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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Direct laser writing of volumetric gradient index lenses and waveguides显示文摘Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer precision.However,these printed structures are limited to the refractive index and dispersive properties of the photopolymer.Here,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica scaffolds.Adjusting the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic dispersion.Combining SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible wavelengths.SCRIBE’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing sequences.SCRIBE also has the potential to form multicomponent optics by cascading optical elements within a scaffold.As a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous silicon.Finally,an all-pass ring resonator was coupled to a subsurface 3D waveguide.The measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple planes.SCRIBE is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports. | Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.Perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 3 | Kidney Transplantation for Primary Focal Segmental Glomerulosclerosis: Outcomes and Response to Therapy for Recurrence显示文摘 | LaTonya J. Hickson Manish Gera Hatem Amer Corey W. Iqbal Therese B. Moore Dawn S. Milliner Fernando G. Cosio Timothy S. Larson Mark D. Stegall Michael B. Ishitani James M. Gloor Matthew D. Griffin | 2009 | Transplantation2009，，8： | 1 |
| 4 | Reduced Endoglin Activity Limits Cardiac Fibrosis and Improves Survival in Heart Failure显示文摘 | Navin K. Kapur Szuhuei Wilson Adil A. Yunis Xiaoying Qiao Emily Mackey Vikram Paruchuri Corey Baker Mark J. Aronovitz S. Ananth Karumanchi Michelle Letarte David A. Kass Michael E. Mendelsohn Richard H. Karas | | Circulation0，，： | 1 |
| 5 | Colonoscopic Splenic Injuries: Incidence and Management显示文摘 | Ashwin S. Kamath Corey W. Iqbal Michael G. Sarr Daniel C. Cullinane Scott P. Zietlow David R. Farley Mark D. Sawyer | 2009 | Journal of Gastrointestinal Surgery2009，，12： | 1 |
| 6 | Impact of Herpes Simplex Virus Type 2 on HIV-1 Acquisition and Progression in an HIV Vaccine Trial (the Step Study)显示文摘 | Ruanne V Barnabas Judith N Wasserheit Yunda Huang Holly Janes Rhoda Morrow Jonathan Fuchs Karen E Mark Martin Casapia Devan V Mehrotra Susan P Buchbinder Lawrence Corey | 2011 | JAIDS Journal of Acquired Immune Deficiency Syndromes2011，，： | 1 |
| 7 | Stability and anti-glycation properties of intermediate moisture apple products fortified with green tea显示文摘 | Vera Lavelli a Mark Corey Takako Yokozawa | 2011 | Food Chemistry2011，127，： | 1 |
| 8 | Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial显示文摘 | J Brooks Jackson Philippa Musoke Thomas Fleming Laura A Guay Danstan Bagenda Melissa Allen Clemensia Nakabiito Joseph Sherman Paul Bakaki Maxensia Owor Constance Ducar Martina Deseyve Anthony Mwatha Lynda Emel Corey Duefield Mark Mirochnick Mary Glenn Fow | 2003 | The Lancet2003，，9387： | 1 |
| 9 | Esophagogastroduodenoscopy-associated gastrointestinal perforations: A single-center experience显示文摘 | Amit Merchea Daniel C. Cullinane Mark D. Sawyer Corey W. Iqbal Todd H. Baron Dennis Wigle Michael G. Sarr Martin D. Zielinski | 2010 | Surgery2010，，4： | 1 |
| 10 | Case man:a case man- agement tool for CFD applications 显示文摘 | ALAN S COREY S MARK D | 2006 | Aerospace Testing Alliance2006，，2356： | 1 |
| 11 | intelligent feature Selection tech- niques for pattern classification of lamb wave signals显示文摘 | Hinders Mark K Miller Corey A | 2014 | AIP confer- ence proceedings2014，1581，1： | 1 |
| 12 | A Mechanistically designed mono-cinchna alkaloid is an excellent catalyst for the enantioselective dihydroxylation of olefins显示文摘 | COREY E J MARK C GROGAN M J | 1994 | Tetrahedron Lett1994，35，35： | 1 |
| 13 | Acute Kidney Injury After Cardiac Surgery: Focus on Modifiable Risk Factors显示文摘 | Keyvan Karkouti Duminda N. Wijeysundera Terrence M. Yau Jeannie L. Callum Davy C. Cheng Mark Crowther Jean-Yves Dupuis Stephen E. Fremes Blaine Kent Claude Laflamme Andre Lamy Jean-Francois Legare C David Mazer Stuart A. McCluskey Fraser D. Rubens Corey S | 2009 | Circulation2009，，4： | 1 |
| 14 | Role of arthropod communities in bioenergy crop litter decomposition显示文摘期望发生相遇的广泛的陆地使用变换为 bioenergy 化工物品要求生产将多半在 agroecosystem 生物多样性和生态系统服务上有普遍影响,包括碳隐遁。尽管节肢动物 detritivores 被知道贡献崽分解,因此,在许多骑车的能量流动和营养素种社区,他们在 bioenergy 化工物品社区的重要性还没被估计了。我们拿了确定的试验性的研究崽团损失并且在三 bioenergy 化工物品 cropsmiscanthus (错误眼角 x giganteus ) 的当面的滋养的骑车和这些有机体的缺席的率, switchgrass (Panicum virgatum ) ,和一个种的大草原社区。全面节肢动物丰富和崽分解率在所有三个社区是类似的。尽管有在经由杀虫药剂申请的试验性的阴谋的节肢动物的有效减小,崽分解率,沥滤的无机的氮,和 carbonnitrogen 比率没在控制之间显著地不同(与节肢动物) 并且处理(没有节肢动物) 在任何三种社区类型的阴谋。我们的调查结果建议在动物区系的作文与 bioenergy 化工物品庄稼的普遍采纳联系了的节肢动物的变化不能与深刻地改变的调停节肢动物的崽分解和滋养的版本被联系。 | Arthur R. Zangerl Saber Miresmailli Paul Nabity Allen Lawrance Alan Yanahan Corey A. Mitchell Kristina J. Anderson-Teixeira Mark B. David May R. Berenbaum Evan H. DeLucia | 2013 | Insect Science2013，20，5： | 0 |
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