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| 1 | YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA显示文摘 | Hailing Shi Xiao Wang Zhike Lu Boxuan S Zhao Honghui Ma Phillip J HSU Chang Liu Chuan He | 2017 | Cell Research2017，27，3： | 156 |
| 2 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 3 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 4 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 5 | Association of N-terminal pro-brain natriuretic peptide with the severity of coronary artery disease in patients with normal left ventricular ejection fraction显示文摘 | Wu NQ Guo YL Li XL Liu J Qing P Xu RX Zhu CG Jia Y J Liu G Dong Q Jiang LX Li J J Ma FL | 2014 | Chinese Medical Journal2014，，4： | 23 |
| 6 | On the combined effect of soil fertility and topography on tree growth in subtropical forest ecosystems—a study from SE China显示文摘Aims The aim of our research was to understand small-scale effects of topography and soil fertility on tree growth in a forest biodiversity and ecosystem functioning(BEF)experiment in subtropical SE China.Methods Geomorphometric terrain analyses were carried out at a spatial resolution of 5×5 m.Soil samples of different depth increments and data on tree height were collected from a total of 566 plots(667 m2 each).The soils were analyzed for carbon(soil organic carbon[SOC]),nitrogen,acidity,cation exchange capacity(CEC),exchangeable cations and base saturation as soil fertility attributes.All plots were classified into geomorphological units.Analyses of variance and linear regressions were applied to all terrain,soil fertility and tree growth attributes.Important Findings In general,young and shallow soils and relatively small differences in stable soil properties suggest that soil erosion has truncated the soils to a large extent over the whole area of the experiment.This explains the concurrently increasing CEC and SOC stocks downslope,in hollows and in valleys.However,colluvial,carbon-rich sediments are missing widely due to the convexity of the footslopes caused by uplift and removal of eroded sediments by adjacent waterways.The results showed that soil fertility is mainly influenced by topography.Monte-Carlo flow accumulation(MCCA),curvature,slope and aspect significantly affected soil fertility.Furthermore,soil fertility was affected by the different geomorphological positions on the experimental sites with ridge and spur positions showing lower exchangeable base cation contents,especially potassium(K),due to leaching.This geomorphological effect of soil fertility is most pronounced in the topsoil and decreases when considering the subsoil down to 50 cm depth.Few soil fertility attributes affect tree height after 1-2 years of growth,among which C stocks proved to be most important while pH_(KCl)and CEC only played minor roles.Nevertheless,soil acidity and a high proportion of Al on the exchange complex affected tree height even after only 1-2 years growth.Hence,our study showed that forest nutrition is coupled to a recycling of litter nutrients,and does not only depend on subsequent supply of nutrients from the mineral soil.Besides soil fertility,topography affected tree height.We found that especially MCCA as indicator of water availability affected tree growth at small-scale,as well as aspect.Overall,our synthesis on the interrelation between fertility,topography and tree growth in a subtropical forest ecosystem in SE China showed that topographic heterogeneity lead to ecological gradients across geomorphological positions.In this respect,small-scale soil-plant interactions in a young forest can serve as a driver for the future development of vegetation and biodiversity control on soil fertility.In addition,it shows that terrain attributes should be accounted for in ecological research. | Thomas Scholten Philipp Goebes Peter Kühn Steffen Seitz Thorsten Assmann Jürgen Bauhus Helge Bruelheide Francois Buscot Alexandra Erfmeier Markus Fischer Werner Härdtle Jin-Sheng He Keping Ma Pascal A.Niklaus Michael Scherer-Lorenzen Bernhard Schmid Xuezheng Shi Zhengshan Song Goddert von Oheimb Christian Wirth Tesfaye Wubet Karsten Schmidt | 2017 | Journal of Plant Ecology2017，10，1： | 22 |
| 7 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 8 | 下肢浅静脉治疗术后的加压疗法:美国静脉论坛血管、外科学会、美国静脉学会、血管医学学会和国际静脉联盟的临床实践指南显示文摘一、指南的由来下肢浅静脉治疗术后应用压力治疗的方式是几代血管外科医师多年临床经验积累所得,现主要应用于大隐静脉剥脱术、下肢静脉点状剥脱术及静脉硬化治疗等。目前单就静脉硬化治疗而言,术后压力治疗的推荐也是基于相关文献及实验验证[1],但对于其他术式,尤其是对于大隐静脉的热消融术,目前还没有形成规范统一的建议,这也使得当前的压力治疗具有很大的临床差异性。 | Lurie F Lal BK Antignani PL Blebea J Bush R Caprini J Davies A Forrestal M Jacobowitz G Kalodiki E Killewich L Lohr J Ma H Mosti G Partsch H Rooke T Wakefield T 李丹(译) 陈程浩(译) 牛传强(译) 张靖(译) 黄建忠(译) | 2020 | 中华介入放射学电子杂志2020，8，4： | 16 |
| 9 | 高危患者目标血压与心血管病预后显示文摘指南推荐血压目标值应〈140/90 mmHg(1mmHg=0.133kPa)以减少心血管事件的发生。但与其他心血管病预后(如冠状动脉事件)相比,包括脑卒中及心力衰竭在内的心血管病预后与收缩压下降关系更密切。一些心血管事件(如冠状动脉事件)风险在收缩压低时亦增高,风险-收缩压关系呈J形曲线,而脑卒中与血压不是J形曲线关系。 | B?hm M Schumacher H Teo KK Lonn EM Mahfoud F Mann JF Mancia G Redon J Schmieder RE Sliwa K Weber MA Williams BYusuf S 曲浥晨 叶鹏 | 2017 | 中华高血压杂志2017，25，6： | 14 |
| 10 | 采用动态推-拉技术增强动脉瘤分流器的导流作用:一项实验和模型研究显示文摘目的 神经血管分流器是治疗颅内动脉瘤的一种有弹性的、纵横交错的网状支架。本研究采用动态推-拉技术调节动脉瘤瘤口分流器的网格密度,以便最大化其导流作用。通过自主研发的高保真虚拟支架计算机模型技术联合计算机流体动力学,探讨动态推-拉技术对特定动脉瘤病人血流动力学的影响。方法采用动态推-拉技术和不同长度的传送导线,将两个Pipeline分流器放置到两个相同侧壁的大脑前动脉动脉瘤模型中。然后数字模拟操作过程,并验证模拟的网格几何结构。通过调节放置在侧壁动脉瘤和基底动脉主干梭形动脉瘤(前期已放置分流器)的分流器,采用计算机流体动力学分析,评估血流动力学的具体变化。同时评估来源于临床病例样本的分流器网格的影像。 | Ma D Xiang J Choi H 周静 郭玉慧 | 2014 | 中国微侵袭神经外科杂志2014，19，6： | 12 |
| 11 | 胡萝卜软腐果胶杆菌巴西亚种(Pectobacterium carotovorum subsp.brasiliense)引起的黄瓜细菌性软腐病在中国发生显示文摘2014—2015年,在中国山东、山西、河北、河南、辽宁等省的黄瓜茎叶上发生了毁灭性的细菌性软腐病,造成了黄瓜产业严重的经济损失。黄瓜叶片、茎、叶柄和果实表面出现流胶;茎基部呈深褐色进而出现湿腐。受侵染的黄瓜叶边缘出现黄斑和湿腐症状,并逐渐扩散至叶片中心。从受侵染组织中分离出45个细菌菌株,在形态学特性鉴定、生理学、生物化学和16Sr RNA基因序列分析的基础上,将病原体鉴定为胡萝卜软腐果胶杆菌(Pectobacterium carotovorum)。多位点序列分析(MLSA)证实,分离菌株是胡萝卜软腐果胶杆菌巴西亚种[Pectobacterium carotovorum subsp.brasiliensis(Pcb)],病原菌归入进化枝II。重新分离获得与原始菌株相同的菌株,证实了分离菌株的致病力。寄主范围测试表明,该菌株具有广泛的寄主范围。目前为止,这是对Pcb引起的黄瓜软腐病——这一对黄瓜生产具有重要经济影响的病害在中国乃至全球范围内的首次报道。 | 冯志琴(译) meng x l chai a l shi y x xie x w ma z h li b j | 2017 | 中国植保导刊2017，37，7： | 10 |
| 12 | Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats显示文摘瞄准:测试假设这项活动的那改进他我有与周期性的肝损伤联系的纤维发生的过程的氧合酶罐头 interfere,我们调查了在表示上的治疗学的潜力他我在 CCl (4 ) 的 oxygense-1 劝诱了微榴状的肝硬化模型。方法:带老鼠 HO-1 或 GFP 基因的 Recombinant 联系 adeno 的病毒被产生。1x 10 (12 )联系 adeno 的病毒的 vg 在肝的正式就职的时候通过门注射被管理纤维变性。结果:有由 rAAV/HO-1 的 HO-1 的在表示上的老鼠肝显著地增加了的调节以一种稳定的方式的 HO 酶的活动。微榴状的肝硬化的开发显著地作为与控制相比在 rAAV/HO-1-transduced 动物被禁止。门静脉高血压显著地作为与控制相比在 rAAV/HO-1-transduced 动物被减少,而在收缩血压没有重要变化。这发现伴有激活的改进的肝生物化学,更少的渗透的巨噬细胞和更少在 rAAV/HO-1-transduced 肝的肝的星形细胞(HSC ) 。结论:改进惊讶在肝的活动压制肝硬化的发展。 | Tung-Yu Tsui Chi-Keung Lau Jian Ma Gabriel Glockzin Aiman Obed Hans J Schlitt Sheung-Tat Fan | 2006 | World Journal of Gastroenterology2006，12，13： | 9 |
| 13 | Palaeoecological and palaeoenvironmental significance of someimportant spores and micro-algae in Quaternary deposits显示文摘Spores of ferns and allied plants, and micro-algae frequently occur in abundance in Quaternary deposits, but their palaeoenvironmental significance is seldom evaluated. This paper presents morphological descriptions of spores of Selaginella sinensis (Desv.) Spring, 1843 (Selaginellaceae) and Ceratopteris cf. thalictroides (L.) Brongniart, 1821 (Parkeriaceae) and the algae Pediastrum boryanum (Turpin) Meneghini, 1840, P. simplex Meyen, 1829, P. integrum N geli, 1849 (all Hydrodictyaceae), Spiniferites Mantell, 1850, emend. Sarjeant, 1970 (Spiniferitaceae) and Concentricystes Rossignal, 1962, emend. Jiabo, 1978 (systematic position unclear), and discusses their occurrence in mostly Quaternary sedimentary successions. All are closely associated with aquatic habitats. Extant Selaginella sinensis often colonizes fairly wet hillsides and gaps between rocks, and shady sides of ravines and slopes; it is also found within thickets of trees and shrubs (boscages) and in forests with calcareous soils. Ceratopteris thalictroides, Pediastrum and Concentricystes inhabit freshwater lakes and both natural and artificial wetlands, such as paddy fields and ditches. Spiniferites is a salt-water genus and usually associated with the marine realm. Fossil and subfossil representatives of all of these taxa can be useful proxies of biodiversity and, therefore, also important for determining environmental conditions during the Quaternary period. | TANG LingYu MAO LiMi Lü XinMiao MA QingFeng ZHOU ZhongZe YANG ChunLei KONG ZhaoChen BATTEN David J | 2013 | Chinese Science Bulletin2013，58，25： | 9 |
| 14 | The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model显示文摘The outcome of hepatitis B viral(HBV)infection is determined by the complex interactions between replicating HBV and the immune system.While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively,the contribution of innate immune mechanisms remains to be defined.Here we examined the role of the interleukin-1 receptor/Toll-like receptor(IL-1R/TLR)signaling pathway in adaptive immune responses and viral clearance by exploring the HBV mouse model.Hydrodynamic injection with a replication-competent HBV genome was performed in wild-type mice(WT)and a panel of mouse strains lacking specific innate immunity component expression.We found higher levels of HBV protein production and replication in Tlr2^(−/−),Tlr23479^(−/−),3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice,which was associated with reduced HBV-specific CD8+T-cell responses in these mice.Importantly,HBV clearance was delayed for more than 2 weeks in 3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice compared to WT mice.HBV-specific CD8+T-cell responses were functionally impaired for producing the cytokines IFN-γ,TNF-αand IL-2 in TLR signaling-deficient mice compared to WT mice.In conclusion,the IL-1R/TLR signaling pathway might contribute to controlling HBV infection by augmenting HBV-specific CD8+T-cell responses. | Zhiyong Ma Jia Liu Weimin Wu Ejuan Zhang Xiaoyong Zhang Qian Li Gennadiy Zelinskyy Jan Buer Ulf Dittmer Carsten J Kirschning Mengji Lu | 2017 | Cellular & Molecular Immunology2017，14，12： | 6 |
| 15 | Purified human bone marrow multipotent mesenchymal stem cells regenerate infarcted myocardium in experimental rats显示文摘 | Zhang S Jia Z Ge J Gong L Ma Y Li T Guo J Chen P Hu Q Zhang P Liu Y Li Z Ma K Li L Zhou C | 2006 | 中国生物学文摘2006，20，5： | 5 |
| 16 | Long-term outcome of patients of over 85 years old with acute coronary syndrome undergoing percutaneous coronary stenting: a comparison of bare metal stent and drug eluting stent显示文摘超过 85 年的背景病人在经皮的冠的干预(一种总线标准) 是未被充分代表的尽管有为一种总线标准的工作分派的增加的试用。在有急性冠的症候群(交流) 的超过 85 年的病人的经皮的冠的 stenting 的长期的安全和功效仍然保持不清楚。而且是否在这特殊 population.Methods 赤裸的金属 stent (BMS ) 和药 eluting stent (DES ) 之间有差别,是未知的,有交流的 80 个病人的一个总数在经历 stenting (BMS 组 n=21 对 DES 组 n=59 ) 的 85 年变老回顾地被学习。在里面医院,一年和包括心脏的死亡的主要不利心脏的事件(权标)的全面临床的后续( 12-36 月),心肌的梗塞,目标损害 revascularization ( TLR )和象击并且另外的主要流血一样的目标容器 revascularization ( TVR )在全部队在二 groups.Results 之间被比较,过程成功率与在93.8%容器一种总线标准以后的 TIMI-3 冠的流动是93.8%,过程联系了复杂并发症是17.5%。在 BMS 组的在里面医院权标的发生更高(14.3% 对 6.8% , P=0.30 ) 。当在 BMS 组没有向时,在 DES 组的权标的 1 年的发生是 7.0% 。为 12-36 月的临床的后续证明从向免费的全面幸存是 82.9% ,在 BMS 组的向的发生更低(5.3% 对 21.1% , P=0.20 ) 。Multivariate 回归分析证明 creatinine 铺平(OR:1.013;95%C1:1.006-1.020;P=0.004 ) 并且高血压(OR:3.201;95%C1:1.000-10.663; P=0.04 ) 是二个主要因素影响在超过 85 年的病人的长期的 MACE.Conclusions 经皮的冠的 stenting 是安全的并且提供好短、长期的功效。有肾的机能障碍和高血压的病人可以有向的相对高的发生。 | MA Han-ying ZHOU Yu-jie Ronald J Dick SHI Dong-mei LIU Yu-yang CHENG Wan-jun GUO Yong-he WANG Jian-long GE Hai-long | 2008 | Chinese Medical Journal2008，，10： | 5 |
| 17 | 钢-混凝土组合桥面板滑移及掀起效应研究显示文摘为了研究钢-混凝土组合桥面板的混凝土开裂、钢与混凝土界面之间的滑移及掀起效应,设计了采用开孔钢板剪力连接件的钢-混凝土组合桥面板试验构件,并进行了负弯矩作用下的全过程试验研究。引入光纤光栅测试技术,完成了试验构件的滑移、掀起及开裂等的测试;采用有限元方法建立了试验构件的数值仿真模型,并将计算结果与试验结果进行了对比分析。研究结果表明:光纤光栅传感器能较准确地观测到开裂荷载,且与应变片测试结果吻合较好;对于普通应变片难以观测的滑移和掀起效应,光纤光栅传感器均表现出较强的优越性。 | 占玉林 宋瑞年 赵人达 牟廷敏 MA Z J | 2014 | 中国公路学报2014，27，11： | 5 |
| 18 | 流感病毒传播能力相关遗传机制的深度解析显示文摘在人与人之间通过呼吸道高效传播的能力是新发流感病毒引起人流感大流行的先决条件,但流感病毒传播能力遗传决定因素至今并不完全清楚。揭示流感病毒传播能力遗传机制对人流感大流行的预警以及防控疫苗和药物研发都至关重要,因此一直是病毒学领域研究的重点。2013年出现在我国的H7N9亚型禽流感病毒已导致1560多人感染,致死率近40%。 | Kong H Ma S Wang J Gu C | 2019 | 中国预防兽医学报2019，41，11： | 5 |
| 19 | 母亲妊娠期焦虑抑郁对孩子应激性心率及血压的影响显示文摘心理障碍,包括焦虑和抑郁在妊娠期间十分常见。该研究目的在于确定母亲的这些心理障碍是否会对后代的心血管反应产生影响。方法:对231名孕妇的心理状态进行评定,在其后代(n=216)7~9岁时进行视频压力反应测试。测定静息时、观看压力视频时和恢复期的心率及血压水平。 | 刘莉 叶鹏 Fan F Zou Y Tian H Zhang Y Zhang J Ma X Meng Y Yue Y Liu K Dart AM | 2015 | 中华高血压杂志2015，23，6： | 5 |
| 20 | The genome-wide mutational landscape of pituitary adenomas显示文摘 | Zhi-Jian Song Zachary J Reitman Zeng-Yi Ma Jian-Hua Chen Qi-Lin Zhang Xue-Fei Shou Chuan-Xin Huang Yong-Fei Wang Shi-Qi Li Ying Mao Lian-g-Fu Zhou Bao-Feng Lian Hai Yan Yong-Yong Shi Yao Zhao | 2016 | Cell Research2016，26，11： | 5 |
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