cohen-Mekelburg Russell Weg Gaurav Ghosh Adam P Buckholz Amit Mehta Xiaoyue Ma Paul J Christos Arun B Jesudian | 2019 | World Journal of Hepatology2019，11，11： | 2 |
| 3 | Brain activation to cues predicting inescapable delay in adolescent attention deficit/hyperactivity disorder: an fMRI pilot study显示文摘 | Lemiere J Danckaerts M Van Hecke W Mehta MA Peeters R Sunaert S | 2012 | Brain Res2012，1450，： | 1 |
| 4 | The neural correlates of declining performance with age:evidence for age-related changes incognitive control显示文摘 | Sharp DJ Scott SK Mehta MA | 2006 | Oxford University Press2006，16，： | 1 |
| 5 | Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis显示文摘 | Jimmy L. Zhao Chao Ma Ryan M. O’Connell Arnav Mehta Race DiLoreto James R. Heath David Baltimore | 2014 | Cell Stem Cell2014，，： | 1 |
| 6 | The dopaminergic basis of human behaviors:a review of molecular imaging studies显示文摘 | Egerton A Mehta MA Montgomery AJ | 2009 | Neurosci Biobehav Rev2009，33，7： | 1 |
| 7 | Neurocognitive and functional asse ssment of patients with brain metastases:a pilot study显示文摘The outcome of patients with brain me tastases is generally poor.Surviva l alone is not necessarily a good measure of clinical outcome.Measures of neurocognitiv e function and the impact of the disease and treatments on functional status also need to be considered.Although these parameters have been measured in patients wi th primary brain tumors,they have not been as thoroughly evaluated in patients with brain metastases.The Mini-Mental State Exam ination provides limited assessmen t of neurocognitive domains impaired in brain tumor patients.It is less sensitive to mild impairment ,does not avoid memorized learning f rom repeat administration,and does not have validated alternative forms necessary for non-English speaking patients.To determine the feasibility of using a more comprehensive neurocognitive test battery,motor,verbal,executive,and daily functions were assessed in30patients with brain metastases.The test battery included the Hopkins Verbal Learning Tests,Controlled Oral Word Association T est,Grooved Pegboard Test,Trailmaking Tests A and B,and t he Barthel Index.In this study,there was complete patient compliance,w ith average test completion time of 23±6minutes.Despite high functional status,most patients demonstrated impairment in memory and fine motor domains.Neurocognitive test batte ries can and should be used in patient s with brain metastases enrolled in c linical trials. | Herman MA Tremont-Lukats I Meyers CA Trask DD Froseth C Renschler MF Mehta MP | 2003 | 癌症2003，22，7： | 1 |
| 8 | Endoscope-assis- ted endonasal versus supraorbital keyhole resection of olfac- tory groove meningiomas:comparison and combination of 2 minimally invasive approaches 显示文摘 | Banu MA Mehta A Ottenhausen M | 2015 | J Neurosurg2015，14，2： | 1 |
| 9 | Ultrashort optical pulse characterization using WS2 monolayers显示文摘 | C Janisch N Mehta D Ma et aL | 2014 | Opt Lett2014，39，2： | 1 |
| 10 | REM sleep loss associated changes in orexin-A levels in discrete brain areas in rats显示文摘 | Mehta R Khanday MA Mallick BN | 2015 | Neurosci Lett2015，590，： | 1 |
| 11 | The nettral correlates of declining performance with age: evi- dence for age-related changes in cognitive control显示文摘 | Sharp DJ Scott SK Mehta MA et oi | 2006 | Cereb Cortex2006，16，12： | 1 |
| 12 | Increased cerebral perfusion in adult attention deficit hyperactivity disorder is normalised by stimulant treatment: a non-invasive MRI pilot study显示文摘 | O'Gorman RL Mehta MA Asherson P | 2008 | Neuroimage2008，42，1： | 1 |
| 13 | Influence of subretinal fluid in advanced stage retinopathy of prematurity on proangiogenic response and cell proliferation显示文摘 | Ma J Mehta M Lam G | 2014 | Mol Vis2014，20，： | 1 |
| 14 | Diminished cardioprotective response to inhibition of angiotensin-converting enzyme and angiotensin II type 1 receptor in B2 kinin receptor gene knockout mice显示文摘 | Yang XP Liu YH Mehta D Cavasin MA Shesely E Xu J | 2001 | Circ Res2001，88，： | 1 |
| 15 | Role of experience and oscillations in the transforming a rate code into a temporal code 显示文摘 | Mehta MR Lee AK Wilson MA | 2002 | Nature2002，417，6890： | 1 |
| 16 | Clinical promise tempered by reality in the delivery of combined chemoradiation for common solid tumors显示文摘 | Harari PM Mehta MP Ritter MA | 2003 | Seminars Radiat Oncol2003，13，1： | 1 |
| 17 | Perfluoroperhydrophenanthrene (Vitreon) in the management of giant retinal tears:results of a collaborative study显示文摘 | Millsap CM Peyman GA Mehta NJ Greve MD Lee KJ Ma PE Dunlap WA | | 0，，11： | 1 |
| 18 | The neural correlates of declining performance with age: evidence for age-related changes in cognitive control 显示文摘 | Sharp DJ Scott SK Mehta MA | 2006 | Oxford University Press2006，16，： | 1 |
| 19 | Endoscope-assisted endonasal versus supraorbital keyhole resection of olfactory groove meningiomas :comparison and combination of 2 minimally invasive approaches 显示文摘 | Banu MA Mehta A Ottenhausen M | 2016 | J Neurosurg2016，124，3： | 1 |
| 20 | Prediction of therapeutic response to cervical epidural steroid injection according to distribution of radicular pain显示文摘 | Shakir A Ma V Mehta B | | 0，，11： | 1 |
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