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| 1 | Outcome of nonerosive gastro-esophageal reflux disease patients with pathological acid exposure显示文摘AIM: To assess the management and outcome of nonerosive gastro-esophageal reflux disease (NERD) patients who were identified retrospectively, after a 5-year follow-up.METHODS: We included patients with gastro-esophageal reflux disease (GERD) symptoms who had a negative endoscopy result and pathological 24-h esophageal pH-monitoring while off therapy. We interviewed them after an average period of 5 years (range 3.5-7 years) by means of a structured questionnaire to assess presence of GERD symptoms, related therapy, updated en-doscopic data and other features. We assessed predictors of esophagitis development by means of univariate and multivariate statistical analysis.RESULTS: 260 patients (137 women) were included. Predominant GERD symptoms were heartburn andregurgitation in 103/260 (40%). 70% received a maintenance treatment, which was proton pump inhibitor (PPI) in 55% of cases. An average number of 1.5 symptomatic relapses per patient/year of follow-up were observed. A progression to erosive gastro-esophageal reflux disease (ERD) was found in 58/193 (30.0%) of patients undergoing repeat endoscopy; 72% of these were Los Angeles grade A-B. CONCLUSION: This study shows that progression to ERD occurs in about 5% of NERD cases per year, despite therapy. Only two factors consistently and independently influence progression: smoking and absence of PPI therapy. | Fabio Pace Stefano Pallotta Gianpiero Manes Annalisa de Leone Patrizia Zentilin Luigi Russo Vincenzo Savarino Matteo Neri Enzo Grossi Rosario Cuomo | 2009 | World Journal of Gastroenterology2009，15，45： | 8 |
| 2 | CUBE, a Cable-driven Device for Limb Rehabilitation显示文摘In this paper, a novel cable-driven parallel robot, CUBE, is introduced for the assistance of patients in rehabilitation exercising of both upper and lower limbs. The system is characterized by a lightweight structure that is easy to set-up and operate, for both clinical and home usage for both pre-determined and customized exercises, with control over the position of the end-effector while locking its rotation around the horizontal axes. Its cable-driven design makes it inherently safe in human/robot interactions also due to the extremely low inertia. While a novel end-effector design makes the device wearable both on the upper and lower limbs without having to disassemble any part of the structure. The design is presented with its kinematic analysis. Then, the manufacturing through 3D?printing and commercial components of a first prototype is reported. Finally, the system is validated through motion tests along simple trajectories and two different spatial exercises. | Daniele Cafolla Matteo Russo Giuseppe Carbone | 2019 | Journal of Bionic Engineering2019，16，3： | 6 |
| 3 | Long term follow-up and outcome of liver transplantation from hepatitis B surface antigen positive donors显示文摘Liver transplant for hepatitis B virus(HBV) currently yields excellent outcomes: it allows to rescue patients with an HBV-related advanced liver disease, resulting in a demographical modification of the waiting list for liver transplant. In an age of patient-tailored treatments, in liver transplantation as well the aim is to offer the best suitable graft to the patient who can benefit from it, also expanding the criteria for organ acceptance and allocation. With the intent of developing strategies to increase the donor pool, we set-up a multicenter study involving 3 Liver Transplant Centers in Italy: patients undergoing liver transplantation between March 03, 2004, and May 21, 2010, were retrospectively evaluated. 1408 patients underwent liver transplantation during the study period, 28(2%) received the graft from hepatitis B surface antigen positive(HBs Ag)-positive deceased donors. The average follow-up after liver transplantation was 63.7 mo [range: 0.1-119.4; SD ± 35.8]. None Primary nonfunction, re-liver transplantation, early or late hepatic artery thrombosis occurred. The 1-, 3-and 5-year graft and patient survival resulted of 85.7%, 82.1%, 78.4%. Our results suggest that the use of HBs Agpositive donors liver grafts is feasible, since HBV can be controlled without affecting graft stability. However, the selection of grafts and the postoperative antiviral therapy should be managed appropriately. | Roberto Ballarin Alessandro Cucchetti Francesco Paolo Russo Paolo Magistri Matteo Cescon Umberto Cillo Patrizia Burra Antonio Daniele Pinna Fabrizio Di Benedetto | 2017 | World Journal of Gastroenterology2017，23，12： | 4 |
| 4 | Effect of ancient Khorasan wheat on gut microbiota,inflammation,and short-chain fatty acid production in patients with fibromyalgia显示文摘BACKGROUND Fibromyalgia(FM)syndrome is mainly characterized by widespread pain,sleeping disorders,fatigue,and cognitive dysfunction.In many cases,gastrointestinal distress is also reported,suggesting the potential pathogenic role of the gut microbiota(GM).The GM is deeply influenced by several environmental factors,especially the diet,and recent findings highlighted significant symptom improvement in FM patients following various nutritional interventions such as vegetarian diet,low-fermentable oligosaccharides,disaccharides,monosaccharides,and polyols based diets,gluten-free diet,and especially an ancient grain supplementation.In particular,a recent study reported that a replacement diet with ancient Khorasan wheat led to an overall improvement in symptom severity of FM patients.AIM To examine the effects of ancient Khorasan wheat on the GM,inflammation,and short-chain fatty acid production in FM patients.METHODS After a 2-wk run-in period,20 FM patients were enrolled in this randomized,double-blind crossover trial.In detail,they were assigned to consume either Khorasan or control wheat products for 8 wk and then,following an 8-wk washout period,crossed.Before and after treatments,GM characterization was performed by 16S rRNA sequencing while the fecal molecular inflammatory response and the short-chain fatty acids(SCFAs)were respectively determined with the Luminex MAGPIX detection system and a mass chromatography-mass spectrometry method.RESULTS The Khorasan wheat replacement diet,in comparison with the control wheat diet,had more positive effects on intestinal microbiota composition and on both the fecal immune and SCFAs profiles such as the significant increase of butyric acid levels(P=0.054),candidatus Saccharibacteria(P=9.95e-06)and Actinobacteria,and the reduction of Enterococcaceae(P=4.97e-04).Moreover,the improvement of various FM symptoms along with the variation of some gut bacteria after the Khorasan wheat diet have been documented;in fact we reported positive correlations between Actinobacteria and both Tiredness Symptoms Scale(P<0.001)and Functional Outcome of Sleep Questionnaire(P<0.05)scores,between Verrucomicrobiae and both Widespread Pain Index(WPI)+Symptom Severity scale(SS)(P<0.05)and WPI(P<0.05)scores,between candidatus Saccharibacteria and SS score(P<0.05),and between Bacteroidales and Sleep-Related and Safety Behaviour Questionnaire score(P<0.05).CONCLUSION The replacement diet based on ancient Khorasan wheat results in beneficial GM compositional and functional modifications that positively correlate with an improvement of FM symptomatology. | Simone Baldi Giuditta Pagliai Monica Dinu Leandro Di Gloria Giulia Nannini Lavinia Curini Marco Pallecchi Edda Russo Elena Niccolai Giovanna Danza Stefano Benedettelli Giovanna Ballerini Barbara Colombini Gianluca Bartolucci Matteo Ramazzotti Francesco Sofi Amedeo Amedei | 2022 | World Journal of Gastroenterology2022，28，18： | 1 |
| 5 | Helicobacter pylori strains and histologically-related lesions affect the outcome of triple eradication therapy:a study from southern Italy显示文摘 | Russo F Berloco P Cuomo R Caruso ML Di Matteo G Giorgio P | 2003 | Aliment Pharmacol Ther2003，17，3： | 1 |
| 6 | Co‐expression of CD133+/CD44+ in human colon cancer and liver metastasis显示文摘 | Antonia Bellizzi Sinto Sebastian Pasquale Ceglia Matteo Centonze Rosa Divella Elvira Foglia Manzillo Amalia Azzariti Nicola Silvestris Severino Montemurro Cosimo Caliandro Raffaele De Luca Giuseppe Cicero Sergio Rizzo Antonio Russo Michele Quaranta Giovan | 2012 | J. Cell. Physiol2012，，2： | 1 |
| 7 | Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation显示文摘 | Andrea Frustaci Cristina Chimente Fulvio Bellocci Emanuela Morgante Matteo A. Russo Attilio Maseri | 1997 | Circulation1997，，4： | 1 |
| 8 | Midarm muscle circumference, physical performance and mortality: Results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study)显示文摘 | Francesco Landi Andrea Russo Rosa Liperoti Marco Pahor Matteo Tosato Ettore Capoluongo Roberto Bernabei Graziano Onder | 2009 | Clinical Nutrition2009，，4： | 1 |
| 9 | SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation显示文摘 | Luigi Sansone Valentina Reali Laura Pellegrini Lidia Villanova Michele Aventaggiato Gabriella Marfe Roberta Rosa Marcella Nebbioso Marco Tafani Massimo Fini Matteo A. Russo Bruna Pucci | 2013 | J Cell Physiol2013，，8： | 1 |
| 10 | Four chamber view plus three-vessel and trachea view for a complete evaluation of the fetal heart during the second trimester显示文摘 | Antongiulio Del Bianco Salvatore Russo Nicola Lacerenza Matteo Rinaldi Giuseppe Rinaldi Luigi Nappi Pantaleo Greco | 2006 | Journal of Perinatal Medicine2006，，4： | 1 |
| 11 | Current application of neurofilaments in amyotrophic lateral sclerosis and future perspectives显示文摘Motor neuron disease includes a heterogeneous group of relentless progressive neurological disorders defined and characterized by the degeneration of motor neurons.Amyotrophic lateral sclerosis is the most common and aggressive form of motor neuron disease with no effective treatment so far.Unfortunately,diagnostic and prognostic biomarkers are lacking in clinical practice.Neurofilaments are fundamental structural components of the axons and neurofilament light chain and phosphorylated neurofilament heavy chain can be measured in both cerebrospinal fluid and serum.Neurofilament light chain and phosphorylated neurofilament heavy chain levels are elevated in amyotrophic lateral sclerosis,reflecting the extensive damage of motor neurons and axons.Hence,neurofilaments are now increasingly recognized as the most promising candidate biomarker in amyotrophic lateral sclerosis.The potential usefulness of neurofilaments regards various aspects,including diagnosis,prognosis,patient stratification in clinical trials and evaluation of treatment response.In this review paper,we review the body of literature about neurofilaments measurement in amyotrophic lateral sclerosis.We also discuss the open issues concerning the use of neurofilaments clinical practice,as no overall guideline exists to date;finally,we address the most recent evidence and future perspectives. | Yuri Matteo Falzone Tommaso Russo Teuta Domi Laura Pozzi Angelo Quattrini Massimo Filippi Nilo Riva | 2021 | Neural Regeneration Research2021，16，10： | 1 |
| 12 | Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation显示文摘 | Andrea Frustaci Cristina Chimente Fulvio Bellocci Emanuela Morgante Matteo A. Russo Attilio Maseri | 1997 | Circulation1997，，4： | 1 |
| 13 | Transoral stapling for Zenker diverticulum: effect of the traction suture-assisted technique on long-term outcomes显示文摘 | Luigi Bonavina Matteo Rottoli Davide Bona Stefano Siboni Iris Russo Daniele Bernardi | 2012 | Surgical Endoscopy2012，，10： | 1 |
| 14 | Reciprocal Regulation of MicroRNA-1 and Insulin-Like Growth Factor-1 Signal Transduction Cascade in Cardiac and Skeletal Muscle in Physiological and Pathological Conditions显示文摘 | Leonardo Elia Riccardo Contu Manuela Quintavalle Francesca Varrone Cristina Chimenti Matteo Antonio Russo Vincenzo Cimino Laura De Marinis Andrea Frustaci Daniele Catalucci Gianluigi Condorelli | 2009 | Circulation2009，，23： | 1 |
| 15 | Histological substrate of human atrial fibrillation显示文摘 | Cristina Chimenti Matteo A. Russo Angelo Carpi Andrea Frustaci | 2009 | Biomedicine & Pharmacotherapy2009，，3： | 1 |
| 16 | Reciprocal Regulation of MicroRNA-1 and Insulin-Like Growth Factor-1 Signal Transduction Cascade in Cardiac and Skeletal Muscle in Physiological and Pathological Conditions显示文摘 | Leonardo Elia Riccardo Contu Manuela Quintavalle Francesca Varrone Cristina Chimenti Matteo Antonio Russo Vincenzo Cimino Laura De Marinis Andrea Frustaci Daniele Catalucci Gianluigi Condorelli | 2009 | Circulation2009，，： | 1 |
| 17 | Effects of viremia and CD4 recovery on gut“microbiome-immunity”axis in treatment-na?ve HIV-1-infected patients undergoing antiretroviral therapy显示文摘BACKGROUND Human immunodeficiency virus type 1(HIV-1)infection is characterized by persistent systemic inflammation and immune activation,even in patients receiving effective antiretroviral therapy(ART).Converging data from many cross-sectional studies suggest that gut microbiota(GM)changes can occur throughout including human immunodeficiency virus(HIV)infection,treated by ART;however,the results are contrasting.For the first time,we compared the fecal microbial composition,serum and fecal microbial metabolites,and serum cytokine profile of treatment-na?ve patients before starting ART and after reaching virological suppression,after 24 wk of ART therapy.In addition,we compared the microbiota composition,microbial metabolites,and cytokine profile of patients with CD4/CD8 ratio<1(immunological non-responders[INRs])and CD4/CD8>1(immunological responders[IRs]),after 24 wk of ART therapy.AIM To compare for the first time the fecal microbial composition,serum and fecal microbial metabolites,and serum cytokine profile of treatment-na?ve patients before starting ART and after reaching virological suppression(HIV RNA<50 copies/m L)after 24 wk of ART.METHODS We enrolled 12 treatment-na?ve HIV-infected patients receiving ART(mainly based on integrase inhibitors).Fecal microbiota composition was assessed through next generation sequencing.In addition,a comprehensive analysis of a blood broad-spectrum cytokine panel was performed through a multiplex approach.At the same time,serum free fatty acid(FFA)and fecal short chain fatty acid levels were obtained through gas chromatography-mass spectrometry.RESULTS We first compared microbiota signatures,FFA levels,and cytokine profile before starting ART and after reaching virological suppression.Modest alterations were observed in microbiota composition,in particular in the viral suppression condition,we detected an increase of Ruminococcus and Succinivibrio and a decrease of Intestinibacter.Moreover,in the same condition,we also observed augmented levels of serum propionic and butyric acids.Contemporarily,a reduction of serum IP-10 and an increase of IL-8 levels were detected in the viral suppression condition.In addition,the same components were compared between IRs and INRs.Concerning the microflora population,we detected a reduction of Faecalibacterium and an increase of Alistipes in INRs.Simultaneously,fecal isobutyric,isovaleric,and 2-methylbutyric acids were also increased in INRs.CONCLUSION Our results provided an additional perspective about the impact of HIV infection,ART,and immune recovery on the'microbiome-immunity axis'at the metabolism level.These factors can act as indicators of the active processes occurring in the gastrointestinal tract.Individuals with HIV-1 infection,before ART and after reaching virological suppression with 24 wk of ART,displayed a microbiota with unchanged overall bacterial diversity;moreover,their systemic inflammatory status seems not to be completely restored.In addition,we confirmed the role of the GM metabolites in immune reconstitution. | Edda Russo Giulia Nannini Gaetana Sterrantino Seble Tekle Kiros Vincenzo Di Pilato Marco Coppi Simone Baldi Elena Niccolai Federica Ricci Matteo Ramazzotti Marco Pallecchi Filippo Lagi Gian Maria Rossolini Alessandro Bartoloni Gianluca Bartolucci Amedeo Amedei | 2022 | World Journal of Gastroenterology2022，28，6： | 0 |
| 18 | Battery with Integrated Power Supply(BALIN)显示文摘The BALIN is a modern device,consisting of a battery with integrated battery charger,dedicated to powering the 24 V services of the carriages.In various Trenitalia rolling stock,used for the regional transport of travelers,there are old and obsolete battery charger devices and there are lead acid batteries that need frequent maintenance operations to be kept efficient.These components,due to their low reliability,are the source of serious disruptions to passenger transport,and the management of their maintenance involves high costs for Trenitalia.In order to solve these problems,Trenitalia has therefore decided to invest resources to develop a new system of integrated power supplies and batteries,therefore the BALIN has been developed.The main advantages of BALIN compared to the original components are the presence of a high energy efficiency battery charger designed to operate in a wide range of temperatures and the presence of sealed lead-acid batteries without maintenance with a life exceeding 6 years.The BALIN is able to disconnect its own batteries from the carriage electrical circuits.The BALIN battery charger also implements an intelligent battery management logic and thanks to the interface with the command and control signals present on the rolling stock,the batteries are isolated from the carriage electric load automatically when the train is off and the service it's over.Another important automatic feature of the BALIN is to protect its batteries from deep discharge,in fact the power supply from the batteries to the electric carriage loads is interrupted when the voltage reaches 21 V.The characteristics mentioned go towards the reduction of the charge/discharge cycles of batteries and contribute to increasing the reliability and durability of batteries throughout the entire life of the rolling stock. | Matteo Nobili Lorenzo Flaccomio David Russo Giuseppe Grande Alfredo Biancucci | 2020 | Journal of Traffic and Transportation Engineering2020，8，3： | 0 |
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