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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 3 | Current concepts and future strategies in the antimicrobial therapy of emerging Gram-positive spontaneous bacterial peritonitis显示文摘Spontaneous bacterial peritonitis(SBP) is the most common infection in end-stage liver disease patients.SBP is defined as an ascitic fluid infection with a polymorphonuclear leucocyte count ≥ 250/mm^3 without an evident intra-abdominal surgically treatable source.Several mechanisms contribute to SBP occurrence,including translocation of gut bacteria and their products,reduced intestinal motility provoking bacterial overgrowth,alteration of the gut's barrier function and local immune responses.Historically,Gram-negative enteric bacteria have been the main causative agents of SBP,thereby guiding the empirical therapeutic choice.However,over the last decade,a worryingly increasing prevalence of Gram-positive and multi-drug resistant(MDR) SBP has been seen.Recently,the microbiological spectrum of SBP seems to have changed in Europe due to a high prevalence of Gram-positive bacteria(48%-62%).The overall proportion of MDR bacteria is up to 22%-73% of cases.Consequently,empirical therapy based on thirdgeneration cephalosporins or amoxicillin/clavulanic acid,can no longer be considered the standard of care,as these drugs are associated with poor outcomes.Theaim of this review is to describe,with an epidemiological focus,the evidence behind this rise in Gram-positive and MDR SBP from 2000 to present,and illustrate potential targeted therapeutic strategies.An appropriate treatment protocol should include daptomycin plus ceftaroline and meropenem,with prompt stepdown to a narrower spectrum when cultures and sensitivity data are available in order to reduce both cost and potential antibiotic resistance development. | Marco Fiore Alberto Enrico Maraolo Ivan Gentile Guglielmo Borgia Sebastiano Leone Pasquale Sansone Maria Beatrice Passavanti Caterina Aurilio Maria Caterina Pace | 2017 | World Journal of Hepatology2017，9，30： | 13 |
| 4 | The role of antioxidant therapy in the treatment of male infertility: an overview显示文摘在最近的年里,许多研究在男 eproductive 系统上集中了于氧化应力,反应的氧种类(ROS ) 和抗氧化剂的效果。在生理的条件下面,精子生产 ROS 的小数量,它为使肥沃, acrosome 反应和 capacitation 被需要。不管多么如果 ROS 的增加的生产没与清除的类似的增加被联系系统,精子血浆膜的 peroxidative 损坏和 DNA 完整的损失典型地发生,它导致房间死亡和减少的富饶。而且,自从在精子质量和怀孕率之间没有线性关联,在精液参数的改进不应该是在抗氧化剂治疗的研究考虑的唯一的结果。当大多数以前的研究缺乏控制组,关于这些治疗的利益的一个权威的结论是困难的获得,在不同联合和剂量的考虑不同抗氧化剂,或没在以前不肥沃的夫妇评估怀孕率。就算有益的效果在男不孕的一些情况中被报导,更多的 multicentre,与一样的标准执行的双窗帘研究为富饶上的各种各样的抗氧化剂的效果的增加的理解是必要的。 | Francesco Lombardo Andrea Sansone Francesco Romanelli DonateUa Paoli Loredana Gandiniand Andrea Lenzi | 2011 | Asian Journal of Andrology2011，13，5： | 10 |
| 5 | Nosocomial spontaneous bacterial peritonitis antibiotic treatment in the era of multi-drug resistance pathogens: A systematic review显示文摘AIM To systematically review literature upon aetiology of nosocomial spontaneous bacterial peritonitis(N-SBP) given the rising importance of multidrug-resistant(MDR) bacteria.METHODS A literature search was performed on MEDLINE and Google Scholar databases from 2000 to 15 th of November 2016, using the following search strategy: 'spontaneous' AND 'peritonitis'.RESULTS The initial search through electronic databases retrieved 2556 records. After removing duplicates, 1958 records remained. One thousand seven hundred and thirty-five of them were excluded on the basis of the screening of titles and abstract, and the ensuing number of remaining articles was 223. Of these records, after careful evaluation, only 9 were included in the qualitative analysis. The overall proportion of MDR bacteria turned out to be from 22% to 73% of cases across the studies.CONCLUSION N-SBP is caused, in a remarkable proportion, by MDR pathogens. This should prompt a careful re-assessment of guidelines addressing the treatment of this clinical entity. | Marco Fiore Alberto Enrico Maraolo Ivan Gentile Guglielmo Borgia Sebastiano Leone Pasquale Sansone Maria Beatrice Passavanti Caterina Aurilio Maria Caterina Pace | 2017 | World Journal of Gastroenterology2017，23，25： | 9 |
| 6 | Effects of percutaneous varicocele repair on testicular volume:results from a 12-month follow-up显示文摘Varicocele is a comm on fin ding in men. Varicocele correcti on has bee n advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular 'catch-up growth' in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (<35 years) with left varicocele who un derwe nt percuta neous treatment, had a minimum of 12 mon ths' ultraso und imagi ng follow-up, and had no other con ditions affecting testicular volume. One hundred and fourteen men (mean±standard deviation [s.d.] of age: 22.8 ± 5.4 years) met the inclusion and exclusion criteria. Left testicular hypotrophy (LTH), defined as a >20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean±s.d.: 14.5 ± 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean±s.d.: 15.7 ± 3.8 ml;P= 0.032). Repeated measures mixed models showed a sign ifica nt in teraction betwee n LTH and time posttreatme nt when correcting for baseli ne left testicular volume (β= 0.114, 95% confidence interval [Cl]: 0.018-0.210, P=0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% Cl: 0.221- 2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95% Cl:-0.135--0.009;P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implicati ons of these findings n eed to be confirmed in Ion ger and larger prospective studies. | Andrea Sansone Danilo Alunni Fegatelli Carlotta Pozza Giorgio Fattorini Rosa Lauretta Marianna Minnetti Francesco Romanelli Pierleone Lucatelli Mario Corona Mario Bezzi Francesco Lombardo Andrea Lenzi Daniele Gianfrilli | 2019 | Asian Journal of Andrology2019，21，4： | 8 |
| 7 | Hepatitis B and C virus reactivation in immunosuppressed patients with inflammatory bowel disease显示文摘In recent years,a number of case reports and clinical studies have highlighted the risk of hepatitis B and C virus reactivation in patients with inflammatory bowel disease who are treated with immunosuppressive drugs.The cases of viral hepatitis reactivation that have been reported are characterized by a wide range of clinical manifestations,from viremia without clinically relevant manifestations to fulminant life-threatening hepatitis.The development and dissemination of biological immunosuppressive drugs have led to a significant increase in the number of reports of interest to physicians in a variety of clinical settings.On this topic,there have been a number of published guidelines and reviews that have collected the available evidence,providing recommendations on prophylactic and therapeutic strategies and methods for monitoring patients at risk.However,it should be noted that,to date,very few clinical studies have been published,and most of the recommendations have been borrowed from otherclinical settings.The published studies are mostly retrospective and are based on very heterogeneous populations,using different therapeutic and prophylactic regimens and obtaining conflicting results.Thus,it seems clear that it is desirable to concentrate our efforts on prospective studies,not conducting further reviews of the literature in the continued absence of new evidence. | Stefano Sansone Maria Guarino Fabiana Castiglione Antonio Rispo Francesco Auriemma Ilaria Loperto Matilde Rea Nicola Caporaso Filomena Morisco | 2014 | World Journal of Gastroenterology2014，20，13： | 6 |
| 8 | Prognostic impact of molecular markers in a series of 220 primary glioblastomas显示文摘 | Houillier C Lejeune J Benouaic h-Amiel A Laigle-Donadey F Criniere E Mokhtari K Thillet J Delattre JY Hoang-Xuan K Sanson M | 2006 | 中国神经肿瘤杂志2006，4，1： | 5 |
| 9 | Helping the Consumers and Producers of Standards,Repositories and Policies to Enable FAIR Data显示文摘Thousands of community-developed(meta)data guidelines,models,ontologies,schemas and formats have been created and implemented by several thousand data repositories and knowledge-bases,across all disciplines.These resources are necessary to meet government,funder and publisher expectations of greater transparency and access to and preservation of data related to research publications.This obligates researchers to ensure their data is FAIR,share their data using the appropriate standards,store their data in sustainable and community-adopted repositories,and to conform to funder and publisher data policies.FAIR data sharing also plays a key role in enabling researchers to evaluate,re-analyse and reproduce each other’s work.We can map the landscape of relationships between community-adopted standards and repositories,and the journal publisher and funder data policies that recommend their use.In this paper,we show how the work of the GO-FAIR FAIR Standards,Repositories and Policies(StRePo)Implementation Network serves as a central integration and cross-fertilisation point for the reuse of FAIR standards,repositories and data policies in general.Pivotal to this effort,the FAIRsharing,an endorsed flagship resource of the Research Data Alliance that maps the landscape of relationships between community-adopted standards and repositories,and the journal publisher and funder data policies that recommend their use.Lastly,we highlight a number of activities around FAIR tools,services and educational efforts to raise awareness and encourage participation. | Peter McQuilton Dominique Batista Oya Beyan Ramon Granell Simon Coles Massimiliano Izzo Allyson L.Lister Robert Pergl Philippe Rocca-Serra Ben Schaap Hugh Shanahan Milo Thurston Susanna-Assunta Sansone | 2020 | Data Intelligence2020，2，1： | 5 |
| 10 | 双河洞中大熊猫-剑齿象动物群化石的发现显示文摘对贵州省境内的双河洞历次科考中发现的第四纪动物群化石进行初步研究和总结,认为目前对双河洞第四纪动物群研究尚处于起步阶段,化石的发现者都是洞穴科考专家,古生物知识相对欠缺且重视不够是洞穴化石研究进展缓慢的原因。为了加快双河洞第四纪动物群的研究进程,以今年中法联合科考过程中发现的大熊猫-剑齿象动物群化石为样本,采用ICP-MS铀系定年方法对这批大熊猫骨骼化石碳酸盐岩包裹物的年龄进行测试,结果表明该化石群化石距今6.75万年,初步判定此动物群可能生存于中更新世-晚更新世早期。这批哺乳动物化石及其地层信息将为贵州(尤其是黔北)第四纪的研究提供重要资料。 | 高占冬 Jean Bottazzi 赵欣楠 贺卫 Eric Sanson 李坡 程海 | 2016 | 中国岩溶2016，35，4： | 4 |
| 11 | FAIR Convergence Matrix:Optimizing the Reuse of Existing FAIR-Related Resources显示文摘The FAIR principles articulate the behaviors expected from digital artifacts that are Findable,Accessible,Interoperable and Reusable by machines and by people.Although by now widely accepted,the FAIR Principles by design do not explicitly consider actual implementation choices enabling FAIR behaviors.As different communities have their own,often well-established implementation preferences and priorities for data reuse,coordinating a broadly accepted,widely used FAIR implementation approach remains a global challenge.In an effort to accelerate broad community convergence on FAIR implementation options,the GO FAIR community has launched the development of the FAIR Convergence Matrix.The Matrix is a platform that compiles for any community of practice,an inventory of their self-declared FAIR implementation choices and challenges.The Convergence Matrix is itself a FAIR resource,openly available,and encourages voluntary participation by any self-identified community of practice(not only the GO FAIR Implementation Networks).Based on patterns of use and reuse of existing resources,the Convergence Matrix supports the transparent derivation of strategies that optimally coordinate convergence on standards and technologies in the emerging Internet of FAIR Data and Services. | Hana Pergl Sustkova Kristina Maria Hettne Peter Wittenburg Annika Jacobsen Tobias Kuhn Robert Pergl Jan Slifka Peter McQuilton Barbara Magagna Susanna-Assunta Sansone Markus Stocker Melanie Imming Larry Lannom Mark Musen Erik Schultes | 2020 | Data Intelligence2020，2，1： | 4 |
| 12 | 少突胶质细胞瘤中PTEN基因突变和10q染色体的杂合性缺失分析显示文摘目的 探讨PTEN基因突变和 10q染色体的杂合性缺失 (LOH)在少突胶质细胞瘤发生和发展中的意义。 方法 以 5 5例少突胶质细胞瘤和混合性胶质细胞瘤为研究对象 ,PCR扩增PTEN基因所有 9个外显子 ,其产物经变性梯度凝胶电泳 (DGGE)后 ,DNA序列分析检测PTEN基因突变。应用不同颜色荧光标记 10q微卫星标志物引物 ,PCR扩增后 ,其产物在自动测序仪上进行聚丙烯酰胺凝胶电泳 ,用GeneScan软件分析LOH。 结果 2 5 5例有PTEN基因突变 ,1例是PTEN的第 9外显子的 2 0号T碱基缺失导致终止密码 35 1易位至 347,另 1例在 139位发生C到A的转换 ,使得Phe变成Leu。 2 3 5 5 (4 2 % )例出现染色体 10q的LOH ,其中 15 / 5 5例位于 10q2 3,3(D10S5 4 1) ,其为PTEN基因位点 ,12 / 5 5例 10q微卫星标志物位点完全缺失。 结论 在少突胶质细胞瘤中PTEN突变较少见 ,而 10qLOH较频繁 ,尤其在恶性度高的少突胶质细胞瘤中表现明显 ,提示 10qLOH与少突胶质细胞瘤恶性进展有关 ,且 | 何杰 汪万英 徐杰 Hoang-Xuan Khe Sanson Marc | 2003 | 解剖学报2003，34，3： | 3 |
| 13 | Thirty years of graph matching in pattern recognition 显示文摘 | CONTE D FOGGIA P SANSONE C | 2004 | International Journal of Pattern Recognition and Artificial Intelligence2004，18，3： | 2 |
| 14 | Effective bowel cleansing before colonoscopy: a randomized study of split-dosage versus non-split dosage regimens of high-volume versus low-volume polyethylene glycol solutions显示文摘 | Riccardo Marmo Gianluca Rotondano Giovanni Riccio Armando Marone Maria Antonia Bianco Italo Stroppa Anna Caruso Nicola Pandolfo Stefano Sansone Elena Gregorio Giuseppe D’Alvano Nicoletta Procaccio Pina Capo Clelia Marmo Livio Cipolletta | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 15 | The basal-like breast carcinoma phenotype is regulated by SLUG gene expression显示文摘 | Storci G Sansone P Trere D | 2008 | J Pathol2008，214，： | 1 |
| 16 | Beta-2-glycoprotein-1 (apolipoprotein H)excretion in chronic renal tubular disorders : comparison with other protein markers of tubular malfunction显示文摘 | Lapsley M Sanson PA Marlow CT Flynn FV Norden AG | 1991 | J Clin Pathol1991，44，10： | 1 |
| 17 | Safety of low-molecularweight heparin in pregnancy:a systematic review显示文摘 | Sanson BJ Lensing AW Prins MH | 1999 | ThrombHaemost1999，81，5： | 1 |
| 18 | Microgels loaded with goldnanorods:photothermally triggered volume transitions underphysiological conditions显示文摘 | Das M Sanson N Kumacheva E | 2007 | Langmuir2007，23，1： | 1 |
| 19 | To rejector not to reject: That is the question-an answer in caseof neural classifiers显示文摘 | Claudio De Stefano Carlo Sansone Mario Vento | 2000 | IEEE Trans on Systems Man andCybernetics2000，30，1： | 1 |
| 20 | Thirty years ofgraph matching in pattern recognition显示文摘 | CONTE D F()GGIA P SANSONE C | 2004 | International Jour-nal of Pattern Recognition and Artificial Intelligence2004，18，3： | 1 |
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