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| 1 | Clostridium perfringens bacteremia caused by choledocholithiasis in the absence of gallbladder stones显示文摘A 67-years-old male presented with periumbilical abdominal pain, fever and jaundice. His anaerobic blood culture was positive for clostridium perfringens. Computed tomogram scan of the abdomen and abdominal ultrasound showed normal gallbladder and common bile duct (CBD). Subsequently magnetic resonance cholangiopancreaticogram showed choledocholithiasis. Endoscopic retrograde cholangiopancreaticogram-with sphincterotomy and CBD stone extraction was performed. The patient progressively improved with antibiotic therapy Choledocholithiasis should be considered as a source of clostridium perfringens bacteremia especially in the setting of elevated liver enzymes with cholestatic pattern. | Antwan Atia Tejas Raiyani Pranav Patel Robert Patton Mark Young | 2012 | World Journal of Gastroenterology2012，18，39： | 11 |
| 2 | Clinical significance of main pancreatic duct dilation on computed tomography: Single and double duct dilation显示文摘AIM: To study the patients with main pancreatic duct dilation on computed tomography (CT) and thereby to provide the predictive criteria to identify patients at high risk of significant diseases, such as pancreatic cancer, and to avoid unnecessary work up for patients at low risk of such diseases. METHODS: Patients with dilation of the main pancreatic duct on CT at Emory University Hospital in 2002 were identified by computer search. Clinical course and ultimate diagnosis were obtained in all the identified patients by abstraction of their computer database records. RESULTS: Seventy-seven patients were identified in this study. Chronic pancreatitis and pancreatic cancer were the most common causes of the main pancreatic duct dilation on CT. Although the majority of patients with isolated dilation of the main pancreatic duct (single duct dilation) had chronic pancreatitis, one-third of patients with single duct dilation but without chronic pancreatitis had pancreatic malignancies, whereas most of patients with concomitant biliary duct dilation (double duct dilation) had pancreatic cancer. CONCLUSION: Patients with pancreatic double duct dilation need extensive work up and careful followup since a majority of these patients are ultimately diagnosed with pancreatic cancer. Patients with single duct dilation, especially such patients without any evidence of chronic pancreatitis, also need careful follow-up since the possibility of pancreatic malignancy, including adenocarcinoma and intraductal papillary mucinous tumors, is still high. | Mark D Edge Maarouf Hoteit Amil P Patel Xiaoping Wang Deborah A Baumgarten Qiang Cai | 2007 | World Journal of Gastroenterology2007，13，11： | 9 |
| 3 | Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer显示文摘gonadal 睾丸激素合成的抑制首先代表标准为变形前列腺癌症的治疗的线治疗。在得阉割抵抗的前列腺癌症(CRPC ) 的病人的多数,然而,通过自己在肾上腺或在肿瘤以内生产的雄激素检测雄激素受体(AR ) 的坚持的激活是可能的。Abiraterone 醋酸盐作为 17 α 与活动作为双功能的细胞色素 P450 酶 CYP17 的一个不可逆的禁止者被开发; -hydroxylase 和 17,20-lyase。CYP17 为从胆固醇的 nongonadal 雄激素的生产是必要的。基于与 abiraterone 和泼尼松对泼尼松在全面幸存(OS ) 显示出重要改进的阶段 III 试用,在 2011 的 abiraterone 的规章的赞同代表了指向 AR 为与 CRPC 在人改进结果是必要的原则的证明。 17 α 的抑制;由 abiraterone 的 -hydroxylase 由于垂体的调停皮质醇的抑制的损失导致在上游的 mineralocorticoids 的累积促肾上腺皮质的荷尔蒙( ACTH ),为 17,20-lyase 为 CYP17 禁止者的开发向一个基本原理提供增加的特性( orteronel , galeterone 和 VT-464 )没有外长的 corticosteroids ,那能潜在地被管理。在这篇文章,我们考察 abiraterone 和另外的 CYP17 禁止者的发展;有 abiraterone 的最近的研究在 quality-of-life,反应的潜在的早预言者,并且关于另外的代理人的 abiraterone 的最佳的定序上通知我们的理解象药效果那样的临床的参数;并且提供卓见进抵抗机制给导致临床的试用,药联合设计了延长 abiraterone 利益或恢复 abiraterone 活动的 CYP17 禁止者的翻译研究结果。 | Mark N Stein | 2014 | Asian Journal of Andrology2014，16，3： | 3 |
| 4 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 5 | Isolated Low Levels of High-Density Lipoprotein Cholesterol Are Associated With an Increased Risk of Coronary Heart Disease: An Individual Participant Data Meta-Analysis of 23 Studies in the Asia-Pacific Region显示文摘 | Rachel R. Huxley Federica Barzi Tai Hing Lam Sebastien Czernichow Xianghua Fang Tim Welborn Jonathan Shaw Hirotsugu Ueshima Paul Zimmet Sun Ha Jee Jeetesh V. Patel Ian Caterson Vlado Perkovic Mark Woodward | 2011 | Circulation2011，，19： | 2 |
| 6 | Long-term outcomes of catheter directed thrombolysis for lower extremity deep venous thrombosis without prophylactic inferior vena cava filter placement显示文摘 | Clinton D. Protack Andrew M. Bakken Nikhil Patel Wael E. Saad David L. Waldman Mark G. Davies | 2007 | Journal of Vascular Surgery2007，，5： | 2 |
| 7 | 物联网:机遇与挑战显示文摘物联网是指通过使用嵌入式传感器、致动器以及可以收集或传送对象信息的其他设备形成的物理关系网。通过分析从这些设备中收集的数据,可优化产品、服务和操作。这种技术最早、最知名的应用之一也许是在能源优化领域:传感器部署在整个电网可以帮助公用事业远程监控能源使用情况。 | 邓强 钱静 Harald Bauer Mark Patel Jan Veira | 2015 | 信息化建设2015，0，1： | 2 |
| 8 | Changes in efficiency and resource utilization after increasing experience with double balloon enteroscopy显示文摘AIM:To investigate changes in efficiency and resource utilization as a single endoscopist's experience increased with each subsequent 100 double balloon enteroscopy(DBE) procedures.METHODS:We reviewed consecutive DBE procedures performed by a single endoscopist at our center over 4 years.DBE was employed when the clinician deemed the procedure was needed for disease management.The approach(oral,anal or both) was chosen based on suspected location of the target lesion.All DBE was performed in a standard endoscopy room with a portable fluoroscopy unit.Fluoroscopy was used to aid in shortening the small intestine and reducing bowel loops.For oral DBE,measurements were taken from the incisors.For anal DBE,measurements were taken from the anal verge.Enteroscopy continued until the target lesion was reached,until the entire small intestine was examined,or until no further progress was deemed possible.The length of small intestine examined(cm),procedure duration(min),and fluoroscopy time(s) were analyzed for sequential groups of 100 DBE.Sub-groups of diagnostic and therapeutic procedures were analyzed using multivariable linear regression.RESULTS:802 consecutive DBE procedures were analyzed.For oral DBE,median [interquartile range(IQR)] length of small bowel examined was 230.8 cm(range:210-248 cm) and for anal DBE was 143.5 cm(range:100-180 cm).No significant increase in length examined was noted for either the oral or anal approach with advancing position in series.In terms of duration of procedure,the median(IQR) for oral DBE was 86 min(range:71-105 min) and for anal DBE was 81.3 min(range:67-105 min).When comparing by the position in series,there was a significant(P value < 0.001) decrease in procedure duration for both upper and lower procedures with increasing experience.Median(IQR) time of exposure to fluoroscopy for oral DBE was 190 s(114-275) compared to anal DBE which was 196.4 s(312-128).This represented a significant(P value < 0.001) decrease in the amount of fluoroscopy used with increasing position in series.For both oral and anal DBE,fluoroscopy time was reduced by greater than 50% over the course of 802 total procedures performed.Sub-group analysis was conducted on therapeutic and diagnostic groups.Out of 802 procedures,a total of 434 were considered therapeutic.Argon plasma coagulation was by far the most common therapeutic intervention performed.There was no evidence of a difference in length examined or fluoroscopy exposure among oral DBE for diagnostic and therapeutic procedures,P = 0.91 and P = 0.32 respectively.The median(IQR) for length was 235 cm(range:178-280 cm) for diagnostic vs 230 cm(range:180-275 cm) for therapeutic procedures;additionally,fluoroscopy time median(IQR) was 180 s(range:110-295 s) and 162 s(range:102-263 s) for no intervention and intervention.However,there was a significant difference in procedure duration among oral DBE(P < 0.001).The median(IQR) was 80 min(range:60-97 min) and 94 min(range:77-110 min) for diagnostic and therapeutic interventions respectively.CONCLUSION:For a single endoscopist,increased DBE experience with number of performed procedures is associated with increased efficiency and decreased resource utilization. | Neal C Patel William C Palmer Kanwar R Gill David Cangemi Nancy Diehl Mark E Stark | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 2 |
| 9 | ACCF/ACR/AHA/NASCI/SCMR 2010 Expert Consensus Document on Cardiovascular Magnetic Resonance显示文摘 | W. Gregory Hundley David A. Bluemke J. Paul Finn Scott D. Flamm Mark A. Fogel Matthias G. Friedrich Vincent B. Ho Michael Jerosch-Herold Christopher M. Kramer Warren J. Manning Manesh Patel Gerald M. Pohost Arthur E. Stillman Richard D. White Pamela K. Wo | 2010 | Journal of the American College of Cardiology2010，，23： | 1 |
| 10 | Determinants of left ventricular mass and hypertrophy in hemodialysis patients assessed by cardiac magnetic resonance imaging显示文摘 | Patel R K Oliver S Mark P B | 2009 | Clin J Am Soc Nephrol2009，4，9： | 1 |
| 11 | Hepatic Artery Stenosis in Liver Transplant Recipients: Primary Treatment with Percutaneous Transluminal Angioplasty显示文摘 | Wael E.A. Saad Mark G. Davies Lawrence Sahler David E. Lee Nikhil C. Patel Takashi Kitanosono Talia Sasson David L. Waldman | 2005 | Journal of Vascular and Interventional Radiology2005，，6： | 1 |
| 12 | Standard dosing of tacrolimus leads to overexposure in pediatric renal transplantation recipients 显示文摘 | Kansman JY Patel B Marks SD | 2008 | Pediatr Transplant2008，12，3： | 1 |
| 13 | Polyethylene glycol (PEG) hydrogel dural sealant and collagen dural graft matrix in transsphenoidal pituitary surgery for prevention of postoperative cere- brospinal fluid leaks 显示文摘 | Clinton J Burkett Samip Patel Mark H Tabor | 2011 | Journal of Clinical Neuroscience2011，18，11： | 1 |
| 14 | Stable carbon isotope ratio analysis of Australian orange juices显示文摘 | Wayne A Simpkins Gordhan Patel Mark Harrison David Goldberg | 2000 | Food Chemistry2000，，3： | 1 |
| 15 | Closing gastroschisis: diagnosis, management, and outcomes显示文摘 | Chris Houben Mark Davenport Niyi Ade-Ajayi Nicki Flack Shailesh Patel | 2009 | Journal of Pediatric Surgery2009，，2： | 1 |
| 16 | Clinical Validation of a Next-Generation Sequencing Screen for Mutational Hotspots in 46 Cancer-Related Genes显示文摘 | Rajesh R. Singh Keyur P. Patel Mark J. Routbort Neelima Reddy Bedia Barkoh Brian Handal Rashmi Kanagal-Shamanna Wesley O. Greaves L. Jeffrey Medeiros Kenneth Aldape Rajyalakshmi Luthra | 2013 | The Journal of Molecular Diagnostics2013，，： | 1 |
| 17 | Intensity modulated radiation therapy with simultaneous integrated boost based dose escalation on neoadjuvant chemoradiation therapy for locally advanced distal esophageal adenocarcinoma显示文摘AIM:To evaluate impact of radiation therapy dose escalation through intensity modulated radiation therapy with simultaneous integrated boost(IMRT-SIB).METHODS:We retrospectively reviewed the patients who underwent four-dimensional-based IMRT-SIBbased neoadjuvant chemoradiation protocol.During the concurrent chemoradiation therapy,radiation therapy was through IMRT-SIB delivered in 28 consecutive daily fractions with total radiation doses of 56 Gy to tumor and 5040 Gy dose-painted to clinical tumor volume,with a regimen at the discretion of the treating medical oncologist.This was followed by surgical tumor resection.We analyzed pathological completion response(p CR) rates its relationship with overall survival and event-freesurvival.RESULTS:Seventeen patients underwent dose escalation with the IMRT-SIB protocol between 2007 and 2014 and their records were available for analysis.Among the IMRT-SIB-treated patients,the toxicity appeared mild,the most common side effects were grade 1-3 esophagitis(46%) and pneumonitis(11.7%).There were no cardiac events.The Ro resection rate was 94%(n = 16),the p CR rate was 47%(n = 8),and the postoperative morbidity was zero.There was one mediastinal failure found,one patient had local failure at the anastomosis site,and the majority of failures were distant in the lung or bone.The 3-year diseasefree survival and overall survival rates were 41%(n = 7) and 53%(n = 9),respectively.CONCLUSION:The dose escalation through IMRT-SIB in the chemoradiation regimen seems responsible for down-staging the distal esophageal with well-tolerated complications. | Ming Zeng Fernando N Aguila Taral Patel Mark Knapp XueQiang Zhu XiLin Chen Phillip D Price | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 1 |
| 18 | Fermenta- tion of sugar cane bagasse hemieellulose hydrolysate to L(+)-lactie acid by a thermotolerant acidophilic Bacillus sp显示文摘 | Milind Patel Mark Ou Ingrain L O | 2004 | Biotechnol Lett2004，26，11： | 1 |
| 19 | ACCF/ACR/AHA/NASCI/SCMR 2010 Expert Consensus Document on Cardiovascular Magnetic Resonance: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents显示文摘 | W. Gregory. Hundley David A. Bluemke J. Paul Finn Scott D. Flamm Mark A. Fogel Matthias G. Friedrich Vincent B. Ho Michael Jerosch-Herold Christopher M. Kramer Warren J. Manning Manesh Patel Gerald M. Pohost Arthur E. Stillman Richard D. White Pamela K. W | 2010 | Circulation2010，，22： | 1 |
| 20 | Pancreatic interstitial pH in human and feline chronic pancreatitis显示文摘 | Ameet G. Patel Mark T. Toyama Carlos Alvarez Thanh N. Nguyen Peter U. Reber Stanley W. Ashley Howard A. Reber | 1995 | Gastroenterology1995，，5： | 1 |
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