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| 1 | Outcome of varicocele repair in men with nonobstructive azoospermia: systematic review and meta-analysis显示文摘这全身的评论的目的是评估与 nonobstructive 精子缺乏(NOA ) 在不肥沃的人修理临床的精索静脉曲张的利益。通过手术获得的精子检索率(SRR ) 和与检索阴囊的精子的使用跟随帮助繁殖技术(艺术) 的怀孕率是主要结果。第二等的结果在手术后的精液包括了可行精子的存在避免阴囊的精子检索和怀孕率(帮助并且无助) 用手术后的呼喊的精子。收集数据的电子搜索用 MEDLINE 和 EMBASE 数据库被执行直到 2015 年 4 月。十八研究在这系统的评论被包括并且说明了与 NOA 和精索静脉曲张被诊断的 468 个病人。这些病人受到也外科的精索静脉曲张修理或经皮的 embolization。评估精子检索结果的三控制研究显示在经历了 varicocelectomy 的病人,没有精索静脉曲张修理, SRR 与那些相比增加了(或:2.65;95% CI:1.69-4.14;P <0.001 ) 。尽管有阴囊的精子的使用的怀孕率赞成了 varicocelectomy 组,结果不是统计上重要的(临床的怀孕率或:2.07;95% CI:0.92-4.65;P = 0.08;实时出生率或:2.19;95% CI:0.99-4.83;P = 0.05 ) 。留下十五研究报导手术后的精液分析结果。在 43.9% 病人(变化:20.8%-55.0%) ,精子在手术后的精液被发现。怀孕率为无助、帮助(在 IVF/ICSI 以后) 分别地在有在手术后的精液的精子的人的组是 13.6% 和 18.9% 。我们的调查结果显示在有 NOA 和临床的精索静脉曲张的病人的 varicocelectomy 与改进 SRR 被联系。另外,约 44% 对待的人将有在精液的足够的精子避免精子检索。有手术后的呼喊的精子和收获阴囊的精子的怀孕结果上的有限数据预防关于在对待的个人的可能的增加的富饶潜力的任何坚挺的结论。在结论,我们的学习的结果显示有 NOA 和临床的精索静脉曲张的不肥沃的人得益于 varicocelectomy。给可得到的证据的低 / 中等的质量,医生们与精索静脉曲张的风险和好处修理的 NOA 与他们的病人讨论,是明智的。 | Sandro C Esteves Ricardo Miyaoka Matheus Roque Ashok Agarwal | 2016 | Asian Journal of Andrology2016，18，2： | 21 |
| 2 | Outcome of assisted reproductive technology in met with treated and untreated varicocele, systematic review and meta-analysis显示文摘 | Sandro C Esteves Matheus Roque Ashok Agarwal | 2016 | Asian Journal of Andrology2016，18，2： | 19 |
| 3 | Efficacy and safety of endoscopic prophylactic treatment with undiluted cyanoacrylate for gastric varices显示文摘AIM:To evaluate the efficacy and safety of undiluted N-butyl-2 cyanoacrylate plus methacryloxysulfolane(NBCM)as a prophylactic treatment for gastric varices(GV)bleeding.METHODS:This prospective study was conducted at a single tertiary-care teaching hospital between October 2009 and March 2013.Patients with portal hypertension(PH)and GV,with no active gastrointestinal bleeding,were enrolled in primary prophylactic treatment with NBCM injection without lipiodol dilution.Initial diagnosis of GV was based on endoscopy and confirmed with endosonography(EUS); the same procedure was used after treatment to confirm eradication of GV.After puncturing the GV with a regular injection needle,1 mL of undiluted NBCM was injected intranasally into GV.The injection was repeated as necessary to achieve eradication or until a maximum total volume of 3 mL of NBCM had been injected.Patients were followed clinically and evaluated with endoscopy at 3,6 and 12 mo.Later follow-ups were performed yearly.The main outcome measures were efficacy(GV eradication),safety(adverse events related to cyanoacrylate injection),recurrence,bleeding from GV and mortality related to GV treatment.RESULTS:A total of 20 patients(15 male)with PH and GV were enrolled in the study and treated with undiluted NBCM injection.Only 2(10%)patients had no esophageal varices(EV); 18(90%)patients were treated with endoscopic band ligation to eradicate EV before inclusion in the study.The patients were followed clinically and endoscopically for a median of 31 mo(range:6-40 mo).Eradication of GV was observed in all patients(13 patients were treated with 1 session and 7 patients with 2 sessions),with a maximum injected volume of 2 mL NBCM.One patient had GV recurrence,confirmed by EUS,at 6-mo follow-up,and another had late recurrence with GV bleeding after 35 mo of follow-up; overall,GV recurrence was observed in 2 patients(10%),after 6 and 35 mo of follow-up,and GV bleeding rate was 5%(1 patient).Mild epigastric pain was reported by 3 patients(15%).No mortality or major complications,including embolism,or damage to equipment were observed.CONCLUSION:Endoscopic injection with NBCM,without lipiodol,may be a safe and effective treatment for primary prophylaxis of gastric variceal bleeding. | Matheus Cavalcante Franco Gustavo Flores Gomes Frank Shigeo Nakao Gustavo Andrade de Paulo Angelo Paulo Ferrari Jr Ermelindo Della Libera Jr | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，6： | 16 |
| 4 | Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review显示文摘BACKGROUND Despite the advent of biological drugs, conventional therapy continues to be used in moderate to severe inflammatory bowel disease(MS-IBD). This study hypothesized that as a standard of treatment and the primary alternative to biologics, conventional therapy should present robust effectiveness results in IBD outcomes.AIM To investigate the effectiveness of conventional therapy for MS-IBD.METHODS A systematic review with no time limit was conducted in July 2017 through the Cochrane Collaboration, MEDLINE, and LILACS databases. The inclusion criteria encompassed meta-analyses, systematic reviews, randomized clinical trials, observational and case-control studies concerning conventional therapy in adult patients with MS-IBD, including Crohn's disease(CD) and ulcerative colitis(UC). Corticosteroids(prednisone, hydrocortisone, budesonide, prednisolone,dexamethasone), 5-aminosalicylic acid(5-ASA) derivatives(mesalazine and sulfasalazine) and immunosuppressants [azathioprine(AZA), methotrexate(MTX), mycophenolate, cyclosporine, tacrolimus, 6-mercaptopurine(6-MP)] were considered conventional therapy. The exclusion criteria were sample size below50; narrative reviews; specific subpopulations(e.g., pregnant women,comorbidities); studies on postoperative IBD; and languages other than English,Spanish, French or Portuguese. The primary outcome measures were clinical remission(induction or maintenance), clinical response and mucosal healing. As secondary outcomes, fecal calprotectin, hospitalization, death, and surgeries were analyzed. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation criteria.RESULTS The search strategy identified 1995 citations, of which 27 were considered eligible(7 meta-analyses, 20 individual studies). For induction of clinical remission, four meta-analyses were selected(AZA and 6-MP showed no advantage over placebo,MTX or 5-ASA in CD; MTX showed no statistically significant difference versus placebo, 6-MP, or 5-ASA in UC; tacrolimus was superior to placebo for UC in two meta-analyses). Only one meta-analysis evaluated clinical remission maintenance, showing no statistically significant difference between MTX and placebo, 5-ASA, or 6-MP in UC. AZA and 6-MP had no advantage over placebo in induction of clinical response in CD. Three meta-analyses showed the superiority of tacrolimus vs placebo for induction of clinical response in UC. The clinical response rates for cyclosporine were 41.7% in randomized controlled trials(RCTs) and 55.4% in non-RCTs for UC. For induction of mucosal healing,one meta-analysis showed a favorable rate with tacrolimus versus placebo for UC. For secondary outcomes, no meta-analyses specifically evaluated fecal calprotectin, hospitalization or death. Two meta-analyses were retrieved evaluating colectomy rates for tacrolimus and cyclosporine in UC. Most of the twenty individual studies retrieved contained a low or very low quality of evidence.CONCLUSION High-quality evidence assessing conventional therapy in MS-IBD treatment is scarce, especially for remission maintenance, mucosal healing and fecal calprotectin. | Adérson Omar Mourao Cintra Damiao Matheus Freitas Cardoso de Azevedo Alexandre de Sousa Carlos Marcela Yumi Wada Taciana Valéria Marcolino Silva Flávio de Castro Feitosa | 2019 | World Journal of Gastroenterology2019，25，9： | 13 |
| 5 | A systematic review of clinical practice guidelines and best practice statements for the diagnosis and management of varicocele in children and adolescents显示文摘系统的评论被进行识别并且象临床的实践指南(CPG ) 和最好的建议一样的方法练习的品质上分析有关在小儿科、青春期的人口的精索静脉曲张的陈述(位/秒) 。电子搜索与 MEDLINE 被执行, EMBASE,科学直接,并且 Scielo 数据库,以及 guidelines’网络站点直到 2015 年 9 月。四个指南在质的合成被包括。一般来说,尽管有一些差距的存在, CPG/BPS 提供的建议是一致的。繁殖的药(ASRM ) 的美国 Urological 协会(AUA ) 和美国社会发出的指南没为给的建议提供基于证据的层次。大多数泌尿学(香水) 和小儿科的泌尿学(ESPU ) 的欧洲社会的欧洲协会给的建议从 nonrandomized 被导出临床的试用,回顾的研究,和专家意见。在所有 CPG/BPS 之中,仅仅明确地为小儿科的人口被设计。学习指南没承担独立划算和风险利益分析。这些指南的主要目的是把最好的证据翻译成实践并且当维持临床的自治和医生判断时,提供标准化照顾的一个框架。然而,在孩子和青少年为精索静脉曲张的诊断和管理在 CPG/BPS 识别的限制在耐心的照顾为研究和高质量的标准的未来加入显示宽大的机会。 | Matheus Roque Sandro C Esteves | 2016 | Asian Journal of Andrology2016，18，2： | 9 |
| 6 | Occlusion of the anterior cerebral artery after head trauma显示文摘Intracranial arterial occlusion is rarely encountered in association with head injury.Only six cases of traumatic occlusion of the anterior cerebral artery(ACA) have previously been reported.In this paper,the authors describe a case of a posttraumatic occlusion of ACA.A 35-year-old male presented to the emergency room with severe head injury.Computed tomography(CT) scan displayed diffuse brain swelling with multiple skull fractures.Follow up CT scan showed extensive cerebral infarction in the territory of ACA.The patient underwent CT angiography that demonstrated occlusion of the ACA by a fracture of the anterior fossa.He died after 3 d.ACA traumatic occlusion is a rare condition,with poor prognosis.In this case,fracture was responsible for dissection and direct obstruction of the artery. | Wellingson Silva Paiva Almir Ferreira de Andrade Matheus Schmidt Soares Robson Luis Amorim Eberval Gadelha Figueiredo Manoel Jacobsen Teixeira | 2013 | World Journal of Radiology2013，5，5： | 7 |
| 7 | Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase显示文摘Recently emerged SARS-CoV-2 caused a major outbreak of coronavirus disease 2019(COVID-19)and instigated a widespread fear,threatening global health safety.To date,no licensed antiviral drugs or vaccines are available against COVID-19 although several clinical trials are under way to test possible therapies.During this urgent situation,computational drug discovery methods provide an alternative to tiresome high-throughput screening,particularly in the hit-to-lead-optimization stage.Identification of small molecules that specifically target viral replication apparatus has indicated the highest potential towards antiviral drug discovery.In this work,we present potential compounds that specifically target SARS-CoV-2 vital proteins,including the main protease,Nsp12 RNA polymerase and Nsp13 helicase.An integrative virtual screening and molecular dynamics simulations approach has facilitated the identification of potential binding modes and favourable molecular interaction profile of corresponding compounds.Moreover,the identification of structurally important binding site residues in conserved motifs located inside the active site highlights relative importance of ligand binding based on residual energy decomposition analysis.Although the current study lacks experimental validation,the structural information obtained from this computational study has paved way for the design of targeted inhibitors to combat COVID-19 outbreak. | Muhammad Usman Mirza Matheus Froeyen | 2020 | Journal of Pharmaceutical Analysis2020，10，4： | 7 |
| 8 | Use of testicular sperm for intracytoplasmic sperm injection in men with high sperm DNA fragmentation: a SWOT analysis显示文摘在整洁的精液与精子 DNA 破碎(SDF ) 的高水平从人的睾丸检索的精子趋于有更好的 DNA 质量。在帮助繁殖技术(艺术) 的结果上给 SDF 的否定影响,增加的兴趣为 intracytoplasmic 精子注射(Testi-ICSI ) 关于阴囊的精子的使用出现了。在这篇文章,我们使用了一 SWOT (力量,软弱,机会,和威胁) 总结这干预的优点和缺点的分析。Testi-ICSI 的基本原理是绕过 DNA 破碎通过 epididymis 在精子运输期间由氧化应力引起了的 posttesticular。因此,由 genomically 未经触动的阴囊的精子的卵母细胞授精可以被优化,因此增加创造一个正常胚胎的染色体和最近完成实时出生,,的可能性的机会与高 SDF 在人示威了。然而,仍然关于 Testi-ICSI 的临床的功效有有限证据,因此在除高 SDF 以外的临床的情形象 Testi-ICSI 的调查一样为进一步确定的临床的研究创造机会。而且, Testi-ICSI 能与为与损坏 DNA 取消选择精子的另外的实验室准备方法相比。目前,当在搭挡们其男性有 posttesticular SDF 的不肥沃的夫妇执行 ICSI 时,可得到的文学支持阴囊的精子的使用。由于精子检索的固有的风险,当为减轻 DNA 损坏的不太侵略的处理失败了时, Testi-ICSI 应该被提供。为连续监视的一个电话尽管如此有关产生后代的健康和精子检索的潜在的复杂并发症被要求。 | Sandro C Esteves Matheus Roque Nicolas Garrido | 2018 | Asian Journal of Andrology2018，20，1： | 6 |
| 9 | Multifaceted role of one-carbon metabolism on immunometabolic control and growth during pregnancy, lactation and the neonatal period in dairy cattle显示文摘Dairy cattle undergo dramatic metabolic, endocrine, physiologic and immune changes during the peripartal period largely due to combined increases in energy requirements for fetal growth and development, milk production, and decreased dry matter intake. The negative nutrient balance that develops results in body fat mobilization,subsequently leading to triacylglycerol(TAG) accumulation in the liver along with reductions in liver function,immune dysfunction and a state of inflammation and oxidative stress. Mobilization of muscle and gluconeogenesis are also enhanced, while intake of vitamins and minerals is decreased, contributing to metabolic and immune dysfunction and oxidative stress. Enhancing post-ruminal supply of methyl donors is one approach that may improve immunometabolism and production synergistically in peripartal cows. At the cellular level, methyl donors(e.g. methionine, choline, betaine and folic acid) interact through one-carbon metabolism to modulate metabolism,immune responses and epigenetic events. By modulating those pathways, methyl donors may help increase the export of very low-density lipoproteins to reduce liver TAG and contribute to antioxidant synthesis to alleviate oxidative stress. Thus, altering one-carbon metabolism through methyl donor supplementation is a viable option to modulate immunometabolism during the peripartal period. This review explores available data on the regulation of one-carbon metabolism pathways in dairy cows in the context of enzyme regulation, cellular sensors and signaling mechanisms that might respond to increased dietary supply of specific methyl donors. Effects of methyl donors beyond the one-carbon metabolism pathways, including production performance, immune cell function,mechanistic target or rapamycin signaling, and fatty acid oxidation will also be highlighted. Furthermore, the effects of body condition and feeding system(total mixed ration vs. pasture) on one-carbon metabolism pathways are explored. Potential effects of methyl donor supply during the pepartum period on dairy calf growth and development also are discussed. Lastly, practical nutritional recommendations related to methyl donor metabolism during the peripartal period are presented. Nutritional management during the peripartal period is a fertile area of research, hence, underscoring the importance for developing a systems understanding of the potential immunometabolic role that dietary methyl donors play during this period to promote health and performance. | Danielle N.Coleman Abdulrahman S.Alharthi Yusheng Liang Matheus Gomes Lopes Vincenzo Lopreiato Mario Vailati-Riboni Juan J.Loor | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 5 |
| 10 | Laparoscopy for ventriculoperitoneal shunt implantation and revision surgery显示文摘Ventriculoperitoneal shunting(VPS) is a widely accepted technique for the treatment of hydrocephalus. The probability of shunt dysfunction is pretty high throughout life. Laparoscopy has become a valuable tool to perform VPS and treat abdominal complications. An electronic literature search was performed to reveal the published data relating laparoscopy and ventriculoperitoneal shunt in Medline, Embase, Scielo and Lilacs databases. The keywords employed were 'laparoscopy' OR 'laparoscopic surgery' AND 'ventriculoperitoneal shunt' OR 'shunt' AND 'surgery' OR 'implantation' OR 'revision' OR 'complication'. No high quality trials were developed comparing conventional laparotomic incision vs laparoscopic approach. Both approaches have evolved and currently there are less invasive options for laparotomy, like periumbilical small incisions; and for laparoscopy, like smaller and less incisions. Operating room time, blood loss and hospital stay may be potentially smaller in laparoscopic surgery and complications are probably the same as laparotomy. In revision surgery for abdominal complications after VPS,visualization of whole abdominal cavity is fundamental to address properly the problem and laparoscopic approach is valuable once it is safe, fast and much less invasive than laparotomy. Ventriculoperitoneal shunting is a widely accepted technique for the treatment of hydrocephalus. Laparoscopy assisted shunt surgery in selected cases might be a less invasive and more effective option for intrabdominal manipulation. The laparoscopic approach allows a better catheter positioning, lysis of fibrotic bundles and peritoneal inspection as well, without any additional complication. | Fernando Campos Gomes Pinto Matheus Fernandes de Oliveira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，9： | 5 |
| 11 | Variational Calculus With Conformable Fractional Derivatives显示文摘Invariant conditions for conformable fractional problems of the calculus of variations under the presence of external forces in the dynamics are studied. Depending on the type of transformations considered, different necessary conditions of invariance are obtained. As particular cases, we prove fractional versions of Noether's symmetry theorem. Invariant conditions for fractional optimal control problems, using the Hamiltonian formalism, are also investigated. As an example of potential application in Physics, we show that with conformable derivatives it is possible to formulate an Action Principle for particles under frictional forces that is far simpler than the one obtained with classical fractional derivatives. | Matheus J.Lazo Delfim F.M.Torres | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，2： | 4 |
| 12 | Cumulative sum analysis score and phacoemulsification competency learning curve显示文摘AIM: To use the cumulative sum analysis score(CUSUM) to construct objectively the learning curve of phacoemulsification competency.METHODS: Three second-year residents and an experienced consultant were monitored for a series of 70 phacoemulsification cases each and had their series analysed by CUSUM regarding posterior capsule rupture(PCR) and best-corrected visual acuity. The acceptable rate for PCR was <5%(lower limit h) and the unacceptable rate was >10%(upper limit h). The acceptable rate for bestcorrected visual acuity worse than 20/40 was <10%(lower limit h) and the unacceptable rate was >20%(upper limit h). The area between lower limit h and upper limit h is called the decision interval. RESULTS: There was no statistically significant difference in the mean age, sex or cataract grades between groups. The first trainee achieved PCR CUSUM competency at his 22 nd case. His best-corrected visual acuity CUSUM was in the decision interval from his third case and stayed there until the end, never reaching competency. The second trainee achieved PCR CUSUM competency at his 39 th case. He could reach best-corrected visual acuity CUSUM competency at his 22 nd case. The third trainee achieved PCR CUSUM competency at his 41 st case. He reached bestcorrected visual acuity CUSUM competency at his 14 th case.CONCLUSION: The learning curve of competency in phacoemulsification is constructed by CUSUM and in average took 38 cases for each trainee to achieve it. | Gustavo Vedana Filipe G.Cardoso Alexandre S.Marcon Licio E.K.Araújo Matheus Zanon Daniella C.Birriel Guilherme Watte Albert S.Jun | 2017 | International Journal of Ophthalmology(English edition)2017，10，7： | 3 |
| 13 | Opinion: How to manage subepithelial lesions of the upper gastrointestinal tract?显示文摘Subepithelial lesions(SELs) in the upper gastrointestinal(GI) tract are relatively frequent findings in patients undergoing an upper GI endoscopy. These tumors, which are located below the epithelium and out of reach of conventional biopsy forceps, may pose a diagnostic challenge for the gastroenterologist, especially when SELs are indeterminate after endoscopy and endoscopic ultrasound(EUS). The decision to proceed with further investigation should take into consideration the size, location in the GI tract, and EUS features of SELs. Gastrointestinal stromal tumor(GIST) is an example of an SEL that has a well-recognized malignant potential. Unfortunately, EUS is not able to absolutely differentiate GISTs from other benign hypoechoic lesions from the fourth layer, such as leiomyomas. Therefore, EUS-guided fine needle aspiration(EUS-FNA) is an important tool for correct diagnosis of SELs. However, small lesions(size < 2 cm) have a poor diagnostic yield with EUS-FNA. Moreover, studies with EUS-core biopsy needles did not report higher rates of histologic and diagnostic yields when compared with EUS-FNA. The limited diagnostic yield of EUS-FNA and EUS-core biopsies of SELs has led to the development of more invasive endoscopic techniques for tissue acquisition. There are initial studies showing good results for tissue biopsy or resection of SELs with endoscopic submucosal dissection, suck-ligate-unroof-biopsy, and submucosal tunneling endoscopic resection. | Matheus Cavalcante Franco Ricardo Teles Schulz Fauze Maluf-Filho | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，18： | 3 |
| 14 | Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models显示文摘BACKGROUND(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species,such as Foeniculum vulgare and Peumus boldus,used to treatment of gastrointestinal diseases.Pharmacological studies report its anti-inflammatory,antioxidant,and antinociceptive activity.AIM To investigate antidiarrheal activity related to gastrointestinal motility,intestinal secretion and antimicrobial activity.METHODS A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity.Intestinal transit and gastric emptying protocols were used to assess a possible antimotility effect.Muscarinic receptors,presynaptic α2-adrenergic and tissue adrenergic receptors,KATP channels,nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms.The antimicrobial activity was evaluated in the minimum inhibitory concentration model,the fractional inhibitory concentration index using the(-)-fenchone association method with standard antifungal agents.RESULTS(-)-Fenchone(75,150 and 300 mg/kg)showed antidiarrheal activity,with a significant decrease in the evacuation index.This activity is possibly related to a percentage of reduced intestinal transit(75,150 and 300 mg/kg).The antimotility effect of(-)-fenchone decreased in the presence of pilocarpine,yohimbine,propranolol,L-NG-nitroarginine methyl ester or glibenclamide.In the enteropooling model,no reduction in intestinal fluid weight was observed.(-)-Fenchone did not show antibacterial activity;on the other hand,inhibits the growth of strains of fungi with a minimum fungicide concentration of 32μg/mL.However,when it was associated with amphotericin B,no synergism was observed.CONCLUSION The antidiarrheal effect of(-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms.(-)-Fenchone presents antifungal activity;however,it did not show antibacterial activity. | Michelle Liz de Souza Pessoa Leiliane Macena Oliveira Silva Maria Elaine Cristina Araruna Catarina Alves de Lima Serafim Edvaldo Balbino Alves Junior Alessa Oliveira Silva Matheus Marley Bezerra Pessoa Hermes Diniz Neto Edeltrudes de Oliveira Lima Leonia Maria Batista | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 15 | Drug-induced liver injury and COVID-19:A review for clinical practice显示文摘Coronavirus disease 2019(COVID-19)consists of a systemic disease that can present many complications.The infection presents broad clinical symptoms and a high rate of transmissibility.In addition to severe acute respiratory syndrome,the patients manifest complications beyond the respiratory system.The frequency of liver damage in COVID-19 patients ranges from 14.8% to 53% of patients.One should pay attention to drug-induced liver injury(DILI)in patients with COVID-19,especially considering the off-label use of drugs in prophylactic and therapeutic regimens applied on large scales.This review aims to present relevant information on the medication used so far in COVID-19 patients and its possible hepatotoxicity.We reviewed liver damage in patients with COVID-19 on PubMed and Virtual Health Library to investigate DILI cases.Four studies were selected,involving the medicines remdesivir,tocilizumab and a pharmacovigilance analysis study.The hepatotoxicity profile of drugs presented in the literature considers use in accordance to usual posology standards for treatment.However,drugs currently used in the management of COVID-19 follow different dosages and posology than those tested by the pharmaceutical industry.The deficiency of uniformity and standardization in the assessment of hepatotoxicity cases hinders the publication of information and the possibility of comparing information among healthcare professionals.It is suggested that severe liver injury in COVID-19 patients should be reported in pharmacovigilance institutions,and physicians should pay attention to any considerable abnormal liver test elevation as it can demonstrate unknown drug hepatotoxicity.Liver disorders in COVID-19 patients and the use of several concomitant off-label medications—with a potential risk of further damaging the liver-should at least be a warning sign for rapid identification and early intervention,thus preventing liver damage from contributing to severe impairment in patients. | Gabriela Xavier Ortiz Gabriele Lenhart Matheus William Becker Karin Hepp Schwambach Cristiane Valle Tovo Carine Raquel Blatt | 2021 | World Journal of Hepatology2021，13，9： | 2 |
| 16 | Sugar Cane (Saccharum officinarum L.) Analysis through Biospeckle and Spectroscopy (NIR)显示文摘The objective of this paper was to evaluate the sugar and water content in sugar cane samples by means of twonon-destructive techniques in comparison with conventional methods. One non-destructive technique is the Biospeckle, aninteraction between the laser and the biological material which provides information about the material. The other technique is thenear infrared spectroscopy (NIR). The Biospeckle technique has been constantly used in agricultural engineering. In this paper, therelation between the water and the sugar contents were obtained. The results for the Biospeckle were acquired through the moment ofinertia (MI). The data acquired through already consolidated methodologies were used to quantify the samples' water and sugarcontents, correlating to the spectroscopy results and also to the Biospeckle. It was obtained a high determination coefficient (R^2 =0.9287) between the predicted Brix by the model generated by NIR spectroscopy and Brix measured by refractometer. It was alsopossible to differentiate the water contents of the sugar cane samples both externally lit (husk) and internally lit (cut) by Biospeckleanalysis through the calculation of MI. It is possible to evaluate the water content and the sugar content in samples combiningBiospeckle and NIR spectroscopy, which are non-invasive and non-destructive methods. | Matheus Sevillano Marcondes Keylla Guiguer Silva Armando Kazuo Fujii Ronei Jesus Poppi Juliana Aparecida Fracarolli | 2017 | Journal of Agricultural Science and Technology(B)2017，7，1： | 2 |
| 17 | Clinical outcomes of endoscopic management of pancreatic fluid collections in cirrhotics vs non-cirrhotics: A comparative study显示文摘BACKGROUND Endoscopic management of symptomatic pancreatic fluid collections (PFCs) using self-expandable metal stents (SEMS) placement has emerged as an innovative therapeutic approach with excellent efficacy, safety, and relatively few adverse outcomes. However, their use has not been studied in patients with cirrhosis. Cirrhotics tend to be considered less than optimal candidates due to concern for portal hypertension and coagulopathy related complications. AIM To compare the efficacy and safety of using SEMS for drainage of symptomatic PFCs in cirrhotic vs non-cirrhotic patients. METHODS We conducted a retrospective comparative analysis of patients with symptomatic PFCs [pancreatic pseudocyst (PP) or walled-off necrosis (WON)] who underwent endoscopic ultrasound (EUS)-guided placement of fully covered self-expandable metals stents or lumen-apposing self-expandable metal stents. All patients were followed clinically until resolution of PFCs or death. Definition:(1) Technical success was defined as successful placement of SEMS;and (2) Clinical success was defined as complete resolution of the PFCs without additional interventions including interventional radiology or surgery. Number of procedures performed per patient, number of patients who achieved complete resolution of the PFCs without additional interventions and procedure related adverse events were recorded.RESULTS From January 2012 to December 2017, a total of 88 patients underwent EUSguided drainage of symptomatic PFCs. Of these, 58 non cirrhotic patients underwent plastic stent insertion for management of PFC and 30 patients, 5 with cirrhosis and 25 without cirrhosis, underwent EUS-guided transmural drainage with SEMS, including 18 (60%) PP and 12 (40%) WON. Technical success was achieved in all 30 patients. Clinical success was achieved in 60% cirrhotic patients and 92% non-cirrhotics (P = 0.12). Procedure-related adverse events were 60% in cirrhotic and 28% non-cirrhotic (P = 0.62). Moreover, fatal adverse events were statistically more common in cirrhotics compared with non-cirrhotics (0 vs 40%;P = 0.023). Successful stent removal following resolution of the PFC, was 60% in cirrhotics and 80% in non-cirrhotics (P = 0.57). Post-procedure length of hospitalization was 18.6 ± 20.3 d in cirrhotics and 5.6 ± 13.7 d in non-cirrhotics (P = 0.084). CONCLUSION EUS-guided management of PFC using SEMS placement has a high technical and clinical success rate in non-cirrhotics. However, in cirrhotics caution must be exercised given the high morbidity and mortality as evidenced by our cohort, particularly for the endoscopic debridement of WONs. Larger, multicenter studies are warranted to further characterize the risk profile and outcomes in these patients. | Sobia Laique Matheus C Franco Tyler Stevens Amit Bhatt John J Vargo Prabhleen Chahal | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，6： | 2 |
| 18 | Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A recep- tom显示文摘 | MANIYKTA P K ANGELO O R MATHEUS M R | 2004 | Nemvscience Letters2004，355，： | 1 |
| 19 | Wireless Technology in Industrial Networks 显示文摘 | Andreas Willig Kirsten Matheus Adam Wolisz | 2005 | Proceedings of the IEEE2005，93，6： | 1 |
| 20 | Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease显示文摘 | Matheu V Back O Mondoc E Issazadeh-Navikas S | 2003 | J Allergy Clin Immunol2003，112，3： | 1 |
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