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| 1 | Pancreatic fistula after pancreatectomy:Evolving definitions,preventive strategies and modern management显示文摘Pancreatic resection is the treatment of choice for pancreatic malignancy and certain benign pancreatic disorders. However, pancreatic resection is technically a demanding procedure and whereas mortality after a pancreaticoduodenectomy is currently < 3%-5% in experienced high-volume centers, post-operative morbidity is considerable, about 30%-50%. At present, the single most significant cause of morbidity and mortality after pancreatectomy is the development of pancreatic leakage and fistula (PF). The occurrence of a PF increases the length of hospital stay and the cost of treatment, requires additional investigations and procedures, and can result in life-threatening complications. There is no universally accepted definition of PF that would allow standardized reporting and proper comparison of outcomes between different centers. However, early recognition of a PF and prompt institution of appropriate treatment is critical to the prevention of potentially devastating consequences. The present article, reviews the evolution of post resection pancreatic fistula as a concept, and discusses evolving definitions, the current preventive strategies and the management of this problem. | Shailesh V Shrikhande Melroy A D'Souza | 2008 | World Journal of Gastroenterology2008，14，38： | 26 |
| 2 | Rac1 regulates the release of Weibel-Palade Bodies in human aortic endothelial cells显示文摘Background The release of Weibel-Palade Bodies (WPB) is a form of endothelial cell activation But the signal transduction pathway leading to WPB release is not yet defined We hypothesized that small G-protein rac1 and reactive oxygen species (ROS) mediate the ligand induced release of Weibel-Palade Bodies Methods We tested this hypothesis by using wild-type and mutant adenoviral rac1 expression vectors, and by manipulating the production and destruction of superoxide and hydrogen peroxide in human aortic endothelial cells (HAEC) KH*2/5DResults Thrombin (1 0 Unit, 30 min) induced the increase of WPB release by 3 7-fold in HAEC, and that H 2O 2 (0 1 mmol/L, 30 min) induced by 4 5-fold These results correlated with thrombin-stimulated activation of rac-GTP binding activity by 3 5-fold, and increase of ROS production by 3 4-fold The dominant negative adenoviral rac-N17 gene transfer dramatically inhibited the release of WPB by 64 2% (control) and 77 3% (thrombin-stimulation), and decreased ROS production by 65 5% (control) and 83 6% (thrombin-stimulation) compared with non-infected cells, respectively Anti-oxidants, catalase and N-acetyl-cysteine significantly decreased the release of WPB by 34% and 79% in control cells, and further decreased by 63 6% and 46 7% in rac-N17 transferred cells compared with non-infected cells We also confirmed that rac1 was located upstream of ROS in the WPB release pathway KH*2/5DConclusions Small G-protein rac1 medicates ligand-induced release of Weibel-Palade Bodies in human aortic endothelial cells, and the signal pathway of WPB release is a rac1-dependent ROS regulating | 杨水祥 闫娟 Shailesh S.Deshpande Kaikobad Irani Charles J.Lowenstein | 2004 | Chinese Medical Journal2004，，8： | 6 |
| 3 | Soil quality assessment across different stands in tropical moist deciduous forests of Nagaland,India显示文摘To analyze the relationship between the management of three forest stand plantations and soil quality in the Dimapur district of the Northeastern Himalayan region,India,three forest soil profiles,covered by different species stands,at three depths were tested for 13 physical and chemical variables.Only four of these variables(electric conductivity,bulk density exchangeable Mg and available P)were included in a minimum data set,after using a varimax rotation algorithm in a principal component analysis,and subsequently used to calculate a soil quality index(SQI).Results showed higher SQIs in the surface layers(0–20 cm depth)than in the deeper ones.Average weighed SQI varied significantly(P<0.05)through the three considered forest sites,with the lowest value at site FS3.These findings reveal that the approach used here is suitable for preliminary screening of the impact of a forestry species on soil,to aid in species selection and improve soil health for afforestation and reforestation projects. | Gaurav Mishra Rossana Marzaioli Krishna Giri Shailesh Pandey | 2019 | Journal of Forestry Research2019，30，4： | 5 |
| 4 | Emulsification of Indian heavy crude oil using a novel surfactant for pipeline transportation显示文摘The most economical way to overcome flow assurance problems associated with transportation of heavy crude oil through offshore pipelines is by emulsifying it with water in the presence of a suitable surfactant.In this research,a novel surfactant,tri-triethanolamine monosunflower ester,was synthesized in the laboratory by extracting fatty acids present in sunflower(Helianthus annuus)oil.Synthesized surfactant was used to prepare oil-in-water emulsions of a heavy crude oil from the western oil field of India.After emulsification,a dramatic decrease in pour point as well as viscosity was observed.All the prepared emulsions were found to be flowing even at 1°C.The emulsion developed with 60%oil content and 2wt%surfactant showed a decrease in viscosity of 96%.The stability of the emulsion was investigated at different temperatures,and it was found to be highly stable.The effectiveness of surfactant in emulsifying the heavy oil in water was investigated by measuring the equilibrium interfacial tension(IFT)between the crude oil(diluted)and the aqueous phase along with zeta potential of emulsions.2wt%surfactant decreased IFT by almost nine times that of no surfactant.These results suggested that the synthesized surfactant may be used to prepare a stable oil-in-water emulsion for its transportation through offshore pipelines efficiently. | Shailesh Kumar Vikas Mahto | 2017 | Petroleum Science2017，14，2： | 5 |
| 5 | Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification显示文摘Heterotopic ossification(HO)is a debilitating condition characterized by the pathologic formation of ectopic bone.HO occurs commonly following orthopedic surgeries,burns,and neurologic injuries.While surgical excision may provide palliation,the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone.Based on these clinical observations,we set out to examine the role of vascular signaling in HO.Vascular endothelial growth factor A(VEGFA)has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis.Our findings,using a validated mouse model of HO,demonstrate that HO lesions are highly vascular,and that VEGFA is critical to ectopic bone formation,despite lacking a contribution of endothelial cells within the developing anlagen. | Charles Hwang Simone Marini Amanda KHuber David MStepien Michael Sorkin Shawn Loder Chase APagani John Li Noelle DVisser Kaetlin Vasquez Mohamed AGarada Shuli Li Jiajia Xu Ching-Yun Hsu Paul BYu Aaron WJames Yuji Mishina Shailesh Agarwal Jun Li Benjamin Levi | 2019 | Bone Research2019，7，4： | 4 |
| 6 | Concurrent removal of intravitreal lens fragments after phacoemulsification with pars plana vitrectomy prevents development of retinal detachment显示文摘AIM: To evaluate the outcomes of 'concurrent vitrectomy' to retrieve dislocated lens fragment during phacoemulsification.METHODS: In a retrospective, observational case series, data of patients who underwent 'concurrent' pars plana vitrectomy(PPV) for dislocated lens fragments between the period 2000 and 2008 were reviewed. Data collected included patient demographics, pre-operative visual acuity, intra-operative occurrence of retinal breaks, duration of follow up, post-operative intraocular pressure, final best-corrected visual acuity(BCVA),presence of cystoid macular edema(CME) and occurrence of rhegmatogenous retinal detachment(RRD).· RESULTS: A total of 58 eyes of 58 patients were included in the study. At 12 mo the mean postoperative BCVA was log MAR 0.17(20/30) with a range of log MAR0 to 0.69(20/20 to 20/100), with 96.6%(56/58) of patients showing post- operative improvement in visual acuity(P =0.005). None of the patients developed postoperative retinal detachment, endophthalmitis or non-resolving uveitis at 12 mo.CONCLUSION: Our study results suggest concurrent PPV for retained lens fragments after cataract surgery is beneficial and may decrease the risk of glaucoma and prevent development of RRD. | Kakarla V Chalam Ravi K Murthy Joshua C Priluck Vijay Khetpal Shailesh K Gupta | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 4 |
| 7 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 8 | Potential groundwater recharge zones within New Zealand显示文摘Water resources in New Zealand are not evenly distributed across the country which makes it difficult to adequately allocate the use of water resources in every basin. Groundwater is a fundamental water resource in New Zealand for agricultural, industrial and domestic use. Detailed knowledge regarding groundwater recharge potential is a pre-requisite for sustainable groundwater management, including the assessment of its vulnerability to contamination by pollutants. In this study, a comprehensive GIS approach was used to map the potential groundwater recharge zones across New Zealand. National data sets of lithology, slope, aspect, land use, soil drainage and drainage density were converted to raster data sets with a spatial resolution of 500 m x 500 m and superimposed to derive groundwater potential zones. The resultant maps demonstrate that the potential is low in urban and mountainous areas, such as the Southern Alps, whereas the highest potential can be found in regions with large lakes and in the lower elevation plains areas, where Quaternary sediments prevail. The resulting maps can be used to identify areas of high nutrient leaching in zones where high groundwater recharge potential exists. | Shailesh Kumar Singh Malte Zeddies Ude Shankar George A.Griffiths | 2019 | Geoscience Frontiers2019，10，3： | 3 |
| 9 | Is laparoscopic colorectal cancer surgery equal to open surgery? An evidence based perspective显示文摘Laparoscopic colorectal surgery(LCS) is an evolving subject.Recent studies show that LCS can not only offer safe surgery but evidence is growing that this new technique can be superior to classical open procedures.Fewer perioperative complications and faster postoperative recovery are regularly mentioned when studies of LCS are presented.Even though the learning curve of LCS is frequently debated when limitations of laparoscopic surgeries are reviewed,studies show that in experienced hands LCS can be a safe procedure for colorectal cancer treatment.The learning curve however,is associated with high conversion rates and economical aspects such as higher costs and prolonged hospital stay.Nevertheless,laparoscopic colorectal cancer surgery(LCCR) offers several advantages such as less co-morbidity and less postoperative pain in comparison with open procedures.Furthermore,the good exposure of the pelvic cavity by laparoscopy and the magnification of anatomical structures seem to facilitate pelvic dissection laparoscopically.Moreover,recent studies describe no difference in safety and oncological radicalness in LCCR compared to the open total mesorectal excision(TME).The oncological adequacy of LCCR still remains unproven today,because long-term results do not yet exist.To date,only a few studies have described the results of laparoscopic TME combined with preoperative adjuvant treatment for colorectal cancer.The aim of this review is to examine the various areas of development and controversy of LCCR in comparison to the conventional open approach. | Beat M Künzli Helmut Friess Shailesh V Shrikhande | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 3 |
| 10 | Genetic Diversity and Population Structure in Landraces and Improved Rice Varieties from India显示文摘A set of 50 rice genotypes comprising landraces, local selections, and improved varieties were characterized using simple sequence repeat(SSR) and inter simple sequence repeat(ISSR) markers to study genetic diversity and population structure. Following unweighted pair group method with arithmetic mean based clustering using binary data of polymorphic markers, the genotypes were grouped into 5 clusters and 11 sub-clusters, whereas population structure analysis separated 50 rice genotypes into 5 sub-populations. Grouping of rice genotypes showed better resemblance with the pedigree information of the genotypes. Both genetic diversity and population structure analysis separated majority of the improved varieties from landraces and local selections. Some of the SSR markers amplified unique alleles which were specific to a particular genotype and could distinguish them from the rest. The results indicate that these rice genotypes exhibit a higher genetic diversity and can be very useful in rice improvement program. | Shailesh D.KUMBHAR Pawan L.KULWAL Jagannath V.PATIL Chandrakant D.SARAWATE Anil P.GAIKWAD Ashok S.JADHAV | 2015 | Rice science2015，22，3： | 3 |
| 11 | Microstructural stability and mechanical properties of a new nickel-based superalloy显示文摘 | Shuangqun Zhao Xishan Xie Gaylord D. Smith Shailesh J. Patel | 2003 | Materials Science & Engineering A2003，，1： | 3 |
| 12 | Extended pancreatic resections and lymphadenectomy:An appraisal of the current evidence显示文摘Surgery remains the mainstay of treatment for pancreatic ductal adenocarcinoma and complete removal of the cancer confers a definite survival advantage,especially in early disease.However,the majority of patients do not present with early disease,thus precluding the chance of a cure by standard pancreatoduodenectomy(PD),distal pancreatectomy or total pancreatectomy.For this reason,pancreatic surgeons have attempted to push the limits of resection over the last three decades.The aim of these resections has been to determine whether obtaining a complete resection by extending the limits of conventional resection in patients with advanced disease will yield the results seen with PD alone in early disease.This article revisits the data from such studies in an attempt to determine if the available literature supports the performance of extended resections for pancreatic cancer in terms of improvement of survival. | Shailesh V Shrikhande Savio G Barreto | 2010 | World Journal of Gastrointestinal Surgery2010，2，2： | 2 |
| 13 | The corrosion of INCONEL alloy 740 in simulated environments for pulverized coal-fired boiler显示文摘 | Shuangqun Zhao Xishan Xie Gaylord D. Smith Shailesh J. Patel | 2004 | Materials Chemistry and Physics2004，，2： | 2 |
| 14 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 15 | Pancreatic Resection for M1 Pancreatic Ductal Adenocarcinoma显示文摘 | Shailesh V. Shrikhande MD J?rg Kleeff MD Carolin Reiser MD Jürgen Weitz MD Ulf Hinz MSc Irene Esposito MD Jan Schmidt MD Helmut Friess MD Markus W. Büchler MD | 2007 | Annals of Surgical Oncology2007，，1： | 2 |
| 16 | 有胰 divisum 的 Choledochocele : 在磁性的回声 cholangiopancreatography 上诊断的稀罕同现显示文摘 We report a case of a 42-year-old male with symptomatic choledochocele and incidental pancreas divisum diagnosed with magnetic resonance cholangiopancreatography (MRCP). Small choledochocele is rare congenital malformation associated with non-specific symptoms and a delay in diagnosis. The coexistence of choledochocele and pancreas divisum is extremely rare with only two case reports published in literature. In both cases MRCP failed to diagnose any biliary or pancreatic abnormality. This case suggests that the patients with recurrent abdominal pain and pancreas divisum should not be presumed to be suffering from pancreatitis. Careful evaluated for additional anomalies in the biliary tree should be sought for refractory symptoms. MRCP is a useful one-stop-shop for diagnosing pancreatic and biliary ductal anomalies. | Yashwant Patidar Nitesh Agarwal Shailesh Gupta Ankur Arora Amar Mukund S Rajesh | 2013 | World Journal of Radiology2013，5，7： | 2 |
| 17 | Evolution of pancreatoduodenectomy in a tertiary cancer center in India: Improved results from service reconfiguration显示文摘 | Shailesh V. Shrikhande Savio George Barreto B.A. Somashekar Kunal Suradkar Guruprasad S. Shetty Sanjay Talole Bhawna Sirohi Mahesh Goel Parul J. Shukla | 2013 | Pancreatology2013，，1： | 2 |
| 18 | Surgery for gallbladder cancer:The need to generate greater evidence显示文摘The outcomes for gallbladder cancer remain largely dismal to this day.Overall,the low incidence of gallbladder cancer around the world coupled with an even lower number of patients amenable to surgery at the time of presentation,has precluded the generation of evidence-based guidelines for the management of this cancer.However,while the incidence of the cancer may be decreasing in some parts of the world,in other countries such as India,Japan and Chile,gallbladder cancer continues to affect a sizeable population of patients.As such,there is a growing need to define what constitutes an adequate surgery for each stage of this cancer,based on sound evidence.This editorial provides a broad overview of the existing problems in the management of gallbladder cancer and appeals for multi-institutional studies aimed at answering some of the pertinent questions on the surgical management of gallbladder cancer. | Shailesh V Shrikhande Savio G Barreto | 2009 | World Journal of Gastrointestinal Surgery2009，1，1： | 2 |
| 19 | Oxidation of propane to acrylic acid and acetic acid over alkaline earth-doped Mo-V-Sb-O_x catalysts显示文摘Alkaline earth metal (Mg,Ca,Sr and Ba)-doped Mo-V-Sb-O x catalysts,prepared by a dry-up method,have been investigated for their catalytic performance in the oxidation of propane under different reaction conditions.The catalysts have been characterized by N2 adsorption-desorption,temperature-programmed desorption (TPD) of NH3,SEM and XRD.Influence of water vapor on the catalytic performance,particularly on the selectivities to acetic acid and acrylic acid,has also been studied.The selectivity to acrylic acid was improved significantly by the doping of alkaline earth metals to Mo-V-Sb-O x catalysts.The surface acidic sites of the catalyst decreased with the doping of the catalyst with alkaline earth metals,which ultimately was found to be beneficial for obtaining high selectivity to acrylic acid.The catalytic activity and product selectivities were found to be influenced by the reaction temperature,C3H8/O2 ratio and space velocity.A significant improvement in the selectivity to acrylic acid has also been observed by the addition of water vapor in the feed of propane and oxygen in the oxidation of propane. | Chandan S.Chaudhari Shailesh S.Sable Hanumant Gurav Ashutosh A.Kelkar Vilas H.Rane | 2010 | Journal of Natural Gas Chemistry2010，19，6： | 2 |
| 20 | Plant profile,phytochemistry and pharmacology of Cordia dichotoma(Indian cherry):A review显示文摘More than half of the world's population relies on the traditional medicine and major role of the traditional medicine including the use of plant extract and their active constituents.Among them,Cordia dichotoma Forst.,a small to moderate size plant of family Boragenaceae.commonly called bhokar,lasura,gonda,Indian cherry and shlesmataka.Plant parts such as leaves,fruit,bark and seed have been reported for possessing antidiabetic,antiulcer,anti-inflammatory,immune-modulator and analgesic activity.Screening of fruit,leaves and seed shows the presence of pyrrolizidine alkaloids,coumarins,flavonoids,saponins,lerpenes and sterols.Present review focuses on details of geographical distribution,physicochemical parameters,phytoconstituents and pharmacological properties of Cordia dichotoma reported so far. | Prasad G.Jamkhande Sonal R.Barde Shailesh L.Patwekar Priti S.Tidke | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，12： | 2 |
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