|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic显示文摘AIM:To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil.METHODS:A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer.Clinical data and pathology features of the tumor were obtained from chart review.RESULTS:Of the 212 CRC patients recruited,61 (29%) reported a family history of CRC,45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC.Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients,respectively.Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype,which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001).Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment.CONCLUSION:A significant proportion of patients with CRC were at high risk for LS.Education and training of health care professionals are essential to ensure proper management. | Patrícia Koehler-Santos Patricia Izetti Jamile Abud Carlos Eduardo Pitroski Silvia Liliana Cossio Suzi Alves Camey Cláudio Tarta Daniel C Damin Paulo Carvalho Contu Mario Antonello Rosito Patricia Ashton-Prolla Joāo Carlos Prolla | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 3 | HLA- G gene polymorphism in human placentas: possible association of ^*0105 allele with preeclampsia and miscarriage显示文摘 | Moreau P Contu L Alba F | 2008 | Biol Reprod2008，79，3： | 1 |
| 4 | The evolution of technological strategies in the prevention of dialysis water pollution:sixteen years'experience显示文摘 | Bolasco P Contu A Meloni P | 2012 | Blood Purificat2012，34，34： | 1 |
| 5 | Epidemiology and genotype distribution of human papillomavirus (HPV) in women of Sardinia ( Italy ) 显示文摘 | Masia G Mazzoleni AP Contu G | 2009 | Vaccine2009，27，： | 1 |
| 6 | HLA-G gene polymorphism in human placentas: possible association of G * 0106 allele with preeclampsia and miscarriage 显示文摘 | Moreau P Contu L Alba F | 2008 | Biol Reprod2008，79，3： | 1 |
| 7 | Acupuncture plus moxibustion to resolve breech presentation: a randomized controlled study 显示文摘 | Neri 1 Airola G Contu G | 2004 | J Matern Fetal Neonatal Med2004，15，4： | 1 |
| 8 | Reciprocal Regulation of MicroRNA-1 and Insulin-Like Growth Factor-1 Signal Transduction Cascade in Cardiac and Skeletal Muscle in Physiological and Pathological Conditions显示文摘 | Elia L Contu R Quintavalle M | 2009 | Circulation2009，，120： | 1 |
| 9 | HLA-G gene polymorphism in human placentas:possible association of G*0106 allele with preeclampsia and miscarriage显示文摘 | Moreau P Contu L Alba F | 2008 | Biol Reprod2008，79，3： | 1 |
| 10 | HLA-B27 and ankylosing spondylitis:a population and family study in Sardinia显示文摘 | CONTU L CAPELLI P SALE S | 1997 | Rheumatol Suppl1997，3，： | 1 |
| 11 | MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice显示文摘 | Zhang D Contu R Latronico MY | | 0，，： | 1 |
| 12 | Fibrin glue in themanagement of complex anal fistula 显示文摘 | Damin DC Rosito MA Contu PC | 2009 | Arq Gastroenterol2009，46，4： | 1 |
| 13 | Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results显示文摘 | Giovanni Mantovani Antonio Macciò Clelia Madeddu Giulia Gramignano Roberto Serpe Elena Massa Mariele Dessì Francesca Maria Tanca Eleonora Sanna Laura Deiana Filomena Panzone Paolo Contu Carlo Floris | 2008 | Nutrition2008，，4： | 1 |
| 14 | Reciprocal reg- ulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiologi- cal and pathological conditions 显示文摘 | ELIA L CONTU R QUINTAVALLE M | 2009 | Circulation2009，120，23： | 1 |
| 15 | HLA-Cw ARMS-PCR typing in the Sardinian population显示文摘 | Contu L Arras M Carcassi C | 1996 | Hum Immunol1996，49，1： | 1 |
| 16 | MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice显示文摘 | Zhang D Contu R Latronico M.V Zhang J Rizzi R Catalucci D Miyamoto S Huang K Ceci M Gu Y Dalton N.D Peterson K.L Guan K.L Brown J.H Chen J Sonenberg N Condorelli G | | 0，，： | 1 |
| 17 | HLA-G gene polymorphism in human placentas : possible association of G * 0106 allele with pre- eelampsia and miscarriage 显示文摘 | Moreau P Contu L Alba F | 2008 | Biol Reprad2008，79，3： | 1 |
| 18 | Reciprocal regulation of mi- croRNA-1 and insulin-like growth factor-1 signal transduction cas- cade in cardiac and skeletal muscle in physiological and pathologi- cal conditions显示文摘 | Elia L Contu R Quintavalle M | 2009 | Circulation2009，120，23： | 1 |
| 19 | HLA-G gene polymorphism in human placentas:possible association of G*0106 allele with preeclampsia and miscarriage显示文摘 | Moreau P Contu L Alba F | 2008 | Biol Reprod2008，79，： | 1 |
| 20 | An FT-IR investigation of epoxy coatings as a function of electrolyte composition显示文摘 | F. Contu L. Fenzy S.R. Taylor | 2012 | Progress in Organic Coatings (-)2012，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员