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| 1 | One hundred and one over-the-scope-clip applications forsevere gastrointestinal bleeding,leaks and fistulas显示文摘AIM: To investigate the efficacy and clinical outcome of patients treated with an over-the-scope-clip(OTSC) system for severe gastrointestinal hemorrhage, perforations and fistulas.METHODS: From 02-2009 to 10-2012, 84 patients were treated with 101 OTSC clips. 41 patients(48.8%) presented with severe upper-gastrointestinal(GI) bleeding, 3(3.6%) patients with lower-GI bleeding, 7 patients(8.3%) underwent perforation closure, 18 patients(21.4%) had prevention of secondary perforation, 12 patients(14.3%) had control of secondary bleeding after endoscopic mucosal resection or endoscopic submucosal dissection(ESD) and 3 patients(3.6%) had an intervention on a chronic fistula. RESULTS: In 78/84 patients(92.8%), primary treatment with the OTSC was technically successful. Clinical primary success was achieved in 75/84 patients(89.28%). The overall mortality in the study patients was 11/84(13.1%) and was seen in patients with life threatning upper GI hemorrhage. There was no mortality in any other treatment group. In detail OTSC application lead to a clinical success in 35/41(85.36%) patients with upper GI bleeding and in 3/3 patients with lower GI bleeding. Technical success of perforation closure was 100% while clinical success was seen in 4/7 cases(57.14%) due to attendant circumstances unrelated to the OTSC. Technical and clinic success was achieved in 18/18(100%) patients for the prevention of bleeding or perforation after endoscopic mucosal resection and ESD and in 3/3 cases of fistula closure. Two application-related complications were seen(2%).CONCLUSION: This largest single center experience published so far confirms the value of the OTSC for GI emergencies and complications. Further clinical experience will help to identify optimal indications for its targeted and prophylactic use. | Edris Wedi Susana Gonzalez Detlev Menke Elena Kruse Kai Matthes Juergen Hochberger | 2016 | World Journal of Gastroenterology2016，22，5： | 28 |
| 2 | Auxin EvoDevo: Conservation and Diversification of Genes Regulating Auxin Biosynthesis, Transport, and Signaling显示文摘The phytohormone auxin has been shown to be of pivotal importance in growth and development of land plants.The underlying molecular players involved in auxin biosynthesis, transport, and signaling are quite well understood in Arabidopsis.However, functional characterizations of auxin-related genes in economically important crops, specifically maize and rice, are still limited.In this article, we comprehensively review recent functional studies on auxirelated genes in both maize and rice, compared with what is known in Arabidopsis, and highlight conservation and diversification of their functions. Our analysis is illustrated by phylogenetic analysis and publicly available gene expression data for each gene family, which will aid in the identification of auxin-related genes for future research.Current challenges and future directions for auxin research in maize and rice are discussed.Developments in gene editing techniques provide powerful tools for overcoming the issue of redundancy in these gene families and will undoubtedly advance auxin research in crops. | Michaela Sylvia Matthes Norman Bradley Best Janlo M.Robil Simon Malcomber Andrea Gallavotti Paula McSteen | 2019 | Molecular Plant2019，12，3： | 3 |
| 3 | Effectiveness of circumferential endoscopic mucosal resection with a novel tissue-anchoring device显示文摘AIM: To evaluate the efficacy of circumferential endoscopic mucosal resection (EMR) with a tissue-anchoring device in comparison to forceps precut EMR and conventional endoscopic submucosal dissection (ESD). METHODS: The study was designed as a prospective, randomized, ex vivo study. Fresh ex vivo specimens were harvested from adult white Yorkshire pigs weighing 30-50 kg. Seventy-five standardized, artificial lesions measuring 3 cm × 3 cm were created by methy- lene blue tattoo at the greater curvature in fresh ex vivo stomachs using the EASIE-R simulator platform (Endosim LLC, Berlin, MA, United States). The three advanced endoscopists performed the three resection techniques such as circumferential EMR using the tissue-anchoring device (TA-EMR), forceps precut EMR (FP-EMR), and endoscopic submucosal dissection. The endoscopists and the type of cutting methods were determined randomly by grouped randomized selection.The resection bed was grossly inspected to determine whether the lesion was resected 'en-bloc ' (defined as no remaining mucosal tattoo remaining on specimen). The resection bed was also probed for evidence of perforation. The procedural time of circumferential resection, submucosal dissection, and injection frequency were recorded by an independent observer.RESULTS: All 75 created lesions were successfully resected by three advanced endoscopists using the three techniques. The mean ± SD size of resected specimens (long axis) were 39.5 ± 5.6 mm, 36.5 ± 7.3 mm, and 44.6 ± 5.6 mm for TA-EMR, FP-EMR, and ESD respectively. The overall mean dissection time of both the TA- EMR and FP-EMR was significant shorter than ESD (TA- EMR: 5.1 ± 3.3 min, FP-EMR: 3.5 ± 2.0 min vs ESD: 15.8 ± 9.5 min, P < 0.001, P < 0.001). The overall mean total procedure time of both the tissue-anchoring and forceps circumferential EMR was significantly shorter than ESD (TA-EMR: 17.5 ± 6.0 min, FP-EMR: 16.6 ± 6.6 min vs ESD: 28.6 ± 13.9 min, P < 0.001, P < 0.001). The en-bloc resection rate of ESD was 100% (25/25) and the en-bloc resection rate of the TA-EMR (84.0%, 21/25) was higher than for the FP-EMR (60.0%, 15/25), yet not statistically significant (P = 0.18). The perforation rate of each technique was 8.0% (2/25). CONCLUSION: TA-EMR appears to be quicker than ESD, and there was a trend towards improved en bloc resection rate with the TA-EMR when compared to the FP-EMR. | Yunho Jung Masayuki Kato Jongchan Lee Mark A Gromski Ram Chuttani Kai Matthes | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，6： | 3 |
| 4 | Effects of temperature and body weight on growth rate and feed conversion ratio in turbot ( Scophthalmus maximus )显示文摘 | Tómas árnason Bj?rn Bj?rnsson Agnar Steinarsson Matthías Oddgeirsson | 2009 | Aquaculture2009，，3： | 2 |
| 5 | 川中丘陵区自然沟渠水体与沉积物中砷的分布特征及污染评价显示文摘通过对川中丘陵区72条自然沟渠水体和沉积物总砷含量的调查与分析,研究了该区自然沟渠水体和沉积物总砷含量的分布特征,并利用综合指数法和地累积指数法分别对该区自然沟渠水体和沉积物总砷的污染状况进行了评价.结果表明:①川中丘陵区自然沟渠水体总砷含量在2.20~44.13μg·L^(-1)之间,平均值为7.44μg·L^(-1),其中,有22.22%的沟渠水体总砷含量超过WHO限定标准;沉积物总砷含量在3.40~17.78 mg·kg^(-1)之间,平均值为8.64 mg·kg^(-1),有5.56%的沟渠沉积物总砷含量超过国家一级土壤标准;②不同类型自然沟渠水体和沉积物总砷含量差异显著,沟渠水体总砷含量大小顺序为:居民区沟渠>水田沟渠>旱地沟渠>荒地沟渠;沉积物总砷含量大小顺序为:居民区沟渠>水田沟渠>荒地沟渠>旱地沟渠;③自然沟渠水体总砷含量与水体总氮、总磷含量呈显著正相关,沉积物总砷含量与沉积物总氮、总磷和有机质含量均呈显著正相关;④水体和沉积物总砷含量评价结果显示,川中丘陵区大部分自然沟渠总砷含量处于清洁水平,但仍有部分自然沟渠处于轻度污染状态,具有潜在的砷污染风险. | 龙虹竹 刘红兵 汪涛 赵原 NSENGA Kumwimba Matthe | 2018 | 环境科学学报2018，38，12： | 2 |
| 6 | The induction of ovulation with pulsatile GnRH administration in hyperandrogenic woman after down -regulation with buserelin or suppression with a oral contraceptive 显示文摘 | Gerhard I Matthes J Runncbaum B | 1993 | HumReprod1993，8，： | 1 |
| 7 | Protein Z 显示文摘 | Kemkes-Matthes B Matthes KJ | 2001 | Semin Thromb Hemost2001，27，5： | 1 |
| 8 | Optimized lentiviral transduction of erythroid precursors from healthy adults and patients with myelodysplastic syndromes显示文摘 | MATTHES T W KINDLER V LEUBA F | 2002 | Leukemia2002，16，7： | 1 |
| 9 | Protection of mouse photoreceptors by survival factors in retinal degeneration 显示文摘 | Lavail MM Yasumura D Matthes MT Lau-Villacorta C Unoki K Sung CH | 1998 | Invest Ophthalmol Vis Sci1998，39，3： | 1 |
| 10 | Protection of mouse photoreceptors by survival factors in retinal degenerations 显示文摘 | LaVail MM Yasumura D Matthes MT Lau-Villacorta C Unoki K Sung CH Steinberg RH | 1998 | Invest Ophthalmol Vis Sci1998，39，3： | 1 |
| 11 | Variability in rate of cone degeneration in the retinal degeneration (rd/rd) mouse显示文摘 | LaVail MM Matthes MT Yasumura D Steinberg RH | 1997 | Exp Eye Res1997，65，1： | 1 |
| 12 | Retrograde fixadon of dietal femoral fractures:results using a new nail system显示文摘 | Stensel D Matthes G | 2003 | J Orthop Trauma2003，17，7： | 1 |
| 13 | Mi- crooptical telescope compound eye 显示文摘 | DUPARRE J SCHREIBER P MATTHES A | | Optics Express0，13，3： | 1 |
| 14 | Protein Z,a new haemostatic factor, in liver disease显示文摘 | Kemkes-Matthes B Matthes KJ | 1995 | Haemostasis1995，25，6： | 1 |
| 15 | Transforming growth factor beta and tumor necrosis factor alpha inhibit both apoptosis and proliferation of activated rat hepatic stellate cells显示文摘 | Saile B Matthes N Knittel T | 1999 | Hepatology1999，30，1： | 1 |
| 16 | Coparison of beta-thrombothlobulin,flow cytometry,and platelet aggrego-metry to study platelet activation显示文摘 | Matzdorff A C Matthes K B Voss R | 1996 | Haemostasis1996，26，2： | 1 |
| 17 | Rx for Healthier Offices显示文摘 | | 1992 | Management Review1992，，： | 1 |
| 18 | Efficacy and costs of a one-day hands-on EASIE endoscopy simulator train-the-trainer workshop显示文摘 | Cohen J Kochman ML | 2005 | Gastrointest Endosc2005，62，6： | 1 |
| 19 | Strategies for training in diagnostic upper endoscopy: a prospective, randomized trial显示文摘 | Anke Ende Yurdaguel Zopf Peter Konturek Andreas Naegel Eckhart G. Hahn Kai Matthes Juergen Maiss | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 20 | Sorption of heavy-metal cations by Al and Zr-hydroxy-intercalated and pillared bentonite显示文摘 | Winnie Matthes Fritz T Madsenand Guenther Kahr | 1999 | Clays and Clay Minerals1999，47，5： | 1 |
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