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| 1 | Intracameral lidocaine as supplement to classic topical anesthesia for relieving ocular pain in cataract surgery显示文摘AIM: To evaluate safety, efficacy, and patient adherence of intracameral lidocaine as supplement of classic topical anesthetic drops in cataract surgery.METHODS: A prospective and controlled trial including a large cohort of 1650 individuals suffering with bilateral cataract not complicated, in program by phacoemulsification surgery, were randomly assigned to 2 different groups for the type of anesthesia received, 0.4% oxybuprocaine hydrochloride(INN) drops, and INN drops associated to intracameral 1% lidocaine hydrochloride monohydrate. At the end of surgery, tables were assigned to each patient indicating the degree of pain(0-3) felt during the operation.RESULTS: Thirty-two percent of patients in group 1 declared to have not felt any pain against the 77% of patients in group 2. Fifty-nine percent of patients in group 1 complained about only a slight discomfort against 20% of group 2 patients. Only a small percentage of patients in group 1(5%) admitted severe pain, while no patient in group 2 admitted severe pain. Four patients of group 2 reported an episode of transient amaurosis, lasting several hours after surgery.CONCLUSION: Intracameral administration of lidocaine is a simple and secure method able to increase the analgesia during the cataract surgery, eliminating the discomfort and increasing also the cooperation of the patients during the steps of manipulation. | Marcella Nebbioso Maria Luisa Livani Valentina Santamaria Aloisa Librando Massimiliano Sepe | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 3 |
| 2 | Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases显示文摘 | Antonello Mai Dante Rotili Domenico Tarantino Angela Nebbioso Sabrina Castellano Gianluca Sbardella Marc Tini Lucia Altucci | 2009 | Bioorganic & Medicinal Chemistry Letters2009，，4： | 2 |
| 3 | Molecular characterization of dissolved organic matter (DOM):a critical review 显示文摘 | NEBBIOSO A PICCOLO A | 2013 | Analytical & Bioanalytical Chemistry2013，405，1： | 1 |
| 4 | Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells显示文摘 | Nebbioso A Clarke N Vohz E | 2005 | Nat Med2005，11，1： | 1 |
| 5 | Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells显示文摘 | Nebbioso A Clarke N Voltz E | 2005 | Nat Med2005，11，1： | 1 |
| 6 | Molecular characterization of dissolved organic matter (DOM): a critical review 显示文摘 | Nebbioso A Piccolo A | 2013 | Analytical and Bioanalytical Chemistry2013，405，： | 1 |
| 7 | Role of the dopaminer- gic system in the development of myopia in children and ado- leseents显示文摘 | Nebbioso M Plateroti AM Pueei B | 2014 | J Child Neurol2014，29，12： | 1 |
| 8 | New pyrrole based histone deacetylase inhibitors: binding mode,enzyme and cell-based investigations显示文摘 | Mai A Valente S Nebbioso A Simeoni S Ragno R Massa S | 2009 | Int J Biochem Cell Biol2009，41，： | 1 |
| 9 | Molecular characterization of dissolved organic matter (DOM) : A critical review 显示文摘 | Nebbioso A Piccolo A | 2013 | Analytical and Bioanalytical Chemistry2013，405，1： | 1 |
| 10 | New insight into visual function with aspherical intraocular lends (IOLs): Tecnis ZCB00 and Acrysof SN60WF 显示文摘 | Salvatore S Lupo S Nebbioso M | 2011 | Int Ophthalmol2011，31，5： | 1 |
| 11 | Role of the dopaminergic system in the development of myopia in children and adolescents显示文摘 | Nebbioso M Plateroti AM Pucci B | 2014 | J Child Neurol2014，29，12： | 1 |
| 12 | Novel uracil-based 2 amin- oanilide and 2-aminoanilide-like derivatives: histone deaeetylase inhibition and in-cell activities显示文摘 | Mai A Perrone A Nebbioso A | 2008 | Bioorg Med Chem Lett2008，18，8： | 1 |
| 13 | Retina in rheumatic diseases:standard full field and multifocal electroretinography in hydroxychloroquine retinal dysfunction显示文摘 | Nebbioso M Livani ML Steigerwalt RD | 2011 | Clin Exp Optom2011，94，3： | 1 |
| 14 | High-mobility group box-1 (HMGB-1) and serum soluble receptor for ad- vanced glycation end products (sRAGE) in children affected by vernal keratoconjunctivitis显示文摘 | Zicari A M Zicari A Nebbioso M | 2014 | Pediatr Allergy Immu- nol2014，25，1： | 1 |
| 15 | Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities显示文摘 | Mai A Perrone A Nebbioso A | 2008 | Bioorg Med Chem Lett2008，18，： | 1 |
| 16 | Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells显示文摘 | Nebbioso A Clarke N Voltz E Germain E Ambrosino C Bontempo P | 2005 | Nat Med2005，11，1： | 1 |
| 17 | Early detection of macular changes with multifocal ERG in patients on antimalarial drug therapy显示文摘 | Nebbioso M Grenga R Karavitis P | 2009 | J Ocul Pharmacal Ther2009，25，3： | 1 |
| 18 | Histone deacetylase inhibitors and hemoglobin F induction in β thalassemia显示文摘 | Anna Rita Migliaccio Dante Rotili Angela Nebbioso | 2008 | Int Biochem Cell Biol2008，40，： | 1 |
| 19 | New insight into visual function with aspherical intraocular lenses (IOLs):Tecnis ZCB00 and Acrysof SN60WF显示文摘 | Salvamre S Lupo S Nebbioso M Huang YH Vingolo EM | | 0，，05： | 1 |
| 20 | Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities 显示文摘 | Mai A Perrone A Nebbioso A | 2008 | Bioorg Med Chem Lett2008，18，： | 1 |
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