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| 1 | Acute cholestatic hepatitis caused by amoxicillin/ clavulanate显示文摘Amoxicillin/clavulanate is a synthetic penicillin that is currently commonly used,especially for the treatment of respiratory and cutaneous infections.In general,it is a well-tolerated oral antibiotic.However,amoxicillin/clavulanate can cause adverse effects,mainly cutaneous,gastrointestinal,hepatic and hematologic,in some cases.Presented here is a case report of a 63-yearold male patient who developed cholestatic hepatitis after recent use of amoxicillin/clavulanate.After 6 wk of prolonged use of the drug,he began to show signs of cholestatic icterus and developed severe hyperbilirubinemia(total bilirubin>300 mg/L).Diagnostic investigation was conducted by ultrasonography of the upper abdomen,serum tests for infection history,laboratory screening of autoimmune diseases,nuclear magnetic resonance(NMR)of the abdomen with bile duct-NMR and transcutaneous liver biopsy guided by ultrasound.The duration of disease was approximately 4 mo,with complete resolution of symptoms and laboratory changes at the end of that time period.Specific treatment was not instituted,only a combination of anti-emetic(metoclopramide)and cholestyramine for pruritus. | Daniel Oliveira Beraldo Joanderson Fernandes Melo Alexandre Vidal Bonfim Andrei Alkmim Teixeira Ricardo Alkmim Teixeira André Loyola Duarte | 2013 | World Journal of Gastroenterology2013，19，46： | 2 |
| 2 | High HIF-1α expression genotypes in oral lichen planus显示文摘 | Carlos Alberto Carvalho Fraga Lucas Rodrigues Alves Luciano Marques-Silva Adriana Alkmim Sousa Antonio Sérgio Barcala Jorge Sabrina Ferreira Jesus Daniel Nogueira Vilela Ugo Borges Pinheiro Kimberly Marie Jones Alfredo Maurício Batista Paula André Luiz Se | 2013 | Clinical Oral Investigations2013，，9： | 1 |
| 3 | Telemedicine application inthe care of diabetes patients : systematic review and meta-analysis 显示文摘 | Marcolino MS Maia JX Alkmim MB | 2013 | PLoS One2013，8，79： | 1 |
| 4 | Telemedicine appli- cation in the care of diabetes patients: systematic review and meta-analysis显示文摘 | Marcolino MS Maia JX Alkmim MB | 2013 | PLoS One2013，8，79： | 1 |
| 5 | Mapping Virtual Networks onto Substrate Networks 显示文摘 | ALKMIM G P BATISTA D M FONSECA N L D | 2013 | Journal of Internet Services and Applications2013，4，1： | 1 |
| 6 | A bacia intracratonica do Sao Francisco: Arcabouco estrutural e cenarios evolutivos 显示文摘 | Alkmim F F Martins-Nero M A | 2001 | Bacia do S&~ Francisco Geologia e Recursos Naturais2001，349，： | 1 |
| 7 | Metamorphism and exhumation of basement gneiss domes in the Quadrilátero Ferrífero:Two stage dome-and-keel evolution?显示文摘The presence of dome-and-keel provinces in Archean cratons has been connected with the initiation of plate tectonics on Earth as these features are most commonly observed in Archean rocks.The Quadrilátero Ferrífero in Brazil has been identified as a Paleoproterozoic dome-and-keel province for more than three decades.The prevailing model suggests that it formed during the Rhyacian Transamazonian orogeny,making it unique among dome-and-keel provinces.However,a lack of appropriate lithologies,datable minerals and the metamorphic overprint of later orogenesis has resulted in a cryptic metamorphic record for the formation of this dome-and-keel province.A clinopyroxene-bearing migmatite from the core of the Bacao dome has peak P-T conditions of 5-7 kbar and 700-750 ℃ and a published age of ca.2730 Ma based on U-Pb ages of zircon from leucosomes,suggesting that this age represents the migmatisation event.A fine-grained epidote-albite-titanite assemblage overprints the coarse-grained clinopyroxene and amphibole,giving P-T conditions of 8-9 kbar and 550℃ with an associated titanite age of ca.2050 Ma.A garnet-bearing amphibolite sample also from the core of the dome has peak P-T conditions of 7-8 kbar and 650-700℃,and texturally late titanite from this sample produces an age of ca.2060 Ma.Three additional samples were collected from the edges of the dome.A garnet-gedrite bearing felsic schist produces peak P-T conditions of 8-9 kbar and 650-700℃ on a clockwise P-T evolution.This sample has a U-Pb zircon age of ca.2775 Ma,which could date metamorphism or be the age of its volcaniclastic protolith.Texturally unconstrained titanite from the sample gives an age of ca.2040 Ma.A garnet-bearing amphibolite that occurs as a boudin within the felsic schist gives both zircon and titanite ages of ca.2050 Ma and has peak P-T conditions of 5-6 kbar and 650-700 ℃ on a near isobaric P-T path.An amphibolite dike,observed to cross-cut the felsic schist produces a zircon U-Pb age of ca.2760 Ma.Altogether this data suggests that the samples were metamorphosed in the Archean (ca.2775-2730 Ma) and again during the Transamazonian event.The most plausible explanation for this data is that dome-and-keel formation occurred in the Archean with migmatisation and high-temperature metamorphism occurring at this time.The Paleoproterozoic event is interpreted as a reactivation of the dome-and-keel formation structures,with Paleoproterozoic keels crosscutting Archean keels and producing metamorphic aureoles.The high radiogenic heat production and the presence of dense sedimentary successions in Archean terranes make dome-and-keel provinces a uniquely Archean feature,but they are susceptible to reworking,resulting in an enigmatic record of formation. | Kathryn Cutts Cristiano Lana Fernando Alkmim Federico Farina Hugo Moreira Viviane Coelho | 2019 | Geoscience Frontiers2019，10，5： | 0 |
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