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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Hyaluronan facilitates invasion of colon carcinoma cells in vitro via interaction with CD44显示文摘 | WHEELER MA WILSON CM | 2004 | Cancer Res2004，64，13： | 1 |
| 3 | Effect of various sludge digestion conditions on sulfonamide, macrolide, and tetracycline resistance genes and class I integrons 显示文摘 | Ma Y Wilson C A Novak J T | 2011 | Environmental Science & Technology2011，45，： | 1 |
| 4 | Sublingual immunotherapy for allergic rhinitis显示文摘 | Radulovic S Calderon MA Wilson D | 2010 | Cochrane Database Syst Rev2010，，00： | 1 |
| 5 | Altered venous function and deep venous thrombosis following proximal femoral fracture显示文摘 | Wilson D Cooke EA McNally MA | 2002 | Injury2002，33，1： | 1 |
| 6 | FDA adverse event reports on statin-associated rhabdomy-olysis显示文摘 | Omar MA Wilson JP | 2002 | Ann Ph-armaeother2002，36，2： | 1 |
| 7 | Coordinated memory replay in the visual cortex and hippocampus during sleep显示文摘 | Ji D Wilson MA | 2007 | Nat Neurosci2007，10，： | 1 |
| 8 | Biomechanical evaluationof arthroscopic rotator cuff repairs: Double-row compared to single-row fixation显示文摘 | Ma C B Cumerford L Wilson J | 2006 | J Bone Joint Surg Am2006，88，2： | 1 |
| 9 | Treatment advances in neonatal neuroprotection and neurointensive care显示文摘 | Johnston MV Fatemi A Wilson MA | 2011 | Lancet Neurol2011，10，4： | 1 |
| 10 | Primary CD4^+T-cell responses rovide both helper and cytotoxic functions during Epstein-barr virus infection and transformation of fetal cord blood B cells显示文摘 | Macarthur GJ Wilson AD Birchall MA | 2007 | J Virol2007，81，9： | 1 |
| 11 | Comparative genomics of BCG vaccines by whole genome DNA microarray显示文摘 | Behr MA Wilson MA Gill WP | 1999 | Science1999，284，： | 1 |
| 12 | Global gene expression in the developing rat brain after hypoxic preconditioning : involvement of apoptotic mechanisms 显示文摘 | Gustavsson M Wilson MA Mallard C | 2007 | Pediatr Res2007，61，4： | 1 |
| 13 | Apology for the classification, description and valuation of ecosystem functions显示文摘 | DE GROOT RS WILSON MA BOUMANS R M J | 2010 | Ecol Econ2010，41，： | 1 |
| 14 | Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans 显示文摘 | Wilson MA Shukitt-Hale B Kalt W | 2006 | Aging Cell2006，5，1： | 1 |
| 15 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 16 | Genetic neuroscience of mammalian learning and memory显示文摘 | Tonegawa S Nakazawa K Wilson MA | 2003 | Philos Trans R SocLond B Biol Science2003，358，1432： | 1 |
| 17 | The Parkinson' s disease protein DJ-1 is neuroprotecfive due to cystcine-sulfinic acid-driven mitochondrial localization 显示文摘 | Canet-Aviles RM Wilson MA Miller DW | 2004 | Proc Natl Acad Sci U S A2004，101，： | 1 |
| 18 | Comparative genomics of BCG vaccines by whole genome DNA microarray显示文摘 | Behr MA Wilson MA Gill WP | 1999 | Science1999，284，： | 1 |
| 19 | Why we scratch an itch: the molecules, cells and circuits of itch 显示文摘 | Bautista DM Wilson SR Hoon MA | 2014 | Nat Neurosci2014，17，： | 1 |
| 20 | A typology for the classification,description and valuation of ecosystem functions,goods and services显示文摘 | Groot RD Wilson MA Bounmansr MJ | 2002 | Ecological Economics2002，41，3： | 1 |
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