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2篇 您的检索式:作者名="Angelo Quattrini"
    题名 作者 年代 出处 被引量
1Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy显示文摘Giorgia Melli Michela Taiana Francesca Camozzi Daniela Triolo Paola Podini Angelo Quattrini Franco Taroni Giuseppe Lauria 2008Experimental Neurology2008,,2:1
2Current application of neurofilaments in amyotrophic lateral sclerosis and future perspectives显示文摘Motor neuron disease includes a heterogeneous group of relentless progressive neurological disorders defined and characterized by the degeneration of motor neurons.Amyotrophic lateral sclerosis is the most common and aggressive form of motor neuron disease with no effective treatment so far.Unfortunately,diagnostic and prognostic biomarkers are lacking in clinical practice.Neurofilaments are fundamental structural components of the axons and neurofilament light chain and phosphorylated neurofilament heavy chain can be measured in both cerebrospinal fluid and serum.Neurofilament light chain and phosphorylated neurofilament heavy chain levels are elevated in amyotrophic lateral sclerosis,reflecting the extensive damage of motor neurons and axons.Hence,neurofilaments are now increasingly recognized as the most promising candidate biomarker in amyotrophic lateral sclerosis.The potential usefulness of neurofilaments regards various aspects,including diagnosis,prognosis,patient stratification in clinical trials and evaluation of treatment response.In this review paper,we review the body of literature about neurofilaments measurement in amyotrophic lateral sclerosis.We also discuss the open issues concerning the use of neurofilaments clinical practice,as no overall guideline exists to date;finally,we address the most recent evidence and future perspectives.Yuri Matteo Falzone Tommaso Russo Teuta Domi Laura Pozzi Angelo Quattrini Massimo Filippi Nilo Riva 2021Neural Regeneration Research2021,16,10:1
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