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| 1 | Liver transplantation and alcoholic liver disease:History,controversies,and considerations显示文摘Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease(ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation(LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a 'self-inflicted disease'. One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide. For a patient to be placed on an LT waiting list, 6 mo of abstinence must have been achieved for most LT centers. However, this '6-mo rule' is an arbitrary threshold and has never been shown to affect survival, sobriety, or other outcomes. Recent studies have shown similar survival rates among individuals who undergo LT for ALD and those who undergo LT for other chronic causes of end-stage liver disease. There are specific factors that should be addressed when evaluating LT patients with ALD because these patients commonly have a high prevalence of multisystem alcohol-related changes. Risk factors for relapse include the presence of anxiety or depressive disorders, short pre-LT duration of sobriety, and lack of social support. Identification of risk factors and strengthening of the social support system may decrease relapse among these patients. Family counseling for LT candidates is highly encouraged to prevent alcohol consumption relapse. Relapse has been associated with unique histopathological changes, graft damage, graft loss, and even decreased survival in some studies. Research has demonstrated the importance of a multidisciplinary evaluation of LT candidates. Complete abstinence should be attempted to overcome addiction issues and to allow spontaneous liver recovery. Abstinence is the cornerstone of ALD therapy. Psychotherapies, including 12-step facilitation therapy, cognitive-behavioral therapy, and motivational enhancement therapy, help support abstinence. Nutritional therapy helps to reverse muscle wasting, weight loss, vitamin deficiencies, and trace element deficiencies associated with ALD. For muscular recovery, supervised physical activity has been shown to lead to a gain in muscle mass and improvement of functional activity. Early LT for acute alcoholic hepatitis has been the subject of recent clinical studies, with encouraging results in highly selected patients. The survival rates after LT for ALD are comparable to those of patients who underwent LT for other indications. Patients that undergo LT for ALD and survive over 5 years have a higher risk of cardiorespiratory disease, cerebrovascular events, and de novo malignancy. | Claudio Augusto Marroni Alfeu de Medeiros Fleck Jr Sabrina Alves Fernandes Lucas Homercher Galant Marcos Mucenic Mario Henrique de Mattos Meine Guilherme Mariante-Neto Ajacio Bandeira de Mello Brandao | 2018 | World Journal of Gastroenterology2018，24，26： | 7 |
| 2 | GPU-accelerated molecular dynamics simulation for study of liquid crystalline flows显示文摘 | Alfeus Sunarso Tomohiro Tsuji Shigeomi Chono | 2010 | Journal of Computational Physics2010，，15： | 1 |
| 3 | A Long-Range Generalized Predictive Control Algorithm for a DFIG Based Wind Energy System显示文摘This paper presents a new Long-range generalized predictive controller in the synchronous reference frame for a wind energy system doubly-fed induction generator based. This controller uses the state space equations that consider the rotor current and voltage as state and control variables, to execute the predictive control action. Therefore, the model of the plant must be transformed into two discrete transference functions, by means of an auto-regressive moving average model, in order to attain a discrete and decoupled controller, which makes it possible to treat it as two independent single-input single-output systems instead of a magnetic coupled multiple-input multiple-output system. For achieving that, a direct power control strategy is used, based on the past and future rotor currents and voltages estimation. The algorithm evaluates the rotor current predictors for a defined prediction horizon and computes the new rotor voltages that must be injected to controlling the stator active and reactive powers. To evaluate the controller performance, some simulations were made using Matlab/Simulink. Experimental tests were carried out with a small-scale prototype assuming normal operating conditions with constant and variable wind speed profiles. Finally, some conclusions respect to the dynamic performance of this new controller are summarized. | J.S.Solis-Chaves Lucas L.Rodrigues C.M.Rocha-Osorio Alfeu J.Sguarezi Filho | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，5： | 1 |
| 4 | Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas显示文摘 | Alfeu Zanotto-Filho Elizandra Braganhol Karina Klafke Fabrício Figueiró Sílvia Resende Terra Francis Jackson Paludo Maurílio Morrone Ivi Juliana Bristot Ana Maria Battastini Cassiano Mateus Forcelini Alexander James Roy Bishop Daniel Pens Gelain José Cláu | 2014 | Cancer Letters2014，，： | 1 |
| 5 | Curcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacologicalefficacy of curcumin in glioma treatment显示文摘 | Alfeu Z F Karine C Elizandra B | 2013 | European Journal ofPharmaceutics and Biopharmaceutics2013，，83： | 1 |
| 6 | Esti mation of the Benefits Yielded by Pressure Management in Wa- ter Distribution Systems 显示文摘 | Ricardo GOMES Alfeu Sd MARQUES Joaquim SOUSA | 2011 | Urban Water Journal2011，8，2： | 1 |
| 7 | A predictive power control for wind energy显示文摘 | Filho Alfeu J Sguarezi de Oliveira Filho M E | 2011 | IEEE Trans on Sustainable Energy2011，2，1： | 1 |
| 8 | Propensity-matched analysis of patients with intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma and hepatocellular carcinoma undergoing a liver transplant显示文摘BACKGROUND Cholangiocarcinoma(CC)is a rare tumor that arises from the epithelium of the bile ducts.It is classified according to anatomic location as intrahepatic,perihilar,and distal.Intrahepatic CC(ICC)is rare in patients with cirrhosis due to causes other than primary sclerosing cholangitis.Mixed hepatocellular carcinoma-CC(HCC-CC)is a rare neoplasm that shows histologic findings of both HCC and ICC within the same tumor mass.Due to the difficulties in arriving at the correct diagnosis,patients eventually undergo liver transplantation(LT)with a presumptive diagnosis of HCC on imaging when,in fact,they have ICC or HCC-CC.AIM To evaluate the outcomes of patients with intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma on pathological examination after liver transplant.METHODS Propensity score matching was used to analyze tumor recurrence(TR),overall mortality(OM),and recurrence-free survival(RFS)in LT recipients with pathologically confirmed ICC or HCC-CC matched 1:8 to those with HCC.Progression-free survival and overall mortality rates were computed with the Kaplan-Meier method using Cox regression for comparison.RESULTS Of 475 HCC LT recipients,1.7%had the diagnosis of ICC and 1.5%of HCC-CC on pathological examination of the explant.LT recipients with ICC had higher TR(46%vs 11%;P=0.006),higher OM(63%vs 23%;P=0.002),and lower RFS(38%vs 89%;P=0.002)than those with HCC when matched for pretransplant tumor characteristics,as well as higher TR(46%vs 23%;P=0.083),higher OM(63%vs 35%;P=0.026),and lower RFS(38%vs 59%;P=0.037)when matched for posttransplant tumor characteristics.Two pairings were performed to compare the outcomes of LT recipients with HCC-CC vs HCC.There was no significant difference between the outcomes in either pairing.CONCLUSION Patients with ICC had worse outcomes than patients undergoing LT for HCC.The outcomes of patients with HCC-CC did not differ significantly from those of patients with HCC. | Ajacio Bandeira de Mello Brandão Santiago Rodriguez Alfeu de Medeiros Fleck Jr Claudio Augusto Marroni Mário B Wagner Alex Hörbe Matheus V Fernandes Carlos TS Cerski Gabriela Perdomo Coral | 2022 | World Journal of Clinical Oncology2022，13，8： | 0 |
| 9 | Co-Simulation of an SRG Wind Turbine Control and GPRS/EGPRS Wireless Standards in Smart Grids显示文摘Wind energy can be considered a push-driver factor in the integration of renewable energy sources within the concept of smart grids.For its full deployment,it requires a modern telecommunication infrastructure for transmitting control signals around the distributed generation,in which,the wireless communication standards stand out for employing modern digital modulation and coding schemes for error correction,in order to guarantee the power plant operability.In some developing countries,such as Brazil,the high penetration of commercial mobile wireless standards GPRS and EGPRS(based on GSM technology)have captivated the interests of the energy sector,and they now seek to perform remote monitoring and control operations.In this context,this article presents a comparative performance analysis of a wireless control system for a wind SRG,when a GPRS or EGPRS data service is employed.The system performance is analyzed by co-simulations,including the wind generator dynamics and the wireless channel effects.The satisfactory results endorse the viability and robustness of the proposed system. | Andre Luiz de Oliveira Carlos Eduardo Capovilla Ivan Roberto Santana Casella JoséLuis Azcue-Puma Alfeu J.Sguarezi Filho | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，3： | 0 |
| 10 | A novel stochastic modeling framework for coal production and logistics through options pricing analysis显示文摘We propose a novel stochastic modeling framework for coal production and logistics using option pricing theory.The problem of valuing the inherent real optionality a coal producer has when mining and processing thermal coal is modelled as pricing spread options of three assets under the stochastic volatility model.We derive a three-dimensional Fast Fourier Transform(“FFT”)lower bound approximation to value the inherent real optionality and for robustness check,we compare the semi-analytical pricing accuracy with the Monte Carlo simulation.Model parameters are estimated from the historical monthly data,and stochastic volatility parameters are obtained by matching the Kurtosis of the low-ash diff data to the Kurtosis of the stochastic volatility process which is assumed to follow Cox–Ingersoll–Ross(“CIR”)model. | Mesias Alfeus James Collins | 2023 | Financial Innovation2023，9，1： | 0 |
| 11 | Correction:Propensity-matched analysis of patients with intrahepatic cholangiocarcinoma or mixed hepatocellularcholangiocarcinoma and hepatocellular carcinoma undergoing a liver transplant显示文摘Rereading the article“Propensity-matched analysis of patients with intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma and hepatocellular carcinoma undergoing a liver transplant”(DOI:10.5306/wjco.v13.i8.688),published on August 24,we observe,with concern,that figures 3 and 4 are wrong.The authors have attached the correct figures for correction. | Ajacio Bandeira de Mello Brandão Santiago Rodriguez Alfeu de Medeiros Fleck Jr Claudio Augusto Marroni Mário B Wagner Alex Hörbe Matheus V Fernandes Carlos TS Cerski Gabriela Perdomo Coral | 2023 | World Journal of Clinical Oncology2023，14，6： | 0 |
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