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| 1 | ^(99)Tc^m-tetrofosmin肺癌显像的临床研究(与^(18)F-FDG PET对比)显示文摘目的评价99Tcmtetrofosmin(TF)显像在肺癌诊断中的临床意义。方法用99TcmTF对16例已证实的肺癌患者进行平面和断层显像研究。所有病人均行CT和18F脱氧葡萄糖(FDG)PET检查。用感兴趣区分析法对99TcmTF和18FFDG图像进行定性及定量分析,计算肿瘤及非肿瘤内放射性比。结果CT共检出14个肿瘤病灶,2个因胸膜广泛渗出未能检出。此外8例患者,CT显示了21个受累纵隔淋巴结(>15cm)。99TcmTF平面和断层显像诊断肺癌病灶的灵敏度分别为88%(14/16)和94%(15/16)。所有肺癌病灶均有18FFDG摄取增高。定量分析示18FFDG在肺癌的摄取明显高于99TcmTF(452±150与155±030,t=4029,P<0001)。CT和病理活检示中心坏死的2个肺癌病灶,99TcmTF和18FFDG显像均示肿瘤中心放射性缺损。对于异常淋巴结,平面显像只发现3例病人中的4个淋巴结,而SPECT显像检出17个淋巴结有99TcmTF异常摄取。CT所示的21个异常淋巴结,18FFDG摄取均增高。结论99TcmTF显像用于肺癌患者的诊断有其临床? | 王辉 Maures,S | 1999 | 中华核医学杂志1999，19，1： | 5 |
| 2 | Biliary carcinoembryonic antigen levels in diagnosis of occult hepatic metastases from colorectal carcinoma显示文摘AIM: To prospectively explore the role of carcinoembryonic antigen (CEA) in gallbladder bile in patients with colorectal carcinoma and the morphological and clinical features of neoplasia and the occurrence of hepatic metastases.METHODS: CEA levels in the gallbladder and peripheral blood were studied in 44 patients with colorectal carcinoma and 10 patients with uncomplicated cholelithiasis. CEA samples were collected from the gallbladder bile and peripheral blood during the operation, immediately before extirpating the colorectal neoplasia or cholecystectomy.Values of up to 5 ng/ml were considered normal for bile and serum CEA.RESULTS: In the 44 patients with colorectal carcinoma who underwent operation with curative intent, the average level of serum CEA was 8.5 ng/ml (range: 0.1 to 111.0 ng/ml) and for bile CEA it was 74.5 ng/ml (range: 0.2 to 571.0ng/ml). In the patients with uncomplicated cholelithiasis who underwent cholecystectomy, the average level of serum CEA was 1.9 ng/ml (range: 1.0 to 3.5 ng/ml) and for bile CEA it was 1.2 ng/ml (range: 0.3 to 2.9 ng/ml).The average duration of follow-up time was 16.5 months (range: 6 to 48 months). Four patients who underwent extirpation of the colorectal carcinoma without evidence of hepatic metastasis and with an average bile CEA value of 213.2 ng/ml presented hepatic metastases between three and seventeen months after removal of the primary colorectal neoplasia. Three of them successfully underwent extirpation of the hepatic lesions.CONCLUSION: High CEA levels in gallbladders of patients undergoing curative operation for colorectal carcinoma may indicate the presence of hepatic metastases. Such patients must be followed up with special attention to the diagnosis of such lesions. | Jaques Waisberg Rogério T.Palma Luís Contim Neto Lourdes C.Martins Maurício S.L.Oliveira Carlos A. Nagashima Antonio C.Godoy Fabio S.Goffi | 2003 | World Journal of Gastroenterology2003，9，7： | 5 |
| 3 | Origin of pit chains in the floor of lunar Copernican craters显示文摘There are small pit chains in the floor of lunar Copernican craters. They are usually so small in scale that there are few lunar spacecrafts to detect their detailed morphology. Combining camera data from Lunar Orbiter, Lunar Reconnaissance Orbiter (LRO), Kaguya and Chang’e-1 missions, 5 representative large Copernican craters on various terrains of the lunar surface are chosen to study the origin of the pit chains in the crater floor. The morphology and distribution characteristic of the pit chains are referred by the high resolution images in this research. It is suggested that it is the magma activities from the subsurface magma layer combining with the existence of fractures and faults under the crater floor that leaded the formation of the pit chains. The model is further verified and discussed using the regolith thickness data in the crater floor. Our model suggests that the pit chains are still developing in the floor of the Copernican craters and the Moon may not be totally cold. Finally, the model limitation and potential future work are discussed based on available data. | XIAO ZhiYong 1* , ZENG ZuoXun 1,2 , XIAO Long 1,2 , FA WenZhe 3 & HUANG Qian 3,4 1 Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 2 Research Center for Space Science and Technology, China University of Geosciences, Wuhan 430074, China 3 Institut de Physique du Globe de Paris, 4 Avenue de Neptune, Saint Maur des Fosse’s, 94100, France 4 Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 4 |
| 4 | Resection of a rapid-growing 40-cm giant liver hemangioma显示文摘Hemangiomas are the most frequent benign tumors of the liver. Most hemangiomas are asymptomatic and therefore largely diagnosed only in routine screening tests. Usually they are small and require no specific treatment. In some situations they can reach great dimensions, causing some discomfort to the patient. Resection of liver hemangioma is indicated in cases of great dimension tumors causing symptoms such as pain, nausea or bloating caused by compression of adjacent organs. We report a case of a rare giant hemangioma with rapid growth in short time:a 50 year old female reported to our institution with a 40 cm giant liver hemangioma and then underwent a left hepatectomy. | Andreas JM Koszka Fabio G Ferreira Caio GG de Aquino Maurício A Ribeiro André S Gallo Elisa MC Aranzana Luiz A Szutan | 2010 | World Journal of Hepatology2010，2，7： | 3 |
| 5 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 6 | High HIF-1α expression genotypes in oral lichen planus显示文摘 | Carlos Alberto Carvalho Fraga Lucas Rodrigues Alves Luciano Marques-Silva Adriana Alkmim Sousa Antonio Sérgio Barcala Jorge Sabrina Ferreira Jesus Daniel Nogueira Vilela Ugo Borges Pinheiro Kimberly Marie Jones Alfredo Maurício Batista Paula André Luiz Se | 2013 | Clinical Oral Investigations2013，，9： | 1 |
| 7 | Synthesis and characterization of novel diazenes bearing pyrrole, thiophene and thiazole heterocycles as efficient photochromic and nonlinear optical (NLO) materials显示文摘 | M. Manuela M. Raposo A. Maurício C. Fonseca M. Cidália R. Castro M. Belsley M. Fátima S. Cardoso Luís M. Carvalho Paulo J. Coelho | 2011 | Dyes and Pigments2011，，1： | 1 |
| 8 | Tailor- ing of arbitrary optical vector beams 显示文摘 | MAURE R JESACHER A F13RHAPTER S | 2007 | New Journal of Physics2007，9，3： | 1 |
| 9 | Effectiveness of the Maze Procedure Using Cooled-Tip Radiofrequency Ablation in Patients With Permanent Atrial Fibrillation and Rheumatic Mitral Valve Disease显示文摘 | Carlos A.C. Abreu Filho Luiz A.F. Lisboa Luís A.O. Dallan Guilherme Sobreira Spina Max Grinberg Maurício Scanavacca Eduardo A. Sosa José Antonio F. Ramires Sérgio A. Oliveira | 2005 | 2005 (9 Su)2005，，9： | 1 |
| 10 | Effect of parasitism on vaccine efficacy against Streptococcus iniae in Nile tilapia显示文摘 | Maurício L M Craig A S Dehai Xu | 2011 | Aquaculture2011，314，： | 1 |
| 11 | The Ndc80 loopregion facilitates formation of kinetochore attachment tothe dynamic microtubule plus end显示文摘 | Maure J F Komoto S Oku Y | 2011 | Current Biology2011，21，3： | 1 |
| 12 | Cardioprotective and antiocodant effects of the terpenoid constituents of Ginkgo biloba extract(EGB761) 显示文摘 | Pietri S Maureli E Drieu K | 1997 | J Mol Cell Rdio1997，29，2： | 1 |
| 13 | Interdisscplinawy rounds显示文摘 | Margo A Mary G Mauring S | 2009 | Clinical Nurse SpecialistTM2009，17，3： | 1 |
| 14 | Structural, biochemical, and expression analysis of two distinct insulin-like growth factor I re- ceptors and their ligands in zebrafish 显示文摘 | Maures T Chan S J Xu B | 2002 | Endocrinology2002，143，： | 1 |
| 15 | Gastrointestinal Symptoms and Nutritional Status in Women and Men on Maintenance Hemodialysis显示文摘 | Luciana Ferreira Silva Gildete Barreto Lopes Cácia Mendes Matos Katherine Quadros Brito Maurício Kauark Amoedo Matheus Freitas Azevedo Meiry Jane Sá Araújo Márcia Silva Martins Antonio Alberto Lopes | 2012 | Journal of Renal Nutrition2012，，3： | 1 |
| 16 | Cardioangioimmunology: the immune implication in the principle cardio vascular pathologies 显示文摘 | Lisson P Bami S Maur O | 1991 | G Ital Cardiol1991，21，6： | 1 |
| 17 | An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery 显示文摘 | Hedley SJ Auf der Maur A Hohn S | 2006 | Gene Ther2006，13，1： | 1 |
| 18 | Detection of Epstein Ban' virus in an hepatic leiomyomatous neoplasm in an adult human immunodeficiency virus 1-infected patient 显示文摘 | Prrvot S N6ris J de Saint Maur PP | 1994 | Virchows Arch1994，425，3： | 1 |
| 19 | Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas显示文摘 | Alfeu Zanotto-Filho Elizandra Braganhol Karina Klafke Fabrício Figueiró Sílvia Resende Terra Francis Jackson Paludo Maurílio Morrone Ivi Juliana Bristot Ana Maria Battastini Cassiano Mateus Forcelini Alexander James Roy Bishop Daniel Pens Gelain José Cláu | 2014 | Cancer Letters2014，，： | 1 |
| 20 | Hydrolysis of oligosaccharides in soybean products by Debaryomyces hansenii UFV-1 α-galactosidases显示文摘 | Pollyanna Amaral Viana Sebasti?o Tavares de Rezende Daniel Luciano Falkoski Thiago de Almeida Leite Inês Chamel José Maurílio Alves Moreira Valéria Monteze Guimar?es | 2006 | Food Chemistry2006，，2： | 1 |
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