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| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | Anti-tumor activity of thalidomide in refractory multiple myeloma显示文摘 | Singhal S Mehta J Desikan R | | 0，，： | 8 |
| 3 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 4 | Healthcare utilization and costs associated with gastroparesis显示文摘AIM To use a national database of United States hospitals to evaluate the incidence and costs of hospital admissions associated with gastroparesis.METHODS We analyzed the National Inpatient Sample Database(NIS)for all patients in whom gastroparesis(ICD-9 code:536.3)was the principal discharge diagnosis during the period,1997-2013.The NIS is the largest publicly available all-payer inpatient care database in the United States.It contains data from approximately eight million hospital stays each year.The statistical significance of the difference in the number of hospital discharges,length of stay and hospital costs over the study period was determined by regression analysis.RESULTS In 1997,there were 3978 admissions with a principal discharge diagnosis of gastroparesis as compared to16460 in 2013(P<0.01).The mean length of stay for gastroparesis decreased by 20%between 1997 and 2013from 6.4 d to 5.1 d(P<0.001).However,during this period the mean hospital charges increased significantly by 159%from$13350(after inflation adjustment)per patient in 1997 to$34585 per patient in 2013(P<0.001).The aggregate charges(i.e.,'national bill') for gastroparesis increased exponentially by 1026%from$50456642±4662620 in 1997 to$568417666±22374060 in 2013(P<0.001).The percentage of national bill for gastroparesis discharges(national bill for gastroparesis/total national bill)has also increased over the last 16 years(0.0013%in 1997 vs 0.004%in2013).During the study period,women had a higher frequency of gastroparesis discharges when compared to men(1.39/10000 vs 0.9/10000 in 1997 and 5.8/10000vs 3/10000 in 2013).There was a 6-fold increase in the discharge diagnosis of gastroparesis amongst type 1 DM and 3.7-fold increase amongst type 2 DM patients over the study period(P<0.001).CONCLUSION The number of inpatient admissions for gastroparesis and associated costs have increased significantly over the last 16 years.Inpatient costs associated with gastroparesis contribute significantly to the national healthcare bill.Further research on cost-effective evaluation and management of gastroparesis is required. | Vaibhav Wadhwa Dhruv Mehta Yash Jobanputra Rocio Lopez Prashanthi N Thota Madhusudhan R Sanaka | 2017 | World Journal of Gastroenterology2017，23，24： | 3 |
| 5 | Early and late effects of clopidogrel in patients with acute coronary syndromes显示文摘 | YUSUF S MEHTA S R ZHAO F | 2003 | Circulation2003，107，7： | 2 |
| 6 | CNS involvement in Ewing's sarcoma 显示文摘 | MEHTA Y HENDRICKSON F R | 1974 | Cancer1974，33，： | 1 |
| 7 | Antitumor activity of thalidomide in refractory multiple myeloma显示文摘 | Singhal S Mehta J Desikan R | 1999 | N Engl J Med1999，341，21： | 1 |
| 8 | Viscosity Measure-Ments of Ferrofluid:Comparison with Various Hydrodynamic Equations 显示文摘 | Rajesh Patel R V Upadhyay R V Mehta | 2003 | Journal of Colloid and Interface Science2003，26，3： | 1 |
| 9 | Concrete deterioration from physical attack by salts 显示文摘 | Haynes H O’Neill R Mehta P K | 1996 | Concr Int1996，18，1： | 1 |
| 10 | Effects of organic compounds on the degradation of p-nitrophenol in lake and industrial wastewater by inoculated bacteria显示文摘 | Zaidi B R Mehta N K | 1995 | Biodesradation1995，6，： | 1 |
| 11 | Building durable structures in the 21st century显示文摘 | Mehta P K Burrows R W | 2001 | Concrete Int2001，23，3： | 1 |
| 12 | Sleep quality in hospitalized patients - a prospective study 显示文摘 | Reznik R Mehta B Thirumala R | 2011 | Am J Respir Crit Care Med2011，183，： | 1 |
| 13 | Recent advances in cancer stem/progenitor cell research:therapeutic implications for overcoming resistance to the most aggressive cancers 显示文摘 | Mimeault M Hauke R Mehta PP | 2007 | J Cell Mol Med2007，11，5： | 1 |
| 14 | A new approach to dose esca-lation in non-small-cell lung cacer显示文摘 | Mehta M Scrimger R Mackie R | 2001 | Int J Radiat Oncol Biol Phys2001，49，： | 1 |
| 15 | Surgical interventions for age-related cataract显示文摘 | Riaz Y Mehta J S Wormald R | 2006 | Cochrane Database Syst Rev2006，18，00： | 1 |
| 16 | Surgical treatment of lumbar tuberculous spondylodiscitis by transforaminal lumbar interbody fusion (TLIF) and posterior instrumentation显示文摘 | Zaveri G R Mehta S S | 2009 | J Spinal Disord Tech2009，22，4： | 1 |
| 17 | Natural history of macular status in recent-onset branch retinal vein occlusion:an optical coherence tomography study显示文摘 | Shroff D Mehta DK Arora R | 2008 | Int Ophthalmol2008，28，： | 1 |
| 18 | Cut slope stability evaluation of NH-21 along Nalayan-Gambhrola section,Bilaspur district,Himachal Pradesh,India显示文摘 | Sharma R K Mehta B S Jamwal C S | | 0，，： | 1 |
| 19 | Face recognition using scale-adap- tive directional and textural features 显示文摘 | MEHTA R EGIAZARIAN K | 2014 | Pattern Recognition2014，47，5： | 1 |
| 20 | Identification of Posttrans lationally Modified 18-Kilodalton Protein from Rice as Eukaryotic Translation Initiation Factor 5A显示文摘 | Mehta A M Saftner R A Mehta R A | 1994 | Plant Physiol1994，106，4： | 1 |
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