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| 1 | 急性肾损伤诊断与分类专家共识显示文摘近几十来.临床和基础的研究工作者们针对急性肾功能衰竭(ARF)进行了广泛的研究,尽管我们在该疾病的生理和发病机制方面都取得了长足的进步,但如何将这些知识用于临床,改进ARF患者预后方面的工作却做得十分有限。ARF是由多种病因导致、可发生在各种临床情况之下(儿童或成人、门诊或住院、ICU或非ICU患者)的一种复杂的肾功能紊乱,其临床表现既可以是血肌酐水平的轻微升高,也可以是无尿性肾功能衰竭。 | RL Mehta JA Kellum S Shah B Molitoris C Ronco D Warnock A Levin 王欣 | 2006 | 中华肾脏病杂志2006，22，11： | 348 |
| 2 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 3 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 4 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 5 | Emerging role of protein kinase C in energy homeostasis: A brief overview显示文摘Protein kinase C-β(PKCβ), a member of the lipidactivated serine/threonine PKC family, has been implicated in a wide range of important cellular processes. Very recently, the novel role of PKCβ in the regulation of triglyceride homeostasis via regulating mitochondrial function has been explored. In this review, I aim to provide an overview of PKCβ regarding regulation by lipids and recently gained knowledge on its role in energy homeostasis. Alterations in adipose PKCβ expression have been shown to be crucial for diet-induced obesity and related metabolic abnormalities. High-fat diet is shown to induce PKCβ expression in white adipose tissue in an isoform- and tissue-specific manner. Genetically manipulated mice devoid of PKCβ are lean with increased oxygen consumption and are resistant to high-fat diet-induced obesity and hepatic steatosis with improved insulin sensitivity. Available data support the model in which PKCβ functions as a 'diet-sensitive' metabolic sensor whose induction in adipose tissue by high-fat diet is among the initiating event disrupting mitochondrial homeostasis via intersecting with p66Shc signaling to amplify adipose dysfunction and have systemic consequences. Alterations in PKCβ expression and/orfunction may have important implications in health and disease and warrants a detailed investigation into the downstream target genes and the underlying mechanisms involved. Development of drugs that target the PKCβ pathway and identification of miRs specifically controlling PKCβ expression may lead to novel therapeutic options for treating age-related metabolic disease including fatty liver, obesity and type 2 diabetes. | Kamal D Mehta | 2014 | World Journal of Diabetes2014，5，3： | 6 |
| 6 | GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma显示文摘 | Jorge A. Marrero Patrick R. Romano Olga Nikolaeva Laura Steel Anand Mehta Claus J. Fimmel Mary Ann Comunale Anthony D’Amelio Anna S. Lok Timothy M. Block | 2005 | Journal of Hepatology2005，，6： | 5 |
| 7 | Obese patients have similar short-term outcomes to nonobese in laparoscopic colorectal surgery显示文摘AIM: To determine whether obese patients undergoing laparoscopic surgery within an enhanced recovery program had worse short-term outcomes.METHODS: A prospective study of consecutive patients undergoing laparoscopic colorectal resection was carried out between 2008 and 2011 in a single institution. Patients were divided in groups based on body mass index(BMI). Short-term outcomes including operative data, length of stay, complications and readmission rates were recorded and compared between the groups. Continuous data were analysed using t-test or oneway Analysis of Variance. χ2 test was used to compare categorical data.RESULTS: Two hundred and fifty four patients were included over the study period. The majority of individuals(41.7%) recruited were of a healthy weight(BMI < 25), whilst 50 patients were classified as obese(19.6%). Patients were matched in terms of the presence of comorbidities and previous abdominal surgery. Obese patients were found to have a statistically significant difference in The American Society of Anesthesiologists grade. Length of surgery and intra-operative blood loss were no different according to BMI.CONCLUSION: Obesity(BMI > 25) does not lead to worse short-term outcomes in laparoscopic colorectal surgery and therefore such patients should not be precluded from laparoscopic surgery. | Manish Chand Henry D De'Ath Muhammed Siddiqui Chetanya Mehta Shahnawaz Rasheed James Bromilow Tahseen Qureshi | 2015 | World Journal of Gastrointestinal Surgery2015，7，10： | 4 |
| 8 | Cardiac involvement in patients with sarcoidosis: diagnostic and prognostic value of outpatient testing显示文摘 | MEHTA D LUBITZ SA FRANKEL Z | 2008 | Chest2008，133，6： | 1 |
| 9 | Improved thermodynamic parameters for prediction of structure hydrate equilibria 显示文摘 | MEHTA A P SLOAN E D | 1996 | AICHE J1996，42，7： | 1 |
| 10 | Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2+ influx显示文摘 | Jho D Mehta D Ahmmed G Gao XP Tiruppathi C Broman M | 2005 | Circ Res2005，96，12： | 1 |
| 11 | Tigecycline: a glycylcycline antimicrobial agent显示文摘 | Doan TL Fung HB Mehta D | 2006 | Clin Ther2006，28，8： | 1 |
| 12 | Natural history of macular status in recent-onset branch retinal vein occlusion:an optical coherence tomography study显示文摘 | Shroff D Mehta DK Arora R | 2008 | Int Ophthalmol2008，28，： | 1 |
| 13 | Early predictive bio- markers for postpartum depression point to a role for estrogen re- ceptor signaling显示文摘 | Mehta D Newport D J Frishman G | 2014 | Psychol Med2014，44，11： | 1 |
| 14 | Detection of elevated right ventricular extracellular volume in pulmonary hypertension using Accelerated and Navigator-Gated Look-Locker Imaging for Cardiac T1 Estimation (ANGLE) cardiovascular magnetic resonance 显示文摘 | MEHTA B B AUGER D A GONZALEZ J A | 2015 | J Cardiovasc Magn Reson2015，17，1： | 1 |
| 15 | Upregulation of endothelial receptor for oxidized cells LDL and implications in apoptosis of human coronaiy artery endothelial cells : evidence from use of antisense LOX-1 mRNA and chemical inhibitors 显示文摘 | Li D Mehta J L | 2000 | Arterioscler Thromb Vasc Biol2000，20，4： | 1 |
| 16 | Vector Analysis and Cintrol of Advanced Static VAR Compensators显示文摘 | Schauder C D Mehta H | 1993 | IEE Proceedings-C1993，140，4： | 1 |
| 17 | Soluble monomeric P - selectin containing only the lectin and epidermal growth factor domains binds to P - selectin glycoprotein ligand - 1 on leukocytes 显示文摘 | MEHTA P PATEL K D LAUE T M | 1997 | Blood1997，90，6： | 1 |
| 18 | Influence of pnzzolanic slag, anti chemical admixtures on pore size distribution and permeability of hardened cement pastes 显示文摘 | Manmohan D Mehta P K | 1981 | Cement Concrete Aggregates1981，3，1： | 1 |
| 19 | Increeased serum neopterin leveels in adults with Donm syndrome 显示文摘 | Mehta P D Patarick B A Dalton A J | 2005 | J Neuroimmunol2005，164，2： | 1 |
| 20 | Polyamine-dependent gene expression显示文摘 | CHILDS A C MEHTA D J GERNER E W | 2003 | Cellular and Molecular Life Sciences2003，60，7： | 1 |
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