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| 1 | Diet and microbiota in inflammatory bowel disease: The gut in disharmony显示文摘Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colitis, reinforcing the hypothesis of dysbiosis as a relevant mechanism underlying inflammatory bowel disease(IBD) pathogenesis. Humans and microbes have coexisted and co-evolved for a long time in a mutually beneficial symbiotic association essential for maintaining homeostasis. However, the microbiome is dynamic, changing with age and in response to environmental modifications. Among such environmental factors, food and alimentary habits, progressively altered in modern societies, appear to be critical modulators of the microbiota, contributing to or co-participating in dysbiosis. In addition, food constituents such as micronutrients are important regulators of mucosal immunity, with direct or indirect effects on the gut microbiota. Moreover, food constituents have recently been shown to modulate epigenetic mechanisms, which can result in increased risk for the development and progression of IBD. Therefore, it is likely that a better understanding of the role of different food components in intestinal homeostasis and the resident microbiota will be essential for unravelling the complex molecular basis of the epigenetic, genetic and environment interactions underlying IBD pathogenesis as well as for offering dietary interventions with minimal side effects. | Davy CM Rapozo Claudio Bernardazzi Heitor Siffert Pereira de Souza | 2017 | World Journal of Gastroenterology2017，23，12： | 24 |
| 2 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 3 | Damage-associated molecular patterns in inflammatory bowel disease:From biomarkers to therapeutic targets显示文摘The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of several components in a genetically susceptible host. These components include environmental elements and gut microbiota a dysbiosis. For decades, immune abnormalities have been investigated as critically important in IBD pathogenesis, and attempts to develop effective therapies have predominantly targeted the immune system. Nevertheless, immune events represent only one of the constituents contributing to IBD pathogenesis within the context of the complex cellular and molecular network underlying chronic intestinal inflammation. These factors need to be appreciated within the milieu of nonimmune components. Damage-associated molecular patterns (DAMPs), which are essentially endogenous stress proteins expressed or released as a result of cell or tissue damage, have been shown to act as direct proinflammatory mediators. Excessive or persistent signalling mediated by such molecules can underlie several chronic inflammatory disorders, including IBD. The release of endogenous DAMPs amplifies the inflammatory response driven by immune and non-immune cells and promotes epigenetic reprogramming in IBD.The effects determine pathologic changes,which may sustain chronic intestinal inflammation and also underlie specific disease phenotypes.In addition to highlighting the potential use of DAMPs such as calprotectin as biomarkers,research on DAMPs may reveal novel mechanistic associations in IBD pathogenesis and is expected to uncover putative therapeutic targets. | Hayandra Ferreira Nanini Claudio Bernardazzi Fernando Castro Heitor Siffert Pereira de Souza | 2018 | World Journal of Gastroenterology2018，24，41： | 7 |
| 4 | Recent advances in non-metal doped titania for solar-driven photocatalytic/photoelectrochemical water-splitting显示文摘Photocatalytic (PC) / Photoelectrochemical (PEC) water splitting under solar light irradiation is considered as a prospective technique to support the sustainable and renewable H_(2) economy and to reach the ultime goal of carbon neutral. TiO_(2) based photocatalysts with high chemical stability and excellent photocatalytic properties have great potential for solar-to-H_(2) conversion. To conquer the challenges of the large band-gap and rapid recombination of photo generated electron-holepairs in TiO_(2), non-metal doping turns out to be economic, facile, and effective on boosting the visible light activity. The localized defect states such as oxygen vacancy and Ti^(3+) generated by non-metal doping are located in the band-gap of TiO_(2), which result in the reduction of band-gap, thus a red-shift of the absorption edge. The hetero doping atoms such as B^(3+), I^(7+), S^(4+)/S^(6+), P^(5+) can also act as electron donors or trap sites which facilitate the charge carrier separation and suppress the recombination of electron-hole pairs. In this comprehensive review, we present the most recent advances on non-metal doped TiO_(2) photocatalysts in terms of fundamental aspects, origin of visible light activity and the PC / PEC behaviours for water splitting. In particular, the characteristics of different non-metal elements (N, C, B, S, P, Halogens) as dopants are discussed in details focusing on the synthesis approaches, characterization as well as the efficiency of PC and PEC water splitting. The present review aims at guiding the readers who want quick access to helpful information about how to efficiently improve the performance of photocatalysts by simple doping strategies and could stimulate new intuitive into the new doping strategies. | Ying-Ying Wang Yan-Xin Chen Tarek Barakat Yu-Jia Zeng Jing Liu Stéphane Siffert Bao-Lian Su | 2022 | Journal of Energy Chemistry2022，31，3： | 4 |
| 5 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 6 | Study on the interaction of titanium dioxide with cellulose fibers in an aqueous medium显示文摘 | Siffert B | 1991 | Colloid Surf1991，53，： | 1 |
| 7 | Ultras0und simulation in bone显示文摘 | Kaufman J J Luo G Siffert R S | 2008 | IEEE Traus Uhrason Ferroelectr Freq Control2008，55，6： | 1 |
| 8 | Total catalytic oxidation of toluene using Pd impregnated on hierarchically porous Nb205 and Ta205 supports显示文摘 | Rooke J C Barakat T Siffert S | 2012 | Catalysis Today2012，192，： | 1 |
| 9 | Association of a human G-protein β 3 subunit variant with hypertension显示文摘 | Siffert W B Rosskopf D Siffert G | 1998 | Nat Genet1998，18，： | 1 |
| 10 | Marital conflict and early adolescents' self-evaluation: The role of parenting quality and early adolescents' appraisals 显示文摘 | SIFFERT A SCHWARZ A STUTZ M | 2012 | J Youth Ado- lescence2012，41，6： | 1 |
| 11 | Acid-base characteristics of aspbahenes isolated from mechanical sheared oil distillation residues 显示文摘 | Siffert B Rageul P Papirer E | 1996 | Fuel1996，75，14： | 1 |
| 12 | Interparental conflict and early adolescents' aggression:Is irregular sleep a vulnerability factor显示文摘 | Lemola S Schwarz B Siffert A | | 0，，： | 1 |
| 13 | Ultrasound simulation in bone显示文摘 | Kaufman J J Luo G Siffert RS | 2008 | IEEE Trans Ultrason Ferroelectr Freq Control2008，55，12： | 1 |
| 14 | Catalytic activity of copper and palladium based catalysts for toluene oxidation显示文摘 | Tidahy H L Siffert S Wyrwalski F | 2007 | Catalysis Today2007，119，1234： | 1 |
| 15 | Gas displacement of viscoplastic liquids in capillary tubes 显示文摘 | De Souza MENDES P R DUTRA E S S SIFFERT J R R | 2007 | Journal of Non-Newtonian Fluid Mechanics2007，145，1： | 1 |
| 16 | G protein and hypertension: an alternative candidate gene approach显示文摘 | Siffert W | 1998 | Kidney Int1998，53，6： | 1 |
| 17 | The angiotensin II receptor antagonist valsartan inhibits endothelin 1-induced vasoconstriction in the skin microcirculation in humans in vivo: influence of the G- protein beta3 subunit (GNB3) C825T polymorphism 显示文摘 | Mitchell A Rushentsova U Siffert W | 2006 | Clin Pharmaeol Ther2006，79，3： | 1 |
| 18 | Study on the interaction of titanium dioxide with cellulose fibers in an aqueous medium 显示文摘 | Siffert B | 1991 | Colloid Surf1991，53，2： | 1 |
| 19 | Association of a human G-protein beta-3 subunit variant with hypertension显示文摘 | Siffert W Rosskopf D Siffert G | 1998 | Nat Genet1998，18，： | 1 |
| 20 | Investigation of the Cu-Zr-Y oxides activity in the carbon black catalytic oxidation by differential thermal analysis and temperature programmed reduction显示文摘 | J F LAMONIER S SIFFERT | 2006 | Thermochimica Acta2006，443，2： | 1 |
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