|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis显示文摘AIM: To investigate the relationship between osteopontin plasma concentrations and the severity of portal hypertension and to assess osteopontin prognostic value.METHODS: A cohort of 154 patients with confirmed liver cirrhosis(112 ethylic, 108 men, age 34-72 years)were enrolled in the study. Hepatic venous pressure gradient(HVPG) measurement and laboratory and ultrasound examinations were carried out for all patients. HVPG was measured using a standard catheterization method with the balloon wedge technique. Osteopontin was measured using the enzyme-linked immunosorbent assay(ELISA) method in plasma. Patients were followed up with a specific focus on mortality. The control group consisted of 137 healthy age- and sex- matched individuals.RESULTS: The mean value of HVPG was 16.18 ± 5.6 mm Hg. Compared to controls, the plasma levels of osteopontin in cirrhotic patients were significantly higher(P < 0.001). The plasma levels of osteopontin were positively related to HVPG(P = 0.0022, r = 0.25) and differed among the individual Child-Pugh groups of patients. The cut-off value of 80 ng/m L osteopontin distinguished patients with significant portal hypertension(HVPG above 10 mm Hg) at 75% sensitivity and 63% specificity. The mean follow-up of patients was 3.7 ± 2.6 years. The probability of cumulative survival was 39% for patients with HVPG > 10 mm Hg and 65% for those with HVPG ≤ 10 mm Hg(P = 0.0086, odds ratio(OR), 2.92, 95% confidence interval(CI): 1.09-7.76). Osteopontin showed a similar prognostic value to HVPG. Patients with osteopontin values above 80 ng/m L had significantly lower cumulative survival compared to those with osteopontin ≤ 80 ng/m L(37% vs 56%, P = 0.00035; OR = 2.23, 95%CI: 1.06-4.68).CONCLUSION: Osteopontin is a non-invasive parameter of portal hypertension that distinguishes patients with clinically significant portal hypertension. It is a strong prognostic factor for survival. | Radan Bruha Marie Jachymova Jaromir Petrtyl Karel Dvorak Martin Lenicek Petr Urbanek Tomislav Svestka Libor Vitek | 2016 | World Journal of Gastroenterology2016，22，12： | 20 |
| 2 | Probiotics in hepatology显示文摘The paper provides a basic review of intestinal micro- flora and its importance in liver diseases. The intestinal microflora has many important functions, above all to maintain the microbial barrier against established as well as potential pathogens. Furthermore, it influences the motility and perfusion of the intestinal wall, stimu- lates the intestinal immune system and therefore also the so-called common mucosal immune system, re- ducing bacterial translocation and producing vitamins. Immune homeostasis at mucosal level results from a controlled response to intestinal luminal antigens. In liver cirrhosis, there are many changes in its function, mostly an increase in bacterial overgrowth and trans- location. In this review, probiotics and their indications in hepatology are generally discussed. According to recent knowledge, these preparations are indicated in clinical practice only for cases of hepatic encephalopa- thy. Probiotics are able to decrease the permeability ofthe intestinal wall, and decrease bacterial translocation and endotoxemia in animal models as well as in clinical studies, which is extremely important in the prevention of complications of liver cirrhosis and infection after liv- er transplantation. Probiotics could limit oxidative and inflammatory liver damage and, in some situations, improve the histological state, and thus non-alcoholic steatohepatitis could be considered as another possible indication. ? 2011 Baishideng. All rights reserved. | Jan Lata Jana Jurankova Marcela Kopacova Petr Vitek | 2011 | World Journal of Gastroenterology2011，17，24： | 19 |
| 3 | Simple N-body potentials for the noble metals and nickel显示文摘 | Ackland G J Tichy G Vitek V | 1987 | Philosophical Magazine A (Physics of Condensed Matter Defects and Mechanical Properties)1987，56，6： | 1 |
| 4 | The impact of intestinal microflora on serum bilirubin levels 显示文摘 | VITEK L ZELENKA J ZADINOVA M | 2005 | J Hepatol2005，42，2： | 1 |
| 5 | The leaf ionome as a muhivariable system to detect a plant's physiological sta- tus显示文摘 | BAXTER I R VITEK O LAHNER B | 2008 | Proceedings of the National Academy of Sciences2008，105，12： | 1 |
| 6 | Improving perception of and response to natural hazards: the need for local education 显示文摘 | Vitek J D Berta S M | 1982 | Journal of Geography1982，81，6： | 1 |
| 7 | Comparison of quantitative competitive polymerase chain reaction-enzyme-linked immunosorbent assay with LightCycler-based polymerase chain reaction for measuring cytomegalovirus DNA in patients after hematopoietic stem cell transplantation显示文摘 | Pumannova M Roubalova K Vitek A | 2006 | Diagn Microbiol Infect Dis2006，54，2： | 1 |
| 8 | The inverse association of elevated serum bilirubin levels with subclinical carotid athersclerosis显示文摘 | Vitek L Novotny L SperL M | 2006 | Cerebrovasc Dis2006，21，56： | 1 |
| 9 | Effect of the distalballoon protection system on microembolization during carotid stenting显示文摘 | Al-Mubarak N Roubin GS Vitek JJ | | 0，，： | 1 |
| 10 | the sigma phase transformation inaustenitic stainless steels显示文摘 | Vitek J M David S A | 1986 | Welding Journal1986，65，4： | 1 |
| 11 | Effect of the distalballoon proteation system on microembolization during carotid stenting显示文摘 | Al-Mubarak N Roubin GS Vitek JJ | 2001 | Circulation2001，104，： | 1 |
| 12 | Simple Nbody potentials for the noble metals and nickel 显示文摘 | ACKLAND G J TICHY G VITEK V | 1987 | Philosophical Magazine A1987，56，： | 1 |
| 13 | Theory of core structures of disloca- tions in body-centered cubic metals显示文摘 | VITEK V | 1974 | Crystal Lattice Defects1974，5，1： | 1 |
| 14 | Many-body potentials and atomic- scale relaxations in noble-metal alloys显示文摘 | Ackland G J Vitek V | 1990 | Phys Rev B1990，41，10： | 1 |
| 15 | Inverse relationship between serum bilirubin and atherosclerosis in men : a meta- analysis of published studies 显示文摘 | NOVOTNY L VITEK L | 2003 | Experimental Biology and Medicine2003，228，5： | 1 |
| 16 | Gilbert syndrome, UGT1A1 * 28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin 显示文摘 | Schwertner H A Vitek L | 2008 | Atherosclerosis2008，198，1： | 1 |
| 17 | Randomized trial of pallidotomy versus medical therapy for Parkinson' s disease 显示文摘 | Vitek JL Bakay RA Freeman A | 2003 | Ann Neuro12003，53，： | 1 |
| 18 | APOE - mimetic pep- tides reduce behavioral deficits, plaques and tangles in alzheimer's disease transgenics 显示文摘 | Vitek MP Christensen DJ Wilcock D | 2012 | Neurodegener Dis2012，10，14： | 1 |
| 19 | APOE genotype- specific differences in the innate immune response显示文摘 | Vitek MP Brown CM Colton CA | 2009 | Neurobiol Aging2009，30，9： | 1 |
| 20 | Effect of the distal-balloon protection system on microembolization during carotid stenting显示文摘 | Al-Mubarak N Roubin GS Vitek JJ | 2001 | Circulation2001，104，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员